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| 1 | Double-stranded DNA in exosomes: a novel biomarker in cancer detection显示文摘 | Basant Kumar Thakur Haiying Zhang Annette Becker Irina Matei Yujie Huang Bruno Costa-Silva Yan Zheng Ayuko Hoshino Helene Brazier Jenny Xiang Caitlin Williams Ruth Rodriguez-Barrueco Jose M Silva Weijia Zhang Stephen Hearn Olivier Elemento Navid Paknejad Katia Manova-Todorova Karl Welte Jacqueline Bromberg Hector Peinado David Lyden | 2014 | Cell Research2014，24，6： | 98 |
| 2 | Mapping wetland changes in China between 1978 and 2008显示文摘Four wetland maps for all China have been produced,based on Landsat and CBERS-02B remote sensing data between 1978 and 2008 (1978,1990,2000 and 2008).These maps were mainly developed by manual interpretation and validated by substantial field investigation in 2009.Based on these maps,we analyzed the 2008 wetland distribution in China and discussed wetland changes and their drivers over the past 30 years.(i) There were about 324097 km 2 of wetlands in 2008,for which inland marshes or swamps were the most common wetland type (35%),with lakes (26%) second.Most of the wetlands were in Heilongjiang,Inner Mongolia,Qinghai and Tibet,occupying about 55% of the national wetland area.(ii) From 1978 to 2008,China's wetland area continually and significantly decreased,by about 33% based on changes in the wetland map.This was in sharp contrast to the increase in artificial wetlands,which increased by about 122%.Inland marshes accounted for the main loss of total wetlands from 1978 to 2000.From 2000 through 2008,riverine and lacustrine wetlands constituted the main wetland loss.Fortunately however,the rate of wetland loss decreased from 5523 to 831 km 2 /a.(iii) The change ratio of lost natural wetlands (including inland and coastal wetlands) to non-wetlands has decreased slightly over the past 30 years.From 1978 to 1990,nearly all natural wetlands (98%) lost were transformed into non-wetlands.However,the ratio declined to 86% from 1990 to 2000,and to 77% from 2000 to 2008.(iv) All Chinese provinces were divided into three groups according to patterns of wetland changes,which could relate to the driving forces of such changes.Tibet was completely different from other provinces,as it was one representative example in which there was a net wetland increase,because of global warming and decreased human activity since 1990.Increased economic development caused considerable wetland loss in most eastern provinces,and artificial wetlands increased. | NIU ZhenGuo ZHANG HaiYing WANG XianWei YAO WenBo ZHOU DeMin ZHAO KuiYi ZHAO Hui LI NaNa HUANG HuaBing LI CongCong YANG Jun LIU CaiXia LIU Shuang WANG Lin LI Zhan YANG ZhenZhong QIAO Fei ZHENG YaoMin CHEN YanLei SHENG YongWei GAO XiaoHong ZHU WeiHong WANG WenQing WANG Hong WENG YongLing ZHUANG DaFang LIU JiYuan LUO ZhiCai CHENG Xiao GUO ZiQi GONG Peng | 2012 | Chinese Science Bulletin2012，57，22： | 51 |
| 3 | Karyotype Stability and Unbiased Fractionation in the Paleo-Allotetraploid Cucurbita Genomes显示文摘 | Honghe Sun Shan WU Guoyu Zhang Chen Jiao Shaogui Guo Yi Ren Jie Zhang Haiying Zhang Guoyi Gong Zhangcai Jia Fan Zhang Jiaxing Tian William J. Lucas Jeff J. Doyle Haizhen Li Zhangjun Fei Yong Xu | 2017 | Molecular Plant2017，10，10： | 33 |
| 4 | Protection efficacy of national wetland reserves in China显示文摘Wetlands have the most abundant biodiversity,the highest carbon sequestration capacity,and the highest values for ecological services per unit area,of all the world's ecosystems.Practice has shown that establishing reserves is the most effective way of protecting typical ecosystems and their biodiversity,and saving rare or endangered wildlife.The Chinese government's policy is to protect wetland systems by establishing reserves that encompass a massive network of wetlands,including wetland nature re-serves,internationally important wetlands,and wetland parks.Many are already established.The effect of protecting wetland nature reserves at the national level has not yet been reported.We used the latest database evaluating the protection value of wet-land reserves,and remotely sensed wetland maps(1978-2008) ,developed by the same mapping specialists and based on the same classification system,and related environmental data,to evaluate the effects of protecting China's national wetland reserves over the last 30 years.We conclude that(i) the total area of wetland in the national wetland reserves has decreased over the last 30 years to 8152.47 km2,and just 8% of China's net decrease in wetlands;(ii) about 79% of the 91 national wetland reserves are in a poor condition.These are generally located around the Yangtze River,Eastern Coast,the Three Rivers Source,and Southwest China.Protection measures should be undertaken urgently in these areas.Only 15% of national wetland reserves are under sound protection,and these are generally located in the upper reaches of the Songhua River;(iii) although 88% of national wetland re-serves are primitive(relatively natural) ,implying that the site selection has been scientific,a high percentage of national wetland reserves show early warning signs of decline and require urgent attention;(iv) based on our evaluation of protection effects and pressures on ecology,we have made a priority list of national wetland reserves,and propose several protection strategies. | ZHENG YaoMin ZHANG HaiYing NIU ZhenGuo GONG Peng | 2012 | Chinese Science Bulletin2012，57，10： | 29 |
| 5 | The first all-season sample set for mapping global land cover with Landsat-8 data显示文摘We report the world's first all-season training and validation sample sets for global land cover classification with Landsat-8 data.Prior to this,such samples were only available at a single date primarily from the growing season.It is unknown how much limitation such a single-date sample has to mapping global land cover in other seasons of the year.To answer this question,we selected available Landsat-8 images from four seasons and collected training and validation samples from them.We compared the performances of training samples in different seasons using Random Forest algorithm.We found that the use of training samples from any individual season would result in the best overall classification accuracy when validated by samples in the same season.The global overall accuracy from combined best seasonal results was 67.2% when classifying the 11 Level-1 classes in the Finer Resolution Observation and Monitoring of Global Land Cover(FROM-GLC) classification system.The use of training samples from all seasons(named all-season training sample set hereafter) produced an overall accuracy of 67.0%.We also tested classification within 10° latitude 60° longitude zones using all-season training subsample within each zone and obtained an overall accuracy of 70.2%.This indicates that properly grouped subsamples in space can help improve classification accuracies.All the results in this study seem to suggest that it is possible to use an all-season training sample set to reach global optimality with universal applicability in classifying images acquired at any time of a year for global land cover mapping. | Congcong Li Peng Gong Jie Wang Zhiliang Zhu Gregory S. Biging Cui Yuan Tengyun Hu Haiying Zhang Qi Wang Xuecao Li Xiaoxuan Liu Yidi Xu Jing Guo Caixia Liu Kwame O. Hackman Meinan Zhang Yuqi Cheng Le Yu Jun Yang Huabing Huang Nicholas Clinton | 2017 | Science Bulletin2017，62，7： | 21 |
| 6 | Ozone sensitivity analysis with the MM5-CMAQ modeling system for Shanghai显示文摘Ozone has become one of the most important air pollution issues around the world. This article applied both O 3 /(NOy-NOx) and H 2 O 2 /HNO 3 indicators to analyze the ozone sensitivity in urban and rural areas of Shanghai, with implementation of the MM5-CMAQ modeling system in July, 2007. The meteorological parameters were obtained by using the MM5 model. A regional emission inventory with spatial and temporal allocation based on the statistical data has been developed to provide input emission data to the MM5-CMAQ modeling system. Results showed that the ozone concentrations in Shanghai show clear regional differences. The ozone concentration in rural areas was much higher than that in the urban area. Two indicators showed that ozone was more sensitive to VOCs in urban areas, while it tended to be NOx sensitive in rural areas of Shanghai. | Li Li Changhong Chen Cheng Huang Haiying Huang Gangfeng Zhang Yangjun Wang Minghua Chen Hongli Wang Yiran Chen D. G. Streets Jiamo Fu | 2011 | Journal of Environmental Sciences2011，23，7： | 18 |
| 7 | Influence of Water Stress on Endogenous Hormone Contents and Cell Damage of Maize Seedlings显示文摘Phytohormones play critical roles in regulating plant responses to stress. We investigated the effects of water stress induced by adding 12% (w/v) polyethylene glycol to the root medium on the levels of abscisic acid (ABA), indole-3-acid (IAA), zeatin (ZT), and gibberellin3 (GA3) in maize leaves. The results suggested that water stress had significant effects on the four hormone levels. There was a transient increase in the IAA content during the initial stage of adaptation to water stress in maize leaves, but it dropped sharply thereafter in response to water stress. ABA content increased dramatically in maize leaves after 24 h of exposure to water stress, and then the high levels of ABA were maintained to the end. The contents of ZT and GA3 rapidly declined in maize leaves subjected to water stress. The effects of water stress on chlorophyll content, electrolyte leakage and malondialdehyde levels in maize leaves were also studied. The variation of cell damage was negatively correlated with ZT and GA3 levels in maize leaves under water stress. Thus, we explored the roles of ZT and GA3 on the growth of maize seedlings under water stress by exogenous application. It is possible that both ZT and GA3 were effective in protecting maize seedlings from water stress, which would be of great importance for the improvement of drought tolerance in maize by genetic manipulation. | Chunrong Wang Aifang Yang Haiying Yin Juren Zhang | 2008 | Journal of Integrative Plant Biology2008，50，4： | 17 |
| 8 | FREQUENTIST MODEL AVERAGING ESTIMATION:A REVIEW显示文摘In applications, the traditional estimation procedure generally begins with model selection.Once a specific model is selected, subsequent estimation is conducted under the selected model withoutconsideration of the uncertainty from the selection process. This often leads to the underreportingof variability and too optimistic confidence sets. Model averaging estimation is an alternative to thisprocedure, which incorporates model uncertainty into the estimation process. In recent years, therehas been a rising interest in model averaging from the frequentist perspective, and some importantprogresses have been made. In this paper, the theory and methods on frequentist model averagingestimation are surveyed. Some future research topics are also discussed. | Haiying WANG Xinyu ZHANG Guohua ZOU Academy of Mathematics and Systems Science,Chinese Academy of Sciences,Beijing 100190,China. | 2009 | Journal of Systems Science & Complexity2009，22，4： | 14 |
| 9 | Experimental study of effect of post processing on fracture toughness and fatigue crack growth performance of selective laser melting Ti-6Al-4V显示文摘For Ti-6Al-4V,a titanium alloy increasingly used in aerospace structure,selective laser melting(SLM)is an attractive additive manufacturing technology,which is attributed to its complex construction capability with high accuracy and good surface quality.In order to obtain qualified mechanical properties,SLM parameters and post processing should be tailored for diverse service conditions.Fracture toughness and fatigue crack growth(FCG)behavior are critical characteristics for damage tolerance evaluation of such metallic structures,and they are affected by post processing technologies significantly.The objective of this study is to obtain the fracture toughness and fatigue crack growth behavior of Ti-6Al-4V manufactured by SLM,and to evaluate the influence of post-SLM thermomechanical treatment and surface machining.Fracture toughness and FCG tests were performed for SLM Ti-6Al-4V in three types of post processing status:as-built,heat treated and hot isostatically pressed(HIPed),respectively.Specimens with as-built and machined surface were tested.The microstructure and fractography were analyzed as well in order to investigate the relevance among manufacture process,microstructure and mechanical properties.The results demonstrate that as-built SLM Ti-6Al-4V presents poor ductility and FCG behavior due to martensitic microstructure and residual stresses.Both heat treatment and hot isostatic pressing improve the plane-stress fracture toughness and FCG performance considerably,while surface machining shows slight effect. | Haiying ZHANG Dengke DONG Shaopu SU An CHEN | 2019 | Chinese Journal of Aeronautics2019，32，10： | 13 |
| 10 | De novo assembly of a Chinese soybean genome显示文摘Soybean was domesticated in China and has become one of the most important oilseed crops. Due to bottlenecks in their introduction and dissemination, soybeans from different geographic areas exhibit extensive genetic diversity. Asia is the largest soybean market; therefore, a high-quality soybean reference genome from this area is critical for soybean research and breeding.Here, we report the de novo assembly and sequence analysis of a Chinese soybean genome for 'Zhonghuang 13' by a combination of SMRT, Hi-C and optical mapping data. The assembled genome size is 1.025 Gb with a contig N50 of 3.46 Mb and a scaffold N50 of 51.87 Mb. Comparisons between this genome and the previously reported reference genome(cv. Williams82) uncovered more than 250,000 structure variations. A total of 52,051 protein coding genes and 36,429 transposable elements were annotated for this genome, and a gene co-expression network including 39,967 genes was also established. This high quality Chinese soybean genome and its sequence analysis will provide valuable information for soybean improvement in the future. | Yanting Shen Jing Liu Haiying Geng Jixiang Zhang Yucheng Liu Haikuan Zhang Shilai Xing Jianchang Du Shisong Ma Zhixi Tian | 2018 | Science China(Life Sciences)2018，61，8： | 11 |
| 11 | Existing drugs as broad-spectrum and potent inhibitors for Zika virus by targeting NS2B-NS3 interaction显示文摘Zika 病毒(ZIKV ) 的最近的爆发为治疗学加亮迫切需要。朊酶建筑群 NS2B-NS3 在 flaviviral polyprotein 处理期间起必要作用,并且因此代表一个吸引人的药目标。这里,我们开发了裂口酶识别直接指向 flavivirus NS2B-NS3 相互作用的 orthosteric 禁止者的基于互补的高产量的屏蔽试金。由屏蔽一个总数 2 816 同意了并且 investigational 药,我们识别了三个有势力候选人, temoporfin, niclosamide,和 nitazoxanide,,有 nanomolar 力量的 flavivirus NS2B-NS3 相互作用禁止者。显著地,在老鼠的在人的胎盘、神经的祖先房间的大多数有势力化合物, temoporfin,不是仅仅禁止的 ZIKV 复制,而且阻止的导致 ZIKV 的 viremia 和死亡当模特儿。结构的停靠建议 temoporfin 潜在地绑保持批评 NS2B 残余的 NS3 衣袋,因此禁止以一种非竞争的方式处理的 flaviviral polyprotein。当这些药已经在 USA 或另外的国家在另外的指示任何一个为临床的使用被同意了,他们由 ZIKV 和另外的 flaviviruses 为感染的管理代表有希望、容易开发的治疗。 | Zhong Li Matthew Brecher Yong-Qiang Deng Jing Zhang Srilatha Sakamuru Binbin Liu Ruili Huang Cheri A Koetzner Christina A Allen Susan A Jones Haiying Chen Na-Na Zhang Min Tian Fengshan Gao Qishan Lin Nilesh Banavali Jia Zhou Nathan Boles Menghang Xia Laura D Kramer Cheng-Feng Qin Hongmin Li | 2017 | Cell Research2017，27，8： | 11 |
| 12 | PandaX: a liquid xenon dark matter experiment at CJPL显示文摘PandaX is a large liquid-xenon detector experiment usable for direct dark-matter detection and 136Xe double-beta decay search.The central vessel was designed to accommodate a staged target volume increase from initially 120 kg(stage I)to 0.5 t(stage II)and eventually to a multi-ton scale.The experiment is located in the Jinping Deep-Underground Laboratory in Sichuan,China.The detector operates in dual-phase mode,allowing detection of both prompt scintillation,and ionization charge through proportional scintillation.In this paper a detailed description of the stage I detector design and performance as well as results established during the commissioning phase are presented. | CAO XiGuang CHEN Xun CHEN YunHua CUI XiangYi FANG DeQing FU ChangBo GIBONI Karl L. GONG HaoWei GUO GuoDong HE Ming HU Jie HUANG XingTao JI XiangDong JU YongLin LI ShaoLi LIN Qing LIU HuaXuan LIU JiangLai LIU Xiang LORENZON Wolfgang MA YuGang MAO YaJun NI KaiXuan PUSHKIN Kirill REN XiangXiang SCHUBNELL Michael SHEN ManBing SHI YuJie STEPHENSON Scott TAN AnDi TARLé Greg WANG HongWei WANG JiMing WANG Meng WANG XuMing WANG Zhou WEI YueHuan WU ShiYong XIAO MengJiao XIAO Xiang XIE PengWei YE Tao YOU YingHui ZEN XiongHui ZHANG Hua ZHANG Tao ZHAO HaiYing ZHAO Li ZHOU XiaoPeng ZHU ZhongHua | 2014 | Science China(Physics,Mechanics & Astronomy)2014，57，8： | 9 |
| 13 | Overexpression of the Watermelon Ethylene Response Factor ClERF069 in Transgenic Tomato Resulted in Delayed Fruit Ripening显示文摘Watermelon fruit undergoes distinct development stages with dramatic changes during fruit ripening.To date,the molecular mechanics of watermelon ripening remain unclear.Genetic and transcriptome evidences suggested that the ethylene response factor(ERF)gene ClERF069 may be an important candidate factor affecting watermelon fruit ripening.To dissect the roles of ClERF069 in fruit ripening,structure and phylogenetic analysis were performed using the amplified full-length sequence.Normal-ripening watermelon 97103,non-ripening watermelon PI296341-FR and the RIL population were used to analyze ClERF069 expression dynamics and the correlation with fruit ripening indexs.The results indicated that ClERF069 belongs to ERF family group VI and show high homology(83%identity)to melon ERF069-like protein.ClERF069 expression in watermelon flesh was negatively correlated with fruit lycopene content and sugar content during fruit ripening progress.Further transgenic evidences indicated that overexpression of 35S:ClERF069 in tomato noticeably delayed the ripening process up to 5.2 days.Lycopene,β-carotenoid accumulation patterns were altered and ethylene production patterns in transgenic fruits was significantly delayed during fruit ripening.Taken together,watermelon ethylene response factor ClERF069 was concluded to be a negative regulator of fruit ripening. | Ming Zhou Shaogui Guo Shouwei Tian Jie Zhang Yi Ren Guoyi Gong Changbao Li Haiying Zhang Yong Xu | 2020 | Horticultural Plant Journal2020，6，4： | 9 |
| 14 | Compound Formula Rehmannia alleviates levodopainduced dyskinesia in Parkinson's disease显示文摘Compound Formula Rehmannia has been shown to be clinically effective in treating Parkinson's disease and levodopa-induced dyskinesia; however,the mechanisms remain unclear.In this study,we established a model of Parkinson's disease dyskinesia in rats,and treated these animals with Compound Formula Rehmannia.Compound Formula Rehmannia inhibited the increase in mRNA expression of N-methyl-D-aspartate receptor subunits 1 and 2 and excitatory amino acid neurotransmitter genes,and it inhibited the reduction in expression of γ-aminobutyric acid receptor B1,an inhibitory amino acid neurotransmitter gene,in the corpus striatum.In addition,Compound Formula Rehmannia alleviated dyskinesia symptoms in the Parkinson's disease rats.These experimental findings indicate that Compound Formula Rehmannia alleviates levodopa-induced dyskinesia in Parkinson's disease by modulating neurotransmitter signaling in the corpus striatum. | Long Teng Fang Hong Chenguang Zhang Jiancheng He Haiying Wang | 2014 | Neural Regeneration Research2014，9，4： | 8 |
| 15 | Evaluation of the mold-filling ability of alloy melt in squeeze casting显示文摘The mold-filling ability of alloy melt in squeeze casting process was evaluated by means of the maximum length of Archimedes spiral line. A theoretical evaluating model to predict the maximum filling length was built based on the flowing theory of the incompressible viscous fluid. It was proved by experiments and calculations that the mold-filling pressure and velocity are prominent influencing factors on the mold-filling ability of alloy melt. The mold-filling ability increases with the increase of the mold-filling pressure and the decrease of the proper mold-filling velocity. Moreover, the pouring temperature relatively has less effect on the mold-filling ability under the experimental conditions. The maximum deviation of theoretical calculating values with experimental results is less than 15%. The model can quantitatively estimate the effect of every factor on the mold-filling ability. | Haiying Zhang Shuming Xing Qinghua Zhang Jianbo Tan Wen Liu | 2006 | Journal of University of Science and Technology Beijing2006，13，1： | 7 |
| 16 | Molecular insights into the heterogeneity of telomere reprogramming in induced pluripotent stem cells显示文摘有各种各样的长度的 telomeres 的返老还童在导致的 pluripotent 干细胞(iPSCs ) 被发现了。telomere 长度规定的机制在 iPSCs 的正式就职和增长期间留下逃犯。我们证明 telomere 动力学在 reprogramming 和经过期间在鼠标 iPSCs 是可变的,并且建议这些差别多半源于多重潜在的因素,包括包括外长的 reprogramming 因素的表示的 telomerase 机械, telomerase 独立的机制和同种细胞的影响。用一个基因模型 telomerase 缺乏(为 iPSCs 的推导和段落的 Terc −/− 和 Terc +/−) 房间,我们发现 telomerase 在 iPSCs 的 reprogramming 和自强起一个关键作用。进一步,当由再结合的延伸和维护的其他的小径也被要求时, telomeres 的 telomerase 维护为真 pluripotency 的正式就职是必要的,然而并非足够。一起, telomere 生物学的几个方面可以在 iPSCs 说明可变 telomere 动力学。尤其是,采用在 iPSC reprogramming 期间维持 telomeres 的机制很类似于胚胎的干细胞的那些。这些调查结果可以也联系到这些机制能为在由体的房间的原子 reprogramming 以后的 telomere 异质负责的克隆的地原子转移。 | Fang Wang Yu Yin Xiaoying Ye Kai Liu Haiying Zhu Lingling Wang Maria Chiourea Maja Okuka Guangzhen Ji Jiameng Dan Bingfeng Zuo Minshu Li Qian Zhang Na Liu Lingyi Chen Xinghua Pan Sarantis Gagos David L Keefe Lin Liu | 2012 | Cell Research2012，22，4： | 7 |
| 17 | Modulation of Sex Expression in Four Forms of Watermelon by Gibberellin, Ethephone and Silver Nitrate显示文摘There has been no systematic research on the effect of plant growth regulators and silver nitrate treatments on the control of sex expression in watermelon. In this study, we tested sex expression responses of four watermelon forms(monoecism, gynoecism, andromonoecism,and hermaphrodite) to gibberellin, ethephon and silver nitrate treatments. Results have shown that, in monoecious plants, gibberellins(GA_3)and ethephon treatments reduced the percentage of female flowers and delayed the occurrence of the first female flower, while silver nitrate induced the formation of bisexual flowers. In gynoecious plants, both ethephon and silver nitrate treatments transformed some female flowers into bisexual flowers, and treatment with ethephon resulted in a mass of abnormal flowers, while no obvious effect of treatment with GA_3 was observed. In andromonoecious plants, ethephon and GA_3 treatments delayed the occurrence of the first bisexual flower, and GA_3 reduced the percentage of bisexual flowers, while no distinct effect for silver nitrate treatment was observed. In hermaphroditic plants, ethephon treatment induced the appearance of numerous abnormal flowers, while no obvious effects for GA_3 and silver nitrate treatments were observed.We analyzed the transcription levels of all the expressed aminocyclopropane-1-carboxylic acid synthase(ACS) homologues in two gynoecious mutants and their wild types. We also tested the gene expression of CitACS4 which had been recognized as the andromonoecious gene in all treatments. All these results suggested that the best masculinizing treatment for breeding of the gynoecious line is silver nitrate, which repressed the expression of CitACS4 and induced many bisexual flowers for use in self-fertilization subsequently. | ZHANG Jie SHI Jianting JI Gaojie ZHANG Haiying GONG Guoyi GUO Shaogui REN Yi FAN Jianguang TIAN Shouwei XU Yong | 2017 | Horticultural Plant Journal2017，3，3： | 6 |
| 18 | Acute high-altitude hypoxic brain injury Identification of ten differential proteins显示文摘Hypobaric hypoxia can cause severe brain damage and mitochondrial dysfunction,and is involved in hypoxic brain injury.However,little is currently known about the mechanisms responsible for mitochondrial dysfunction in hypobaric hypoxic brain damage.In this study,a rat model of hypobaric hypoxic brain injury was established to investigate the molecular mechanisms associated with mitochondrial dysfunction.As revealed by two-dimensional electrophoresis analysis,16,21,and36 differential protein spots in cerebral mitochondria were observed at 6,12,and 24 hours post-hypobaric hypoxia,respectively.Furthermore,ten protein spots selected from each hypobaric hypoxia subgroup were similarly regulated and were identified by mass spectrometry.These detected proteins included dihydropyrimidinase-related protein 2,creatine kinase B-type,isovaleryl-CoA dehydrogenase,elongation factor Ts,ATP synthase beta-subunit,3-mercaptopyruvate sulfurtransferase,electron transfer flavoprotein alpha-subunit,Chain A of 2-enoyl-CoA hydratase,NADH dehydrogenase iron-sulfur protein 8 and tropomyosin beta chain.These ten proteins are all involved in the electron transport chain and the function of ATP synthase.Our findings indicate that hypobaric hypoxia can induce the differential expression of several cerebral mitochondrial proteins,which are involved in the regulation of mitochondrial energy production. | Jianyu Li Yuting Qi Hui Liu Ying Cui Li Zhang Haiying Gong Yaxiao Li Lingzhi Li Yongliang Zhang | 2013 | Neural Regeneration Research2013，8，31： | 6 |
| 19 | Differential expression of microRNAs in dorsal root ganglia after sciatic nerve injury显示文摘This study investigated the possible involvement of microRNAs in the regulation of genes that participate in peripheral neural regeneration.A microRNA microarray analysis was conducted and 23 microRNAs were identified whose expression was significantly changed in rat dorsal root ganglia after sciatic nerve transection.The expression of one of the downregulated microRNAs,microRNA-214,was validated using quantitative reverse transcriptase-PCR.MicroRNA-214 was predicted to target the 3′-untranslated region of Slit-Robo GTPase-activating protein 3.In situ hybridization verified that microRNA-214 was located in the cytoplasm of dorsal root ganglia primary neurons and was downregulated following sciatic nerve transection.Moreover,a combination of in situ hybridization and immunohistochemistry revealed that microRNA-214 and Slit-Robo GTPase-activating protein 3 were co-localized in dorsal root ganglion primary neurons.Western blot analysis suggested that Slit-Robo GTPase-activating protein 3 was upregulated in dorsal root ganglion neurons after sciatic nerve transection.These data demonstrate that microRNA-214 is located and differentially expressed in dorsal root ganglion primary neurons and may participate in regulating the gene expression of Slit-Robo GTPase-activating protein 3 after sciatic nerve transection. | Anjie Lu Zufa Huang Chaoyue Zhang Xianfang Zhang Jiuhong Zhao Haiying Zhang Quanpeng Zhang Song Wu Xinan Yi | 2014 | Neural Regeneration Research2014，9，10： | 5 |
| 20 | Sensitive electrochemical DNA sensor for the detection of HIV based on a polyaniline/graphene nanocomposite显示文摘A nanocomposite of polyaniline/graphene(PAN/GN)was prepared using reverse-phase polymerization.The nanocomposite material was dropcast onto a glassy carbon electrode(GCE).Then,a single-stranded DNA(ssDNA)probe for HIV-1 gene detection was immobilized on the modified electrode,and the negative charged phosphate backbone of the HIV-1 was bound to the modified electrode surface via p-p*stacking interactions.The hybridization between the ssDNA probe and the target HIV-1 formed doublestranded DNA(dsDNA),and the electron transfer resistance of the electrode was measured using impedimetric studies with a[Fe(CN)6]^(3-/4-)redox couple.Under the optimized experimental conditions,the change of the impedance value was linearly related to the logarithm of the concentration of HIV genes in the range from 5.0×10^(-16)M to 1.0×10^(-10)M(R=0.9930),and the HIV sensor exhibited a lower detection limit of 1.0×10^(-16)M(S/N=3).The results show that this biosensor presented wonderful selectivity,sensitivity and specificity for HIV-1 gene detection.Thus,this biosensor provides a new method for the detection of HIV gene fragments. | Qiaojuan Gong Haixia Han Haiying Yang Meiling Zhang Xiaoling Sun Yunxia Liang Zhaorong Liu Wenchan Zhang Jinli Qiao | 2019 | Journal of Materiomics2019，5，2： | 5 |
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