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| 1 | A Chromosome-Level Genome Assembly of Garlic (Allium sativum) Provides Insights into Genome Evolution and Allicin Biosynthesis显示文摘Garlic,an economically important vegetable,spice,and medicinal crop,produces highly enlarged bulbs and unique organosulfur compounds.Here,we report a chromosome-level genome assembly for garlic,with a total size of approximately 16.24 Gb,as well as the annotation of 57561 predicted protein-coding genes,making garlic the first Allium species with a sequenced genome.Analysis of this garlic genome assembly reveals a recent burst of transposable elements,explaining the substantial expansion of the garlic genome.We examined the evolution of certain genes associated with the biosynthesis of allicin and inulin neoseries-type fructans,and provided new insights into the biosynthesis of these two compounds.Furthermore,a large-scale transcriptome was produced to characterize the expression patterns of garlic genes in different tissues and at various growth stages of enlarged bulbs.The reference genome and large-scale transcriptome data generated in this study provide valuable new resources for research on garlic biology and breeding. | Xiudong Sun Siyuan Zhu Ningyang Li Yi Cheng Jing Zhao Xuguang Qiao Li Lu Shiqi Liu Yanzhou Wang Chan Liu Benping Li Wu Guo Shuang Gao Zemao Yang Fu Li Zheng Zeng Qing Tang Yupeng Pan Mengjiao Guan Jian Zhao Xiaomi ng Lu Huanwe n Meng Zhenlin Han Chun she ng Gao Wenkai Jiang Xing Zhao Shilin Tian Jianguang Su Zhihui Cheng Touming Liu | 2020 | Molecular Plant2020，13，9： | 14 |
| 2 | Role of Fas/FasL Pathway-mediated Alveolar Macrophages Releasing Inflammatory Cytokines in Human Silicosis显示文摘The role of Fas/Fas ligand (FasL) in mediating alveolar macrophage (AM)-derived inflammatory cytokines in 29 human lung silicosis patients and 6 controls was studied.It showed that the serum levels of IL-1β,TNF-α,IL-8,MIP-1α,MCP-1,and TGF-β1were higher in silicosis patients than in controls,and increased with the progression of silicosis except TGF-β1 and IL-8.TGF-β1,IL-8,MCP-1,MIP-1αwere efficiently down-regulated by anti-FasL antibody or caspase-8 inhibitor,indicating that Fas/FasL signaling promotes the | YAO San Qiao HE Qin Cheng YUAN Ju Xiang CHEN Jie CHEN Gang LU Yao BAI Yu Ping ZHANG Chun Min YUAN Yang XU Ying Jun | 2013 | Biomedical and Environmental Sciences2013，26，11： | 13 |
| 3 | Association of Overlapped and Un-overlapped Comorbidities with COVID-19 Severity and Treatment Outcomes: A Retrospective Cohort Study from Nine Provinces in China显示文摘Objective Several COVID-19 patients have overlapping comorbidities. The independent role of each component contributing to the risk of COVID-19 is unknown, and how some non-cardiometabolic comorbidities affect the risk of COVID-19 remains unclear.Methods A retrospective follow-up design was adopted. A total of 1,160 laboratory-confirmed patients were enrolled from nine provinces in China. Data on comorbidities were obtained from the patients’ medical records. Multivariable logistic regression models were used to estimate the odds ratio(OR) and 95% confidence interval(95% CI) of the associations between comorbidities(cardiometabolic or non-cardiometabolic diseases), clinical severity, and treatment outcomes of COVID-19.Results Overall, 158(13.6%) patients were diagnosed with severe illness and 32(2.7%) had unfavorable outcomes. Hypertension(2.87, 1.30–6.32), type 2 diabetes(T2 DM)(3.57, 2.32–5.49),cardiovascular disease(CVD)(3.78, 1.81–7.89), fatty liver disease(7.53, 1.96–28.96), hyperlipidemia(2.15, 1.26–3.67), other lung diseases(6.00, 3.01–11.96), and electrolyte imbalance(10.40, 3.00–26.10)were independently linked to increased odds of being severely ill. T2 DM(6.07, 2.89–12.75), CVD(8.47,6.03–11.89), and electrolyte imbalance(19.44, 11.47–32.96) were also strong predictors of unfavorable outcomes. Women with comorbidities were more likely to have severe disease on admission(5.46,3.25–9.19), while men with comorbidities were more likely to have unfavorable treatment outcomes(6.58, 1.46–29.64) within two weeks.Conclusion Besides hypertension, diabetes, and CVD, fatty liver disease, hyperlipidemia, other lung diseases, and electrolyte imbalance were independent risk factors for COVID-19 severity and poor treatment outcome. Women with comorbidities were more likely to have severe disease, while men with comorbidities were more likely to have unfavorable treatment outcomes. | MA Yan ZHU Dong Shan CHEN Ren Bo SHI Nan Nan LIU Si Hong FAN Yi Pin WU Gui Hui YANG Pu Ye BAI Jiang Feng CHEN Hong CHEN Li Ying FENG Qiao GUO Tuan Mao HOU Yong HU Gui Fen HU Xiao Mei HU Yun Hong HUANG Jin HUANG Qiu Hua HUANG Shao Zhen JI Liang JIN Hai Hao LEI Xiao LI Chun Yan LI Min Qing LI Qun Tang LI Xian Yong LIU Hong De LIU Jin Ping LIU Zhang MA Yu Ting MAO Ya MO Liu Fen NA Hui WANG Jing Wei SONG Fang Li SUN Sheng WANG Dong Ting WANG Ming Xuan WANG Xiao Yan WANG Yin Zhen WANG Yu Dong WU Wei WU Lan Ping XIAO Yan Hua XIE Hai Jun XU Hong Ming XU Shou Fang XUE Rui Xia YANG Chun YANG Kai Jun YUAN Sheng Li ZHANG Gong Qi ZHANG Jin Bo ZHANG Lin Song ZHAO Shu Sen ZHAO Wan Ying ZHENG Kai ZHOU Ying Chun ZHU Jun Teng ZHU Tian Qing ZHANG Hua Min WANG Yan Ping WANG Yong Yan 无 | 2020 | Biomedical and Environmental Sciences2020，33，12： | 8 |
| 4 | Untreated Prior Pulmonary Tuberculosis Adversely Affects Pregnancy Outcomes in Infertile Women Undergoing in vitro Fertilization and Embryo Transfer: A Large Retrospective Cohort Study显示文摘Objective Prior pulmonary tuberculosis(PTB) on chest X-ray(CXR) was commonly found in infertile patients receiving examinations before in vitro fertilization and embryo transfer(IVF-ET). It was unclear whether untreated PTB would affect pregnancy outcomes after IVF-ET.Method We conducted a retrospective cohort study of 14,254 infertile patients who had received IVFET at Peking University Third Hospital in 2017. Prior PTB was defined as the presence of signs suggestive of old or inactive PTB on CXR, with or without a clinical TB history. Patients who had prior PTB on CXR but had not received a clinical diagnosis and anti-TB therapy were included for analysis. Live birth,clinical pregnancy, and miscarriage rates were compared between the untreated PTB and non-PTB groups.Results The untreated PTB group had significantly lower clinical pregnancy(31.7% vs. 38.1%) and live birth(23.8% vs. 30.6%) rates than the non-PTB group(both P < 0.001). Multivariate analysis revealed that untreated PTB was a risk factor for decreased live birth rate [odds ratio(OR), 0.80;95% confidence interval(CI), 0.66–0.98;P = 0.028] in all patients and for increased miscarriage(OR, 4.19;95% CI,1.69–10.39;P = 0.002) and decreased live birth(OR, 0.45;95% CI, 0.24–0.83;P = 0.011) rates in patients with unexplained infertility.Conclusions Untreated PTB was associated with adverse pregnancy outcomes after IVF-ET, especially in patients with unexplained infertility, highlighting the clinical significance of PTB in this specific patient population. | GAI Xiao Yan CHI Hong Bin ZENG Lin CAO Wen Li CHEN Li Xue ZHANG Chen LU Ming NING Lan Ding CHANG Chun ZHANG Wei Xia LIU Ping LI Rong SUN Yong Chang QIAO Jie | 2021 | Biomedical and Environmental Sciences2021，34，2： | 6 |
| 5 | Effect of experimental warming on soil respiration under conventional tillage and no-tillage farmland in the North China Plain显示文摘Understanding the response of soil respiration to global warming in agro-ecosystem is crucial for simulating terrestrial carbon(C) cycle.We conducted an infrared warming experiment under conventional tillage(CT) and no-tillage(NT) farmland for winter wheat and summer maize rotation system in North China Plain(NCP).Treatments include CT with and without warming(CTW and CTN),NT with and without warming(NTW and NTN).The results indicated that warming had no significant effect on soil moisture in irrigated farmland of NCP(P>0.05).The elevated average soil temperature of 1.1-1.6°C in crop growing periods could increase annual soil CO_2 emission by 10.3%in CT filed(P>0.05),but significantly increase it by 12.7%in NT field(P<0.05),respectively.The disturbances such as plowing,irrigation and precipitation resulted in the obvious soil CO_2 emission peaks,which contributed 36.6-40.8%of annual soil cumulative CO_2 emission.Warming would enhance these soil CO_2 emission peaks;it might be associated with the warming-induced increase of autotrophic respiration and heterotrophic respiration.Compared with un-warming treatments,dissolved organic carbon(DOC) and soil microbial biomass carbon(MBC) in warming treatments were significantly increased by 11.6-23.4 and 12.9-23.6%,respectively,indicating that the positive responses of DOC and MBC to warming in both of two tillage systems.Our study highlights that climate warming may have positive effects on soil C release in NCP in association with response of labile C substrate to warming. | TU Chun LI Fa-dong QIAO Yun-feng ZHU Nong GU Cong-ke ZHAO Xin | 2017 | Journal of Integrative Agriculture2017，16，4： | 6 |
| 6 | The Impact of Relative Humidity and Atmospheric Pressure on Mortality in Guangzhou, China显示文摘Objective Although many studies have examined the effects of ambient temperatures on mortality, little evidence is on health impacts of atmospheric pressure and relative humidity. This study aimed to assess the impacts of atmospheric pressure and relative humidity on mortality in Guangzhou, China. Methods This study included 213,737 registered deaths during 2003-2011 in Guangzhou, China. A quasi-Poisson regression with a distributed lag non-linear model was used to assess the effects of atmospheric pressure/relative humidity. Results We found significant effect of low atmospheric pressure/relative humidity on mortality. There was a 1.79%(95% confidence interval: 0.38%-3.22%) increase in non-accidental mortality and a 2.27%(0.07%-4.51%) increase in cardiovascular mortality comparing the 5th and 25 th percentile of atmospheric pressure. A 3.97%(0.67%-7.39%) increase in cardiovascular mortality was also observed comparing the 5th and 25 th percentile of relative humidity. Women were more vulnerable to decrease in atmospheric pressure and relative humidity than men. Age and education attainment were also potential effect modifiers. Furthermore, low atmospheric pressure and relative humidity increased temperature-related mortality. Conclusion Both low atmospheric pressure and relative humidity are important risk factors of mortality. Our findings would be helpful to develop health risk assessment and climate policy interventions that would better protect vulnerable subgroups of the population. | OU Chun Quan YANG Jun OU Qiao Qun LIU Hua Zhang LIN Guo Zhen CHEN Ping Yan QIAN Jun GUO Yu Ming | 2014 | Biomedical and Environmental Sciences2014，27，12： | 5 |
| 7 | Impacts of smoking status on the clinical outcomes of coronary non-target lesions in patients with coronary heart disease:a single-center angiographic study显示文摘Background:Coronary atherosclerotic plaque could go through rapid progression and induce adverse cardiac events.This study aimed to evaluate the impacts of smoking status on clinical outcomes of coronary non-target lesions.Methods:Consecutive patients with coronary heart disease who underwent two serial coronary angiographies were included.All coronary non-target lesions were recorded at first coronary angiography and analyzed using quantitative coronary angiography at both procedures.Patients were grouped into non-smokers,quitters,and smokers according to their smoking status.Clinical outcomes including rapid lesion progression,lesion re-vascularization,and myocardial infarction were recorded at second coronary angiography.Multivariable Cox regression analysis was used to investigate the association between smoking status and clinical outcomes.Results:A total of 1255 patients and 1670 lesions were included.Smokers were younger and more likely to be male compared with nonsmokers.Increase in percent diameter stenosis was significantly lower(2.7[0.6,7.1]%vs.3.5[0.9,8.9]%)and 3.4[1.1,7.7]%,P=0.020)in quitters than those in smokers and non-smokers.Quitters tended to have a decreased incidence of rapid lesions progression(15.8%[76/482]vs.21.6%[74/342]and 20.6%[89/431],P=0.062),lesion re-vascularization(13.1%[63/482]vs.15.5%[53/432]and 15.5%[67/431],P=0.448),lesion-related myocardial infarction(0.8%[4/482]vs.2.6%[9/342]and 1.4%[6/431],P=0.110)and all-cause myocardial infarction(1.9%[9/482]vs.4.1%[14/342]and 2.3%[10/431],P=0.128)compared with smokers and non-smokers.In multivariable analysis,smoking status was not an independent predictor for rapid lesion progression,lesion re-vascularization,and lesion-related myocardial infarction except that a higher risk of all-cause myocardial infarction was observed in smokers than non-smokers(hazards ratio:3.00,95%confidence interval:1.04-8.62,P=0.042).Conclusion:Smoking cessation mitigates the increase in percent diameter stenosis of coronary non-target lesions,meanwhile,smokers are associated with increased risk for all-cause myocardial infarction compared with non-smokers. | Hao-Bo Xu Juan Wang Ji-Lin Chen Chao Guo Jian-Song Yuan Xin Duan Feng-Huan Hu Wei-Xian Yang Xiao-Liang Luo Rong Liu Jin-Gang Cui Sheng-Wen Liu Xiao-Jin Gao Yu-Shi Chun Shu-Bin Qiao | 2020 | Chinese Medical Journal2020，，19： | 5 |
| 8 | Preparation,structural characterization of a novel egg-shell palladium sulfide catalyst and its application in selective reductive alkylation reaction显示文摘有核心和钯硫化物的膜被 sulphidizing Pd/C 与 H2S 作为表面准备了的钯金属的新奇卵壳 PdS 催化剂。这催化剂是有效的让 p 氨基的二苯胺(PADPA ) 和 methylisobutyl 酉同类(MIBK ) 的减少的完化负担得起 N-(1,3-dimethylbutyl ) 有直到 99.42% 的变换和到 97.46% 的选择的 -N-phenyl-p-phenylenedianine (DBPPD ) 。与另外的普通的钯硫化物催化剂作比较,表面上的硫化物和钯金属的核心在更低的硫协作在新催化剂的表面上引起 Pd 的钯的膜,它改进它的活动。我们的结果显示这新卵壳 PdS/C 是有效加氢催化剂。 | Qun Feng Zhang Jia Chun Wu Chang Su Feng Feng Qiao Ling Ding Zhao Lian Yuan Hong Wang Lei Ma Chun Shan Lu Xiao Nian Li | 2012 | Chinese Chemical Letters2012，23，10： | 5 |
| 9 | Erlotinib versus gemcitabine plus cisplatin as neoadjuvant treatment of stage IIIA-N2 EGFR-mutant non-small-cell lung cancer:final overall survival analysis of the EMERGING-CTONG 1103 randomised phase II trial显示文摘EMERGING-CTONG 1103 showed improved progression-free survival(PFS)with neoadjuvant erlotinib vs.chemotherapy for patients harbouring EGFR sensibility mutations and R0 resected stage IIIA-N2 non-small cell lung cancer(NSCLC)(NCT01407822).Herein,we report the final results.Recruited patients were randomly allocated 1:1 to the erlotinib group(150 mg/day orally;neoadjuvant phase for 42 days and adjuvant phase to 12 months)or to the GC group(gemcitabine 1250 mg/m2 plus cisplatin 75 mg/m2 intravenously;2 cycles in neoadjuvant phase and 2 cycles in adjuvant phase).Objective response rate(ORR),complete pathologic response(pCR),PFS,and overall survival(OS)were assessed along with safety.Post hoc analysis was performed for subsequent treatments after disease recurrence.Among investigated 72 patients(erlotinib,n=37;GC,n=35),the median follow-up was 62.5 months.The median OS was 42.2 months(erlotinib)and 36.9 months(GC)(hazard ratio[HR],0.83;95%confidence interval[CI],0.47-1.47;p=0.513).The 3-and_(5-y)ear OS rates were 58.6%and 40.8%with erlotinib and 55.9%and 27.6%with GC(p_(3-y)=0.819,p_(5-y)=0.252).Subsequent treatment was administered in 71.9%and 81.8%of patients receiving erlotinib and GC,respectively;targeted therapy contributed mostly to OS(HR,0.35;95%CI,0.18-0.70).After disease progression,the ORR was 53.3%,and the median PFS was 10.9 months during the EGFR-TKI rechallenge.During postoperative therapy,grade 3 or 4 adverse events(AEs)were 13.5%in the erlotinib group and 29.4%in the GC group.No serious adverse events were observed.Erlotinib exhibited clinical feasibility for resectable IIIA-N2 NSCLC over chemotherapy in the neoadjuvant setting. | Wen-Zhao Zhong Hong-Hong Yan Ke-Neng Chen Chun Chen Chun-Dong Gu Jun Wang Xue-Ning Yang Wei-Min Mao Qun Wang Gui-Bin Qiao Ying Cheng Lin Xu Chang-Li Wang Ming-Wei Chen Xiao-Zheng Kang Wan-Pu Yan Ri-Qiang Liao Jin-Ji Yang Xu-Chao Zhang Si-Yang Liu Qing Zhou Yi-Long Wu | 2023 | Signal Transduction and Targeted Therapy2023，8，3： | 4 |
| 10 | Derivation and characterization of human embryonic stem cell lines from the Chinese population显示文摘人的胚胎的干细胞(hESCs ) 无止境地装自我更新并且在人的身体区分进所有房间类型。因此,他们在再生药,人的发展生物学和药发现是珍贵的。很多根 hESC 线从中国人口被导出,但是他们限制了为研究目的是可得到的。这里,我们报导线从中国起源的人的胚囊导出的二 hESC 的推导和描述。这些 hESCs 快车碱的磷酸酶和 hESC 特定的标记,包括的 Oct4, Nanog, SSEA-3, SSEA-4, TRA-1-60 和 TRA-1-81。他们也有 telomerase 活动和正常 karyotypes 的高水平。这些房间能在 vitro 形成胚胎植物或动物身体并且能被 teratoma 形成在 vivo 区分进所有三细菌层。最新确定的 hESCs 将为研究目的被散布。从中国人口的 hESC 线的可获得性将从不同的种族组在 hESCs 在差别上便于研究。 | Zhao Wu Hui Li Lingjun Rao Lixiaz iHe Lei Bao Jing Liao Chun Cui Zhenyu Zuo Qiao Li Huimin Dai Lei Qian Qing Tian Lei Xiao Xiao junTan | 2011 | Journal of Genetics and Genomics2011，38，1： | 3 |
| 11 | Clinical Manifestation of Calreticulin Gene Mutations in Essential Thrombocythemia without Janus Kinase 2 and MPL Mutations: A Chinese Cohort Clinical Study显示文摘 | Chao Sun Xin Zhou Zhi-Jian Zou Hong-Feng Guo Jian-Yong Li Chun Qiao | 2016 | Chinese Medical Journal2016，，15： | 2 |
| 12 | Efficacy and safety of decitabine combined with low-dose cytarabine, aclarubicin, and granulocyte colony-stimulating factor compared with standard therapy in acute myeloid leukemia patients with TP53 mutation显示文摘Tumor suppressor gene P53(TP53)is a critical tumor suppressor gene.The mutant p53 protein enhances the activity,invasion and metastasis of tumor cells.Acute myeloid leukemia(AML)patients with TP53 mutations respond poorly to conventional chemotherapy and have poor clinical outcomes.We previously conducted a multi-center phase II clinical trial(No.ChiCTRONC-11001700)in elderly AML patients with decitabine,low-dose cytarabine,aclarubicin,and granulocyte colony-stimulating factor(G-CSF)(DCAG regimen),which showed an overall response rate(ORR)of 82.4%and a complete remission(CR)rate of 64.7%.[1]Given this satisfactory effect of DCAG regimen,the present study has been designed to compare the efficacy and safety of DCAG regimen with standard therapy in AML patients with TP53 mutations. | Si-Si Chen Qian Sun Lan Cao Wen-Zhong Wu Yue Xie Chun Qiao Jian-yong Li Si-Xuan Qian Ming Hong | 2021 | Chinese Medical Journal2021，，12： | 2 |
| 13 | Seasonal dynamics of soil water content in the typical vegetation and its response to precipitation in a semi-arid area of Chinese Loess Plateau显示文摘Soil water content is a key limiting factor for vegetation growth in the semi-arid area of Chinese Loess Plateau and precipitation is the main source of soil water content in this area.To further understand the impact of vegetation types and environmental factors such as precipitation on soil water content,we continuously monitored the seasonal dynamics in soil water content in four plots(natural grassland,Caragana korshinskii,Armeniaca sibirica and Pinus tabulaeformis)in Chinese Loess Plateau.The results show that the amplitude of soil water content fluctuation decreases with an increase in soil depth,showing obvious seasonal variations.Soil water content of artificial vegetation was found to be significantly lower than that of natural grassland,and most precipitation events have difficulty replenishing soil water content below a depth of 40 cm.Spring and autumn are the key seasons for replenishment of soil water by precipitation.Changes in soil water content are affected by precipitation,vegetation types,soil evaporation and other factors.The interception effect of vegetation on precipitation and the demand for water consumption by transpiration are the key factors affecting the efficiency of soil water replenishment by precipitation in this area.Due to artificial vegetation plantation in this area,soil will face a water deficit crisis in the future. | ZHOU Tairan HAN Chun QIAO Linjie REN Chaojie WEN Tao ZHAO Changming | 2021 | Journal of Arid Land2021，13，10： | 2 |
| 14 | Immuno-protective effect of tumor cell vaccine on Kunming mice bearing Ehrlich ascites tumor显示文摘INTRODUCTIONBiotherapyrepresentsanalternativeoptionaftersurgery,radiotherapyandchemotherapyforcancer.Tumorvaccineandtheinduct... | MA Zheng, ZHOU Shao Juan, WU Kai Chun, PAN Bo Rong, QIAO Tai Dong, CHEN Bao Jun and FAN Dai Ming | 1998 | World Journal of Gastroenterology1998，4，5： | 2 |
| 15 | Effect of surface ligand density on cytotoxicity and pharmacokinetic profile of docetaxel loaded liposomes显示文摘Various biotin-modified liposomes incorporated with docetaxel(DTX) were prepared to study the effect of surface biotin density on the pharmacokinetic profile of the liposome. Four types of liposomes such as PEG modified liposome(PDL), 0.5%(mol) biotin modified liposome(0.5 BDL), 1%(mol) biotin modified liposome(1 BDL) and 2%(mol) biotin modified liposome(2 BDL) were prepared using thin film dispersion method. The prepared liposomes were characterized by measuring encapsulation efficiency(EE), particle size, Zeta-potential, physical stability and drug release profiles in vitro. MTT assay was performed to elevate the cytotoxicity of liposomes on MCF-7 cells. In vivo evaluation was further performed to investigate the effect of biotin surface density on the pharmacokinetic profiles. All the prepared liposomes exhibited high encapsulation efficiency, small particle size, narrow particle distribution and sustained release profiles in vitro. In MTT assay, 0.5 BDL showed largest tumor cell toxicity, compared with DTX solution. All liposomes containing DTX showed prolonged blood circulation in vivo, and 0.5 BDL showed the longest circulation time among the biotin modified liposome. Surface modification of liposome had a negative impact on the circulation of liposomes in the blood, which needs to be considered when designing the ligand mediated targeting delivery systems. A proper amount of biotin liposome with 0.5% molar ratio is expected to produce the best anti-tumor effect. | Chun Chu Ping Xu Haoyue Zhao Qing Chen Dawei Chen Haiyang Hu Xiuli Zhao Mingxi Qiao | 2016 | Asian Journal of Pharmaceutical Sciences2016，11，5： | 2 |
| 16 | A general chelate-assisted co assembly to metallic nanoparticles-incorporated ordered mesoporous car- bon catalysts for fischer-tropsch synthesis显示文摘 | Sun Zhenkun Sun Bo Qiao Minghua Wei Jing Yue Q Wang Chun | 2012 | Journal of the American Chemical Society2012，134，17： | 1 |
| 17 | Photonic quantnm- well structures: multiple channeled filtering phenomena 显示文摘 | Qiao Feng Zhang Chun Wan Jun | 2000 | Appl Phys Lett2000，77，23： | 1 |
| 18 | Vitamin D: a negative endocrine regulator of the renin–angiotensin system and blood pressure显示文摘 | Yan Chun Li Guilin Qiao Milan Uskokovic Wei Xiang Wei Zheng Juan Kong | 2004 | Journal of Steroid Biochemistry and Molecular Biology2004，，： | 1 |
| 19 | Study of sampling in CCD photoelectric imaging system 显示文摘 | Nao Sheng Qiao Chun Mei Yao | 2012 | Applied Mechanics and Materials2012，，： | 1 |
| 20 | HIV,HCV,and HBV Co-Infections in a Rural Area of Shanxi Province with a History of Commercial Blood Donation显示文摘Background:Unhygienic blood collection in the early 1990s led to blood‐borne infections in Central China.This study aimed to estimate human immunodeficiency virus (HIV) co‐infection with hepatitis C and B viruses (HCV and HBV) and their risk factors in a rural area of Shanxi Province with a history of commercial blood donation.Methods:A cross‐sectional study was conducted in 2004.All adult residents in the target area were invited to participate in the study.Face‐to‐face interviews were completed and blood specimens were tested for HIV,HCV,and HBV surface antigen (HBsAg).Results:Prevalence rates of HIV,HCV,and HBsAg were 1.3% (40/3 062),12.7% (389/3 062),and 3.5% (103/2982),respectively.Of the 40 HIV‐positive specimens,85% were HCV positive and 2.5% were HBsAg positive.The history of commercial blood donation was positively associated with HIV,HCV,and HIV/HCV co‐infections,but was negatively associated with HBsAg seropositivity.Migration for employment in the last 5 years was positively related to HIV,HBsAg,and HIV/HCV co‐infections.Univariate logistic analysis showed that illegal drug use,number of sex partners,extramarital sex behavior,commercial sex behavior,and condom use rate were not related to anti‐HIV,anti‐HCV,HBsAg seropositivity or their co‐infections.Conclusion:The history of commercial blood donation was the main risk factor for HIV,HCV,and HIV/HCV co‐infections in this former commercial blood donation area.HIV and HCV prevention and treatment interventions are important in this area. | DONG RuiLing QIAO Xiao Chun JIA WangQian WONG Michelle QIAN HanZhu ZHENG XiWen XING WenGe LAI ShengHan WU ZhengLai JIANG Yan WANG Ning | 2011 | Biomedical and Environmental Sciences2011，24，3： | 1 |
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