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您的检索式：作者名="Claudia Maggi"
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| 1 | Role of MGMT as biomarker in colorectal cancer显示文摘O6-methylguanine DNA methyltransferase(MGMT) gene promoter methylation plays an important role in colorectal carcinogenesis, occurring in about 30%-40% of metastatic colorectal cancer. Its prognostic role has not been defined yet, but loss of expression of MGMT, which is secondary to gene promoter methylation, results in an interesting high response to alkylating agents such as dacarbazine and temozolomide. In a phase 2 study on heavily pre-treated patients with MGMT methylated metastatic colorectal cancer, temozolomide achieved about 30% of disease control rate. Activating mutations of RAS or BRAF genes as well as mismatch repair deficiency may represent mechanisms of resistance to alkylating agents, but a dose-dense schedule of temozolomide may potentially restore sensitivity in RAS-mutant patients. Further development of temozolomide in MGMT methylated colorectal cancer includes investigation of synergic combinations with other agents such as fluoropyrimidines and research for additional biomarkers, in order to better define the role of temozolomide in the treatment of individual patients. | Alessandro Inno Giuseppe Fanetti Maria Di Bartolomeo Stefania Gori Claudia Maggi Massimo Cirillo Roberto Iacovelli Federico Nichetti Antonia Martinetti Filippo de Braud Ilaria Bossi Filippo Pietrantonio | 2014 | World Journal of Clinical Cases2014，2，12： | 10 |
| 2 | Implication of ge- netic variants near NEGR1, SEC16B, TMEM18, ETV5/ DGKG, GNPDA2, LIN7C/BDNF, MTCH2, BCDIN3D/ FAIM2, SH2B1, Fro, MC4R, and KCTDI5 with obesity and type 2 diabetes in 7705 Chinese显示文摘 | Maggie C Claudia H Wing Y | 2010 | J Clin Endocri- nol Metab2010，95，5： | 1 |
| 3 | Depressive Symptoms, Vascular Risk Factors and Mild Cognitive Impairment显示文摘 | D’introno Alessia Colacicco Anna M Capurso Cristiano Del Parigi Angelo Caselli Richard J Todarello Orlando Pellicani Vincenza Santamato Andrea Scapicchio Pierluigi Maggi Stefania Scafato Emanuele Gandin Claudia Capurso Antonio Solfrizzi Vinc | 2008 | Dementia and Geriatric Cognitive Disorders2008，，4： | 1 |
| 4 | Replication and Identification of Novel Variants at TCF7L2 Associated with Type 2 Diabetes in Hong Kong Chinese显示文摘 | Maggie C. Y. Ng Claudia H. T. Tam Vincent K. L. Lam Wing-Yee So Ronald C. W. Ma Juliana C. N. Chan | 2007 | The Journal of Clinical Endocrinology & Metabolism2007，，9： | 1 |
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