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| 1 | 胆固醇酯转移蛋白基因的蛋白质截断型变异体与冠状动脉性心脏病风险的关系显示文摘随机对照试验结果表明,抑制胆固醇酯转运蛋白(cholesteryl ester transfer protein,CETP)的疗法并不能降低冠状动脉性心脏病(coronary heart disease,CHD)的发生风险。研究失败的可能原因包括靶目标无效、靶目标外小分子的不良反应和随机对照设计因素影响等。在编码药物靶点的基因中具有天然存在的遗传变异,以此为基础,人类研究可以深入了解针对基因产物的治疗的潜在功效和安全性。 | Nomura A Won HH Khera AV Takeuchi F Ito K McCarthy S Emdin CA Klarin D Natarajan P Zekavat SM Gupta N Peloso GM Borecki IB Teslovich TM Asselta R Duga S Merlini PA Correa A Kessler T Wilson JG Bown MJ Hall AS Braund PS Carey DJ Murray MF Kirchner HL Leader JB Lavage DR Manus JN Hartze DN Samani NJ Schunkert H Marrugat J Elosua R McPherson R Farrall M Watkins H Juang JJ Hsiung CA Lin SY Wang JS Tada H Kawashiri MA Inazu A Yamagishi M Katsuya T Nakashima E Nakatochi M Yamamoto K Yokota M Momozawa Y Rotter JI Lander ES Rader DJ Danesh J Ardissino D Gabriel S Willer CJ Abecasis GR Saleheen D Kubo M Kato N Ida Chen YD Dewey FE Kathiresan S 刘莉 叶鹏 | 2017 | 中华高血压杂志2017，25，9： | 2 |
| 2 | Seroprevalence and national distribution of human toxoplasmosis in Mexico: analysis of the 2000 and 2006 National Health Surveys显示文摘 | Heriberto Caballero-Ortega Felipe Javier Uribe-Salas Carlos J. Conde-Glez Carlos Cedillo-Pelaez José Antonio Vargas-Villavicencio Héctor Luna-Pastén Irma Ca?edo-Solares Luz Belinda Ortiz-Alegría Dolores Correa | 2012 | Transactions of the Royal Society of Tropical Medicine and Hygiene2012，，11： | 1 |
| 3 | Intestinal metaplasia of human stomach displays distinct of mucin(MUC1,MUC2,MUC5AC and MUC6) expression 显示文摘 | David L Correa P | 1999 | Cancer Res1999，59，5： | 1 |
| 4 | Intestinal metaplasia of human stomach displays distinct patterns lf mucin(Muc1,Muc2,Muc5AC,Muc6)expression显示文摘 | Reis CA David L Correa P | 1999 | Cancer Res1999，59，5： | 1 |
| 5 | Downregulation of the RECK-tumor and metastasis suppressor gene in glioma inva-siveness显示文摘 | Correa TC Brohem CA Winnischofer SM | | 0，，01： | 1 |
| 6 | Intestinal metaplasia of human stomach displays distinct patterns of mucin (MUC1,MUC2,MUC5AC,and MUC6) expression显示文摘 | Reis CA David L Correa P | 1999 | Cancer Res1999，59，： | 1 |
| 7 | Risk factros for pulmonary valve stenosis显示文摘 | Ferencz C Loffredo CA Correa Villasasnor A | 1996 | Teratology1996，52，2： | 1 |
| 8 | The epidemiology of transposition of the great arteries: environmental risk factors显示文摘 | Loffredo CA Ferencz C Correa - Villasenor | 1993 | Teratology1993，47，5： | 1 |
| 9 | Higher expression and activity of metaUoproteinases in human cervical carcinoma cell lines is associated with HPV presence 显示文摘 | da Silva Cardeal LB Brohem CA Correa TC | 2006 | Biochem Cell Biol2006，84，5： | 1 |
| 10 | New correlations for the weighted sum of-gray-gases- model in oxy-fuel conditions based on HITEMP 2010 database显示文摘 | TANIN KANGWANPONGPAN FRANCIS H R FRAN- CA Rodrigo Correa da Silva | 2012 | International J Heat Mass Transfer2012，35，74： | 1 |
| 11 | Intestinal metaplasia of human stomach displays distinct of mucin(MUC1,MUC2,MUC5AC and MUC6) expression显示文摘 | David L Correa P | 1999 | Cancer Res1999，59，： | 1 |
| 12 | Intestinal metaplasia of human stomach displays distinct patterns of mucin (MUC1,MUC2, MUC5AC, MUC6) expression 显示文摘 | Reis CA David L Correa P | 1999 | Cancer Res1999，59，50： | 1 |
| 13 | Use of ozone-photocatalytic oxidation (O3/UV/TiO2) and biological remediation for treatment of produced water from petroleum refineries显示文摘 | Correa AXR Tiepo EN Somensi CA | 2010 | Journal of Environmental Engineering-Asce2010，136，1： | 1 |
| 14 | Intestinal metaplasia of human stomach displays distinct patterns of mucin (MUC1, MUC2, MUC5AC, and MUC6) expression 显示文摘 | Reis CA David L Correa P | 1999 | Cancer Res1999，59，5： | 1 |
| 15 | Intestinal metaplasia of human stomach displays distinct patterns of mucin (MUC1, MUC2, MUC5 AC, and MUC6)expression 显示文摘 | Reis CA David L Correa P | 1999 | Cancer Res1999，59，5： | 1 |
| 16 | Resistivity changes in conductive silicone sheets under stretching显示文摘 | Correa CA Screaton G Hose DR | 2002 | Physiol Meas2002，23，2： | 1 |
| 17 | Use of ozone-photocatalytic oxidation (O3/SV/TiO2) and biological remediation for treatment of produced water from petroleum refineries显示文摘 | Correa AXR Tiepo EN Somensi CA | 2010 | Journal of Environmental Engineering-Asce2010，136，1： | 1 |
| 18 | Downerregulation of the RECK-tumor and metastasis suppressor gene in glima invasiveness显示文摘 | Correa TC Brohem CA Winnischofer SM | 2006 | J Cell Biochem2006，99，1： | 1 |
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