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| 1 | Isolation and characterization of dengue virus serotype 2 from the large dengue outbreak in Guangdong, China in 2014显示文摘Dengue has been well recognized as a global public health threat,but only sporadic epidemics and imported cases were reported in recent decades in China.Since July 2014,an unexpected large dengue outbreak has occurred in Guangdong province,China,resulting in more than 40000 patients including six deaths.To clarify and characterize the causative agent of this outbreak,the acute phase serum from a patient diagnosed with severe dengue was subjected to virus isolation and high-throughput sequencing(HTS).Traditional real-time RT-PCR and HTS with Ion Torrent PGM detected the presence of dengue virus serotype 2(DENV-2).A clinical DENV-2 isolate GZ05/2014 was obtained by culturing the patient serum in mosquito C6/36 cells.The complete genome of GZ05/2014 was determined and deposited in Gen Bank under the access number KP012546.Phylogenetic analysis based on the complete envelope gene showed that the newly DENV-2 isolate belonged to Cosmopolitan genotype and clustered closely with other Guangdong strains isolated in the past decade.No amino acid mutations that are obviously known to increase virulence or replication were identified throughout the genome of GZ05/2014.The high homology of Guangdong DENV-2 strains indicated the possibility of establishment of local DENV-2 circulation in Guangdong,China.These results help clarify the origin of this epidemic and predict the future status of dengue in China. | ZHAO Hui ZHAO Ling Zhai JIANG Tao LI Xiao Feng FAN Hang HONG Wen Xin ZHANG Yu ZHU Qin YE Qing TONG Yi Gang CAO Wu Chun ZHANG Fu Chun QIN Cheng Feng | 2014 | Science China(Life Sciences)2014，57，12： | 21 |
| 2 | On environment-driven software model for Internetware显示文摘Internetware is envisioned as a general software paradigm for the application style of resources integration and sharing in the open, dynamic and uncertain platforms such as the Internet. Continuing the agent-based Internetware model presented in a previous paper, in this paper, after an analysis of the behavioral patterns and the technical challenges of environment-driven applications, a software-structuring model is proposed for environment-driven Internetware applications. A series of explorations on the enabling techniques for the model, especially the modeling, management and utilization of context information are presented. Several prototypical systems have also been built to prove the concepts and evaluate the techniques. These research efforts make a further step toward the Internetware paradigm by providing an initial framework for the construction of context-aware and self-adaptive software application systems in the open network environment. | Lǔ Jian MA XiaoXing TAO XianPing CAO Chun HUANG Yu YU Ping | 2008 | Science in China(Series F)2008，51，6： | 17 |
| 3 | Research on power electronic transformer applied in AC/DC hybrid distribution networks显示文摘The AC/DC hybrid distribution network is one of the trends in distribution network development, which poses great challenges to the traditional distribution transformer. In this paper, a new topology suitable for AC/DC hybrid distribution network is put forward according to the demands of power grid, with advantages of accepting DG and DC loads, while clearing DC fault by blocking the clamping double sub-module(CDSM) of input stage. Then, this paper shows the typical structure of AC/DC distribution network that is hand in hand. Based on the new topology, this paper designs the control and modulation strategies of each stage, where the outer loop controller of input stage is emphasized for its twocontrol mode. At last, the rationality of new topology and the validity of control strategies are verified by the steady and dynamic state simulation. At the same time, the simulation results highlight the role of PET in energy regulation. | Yiqun Miao Jieying Song Haijun Liu Zhengang Lu Shufan Chen Chun Ding Tianzhi Cao Linhai Cai Yuzhong Gong | 2018 | Global Energy Interconnection2018，1，3： | 14 |
| 4 | In vitro differentiation of rat embryonic stem cells into functional cardiomyocytes显示文摘在老鼠的产生的最近的突破胚胎的干细胞(rESCs ) 打开门到基因指向为人的疾病的学习创造模型的申请。另外,在里面从进三细菌层的衍生物的 rESCs 的 vitro 区别系统将为哺乳动物的开发,房间函数,织物修理,和药发现的调查用作一个强大的工具和资源。然而,这些使用被困难限制了在 vitro 区别。这研究的目的是建立一在里面从 rESCs 并且到的 vitro 区别系统调查 rESCs 是否能够形成区分终端的 cardiomyocytes。用最新确定的 rESCs,我们发现那胚胎植物或动物身体(EB ) 基于在没能为没有浆液的栽培 rESCs 工作的老鼠转换字符(mESC ) 区别使用的方法。我们然后由三个化学禁止者和喂调节媒介的联合开发了一个协议。在这个条件下面, rESCs 变成了 EB,宣传并且区分三胚胎的细菌层。而且,形成 rESC 的 EB 能区分进自发地在 plating 以后打败 cardiomyocytes。分子、结构、功能的性质的分析表明导出 rESC 的 cardiomyocytes 类似于从胎儿的老鼠心和 mESCs 导出的那些。在结论,我们成功地发展了一在里面为功能的 myocytes 通过被产生并且显示老鼠的显型的 rESCs 的 vitro 区别系统胎儿的 cardiomyocytes。这个唯一的细胞的系统将提供一条新途径学习早开发和心脏的功能,并且在测试的药理学和房间治疗用作一个重要工具。 | Nan Cao Jing Liao Zumei Liu Wenmin Zhu Jia Wang Lijun Liu Lili Yu Ping Xu Chun Cui Lei Xiao Huang-Tian Yang | 2011 | Cell Research2011，21，9： | 13 |
| 5 | Optimal proportion of wind and PV capacity in provincial power systems based on bilevel optimization algorithm under low-carbon economy显示文摘In order to boost contributions of power systems to a low-carbon economy,the installed capacity of renewable power generation,such as wind and photovoltaic(PV)power generation should be well planned.A bilevel formulation is presented to optimize the proportion of wind and PV capacity in provincial power systems,in which,carbon emissions of generator units and features of renewable resources are taken into account.In the lowerlevel formulation,a time-sequence production simulation(TSPS)model that is suitable for actual power system has been adopted.In order to maximize benefits of energy conservation and emissions reduction resulting from renewable power generation,the commercial software called General Algebraic Modeling System(GAMS)is employed to optimize the annual operation of the power system.In the upper-level formulation,the optimal pattern search(OPS)algorithm is utilized to optimize the proportion of wind and PV capacity.The objective of the upper-level formulation is to maximize benefits of energy conservation and carbon emissions reductions optimized in the lowerlevel problem.Simulation results in practical provincial power systems validate the proposed model and corresponding solving algorithms.The optimization results can provide support to policy makers to make the polices related to renewable energy. | Yue YUAN Yang CAO Xinsong ZHANG Chun LIU Yuehui HUANG Peng LI Kejun QIAN | 2015 | Journal of Modern Power Systems and Clean Energy2015，3，1： | 11 |
| 6 | Fabrication of submicron barium sulfate aggregates in the presence of ethylenediaminetetraacetic acid anions显示文摘Barium sulfate aggregates with an average size of 0.5 μm were synthesized at pH 7,directed by ethylenediaminetetraacetic acid(EDTA) anions.The particle morphology,chemical composition,and size distribution of the BaSO_4 aggregates were characterized.The as-synthesized BaSO_4 particles were spherical and comprised many interconnected nanoballs,of which the surface properties were affected by the EDTA anions.The adsorption of EDTA anions reversed the charge and weakened the surface polarity of BaSO_4,instigating the formation of aggregates by a self-assembly and transformation process.The resulting BaSO_4 particles at pH 9-10 were ellipsoidal and featured smooth surfaces.Based on the zeta potential of BaSO_4,variations in the morphology induced by changes in pH were closely related to the adsorption of mono- and multi-valent anions onto the electrical double layer of BaSO_4. | Linna Hu Guangxiu Wang Chun Yang Rong Cao | 2015 | Particuology2015，13，5： | 11 |
| 7 | A 12-year cohort study on the efficacy of plasmaderived hepatitis B vaccine in rural newborns显示文摘AIM To understand the anti-HBs persistenceand the long-term preventive efficacy in ruralnewborns after vaccination with plasma-derivedhepatitis B vaccine.METHODS In the time of expanded program onimmunization(EPI),the newborns werevaccinated with 10μg×3 doses of hepatitis Bvaccine and 762 newborns who were HBsAgnegative after primary immunization wereselected for cohort observation from 1986 to1998.Their serum samples were detectedqualitatively and quantitatively for hepatitis Binfecting markers,including HBsAg,anti-HBsand anti-HBc by SPRIA Kits.The annual HBsAgpositive conversion rate was counted by life-table method.RESULTS①The anti-HBs positive rate was94.44% for the babies born to HBsAg negativemothers and 84.21% for those born to HBsAgpositive mothers in the 1st year afterimmunization,and dropped to 51.31% and52.50% in the 12th year respectively.GMT valuewas dropped from 31.62 to 3.13 and 23.99 to 3.65in the 2nd to the 12th year respectively.Therewas a marked drop in GMT at the 3rd to the 5thyear,and in anti-HBs positive rate at the 9th tothe 10th year.②In the period of 12 yearsobservation,the person-year HBsAg positive conversion rates were 0.12%(5/4150.0)innewborns born to HBsAg negative mothers and0.20%(1/508.0)in those born to HBsAgpositive mothers,and none of the HBsAgpositive converted children became HBsAgchronic carriers.Compared with the baselinebefore immunization,the protective rates were97.19% and 95.32% respectively.CONCLUSION The protective efficacy ofplasma-derived hepatitis B vaccine persisted atleast 12 years,and a booster dose seems notnecessary within at least 12 years after theprimary three-doses immunization to newbornsborn to HBsAg negative mothers. | Hong Bin Liu Zong Da Meng Jing Chen Ma Chang Quan Han Ying Lin Zhang Zhan Chun Xing Yu Wei Zhang Yu Zhong Liu Hui Lin Cao | 2000 | World Journal of Gastroenterology2000，6，3： | 11 |
| 8 | Anelasticity of twinned CuO nanowires显示文摘CuO nanowires (NW ) 的机械行为被调查由在 situ 传播电子显微镜学。在压缩期间, NW 展出了与高机械的应力联系的高弯曲的能力。有趣地,滞弹性一致地在压力版本以后被观察。进一步的调查显示滞弹性对 CuO NW 内在,尽管 electronbeam 照耀加速形状恢复被证明有能力。机制基于联系双胞胎的原子的合作运动被建议说明这现象。结果提供卓见进 CuO NW 的机械性质,它是为抑制系统的 nanoscale 的有希望的材料。 | Huaping Sheng He Zheng Fan Cao Shujing Wu Lei Li Chun Liu Dongshan Zhao Jianbo Wang | 2015 | Nano Research2015，8，11： | 9 |
| 9 | Spatial-temporal Pattern and Differences of Land Use Changes in the Three Gorges Reservoir Area of China during 1975-2005显示文摘Regional land use changes are an important part of global changes.The research on land use changes in the Three Gorges Reservoir Area of China attracts a lot of attention owing to the Three Gorges Dam building.The Three Gorges Reservoir Area becomes one of the important research areas.This study analyzed the transforming processes and traits of each land use type and the regional differences of land use changes during the past 30 years,summarized the distribution of different land use types in different buffer zones and regresses the equation areas and different buffer distances based on buffer analyses and regression analyses,and then analyzed the transforming rules in different buffer distances,got the optimal influence distances.The research results indicate that,(1) cultivated land lies at the northwest of the reservoir and was decreasing,however,the construction land was increasing,especially the urban construction land,a large number of land was flooded because of the reservoir water level rise;(2) urban area was sprawling quickly in developed and neighboring areas,and a great deal of cultivated land and a considerable amount of grassland were occupied;in the earlier time,rural settlements occupied lots of cultivated land and a sum of forestry land in the later time;(3) the optimum influenced distances for cultivated land and forestry land were 10-35 km,and for urban and rural settlements were in 5-20 km.Overall,this research can reflect the spatial-temporal characteristics of land use changes during the 30 years,and it is helpful for urban planning and land use planning in the reservoir area. | CAO Yingui ZHOU Weit WANG Jing YUAN Chun | 2011 | Journal of Mountain Science2011，8，4： | 9 |
| 10 | Investigation of Induced Distortions in a-Si∶H/a-SiN_x∶H Multilayers by Raman Scattering Technique显示文摘The a Si∶H/SiN x ∶H sample series are investigated by means of Raman scattering technique(RST). The result shows that due to the structural mismatch between a Si∶H and a SiN x ∶H, severe induced distortions are produced in the interface of the heterojunction, and these induced distortions tend towards a certain energy state. The ordering of the interface structure depends on the periodic number of multilayer thin films. | CAO Guo rong 1, GUO Shen kang 1, WANG Zhi chao 2, LIU Yin chun 2, SUN Mei xiang 2 (1.Dept. of Phys., Jiangsu University, Zhenjiang 212003, CHN 2.Dept. of Phys., Nanjing University, Nanjing 210093, CHN) | 2002 | Semiconductor Photonics and Technology2002，8，4： | 8 |
| 11 | The internalization pathway,metabolic fate and biological effect of superparamagnetic iron oxide nanoparticles in the macrophage-like RAW264.7 cell显示文摘The potential applications of superparamagnetic iron oxide nanoparticles (SPIONs) in several nanomedical fields have attracted intense interest based on the cell-nano interaction. However, the mechanisms underlying cell uptake, the intracellular trail, final fate and the biological effects of SPIONs have not yet been clearly elucidated. Here, we showed that multiple endocytic pathways were involved in the internalization process of SPIONs in the RAW264.7 macrophage. The internalized SPIONs were biocompatible and used three different metabolic pathways: The SPIONs were distributed to daughter cells during mitosis; they were degraded in the lysosome and free iron was released into the intracellular iron metabolic pool; and, the intact SPIONs were potentially exocytosed out of the cells. The internalized SPIONs did not induce cell damage but affected iron metabolism, inducing the upregulation of ferritin light chain at both the mRNA and protein levels and ferroportin 1 at the mRNA level. These results may contribute to the development of nanobiology and to the safe use of SPIONs in medicine when administered as a contrast medium or a drug delivery tool. | GU JingLi XU HaiFei HAN YeHua DAI Wei HAO Wei WANG Chun Yu GU Ning XU HaiYan CAO JiMin | 2011 | Science China(Life Sciences)2011，54，9： | 8 |
| 12 | Untreated Prior Pulmonary Tuberculosis Adversely Affects Pregnancy Outcomes in Infertile Women Undergoing in vitro Fertilization and Embryo Transfer: A Large Retrospective Cohort Study显示文摘Objective Prior pulmonary tuberculosis(PTB) on chest X-ray(CXR) was commonly found in infertile patients receiving examinations before in vitro fertilization and embryo transfer(IVF-ET). It was unclear whether untreated PTB would affect pregnancy outcomes after IVF-ET.Method We conducted a retrospective cohort study of 14,254 infertile patients who had received IVFET at Peking University Third Hospital in 2017. Prior PTB was defined as the presence of signs suggestive of old or inactive PTB on CXR, with or without a clinical TB history. Patients who had prior PTB on CXR but had not received a clinical diagnosis and anti-TB therapy were included for analysis. Live birth,clinical pregnancy, and miscarriage rates were compared between the untreated PTB and non-PTB groups.Results The untreated PTB group had significantly lower clinical pregnancy(31.7% vs. 38.1%) and live birth(23.8% vs. 30.6%) rates than the non-PTB group(both P < 0.001). Multivariate analysis revealed that untreated PTB was a risk factor for decreased live birth rate [odds ratio(OR), 0.80;95% confidence interval(CI), 0.66–0.98;P = 0.028] in all patients and for increased miscarriage(OR, 4.19;95% CI,1.69–10.39;P = 0.002) and decreased live birth(OR, 0.45;95% CI, 0.24–0.83;P = 0.011) rates in patients with unexplained infertility.Conclusions Untreated PTB was associated with adverse pregnancy outcomes after IVF-ET, especially in patients with unexplained infertility, highlighting the clinical significance of PTB in this specific patient population. | GAI Xiao Yan CHI Hong Bin ZENG Lin CAO Wen Li CHEN Li Xue ZHANG Chen LU Ming NING Lan Ding CHANG Chun ZHANG Wei Xia LIU Ping LI Rong SUN Yong Chang QIAO Jie | 2021 | Biomedical and Environmental Sciences2021，34，2： | 6 |
| 13 | FED:a web tool for foreign element detection of genome-edited organism显示文摘Dear Editor,Genome editing,especially the newly developed CRISPR technology,is now widely implemented for diverse medical and agricultural applications(Puchta,2018).However,for genome editing,the DNA cassettes encoding the editing components are usually assembled and delivered into the cells of organisms(Cong et al.,2013). | Qing Liu Xiaozhen Jiao Xiangbing Meng Chun Wang Cao Xu Zhixi Tian Chuanxiao Xie Genying Li Jiayang Li Hong Yu Kejian Wang | 2021 | Science China(Life Sciences)2021，64，1： | 6 |
| 14 | Predictors of post coronary artery bypass grafting atrial fibrillation显示文摘Objective: To investigate the incidence and relative risk factors of post coronary artery bypass grafting(post-CABG) atrial fibrillation(AF). Methods: 312 patients with CABG were reviewed and divided into an AF group and a non-AF group. Statistical analysis was used to compare the data between the two groups and screen for risk factors of post-CABG AF. Results: 103/312 (33.01%) patients developed post-CABG AF. Univariate analysis showed that patients in AF group compared with those in non-AF group were more likely to have advanced age (≥70 years), early postoperative withdrawal of β-blockers, hypertension, left atrial enlargement (≥40 mm), a history of AF, prolonged p-wave duration (≥120 ms) and increased number of grafts (≥3). Multivariate logistic regression analysis showed that advanced age (≥70 years), early postoperative withdrawal of β-blockers, hypertension, left atrial enlargement (≥40 mm) and a history of AF were highly related to post-CABG AF. Conclusion: The incidence of AF in patients following CABG was 33.01% in this study. Advanced age, early postoperative withdrawal of β-blockers, hypertension, left atrial enlargement and a history of AF were independent risk factors of post-CABG AF. | Tongtong Shen Qijun Shan Biao Yuan Bing Yang Chun Chen Dongjie Xu Minglong Chen Jiangang Zou Kejiang Cao | 2007 | Journal of Nanjing Medical University2007，21，3： | 5 |
| 15 | Towards context consistency by concurrent checking for Internetware applications显示文摘Internetware applications are emerging and being widely used.They can adapt their behavior based on environmental contexts and deliver smart services.These contexts can be subject to various noises,which cause them to be inaccurate,incomplete,or even to conflict with each other.This is known as context inconsistency problem.Context inconsistency can trigger unexpected behavior to applications,and therefore should be prevented.One promising approach is to check contexts against consistency constraints so as to detect the occurrences of context inconsistency at runtime.Existing techniques have attempted different ways to improve the checking efficiency or effectiveness with different trade-offs in space overhead or communication cost.However,none of them has exploited multi-core computing capability to systematically improve the checking efficiency.In this paper,we propose a novel concurrent checking technique Con-C to efficiently detect inconsistencies in huge volumes of dynamic contexts.Con-C derives checking subtasks for each consistency constraint based on its structure and semantics.It achieves this in a fully automated way,and at the same time can guarantee its derived checking subtasks to be persistently balanced.We evaluated Con-C by controlled experiments through a large-scale real-world application.It reported promising results that Con-C improved the checking efficiency by extra 57.0%,in addition to what had been gained by incremental checking. | XU Chang LIU YePang CHEUNG S.C. CAO Chun LV Jian | 2013 | Science China(Information Sciences)2013，56，8： | 5 |
| 16 | Lipid-dependent conformational dynamics underlie the functional versatility of T-cell receptor显示文摘T 房间 receptor-CD3 建筑群(TCR ) 是能基于 CD3 细胞质的领域的各种各样的生物化学的变化开始抗原特定的有免疫力的回答的一台万用的发信号机器,但是内在的结构的基础留下逃犯。这里,我们开发了生物物理的途径学习 CD3 细胞质的领域的 conformational 动力学(CD3 CD ) 。在单个分子的水平,我们发现那 CD3 CD 能与三个功能的主题的不同坦诚有多重 conformational 状态,即, ITAM, BRS 和 PRS。因为,这些符合构造被产生 CD3 CD 有异构的类脂化合物绑定性质因此有异构的动力学。实时房间的成像实验证明不同抗原刺激能稳定 CD3 在不同符合构造的 CD 。类脂化合物依赖者 conformational 动力学因此为 TCR 的万用的发信号性质提供结构的基础。 | Xingdong Guo Chengsong Yan Hua Li Wenmao Huan Xiaoshan Shi Min Huang Yingfang Wang Weiling Pan Mingjun Cai Lunyi Li Wei Wu Yibing Bai Chi Zhang Zhijun Liu Xinyan Wang Xiaohui F Zhang Chun Tang Hongda Wang Wanli Liu Bo Ouyang Catherine C Wong Yi Cao Chenqi Xu | 2017 | Cell Research2017，27，4： | 5 |
| 17 | Extinction and Positivity for a Doubly Nonlinear Degenerate Parabolic Equation显示文摘这篇论文的目的是为起始的边界价值问题和 u_t = div (|▽ u ~m|^(p-2 )▽ u ~ m ) 的 Cauchy 问题的答案讨论扑灭和确实。弱答案将为 1 是绝灭的,这被证明 < 1 + 1/m 和愿望是的 p ≤为 p 积极 < 为大 t 的 1 + 1/m,在此 m < 0。 | Hong Jun YUAN Song Zhe LIAN Chun Ling CAO Wen Jie GAO Xiao Jing XU | 2007 | Acta Mathematica Sinica,English Series2007，23，10： | 5 |
| 18 | Mesoporous silica rods with cone shaped pores modulate inflammation and deliver BMP-2 for bone regeneration显示文摘Biomaterials with suitable osteoimmunomodulation properties and ability to deliver osteoinductive biomolecules,such as bone morphogenetic proteins,are desired for bone regeneration.Herein,we report the development of mesoporous silica rods with large cone-shaped pores(MSR-CP)to load and deliver large protein drugs.It is noted that those cone-shaped pores on the surface modulated the immune response and reduced the pro-inflammatory reaction of stimulated macrophage.Furthermore,bone morphogenetic proteins 2(BMP-2)loaded MSR-CP facilitated osteogenic differentiation and promoted osteogenesis of bone marrow stromal cells.In vivo tests confirmed BMP-2 loaded MSR-CP improved the bone regeneration performance.This study provides a potential strategy for the design of drug delivery systems for bone regeneration. | Chun Xu Lan Xiao Yuxue Cao Yan He Chang Lei Yin Xiao Wujin Sun Samad Ahadian Xueting Zhou Ali Khademhosseini Qingsong Ye | 2020 | Nano Research2020，13，9： | 5 |
| 19 | Expanding the scope of genome editing with SpG and SpRY variants in rice显示文摘Dear Editor,The clustered regularly interspaced short palindromic repeats/CRISPR-associated nuclease 9(CRISPR/Cas9)system,since it was excavated,has been rapidly developed and sparked a revolution in the genome editing field.In principle,CRISPR/Cas9 system relies on the recognition of specific loci on the genome,which is titled the protospacer adjacent motif(PAM).However,the canonical Streptococcus pyogenes Cas9(SpCas9)nuclease only recognizes NGG or NAG PAMs,rendering an inherent obstacle in amplifying the application of CRISPR/Cas9 technology. | Jun Ren Xiangbing Meng Fengyue Hu Qing Liu Yuexuan Cao Huiying Li Changjie Yan Jiayang Li Kejian Wang Hong Yu Chun Wang | 2021 | Science China(Life Sciences)2021，64，10： | 4 |
| 20 | Highly dispersed Co-Mo sulfide nanoparticles on reduced graphene oxide for lithium and sodium ion storage显示文摘A novel hybrid,highly dispersed spinel Co-Mo sulfide nanoparticles on reduced graphene oxide(Co3S4/CoMo2S4@rGO),is reported as anode for lithium and sodium ion storage.The hybrid is synthesized by one-step hydrothermal method but exhibits excellent lithium and sodium storage performances.The as-synthesized Co3S4/CoMo2S4@rGO presents reversible capacity of 595.4 mA·h·g^−1 and 408.8 mA·h·g^−1 after 100 cycles at a current density of 0.2 A·g^−1 for lithium and sodium ion storages,respectively.Such superior performances are attributed to the unique composition and structure of Co3S4/CoMo2S4@rGO.The rGO provides a good electronically conductive network and ensures the formation of spinel Co3S4/CoMo2S4 nanoparticles,the Co3S4/CoMo2S4 nanoparticles provide large reaction surface for lithium and sodium intercalation/deintercalation,and the spinel structure allows fast lithium and sodium ion diffusion in three dimensions. | Yuqing Liao Chun Wu Yaotang Zhong Min Chen Luyang Cai Huirong Wang Xiang Liu Guozhong Cao Weishan Li | 2020 | Nano Research2020，13，1： | 4 |
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