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| 1 | Anticancer immunotherapy by CTLA-4 blockade: obligatory contribution of IL-2 receptors and negative prognostic impact of soluble CD25显示文摘堵住抗体 ipilimumab 的细胞毒素的 T 淋巴细胞 antigen-4 (CTLA-4 ) 在很少的病人导致变形黑瘤的调停免疫者的长期的控制。尽管 ipilimumab 无疑经由 immunostimulation 施加它的治疗学的效果,这样远的临床上有用的、 immunologically 相关的 biomarkers 预言治疗效率是逃犯的。这里,我们显示出 IL-2 的那中立化或堵住 α并且 βIL-2 受体的子单元(CD25 和 CD122,分别地) 否则在现出症状之前的潜的老鼠模型由 CTLA-4 封锁导致了,废除了 antitumor 效果和 intratumoral T 受动器对规章的房间(Tregs ) 的比率的伴随的改进,它是。CTLA-4 封锁导致了在失去了 FoxP3 表示并且在 regressing 肿瘤积累了的 IL-2-producing 受动器房间与伴随物上升表示 Lag3, ICOS, IL-10 和 Egr2 的一个镇压 CD4 + T 房间子集的减小。当 recombinant IL-2 改进了 CTLA-4 封锁的治疗学的功效时,圈套 IL-2 受体 α(IL-2Rα, sCD25 ) 禁止了 CTLA-4 的 anticancer 效果封锁。在收到 ipilimumab 的 262 个变形黑瘤病人, sCD25 的基线浆液集中代表了全面幸存的独立指示物,与预言到治疗的抵抗的高水平。总的来说,这些结果解开为在 CTLA-4 的 anticancer 活动的 IL-2 和 IL-2 受体的一个角色封锁。重要地,我们的学习提供第一 immunologically 相关的 biomarker,也就是提高的浆液 sCD25,那与黑瘤在病人预言抵抗到 CTLA-4 封锁。 | Dalil Hannani Marie Vetizou David Enot Sylvie Rusakiewicz Nathalie Chaput David Klatzmann Melanie Desbois Nicolas Jacquelot Nadege Vimond Salem Chouaib Christine Mateus James P Allison Antoni Ribas Jedd D Wolchok Jianda Yuan Philip Wong Michael Postow Andrzej Mackiewicz Jacek Mackiewicz Dirk Schadendorff Dirk Jaeger Alan J Korman Keith Bahjat Michele Maio Luana Calabro Michele WL Teng Mark J Smyth Alexander Eggennont Caroline Robert Guido Kroemer Laurence Zitvogel | 2015 | Cell Research2015，25，2： | 14 |
| 2 | Assessing cypermethrin-contaminated soil with three different earthworm test methods显示文摘A series of tests (lethal,sublethal,and behavioral) on earthworms were conducted as an eco-assessment of pesticides.In this study,the toxicity of cypermethrin-contaminating soil on adult and juvenile earthworms was assessed.Beside the acute and chronic tests,an avoidance response test was carried out.It was shown that the all-round toxicity from cypermethrin was weak on adult earthworms.Compared with adult earthworms,the toxicity of juvenile earthworms from cypermethrin especially chronic toxicity increased significantly.Growth and reproduction of earthworms appeared to be more severely affected by cypermethrin at juvenile stage than at adult stage.Applied at 10 mg/kg,cypermethrin had obvious adverse impact on the growth of juvenile earthworms,while 20 mg/kg,cypermethrin caused significant toxic effects in reproduction.The results also indicated that ecotoxicological risk assessment using only adult specimens may underestimate the effects of cypermethrin on soil invertebrate populations. | Wong Hang Gi Michelle | 2008 | Journal of Environmental Sciences2008，20，11： | 7 |
| 3 | Endoscopic Tri-Modal Imaging Is More Effective Than Standard Endoscopy in Identifying Early-Stage Neoplasia in Barrett’s Esophagus显示文摘 | Wouter L. Curvers Lorenza Alvarez Herrero Michael B. Wallace Louis–Michel Wong Kee Song Krish Ragunath Herbert C. Wolfsen Ganapathy A. Prasad Kenneth K. Wang Venkataraman Subramanian Bas L.A.M. Weusten Fiebo J. Ten Kate Jacques J.G.H.M. Bergman | 2010 | Gastroenterology2010，，4： | 6 |
| 4 | Individual and combined toxic effects of cypermethrin and chlorpyrifos on earthworm显示文摘Toxicities were assessed for a pyrethroid (cypermethrin) and an organophosphate insecticide (chlorpyrifos) individually and in combination. A series of tests were conducted on different responses (acute, chronic, behavioral) of earthworms of species Eisenia fetida andrei in the ecological risk assessment of these pesticides. The results showed that the toxicity of the mixture of cypermethrin and chlorpyrifos was significantly higher than either of these pesticides individually, especially on the earthworm's chronic responses. At a concentration of 5 mg/kg, the mixture caused significant reductions on the growth and reproduction rates of earthworms, but did not cause any significant effect when the individual was tested. The increase in toxicity of the pesticide mixture means that the use of toxicity data obtained exclusively from single-pesticide experiments may underestimate the ecological risk of pesticides that actually present in the field. | Shiping Zhou Changqun Duan Wong Hang Gi Michelle Fazhong Yang Xuehua Wang | 2011 | Journal of Environmental Sciences2011，23，4： | 5 |
| 5 | Antiviral activity of quercetin-3-β-O-D-glucoside against Zika virus infection显示文摘Dear Editor,The 2015–2016 outbreak of Zika virus(ZIKV)fever,first reported in Brazil during early 2015(Zanluca et al.,2015),has infected millions of people and is a global public health concern.ZIKV infections are associated with fetal microcephaly,as well as neurological | gary wong shihua he vinayakumar siragam yuhai bi majambu mbikay michel chretien xiangguo qiu | 2017 | Virologica Sinica2017，32，6： | 5 |
| 6 | COX-mediated endothelium-dependent contractions: from the past to recent discoveries显示文摘Endothelial 房间释放各种各样的物质控制内在的脉管的光滑的肌肉的音调。氮的氧化物(没有) 最好被定义导出内皮细胞层的令人放松因素(EDRF ) 。Endothelial 房间能也由释放导出内皮细胞层的收缩因素(EDCF ) 增加脉管的音调。EDCF 的生产过剩贡献伴随各种各样的脉管的疾病的 endothelial 机能障碍。现在的评论总结并且讨论导致从 arachidonic 酸的新陈代谢导出的 EDCF 的版本的机制。这个版本能被象醋胆素那样的收缩筋触发,腺苷核苷酸或旁边段。所有这些刺激能导致钙流入进 endothelial 房间,能被钙 ionophores 模仿的效果。在细胞内部的钙离子集中的扩大开始 EDCF 的版本。下游的过程包括 phospholipase 的激活 A2 ( PLA2 ), cyclooxygenases (艇长)和反应的氧种类( ROS )和随后扩散到的血管收缩的 prostanoids ( endoperoxides , prostacyclin , thromboxane A2 和另外的前列腺素)的生产,并且激活 thromboxane-prostanoid ( TP )脉管的光滑的肌肉上的受体房间导致收缩。 | Michael Sze-Ka WONG Paul Michel VANHOUTTE | 2010 | Acta Pharmacologica Sinica2010，31，9： | 4 |
| 7 | Roles of the Raf/MEK/ERK pathway in cell growth, malignant transformation and drug resistance显示文摘 | James A. McCubrey Linda S. Steelman William H. Chappell Stephen L. Abrams Ellis W.T. Wong Fumin Chang Brian Lehmann David M. Terrian Michele Milella Agostino Tafuri Franca Stivala Massimo Libra Jorg Basecke Camilla Evangelisti Alberto M. Martelli Richard | 2006 | BBA - Molecular Cell Research2006，，8： | 3 |
| 8 | Endoscopic mucosal resection and endoscopic submucosal dissection显示文摘 | Sergey V. Kantsevoy Douglas G. Adler Jason D. Conway David L. Diehl Francis A. Farraye Richard Kwon Petar Mamula Sarah Rodriguez Raj J. Shah Louis Michel Wong Kee Song William M. Tierney | 2008 | Gastrointestinal Endoscopy2008，，1： | 2 |
| 9 | A rare case of Staphylococcus lugdunensis septicemia associated with myocarditis and atrioventricular block显示文摘Myocarditis is a relatively rare,possibly life-threatening disease characterized by the inflammation of the myocardium.111 The disease pathogenesis is primarily initiated by acute injury and necrosis of cardiomyocytes,leading to an inflammatory response mediated by the immune system that can potentially cause further aggravation of myocardial damage and organ dysfunction.Prognosis in patients with myocarditis depends on the clinical presentation,which ranges from an asymptomatic disease course to the concomitant development of cardiac arrhythmias,heart failure,cardiogenic shock and even the occurrence of death in extreme cases[1]. | Alex Tsz Lai Nganh Sharen Lee Tong LIU Mark Tam Ka Hou Christien Li Michelle Vangi Wong Michael Huen Sum Lam Gary Tse Ishan Lakhani | 2019 | Journal of Geriatric Cardiology2019，16，1： | 2 |
| 10 | LRRK2, GBA and their interaction in the regulation of autophagy: implications on therapeutics in Parkinson’s disease显示文摘Mutations in leucine-rich repeat kinase 2 (LRRK2) and glucocerebrosidase (GBA) represent two most common genetic causes of Parkinson’s disease (PD). Both genes are important in the autophagic-lysosomal pathway (ALP), defects of which are associated with α-synuclein (α-syn) accumulation. LRRK2 regulates macroautophagy via activation of the mitogen activated protein kinase/extracellular signal regulated protein kinase (MAPK/ERK) kinase (MEK) and the calcium-dependent adenosine monophosphate (AMP)-activated protein kinase (AMPK) pathways. Phosphorylation of Rab GTPases by LRRK2 regulates lysosomal homeostasis and endosomal trafficking. Mutant LRRK2 impairs chaperone-mediated autophagy, resulting in α-syn binding and oligomerization on lysosomal membranes. Mutations in GBA reduce glucocerebrosidase (GCase) activity, leading to glucosylceramide accumulation, α-syn aggregation and broad autophagic abnormalities. LRRK2 and GBA influence each other: GCase activity is reduced in LRRK2 mutant cells, and LRRK2 kinase inhibition can alter GCase activity in GBA mutant cells. Clinically, LRRK2 G2019S mutation seems to modify the effects of GBA mutation, resulting in milder symptoms than those resulting from GBA mutation alone. However, dual mutation carriers have an increased risk of PD and earlier age of onset compared with single mutation carriers, suggesting an additive deleterious effect on the initiation of PD pathogenic processes. Crosstalk between LRRK2 and GBA in PD exists, but its exact mechanism is unclear. Drugs that inhibit LRRK2 kinase or activate GCase are showing efficacy in pre-clinical models. Since LRRK2 kinase and GCase activities are also altered in idiopathic PD (iPD), it remains to be seen if these drugs will be useful in disease modification of iPD. | Shirley Yin-Yu Pang Rachel Cheuk Nam Lo Philip Wing-Lok Ho Hui-Fang Liu Eunice Eun Seo Chang Chi-Ting Leung Yasine Malki Zoe Yuen-Kiu Choi Wing Yan Wong Michelle Hiu-Wai Kung David Boyer Ramsden Shu-Leong Ho | 2022 | Translational Neurodegeneration2022，11，1： | 2 |
| 11 | Testability of Vision and Refraction in Preschoolers: The Strabismus, Amblyopia, and Refractive Error Study in Singaporean Children显示文摘 | Michelle J. Trager Mohamed Dirani Qiao Fan Gus Gazzard Prabakaran Selvaraj Audrey Chia Tien-Yin Wong Terri L. Young Rohit Varma Seang-Mei Saw | 2009 | American Journal of Ophthalmology2009，，2： | 1 |
| 12 | Recent Advances in Plastic Packaging of Flip-Chip and Multichip Modules (MCM) of Microelectronics显示文摘 | Wong C P Wong Michelle M | 1999 | IEEE Transaction on Components and Packaging Technology1999，22，1： | 1 |
| 13 | Chromoendoscopy显示文摘 | Louis Michel Wong Kee Song Douglas G. Adler Bipan Chand Jason D. Conway Joseph M.B. Croffie James A. DiSario Daniel S. Mishkin Raj J. Shah Lehel Somogyi William M. Tierney Bret T. Petersen | 2007 | Gastrointestinal Endoscopy2007，，4： | 1 |
| 14 | Visual function and vision-related quality of life after macular hole surgery with short-duration, 3-day face-down positioning显示文摘 | Jaspreet Rayat David R.P. Almeida Michel Belliveau Jonathan Wong Jeffrey Gale | 2011 | Canadian Journal of Ophthalmology/Journal canadien d’ophtalmologie2011，，5： | 1 |
| 15 | EUS accessories显示文摘 | Douglas G. Adler Jason D. Conway Joseph M.B. Coffie James A. DiSario Daniel S. Mishkin Raj J. Shah Lehel Somogyi William M. Tierney Louis Michel Wong Kee Song Bret T. Petersen | 2007 | Gastrointestinal Endoscopy2007，，6： | 1 |
| 16 | Polarization-Independent One-Pump Fiber- OpticalParametric Amplifier 显示文摘 | Wong Kenneth K Y Marhic Michel E Uesaka Katsu- mi | 2002 | IEEE P T letter2002，14，11： | 1 |
| 17 | Hepatitis C Virus Infection of Neuroepithelioma Cell Lines显示文摘 | Nicola F. Fletcher Jian Ping Yang Michelle J. Farquhar Ke Hu Christopher Davis Qiuchen He Kimberly Dowd Stuart C. Ray Sophie E. Krieger Johan Neyts Thomas F. Baumert Peter Balfe Jane A. McKeating Flossie Wong–Staal | 2010 | Gastroenterology2010，，4： | 1 |
| 18 | Narrow band imaging and multiband imaging显示文摘 | Louis Michel Wong Kee Song Douglas G. Adler Jason D. Conway David L. Diehl Francis A. Farraye Sergey V. Kantsevoy Richard Kwon Petar Mamula Betsy Rodriguez Raj J. Shah William M. Tierney | 2008 | Gastrointestinal Endoscopy2008，，： | 1 |
| 19 | Recent advances in plastic packaging of flip-chip and multichip modules ( MCM ) of microelectronics 显示文摘 | WONG C P MICHELE M W | 1999 | IEEE Transaction on Components and Packaging Technology1999，22，1： | 1 |
| 20 | An international Delphi consensus statement on metabolic dysfunction-associated fatty liver disease and risk of chronic kidney disease显示文摘Background:With the rising global prevalence of fatty liver disease related to metabolic dysfunction,the association of this common liver condition with chronic kidney disease(CKD)has become increasingly evident.In 2020,the more inclusive term metabolic dysfunction-associated fatty liver disease(MAFLD)was proposed to replace the term non-alcoholic fatty liver disease(NAFLD).The observed association between MAFLD and CKD and our understanding that CKD can be a consequence of underlying metabolic dysfunction support the notion that individuals with MAFLD are at higher risk of having and developing CKD compared with those without MAFLD.However,to date,there is no appropriate guidance on CKD in individuals with MAFLD.Furthermore,there has been little attention paid to the link between MAFLD and CKD in the Nephrology community.Methods and Results:Using a Delphi-based approach,a multidisciplinary panel of 50 international experts from 26 countries reached a consensus on some of the open research questions regarding the link between MAFLD and CKD.Conclusions:This Delphi-based consensus statement provided guidance on the epidemiology,mechanisms,management and treatment of MAFLD and CKD,as well as the relationship between the severity of MAFLD and risk of CKD,which establish a framework for the early prevention and management of these two common and interconnected diseases. | Dan-Qin Sun Giovanni Targher Christopher D.Byrne David C.Wheeler Vincent Wai-Sun Wong Jian-Gao Fan Herbert Tilg Wei-Jie Yuan Christoph Wanner Xin Gao Michelle T.Long Mehmet Kanbay Mindie H.Nguyen Sankar D.Navaneethan Yusuf Yilmaz Yuli Huang Rino A.Gani Pierluigi Marzuillo Jérôme Boursier Huijie Zhang Chan-Young Jung Jin Chai Luca Valenti George Papatheodoridis Giovanni Musso Yu-Jun Wong Mohamed El-Kassas Nahum Méndez-Sánchez Silvia Sookoian Michael Pavlides Ajay Duseja Adriaan G.Holleboom Junping Shi Wah-Kheong Chan Yasser Fouad Junwei Yang Sombat Treeprasertsuk Helena Cortez-Pinto Masahide Hamaguchi Manuel Romero-Gomez Mamun Al Mahtab Ponsiano Ocama Atsushi Nakajima Chunsun Dai Mohammed Eslam Lai Wei Jacob George Ming-Hua Zheng | 2023 | Hepatobiliary Surgery and Nutrition2023，12，3： | 1 |
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