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| 1 | Efficacy and safety of Xinfeng capsule in patients with rheumatoid arthritis:a multi-center parallel-group double-blind randomized controlled trial显示文摘OBJECTIVE:To evaluate the efficacy and safety of Xinfeng capsule in patients suffering rheumatoid arthritis(RA).METHODS:A multi-center parallel-group designed,double-blind,randomized,controlled trial was conducted.Totally 304 RA patients were assigned to two groups:one group was administered Xinfeng capsule(XFC) plus the placebo of leflunomide and the other given leflunomide(LEF) plus the placebo of XFC for twelve weeks.The clinical and laboratory parameters were compared at baseline and fourth,eighth,and twelfth weeks.RESULTS:After twelve-week treatment,patients in two groups all showed some trend of effectiveness when compared in terms of American Rheumatism Association(ACR) recommended 20%,50%,70%improvement criteria,but it was insignificant.The validity in ameliorate modified disease activity score(DAS28) and laboratory indexes as erythrocyte sedimentation rate(ESR),C-reactive protein(CRP),rheumatoid factor(RF) were also found no difference.The score of health assessment questionnaire(HAQ),self-rating anxiety scale(SAS),self-rating depression scale(SDS) and quality of life questionnaire with rheumatoid arthritis(RAQOL)both lower than the first week and the changes showed no difference.However,the score of SDS dropped more in XFC group than in the other.A total of 147 adverse reaction cases were reported,which shows no difference between the two groups.The most common adverse reactions were hepatic impairment,anemia,leukocytopenia,epigastric discomfort and phalacrosis.CONCLUSION:XFC demonstrated better improvement in the scores of SDS and compared with those of LEF group. | Liu Jian Wang Yuan Huang Chuanbing Xu Jianhua Li Zhijun Xu Liang He Liyun Sun Yue Wang Yali Xu Shengqian Zhao Ping Mao Tongjun Tan Bin Zhu Fubing Zhang Pingheng Fang Li | 2015 | Journal of Traditional Chinese Medicine2015，35，5： | 27 |
| 2 | Effects of Xinfeng capsule on pulmonary function based on treg-mediated notch pathway in a rat model of adjuvant arthritis显示文摘OBJECTIVE:To observe the impact of xinfeng xapsule(XFC) on pulmonary function in a rat model of adjuvant arthritis(AA) and to investigate the mechanism of action.METHODS:Forty rats were randomly divided into four groups of ten:normal control(NC);model control(MC);tripterygium glycosides tablet(TPT);and xinfeng capsule(XFC).Except for the NC group,AA was induced in all rats by intracutaneous injection of 0.1 mL Freund's complete adjuvant in the right paw on the 19th day.NC and MC groups were given(0.9%) physiological saline.The TPT and XFC groups were given TPT(10 mg/kg) and XFC(1.2 g/kg),respectively.Thirty days after administration,changes in paw edema(E),the arthritis index(AI),pulmonary function,levels of regulatory T-cells(Treg),ultrastructure of lung tissue,and expression of Notch receptors and ligands in lung tissue were observed.RESULTS:In the MC group,E and the AI were increased and pulmonary function significantly decreased;the structure of alveolar type-II cells was damaged;ratios of Treg in peripheral blood were reduced;and expression of Notch receptors such as Notch3 and Notch4 and ligands such as Delta1 in lung tissue were significantly increased whereas expression of Notch1,Jagged1 and Jagged2 were significantly decreased.After intervention with XFC,E and the AI were decreased;pulmonary function was enhanced;the structure of alveolar type-II cells was improved;and expression of Treg,Notch1,Jagged1,Jagged2 was elevated,whereas that of Notch3,Notch4 and Delta1 was reduced.CONCLUSION:XFC can not only inhibit E and the AI and improve joint symptoms,it can also improve pulmonary function and reduce inflammation in lung tissue.These actions could be carried out through increases in the expression of Treg,Notch receptors(Notch1) and ligands(Jagged1,Jagged2),and reductions in the expression of Notch3,Notch4 and Delta1.These phenomena would reduce the deposition of immune complexes and the inflammatory response in lung tissue,thereby improving joint symptoms and pulmonary function. | Lei Wan Jian Liu Chuanbing Huang Yuan Wang Xi Shen Wandong Zhang Guizheng Wang Haixia Fan Yao Ge Ruilian Chen Yunxiang Cao Ruikai Zong Li Lei | 2012 | Journal of Traditional Chinese Medicine2012，32，3： | 17 |
| 3 | Different properties of GaN-based LED grown on Si(111) and transferred onto new substrate显示文摘InGaN MQW LEDs, grown by metal-organic chemical vapor deposition (MOCVD) on Si(111) substrates, were successfully bonded and transferred onto new Si substrate. After chemical etching Si(111) substrate and inductively coupled plasma (ICP) etching the transferred LED film to Si-doped layer, a vertical structure GaN blue LEDs were then fabricated. The characteristics of the lateral structure LED (grown on Si) and the vertical structure LED (bonded on Si) were investigated. It shows the performance of ver- tical structure LEDs had obviously been improved compared to the lateral structure LEDs and the tensile stress in GaN layer of vertical structure LEDs is smaller than that in lateral structure LEDs. | XIONG Chuanbing JIANG Fengyi FANG Wenqing WANG Li LIU Hechu MO Chunnan | 2006 | Science China(Technological Sciences)2006，49，3： | 12 |
| 4 | Effect of Xinfeng capsule on pulmonary function in a adjuvant arthritis rat model显示文摘OBjECTIVE:To observe the relationship between reduced pulmonary function and regulatory T cells(Tregs)and helper T cells(Th)1/Th2 drift in a rat model of adjuvant arthritis(AA),and to study the impact of Xinfeng capsule(XFC)on pulmonary function and investigate the mechanism of action.METHODS:Forty rats were randomly divided into normal control group(NC),model control group(MC),Tripterygium glycosides tablet group(TPT),and XFC group,with 10 in each.Except for the NCgroup,AA was induced in all rats by intracutaneous injection of 0.1 mL Freund's complete adjuvant in the right paw.On the 19th day after modeling,the NC and MC groups were given physiological saline(0.9%),while the TPT and XFC groups were given TPT(10 mg/kg)and XFC(2.4 g/kg),once daily,respectively.Thirty days after administration,changes in paw swelling,arthritis index(AI),pulmonary function,levels of serumγ-interferon(IFN-γ)and interleukin(IL)-4,Tregs in peripheral blood,and IFN-γ,IL-4,Forkhead box transcription factor 3(FoxP3)in lung tissue were observed by enzyme-linked immunosorbent assay,flow cytometry,polymerase chain reaction,and western blot.RESULTS:Compared with the NC group,paw swelling,AI,IFN-γ,and Th1/Th2 were increased,and pulmonary function parameters,IL-4,FoxP3 were decreased significantly in the MC group(P<0.05 or P<0.01).Pulmonary function parameters,Treg,IL-4,FoxP3(and mRNA)were higher,and paw swelling,AI,and IFN-γ(and mRNA)were lower in the XFC group than those in the MC group.The XFC group was also much better than theTPT group in improving pulmonary function,FoxP3 mRNA,IFN-γ,IL-4,Th1/Th2,and IL-10(P<0.05 or P<0.01).CONCLUSION:Xinfeng capsule can improve pulmonary function by regulating the levels of Tregs,inhibiting the activation of Th1 to Th2 cells,inducing drift,maintaining cell immune suppression,correcting the imbalance of Th1/Th2,and reducing inflammatory mediators. | Lei Wan Jian Liu Chuanbing Huang Yuan Wang Li Zheng | 2014 | Journal of Traditional Chinese Medicine2014，34，1： | 5 |
| 5 | Recent Advances in Design Strategies and Multifunctionality of Flexible Electromagnetic Interference Shielding Materials显示文摘With rapid development of 5G communication technologies,electromagnetic interference(EMI)shielding for electronic devices has become an urgent demand in recent years,where the development of corresponding EMI shielding materials against detrimental electromagnetic radiation plays an essential role.Meanwhile,the EMI shielding materials with high flexibility and functional integrity are highly demanded for emerging shielding applications.Hitherto,a variety of flexible EMI shielding materials with lightweight and multifunctionalities have been developed.In this review,we not only introduce the recent development of flexible EMI shielding materials,but also elaborate the EMI shielding mechanisms and the index for'green EMI shielding'performance.In addition,the construction strategies for sophisticated multifunctionalities of flexible shielding materials are summarized.Finally,we propose several possible research directions for flexible EMI shielding materials in near future,which could be inspirational to the fast-growing next-generation flexible electronic devices with reliable and multipurpose protections as offered by EMI shielding materials. | Junye Cheng Chuanbing Li Yingfei Xiong Huibin Zhang Hassan Raza Sana Ullah Jinyi Wu Guangping Zheng Qi Cao Deqing Zhang Qingbin Zheng Renchao Che | 2022 | Nano-Micro Letters2022，14，5： | 5 |
| 6 | Overview of the Solar Polar Orbit Telescope Project for Space Weather Mission显示文摘The Solar Polar ORbit Telescope(SPORT) project for space weather mission has been under intensive scientific and engineering background studies since it was incorporated into the Chinese Space Science Strategic Pioneer Project in 2011.SPORT is designed to carry a suite of remote-sensing and in-situ instruments to observe Coronal Mass Ejections(CMEs),energetic particles,solar high-latitude magnetism,and the fast solar wind from a polar orbit around the Sun.The first extended view of the polar regions of the Sun and the ecliptic enabled by SPORT will provide a unique opportunity to study CME propagation through the inner heliosphere,and the solar high-latitude magnetism giving rise to eruptions and the fast solar wind.Coordinated observations between SPORT and other spaceborne/ground-based facilities within the International Living With a Star(ILWS) framework can significantly enhance scientific output.SPORT is now competing for official selection and implementation during China's 13 th Five-Year Plan period of 2016-2020. | XIONG Ming LIU Ying LIU Hao LI Baoquan ZHENG Jianhua ZHANG Cheng XIA Lidong ZHANG Hongxin RAO Wei CHEN Changya SUN Weiying WU Xia DENG Yuanyong HE Han JIANG Bo WANG Yuming WANG Chuanbing SHEN Chenglong ZHANG Haiying ZHANG Shenyi YANG Xuan SANG Peng WU Ji | 2016 | 空间科学学报2016，36，3： | 3 |
| 7 | Preparation and wear performance of NiCr/Cr 3 C 2 –NiCr/hBN plasma sprayed composite coating显示文摘 | Lingzhong Du Chuanbing Huang Weigang Zhang Tiegang Li Wei Liu | 2011 | Surface & Coatings Technology2011，，12： | 2 |
| 8 | ZNF411, a novel KRAB-containing zinc-finger protein, suppresses MAP kinase signaling pathway显示文摘 | Hui Liu Chuanbing Zhu Jian Luo Yuequn Wang Dali Li Yongqing Li Junmei Zhou Wuzhou Yuan Ying Ou Mingyao Liu Xiushan Wu | 2004 | Biochemical and Biophysical Research Communications2004，，1： | 1 |
| 9 | Research Progress of Electromagnetic Properties of MgB2 Induced by Carbon-Containing Materials Addition and Process Techniques显示文摘For the high transition temperature(Tc) and low cost taking both raw materials and fabrication process into account,MgB2 has been a competitive candidate to replace the conventional NiTi superconductor for high-temperature application in fault current limiters,transformers,motors,magnetic resonance imaging,adiabatic demagnetization refrigerators,generators,etc.The carbon-containing materials addition induced high critical current density(Jc) is reviewed based on their influences on the upper critical field(Hc2),flux pinning force,and connectivity.The doping effects were compared in the overview focusing on SiC,organic dopants,and graphene-related dopants.SiC doping is featured for the high-field critical current density,which is caused by the increased Hc2 attributed to the substitution of carbon on boron site and the strong flux pinning force offered by the nanosized secondary phases in the MgB2 matrix.Organic dopants have the advantage over SiC dopant for their relatively homogeneous distribution in the MgB2 matrix based on wet mixing of the organics and the raw boron powders.Low doping level of two-dimensional materials can improve the superconducting properties in all measured fields because of the combined advantages of carbon substitution effect and grain connectivity.MgB2 fabricated with carbon-encapsulated boron also introduces strong flux pinning centers in MgB2,which show weak destruction of the connectivity of the MgB2 grains as reflected by the low-magnetic-supercurrent behavior.High-pressure treatment and diffusion method can fabricate highdensity MgB2 superconductors with better connectivity and increase the Jc compared with the in situ and ex situ methods. | Jiancheng Li Haobo Liu Ying Li Chuanbing Cai Shixue Dou Wenxian Li | 2020 | Acta Metallurgica Sinica(English Letters)2020，33，4： | 1 |
| 10 | A novel six-transmembrane protein hhole functions as a suppressor in MAPK signaling pathways显示文摘 | Junmei Zhou Yongqing Li Pei Liang Wuzhou Yuan Xiangli Ye Chuanbing Zhu Yingduan Cheng Yuequn Wang Guan Li Xiushan Wu Mingyao Liu | 2005 | Biochemical and Biophysical Research Communications2005，，2： | 1 |
| 11 | ZNF418, a novel human KRAB/C2H2 zinc finger protein, suppresses MAPK signaling pathway显示文摘 | Yongqing Li Dan Yang Yan Bai Xiaoyang Mo Wen Huang Wuzhou Yuan Zhaochu Yin Yun Deng Oleg Murashko Yuequn Wang Xiongwei Fan Chuanbing Zhu Karen Ocorr Rolf Bodmer Xiushan Wu | 2008 | Molecular and Cellular Biochemistry (-)2008，，1： | 1 |
| 12 | The potential of carcinoembryonic antigen,p53,Ki-67 and glutathion Stransferase-π as clinico-histopathological markers for colorectal cancer显示文摘Objective:Colorectal cancer is one of the major contributors to cancer death worldwide.Lack of reliable colorectal cancer markers has hampered the management of these cancer patients.Our main purpose was to study the correlation between histopathological variables of colorectal adenocarcinomas and identify histopathological markers that are of prognostic value in patients with colorectal cancer.Methods:In the present study,we examined the expression of carcinoembryonic antigen(CEA),p53,Ki-67 and glutathion Stransferase(GST)-πby using immunohistochemical staining methods in 126 colorectal carcinoma patients and evaluated the lymph node metastasis status in these patients by histopathological examination.Results:The positive rates of CEA,p53, Ki-67 and GST-πexpression in the colorectal cancer tissue specimens examined were 95.23%,55.56%,53.38% and 82.30%,respectively.Expression of p53 and Ki-67 was significantly correlated with the Dukes stages of the tumor,with higher levels of these proteins in Dukes'C and D tumors than those in Dukes'A and B tumors. Furthermore,the expression of p53,GST-πand Ki-67 correlated with prognosis of patients with colorectal cancer. Additionally,the expression of p53 in colorectal cancer was closely related to the expression of Ki-67 and the expression of GST-πwas directly correlated with that of p53.Conclusion:The expression of CEA,p53,Ki-67 and GST-πwas correlated with various clinical features of patients with colorectal cancer.The combined use of these histopathological markers appeared to be a promising tool in predicting the prognosis of patients with this type of cancer. | Zhenyu He Chuanbing Shi Hao Wen Fanglong Li Baolin Wang Jie Wang | 2010 | The Journal of Biomedical Research2010，24，1： | 1 |
| 13 | The characteristics of GaN-based blue LED on Si substrate显示文摘 | Xiong Chuanbing Jiang Fengyi Fang Wenqing Wang Li Mo Chunna Liu Hechu | 2007 | Journal of Luminescence2007，，： | 1 |
| 14 | Effect of growth temperature on properties of single crystalline ZnO films prepared by atmospheric MOCVD显示文摘 | Xiong Chuanbing Fang Wenqing Pu Yong Dai Jiangna Wang Li Mo Chunna Jiang Fengyi | 2004 | Chinese Journal of Semiconductors2004，25，12： | 1 |
| 15 | Mapping the transcription repressive domain in the highly conserved human gene hnulp1显示文摘HNULP1,a new member of the basic helixloop-helix transcription factors,contains a DUF654 domain in its C-terminus and is highly conserved from Drosophilae,yeast,zebrafish to mouse.The function of this motif,however,is currently unknown.In this research,we fused five deletion fragments of the DUF654 domain to the GAL4 DNA-binding domain and then co-transfected with plasmids L8G5-Luc and VP-16.The analysis of the GAL4 luciferase reporter gene indicated that fragments from 228 to 407 amino acids in the DUF654 domain had a strong transcription repression activity.Therefore,this study lays a solid foundation for research on the mechanism of hnulp1 transcriptional regulation and the function of the DUF654 domain. | Yuequn WANG Lian LIU Zhenyu CAI Yongqing LI Wuzhou YUAN Chuanbing ZHU Yun DENG Xiaoyang MO Xiushan WU | 2008 | Frontiers in Biology2008，3，2： | 0 |
| 16 | Role of the domains of human gene ZNF569 in MAPK pathway显示文摘Mitogen-activated protein kinase(MAPK)signal pathways are important components in signal transduction connecting cell-surface receptors to critical regulatory targets within cells,mediating multiple intracellular signal cascades and phosphorylating their target proteins,such as transcriptional factors ELK-1,SRE and AP-1,and finally activating the expression of intracellular functional genes.Zinc finger genes are some of the largest gene families in humans,and Zinc finger proteins play an essential role in altering gene expression by acting as transcription factors.Zinc finger proteins are also involved in multiple cell processes,including proliferation,differentiation and development,by interacting with DNA.Here,we reported the transcriptional activities of the domains of zinc finger gene ZNF569 taking advantage of MAPK pathway.Overexpression of ZNF569 in COS-7 cells dramatically inhibited the transcriptional repressor activities of SRE and AP-1,which was also confirmed by subcellular localization analysis.Report assays indicated that the potent repression domains of ZNF569 were the KRAB and ZNF motifs.The results suggested that ZNF569 protein might act as a transcriptional repressor in MAPK signaling pathway to regulate cellular processes. | YUAN Wuzhou HUANG Xinqiong ZHU Chuanbing WANG Yuequn LI Yongqing WU Xiushan | 2006 | Frontiers in Biology2006，1，4： | 0 |
| 17 | Antifouling and antimicrobial cobaltocenium-containing metallopolymer double-network hydrogels显示文摘Compared with single-network hydrogels,double-network hydrogels offer higher mechanical strength and toughness.Integrating useful functions into double-network hydrogels can expand the portfolios of the hydrogels.We report the preparation of double-network metallopolymer hydrogels with remarkable hydration,antifouling,and antimicrobial properties.These cationic hydrogels are composed of a first network of cationic cobaltocenium polyelectrolytes and a second network of polyacrylamide,all prepared via radical polymerization.Antibiotics were further installed into the hydrogels via ion-complexation with metal cations.These hydrogels exhibited significantly enhanced hydration,compared with polyacrylamide-based hydrogels,while featuring robust mechanical strength.Cationic metallopolymer hydrogels exhibited strong antifouling against oppositely charged proteins.These antibiotic-loaded hydrogels demonstrated a synergistic effect on the inhibition of bacterial growth and antifouling of bacteria,as a result of the unique ion complexation of cobaltocenium cations. | Hui Li Peng Yang JiHyeon Hwang Parasmani Pageni Alan W.Decho Chuanbing Tang | 2022 | Biomaterials Translational2022，3，2： | 0 |
| 18 | Advanced studies on human gene ZNF322显示文摘The human novel gene of ZNF322 is cloned from human fetal cDNA library using the primers on the basis of the ZNF322 sequence analyzed with computer.The gene is located on Chromosome 6p22.1,and encodes a protein con-sisting of 402 amino acid residues and containing nine tandem C_(2)H_(2)-type zinc-finger motifs.Northern blot result shows that the gene is expressed in all examined adult tissues.Sub-cellular location study indicates that ZNF322-EGFP fusion protein is distributed in the nucleus and cytoplasm.Reporter gene assays show that ZNF322 is a potential transcriptional activator. | LI Yongqing WANG Yuequn YUAN Wuzhou DENG Yun ZHU Chuanbing WU Xiushan | 2007 | Frontiers in Biology2007，2，4： | 0 |
| 19 | Nucleation and epitaxy growth of high-entropy REBa_(2)Cu_(3)O_(7-δ)(RE=Y,Dy,Gd,Sm,Eu)thin films by metal organic deposition显示文摘High-entropy REBa_(2)Cu_(3)O_(7-δ)(RE=Y_(0.7)+Dy_(0.2)+Gd_(0.2)+Sm_(0.2)+Eu_(0.2))(HE-REBCO) superconducting films doped with multiple rare earth elements were successfully fabricated with thickness up to 800 nm by a trifluoroacetate-metal organic deposition(TFA-MOD).The enhanced entropy change ΔS of the HEREBCO system promotes the c-axis growth of REBCO thin film in the competition with a/b-axis growth.The microstructure and element distribution were investigated by the transmission electron microscopy(TEM) and energy dispersive spectroscopy(EDS).The results show that HE-REBCO films have a great amount of stacking defects,lattice distortions and various rare earth oxides.Furthermore,the microstrain of HE-REBCO films increases significantly compared to the undoped YBCO and(Y,Dy)BCO films.Finally,the superco nducting critical temperature(T_c^(onset)) of HE-REBCO films is about 93 K,and the in-field properties are significantly improved,especially at the temperature of about 77 K.The maximum pinning force density(F_(p,max)) of the HE-REBCO samples at 77 K is 1.7 times higher than that of the undoped YBCO films. | Jing Chen Rongtie Huang Xinghang Zhou Difan Zhou Minjuan Li Chuanyi Bai Zhiyong Liu Chuanbing Cai | 2023 | Journal of Rare Earths2023，41，7： | 0 |
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