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| 1 | Research on optimization and design methods for air distribution system based on target values显示文摘To achieve sufficient air conditioning of large buildings,reasonable air distribution in indoor spaces is an effective method for creating stratified air conditioning.Therefore,optimizing the air distribution in large buildings is extremely significant.In this paper,we expound on a new method for air distribution design and optimization based on target value evaluation and summarize the relevant design processes based on an orthogonal test and by decoupling the effects of the size of the tuyere,airflow temperature,air-supply angle and velocity on air distribution.Then,we present a design case.To optimize the distribution of a lateral air supply in winter,the deflection angle,velocity and temperature of the air supply can be determined in turn.For the large and tall building types addressed in this paper,the optimal air-supply angle is 2°,the optimal air-supply velocity is 8 m/s,and the optimal air-supply temperature is 19℃. | Ran Gao Hengchun Zhang Angui Li Shihao Wen Wuyi Du Baoshun Deng | 2021 | Building Simulation2021，14，3： | 3 |
| 2 | Acetytation of ACAP4 regutates CCL18-elicited breast cancer cell migration and invasion显示文摘Tumor metastasis represents the main causes of cancer-related death.Our recent study showed that chemokine CCL18 secreted from tumor-associated macrophages regulates breast tumor metastasis,but the underlying mechanisms remain less clear.Here, we show that ARF6 GTPase-activating protein ACAP4 regulates CCL18-elicited breast cancer cell migration via the acetyltransferase PCAF-mediated acetylation.CCL18 stimulation elicited breast cancer cell migration and invasion via PCAF-dependent acetylation.ACAP4 physically interacts with PCAF and is a cognate substrate of PCAF during CCL18 stimulation.The acetylation site of ACAP4 by PCAF was mapped to Lys311 by mass spectrometric analyses.Importantly,dynamic acetylation of ACAP4 is essential for CCL18-induced breast cancer cell migration and invasion,as overexpression of the persistent acetylation-mimicking or nonacetylatable ACAP4 mutant blocked CCL18-elicited cell migration and invasion.Mechanistically,the acetylation of ACAP4 at Lys311 reduced the lipid-binding activity of ACAP4 to ensure a robust and dynamic cycling of ARF6-ACAP4 complex with plasma membrane in response to CCL18 stimulation.Thus,these results present a previously undefined mechanism by which CCL18-elicited acetylation of the PH domain controls dynamic interaction between ACAP4 and plasma membrane during breast cancer cell migration and invasion. | Xiaoyu Song Wei Liu Xiao Yuan Jiying Jiang Wanjuan Wang McKay Mullen Xuannv Zhao Yin Zhang Fusheng Liu Shihao Du Adeel Rehman Ruijun Tian Jian Li Andra Frost Zhenwei Song Hadiyah-Nicole Green Calmour Henry Xing Liu Xia Ding Dongmei Wang Xuebiao Yao | 2018 | Journal of Molecular Cell Biology2018，10，6： | 3 |
| 3 | Tacrolimus reduces scar formation and promotes sciatic nerve regeneration显示文摘A sciatic nerve transection and repair model was established in Sprague-Dawley rats by transecting the tendon of obturator internus muscle in the greater sciatic foramen and suturing with nylon sutures. The models were treated with tacrolimus gavage (4 mg/kg per day) for 0, 2, 4 and 6 weeks. Specimens were harvested at 6 weeks of intragastric administration. Masson staining revealed that the collagen fiber content and scar area in the nerve anastomosis of the sciatic nerve injury rats were significantly reduced after tacrolimus administration. Hematoxylin-eosin staining showed that tacrolimus significantly increased myelinated nerve fiber density, average axon diameter and myelin sheath thickness. Intragastric administration of tacrolimus also led to a significant increase in the recovery rate of gastrocnemius muscle wet weight and the sciatic functional index after sciatic nerve injury. The above indices were most significantly improved at 6 weeks after of tacrolimus gavage. The myelinated nerve fiber density in the nerve anastomosis and the sciatic nerve functions had a significant negative correlation with the scar area, as detected by Spearman's rank correlation analysis. These findings indicate that tacrolimus can promote peripheral nerve regeneration and accelerate the recovery of neurological function through the reduction of scar formation. | Jun Que Quan Cao Tao Sui Shihao Du Ailiang Zhang Dechao Kong Xiaojian Cao | 2012 | Neural Regeneration Research2012，7，32： | 2 |
| 4 | Nb_2O_5 nanowires in-situ grown on carbon fiber: A high-efficiency material for the photocatalytic reduction of Cr(Ⅵ)显示文摘Niobium oxide nanowire-deposited carbon fiber(CF) samples were prepared using a hydrothermal method with amorphous Nb_2O_5·nH_2O as precursor. The physical properties of the samples were characterized by means of numerous techniques, including X-ray diffraction(XRD), energy-dispersive spectroscopy(EDS), scanning electron microscopy(SEM), transmission electron microscopy(TEM), selected-area electron diffraction(SAED), UV–visible spectroscopy(UV–vis), N_2 adsorption–desorption, Fourier transform infrared spectroscopy(FT-IR), and X-ray photoelectron spectroscopy. The efficiency for the removal of Cr(VI) was determined.Parameters such as pH value and initial Cr(VI) concentration could influence the Cr(VI) removal efficiency or adsorption capacity of the Nb_2O_5/carbon fiber sample obtained after hydrothermal treatment at 160°C for 14 hr. The maximal Cr(VI) adsorption capacity of the Nb_2O_5 nanowire/CF sample was 115 mg/g. This Nb_2O_5/CF sample also showed excellent photocatalytic activity and stability for the reduction of Cr(VI) under UV-light irradiation: the Cr(VI) removal efficiency reached 99.9% after UV-light irradiation for 1 hr and there was no significant decrease in photocatalytic performance after the use of the sample for 10 repeated cycles. Such excellent Cr(VI) adsorption capacity and photocatalytic performance was related to its high surface area,abundant surface hydroxyl groups, and good UV-light absorption ability. | Yucheng Du Shihao Zhang Jinshu Wang Junshu Wu Hongxing Dai | 2018 | Journal of Environmental Sciences2018，30，4： | 2 |
| 5 | Advanced Li-SexSy battery system:Electrodes and electrolytes显示文摘The worldwide energy shortage has led to numerous researches for the exploration of new-type battery materials to deal with the energy crisis.To achieve a great leap in energy density,the study of high capacity electrode materials plays a major role.As a replacement to the energy accumulation system of lithium-sulfur(Li-S) and lithium-selenium(Li-Se) batteries,great concern is generated over lithium/selenium-sulfur(Li-SexSy) batteries as they combine the advantages of S(high capacity) and Se(improved electrical conductivity),consequently stands for extensive new cathode materials.In recent years,widespread researches have been conducted and great achievements have been published.This review sums up the research status on Li-SexSy batteries and concentrates on the outstanding work of SexSy cathode materials.The reaction mechanism and capacity fading mechanism are discussed.The performance-structure relationship is stated in regard of different cathode structures,including a variety of carbon hosts,conducting polymer hosts,transition metal-doped carbon electrodes and various Se/S ratio.The compatibilities of frequently-used carbonate-based and ether-based electrolyte and other new-type electrolytes for Li-SexSy battery are demonstrated.Prospects for the future developments of Li-SexSy batteries are finally proposed. | Huan Du Shihao Feng Wen Luo Liang Zhou Liqiang Mai | 2020 | Journal of Materials Science & Technology2020，52，20： | 2 |
| 6 | Modeling of COVID-19 disease disparity in gastric organoids reveals the spatiotemporal dynamics of SARS-CoV-2 infectivity显示文摘Dear Editor,The promptness and continuous expansion of the coronavirus disease 2019(COVID-19)pandemic,elicited by severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)and its variants,has presented an unprecedented impact on human health(WHO Coronavirus(COVID-19)Dashboard,2021).Although vaccination has attenuated the severe symptoms,there is no specific antiviral medication available for preventing the viral spread(Drayman et al.,2021). | Wenwen Wang Fengrui Yang Jie Lin Saravanakumar Muthusamy Shihao Du McKay Mullen Fatima Garba Wanjuan Wang Xu Liu Tao Li Zhihong Yang Xia Ding Felix Aikhionbare Xinjiao Gao Zhikai Wang Xing Liu Xuebiao Yao | 2022 | Journal of Molecular Cell Biology2022，14，2： | 1 |
| 7 | Acetylation of ezrin regulates membrane–cytoskeleton interaction underlying CCL18-elicited cell migration显示文摘Ezrin,a membrane–cytoskeleton linker protein,plays an essential role in cell polarity establishment,cell migration,and division.Recent studies show that ezrin phosphorylation regulates breast cancer metastasis by promoting cancer cell survivor and promotes intrahepatic metastasis via cell migration.However,it was less characterized whether there are additional post-translational modifications and/or post-translational crosstalks on ezrin underlying context-dependent breast cancer cell migration and invasion.Here we show that ezrin is acetylated by p300/CBP-associated factor(PCAF)in breast cancer cells in response to CCL18 stimulation.Ezrin physically interacts with PCAF and is a cognate substrate of PCAF.The acetylation site of ezrin was mapped by mass spectrometric analyses,and dynamic acetylation of ezrin is essential for CCL18-induced breast cancer cell migration and invasion.Mechanistically,the acetylation reduced the lipid-binding activity of ezrin to ensure a robust and dynamic cycling between the plasma membrane and cytosol in response to CCL18 stimulation.Biochemical analyses show that ezrin acetylation prevents the phosphorylation of Thr567.Using atomic force microscopic measurements,our study revealed that acetylation of ezrin induced its unfolding into a dominant structure,which prevents ezrin phosphorylation at Thr567.Thus,these results present a previously undefined mechanism by which CCL18-elicited crosstalks between the acetylation and phosphorylation on ezrin control breast cancer cell migration and invasion.This suggests that targeting PCAF signaling could be a potential therapeutic strategy for combating hyperactive ezrin-driven cancer progression. | Xiaoyu Song Wanjuan Wang Haowei Wang Xiao Yuan Fengrui Yang Lingli Zhao McKay Mullen Shihao Du Najdat Zohbi Saravanakumar Muthusamy Yalei Cao Jiying Jiang Peng Xia Ping He Mingrui Ding Nerimah Emmett Mingming Ma Quan Wu Hadiyah-Nicole Green Xia Ding Dongmei Wang Fengsong Wang Xing Liu | 2020 | Journal of Molecular Cell Biology2020，12，6： | 1 |
| 8 | Progress and Prospect of Photothermal Catalysis显示文摘Recently,solar-driven synthesis due to its energy-saving and environmentally friendly advantages has attracted more and more attention,whereas the low solar-to-chemical conversion efficiency significantly hindered its development.New effective options that fully utilize full-band sunlight are urgently needed.Novel photothermal catalysis combined with the advantages of photocatalysis and thermalcatalysis can improve the utilization efficiency of solar energy and lower the reaction temperature,thus becoming a promising technology.This review divides photothermal catalysis into photo-assisted thermalcatalysis,thermal-assisted photocatalysis,and photothermal synergistic catalysis.Furthermore,the catalytic mechanical understanding of how photothermal affects the catalytic property of different applications(e.g.,water splitting,CO_(2)/N_(2) reduction,and environmental treatment)was also summed up and discussed in detail.The discussion ends with unsolved challenges in photothermal catalysis,particularly emphasizing the effect of temperature or sunlight on catalytic performance. | DU Shihao BIAN Xuanang ZHAO Yunxuan SHI Run ZHANG Tierui | 2022 | Chemical Research in Chinese Universities2022，38，3： | 1 |
| 9 | Potential risk of mitomycin C at high concentrations on peripheral nerve structure显示文摘Although the local application of mitomycin C may prevent epidural adhesion after laminectomy, mitomycin C can induce neurotoxicity in optic and acoustic nerves at high concentrations. To determine the safe concentration range for mitomycin C, cotton pads soaked with mitomycin C at different concentrations(0.1, 0.3, 0.5, and 0.7 mg/mL) were immediately applied for 5 minutes to the operation area of rats that had undergone laminectomy at L1. Rat sciatic nerves, instead of dorsal nerves, were used in this study. The results showed that mitomycin C at 0.1–0.5 mg/mL did not damage the structure and function of the sciatic nerve, while at 0.7 mg/mL, mitomycin C significantly reduced the thickness of the sciatic nerve myelin sheath compared with lower concentrations, though no functional change was found. These experimental findings indicate that the local application of mitomycin C at low concentrations is safe to prevent scar adhesion following laminectomy, but that mitomycin C at high concentrations(> 0.7 mg/mL) has potential safety risks to peripheral nerve structures. | Tao Sui Jinhong Zhang Shihao Du Changhui Su Jun Que Xiaojian Cao | 2014 | Neural Regeneration Research2014，9，8： | 1 |
| 10 | CNT-Modified MIL-88(NH_(2))-Fe for Enhancing DNA-Regulated Peroxidase-Like Activity显示文摘Over the past few decades,the enzyme-mimicking activity of metal-organic frameworks(MOFs)accompanied with struc-tural characteristics has aroused much attention.However,pure MOFs have low affinity with DNA.Here,iron-based MOFs with acidized carbon nanotubes(CNTs)via a simple hydrothermal process have been synthesized,named as MIL-88(NH_(2))-Fe@CNTs.CNTs can enhance the affinity between MOF and DNA,achieving flexible regulation of their catalytic activity benefiting from the strongπ−πstacking between CNTs and DNA.Meanwhile,in comparison with conventional iron-based MOFs,the addition of CNTs,which contributes to the acceleration of electron transfer,endowing as-prepared nanocomposites remarkably enhanced peroxidase-like activity to achieve an ultrasensitive detection of H_(2)O_(2) with the LOD of 17.64μg/L.Notably,the as-prepared nanocomposites with adsorbed DNA displayed excellent affinity towards both TMB(3,3′,5,5′-tetramethylbenzidine)substrates and H_(2)O_(2) as well as high catalytic velocity.On the basis of their switchable peroxidase-like activity regulated by different length or sequence of ssDNA,it is believed that our-prepared MOF-based nanomaterials would be promising for fabricating versatile and sensitive label-free colorimetric assays for diverse targets. | Shihao Sun Yaofang Fan Jiaoyang Du Zhilian Song Huimin Zhao | 2019 | Journal of Analysis and Testing2019，3，3： | 1 |
| 11 | Methylation of PLK1 by SET7/9 ensures accurate kinetochore–microtubule dynamics显示文摘Faithful segregation of mitotic chromosomes requires bi-orientation of sister chromatids, which relies on the sensing of correct attachments between spindle microtubules and kinetochores. Although the mechanisms underlying PLK1 activation have been extensively studied, the regulatory mechanisms that couple PLK1 activity to accurate chromosome segregation are not well understood. In particular, PLK1 is implicated in stabilizing kinetochore–microtubule attachments, but how kinetochore PLK1 activity is regulated to avoid hyperstabilized kinetochore–microtubules in mitosis remains elusive. Here, we show that kinetochore PLK1 kinase activity is modulated by SET7/9 via lysine methylation during early mitosis. The SET7/9-elicited dimethylation occurs at the Lys191 of PLK1, which tunes down its activity by limiting ATP utilization. Overexpression of the non-methylatable PLK1 mutant or chemical inhibition of SET7/9 methyltransferase activity resulted in mitotic arrest due to destabilized kinetochore–microtubule attachments. These data suggest that kinetochore PLK1 is essential for stable kinetochore–microtubule attachments and methylation by SET7/9 promotes dynamic kinetochore–microtubule attachments for accurate error correction. Our findings define a novel homeostatic regulation at the kinetochore that integrates protein phosphorylation and methylation with accurate chromosome segregation for maintenance of genomic stability. | Ruoying Yu Huihui Wu Hazrat Ismail Shihao Du Jun Cao Jianyu Wang Tarsha Ward Fengrui Yang Ping Gui Mahboob Ali Lingluo Chu Fei Mo Qi Wang Youjun Chu Jianye Zang Yun Zhao Mingliang Ye Guowei Fang Peng RChen Zhen Dou Xinjiao Gao Wenwen Wang Xing Liu Xuebiao Yao | 2020 | Journal of Molecular Cell Biology2020，12，6： | 0 |
| 12 | Transformer and GAN-Based Super-Resolution Reconstruction Network for Medical Images显示文摘Super-resolution reconstruction in medical imaging has become more demanding due to the necessity of obtaining high-quality images with minimal radiation dose,such as in low-field magnetic resonance imaging(MRI).However,image super-resolution reconstruction remains a difficult task because of the complexity and high textual requirements for diagnosis purpose.In this paper,we offer a deep learning based strategy for reconstructing medical images from low resolutions utilizing Transformer and generative adversarial networks(T-GANs).The integrated system can extract more precise texture information and focus more on important locations through global image matching after successfully inserting Transformer into the generative adversarial network for picture reconstruction.Furthermore,we weighted the combination of content loss,adversarial loss,and adversarial feature loss as the final multi-task loss function during the training of our proposed model T-GAN.In comparison to established measures like peak signal-to-noise ratio(PSNR)and structural similarity index measure(SSIM),our suggested T-GAN achieves optimal performance and recovers more texture features in super-resolution reconstruction of MRI scanned images of the knees and belly. | Weizhi Du Shihao Tian | 2024 | Tsinghua Science and Technology2024，29，1： | 0 |
| 13 | Polymeric nanocomposites for electrocaloric refrigeration显示文摘Electrocaloric refrigeration represents an alternative solid-state cooling technology that has the potential to reach the ultimate goal of achieving zero-global-warming potential,highly efficient refrigeration,and heat pumps.To date,both polymeric and inorganic oxides have demonstrated giant electrocaloric effect as well as respective cooling devices.Although both polymeric and inorganic oxides have been identified as promising cooling methods that are distinguishable from the traditional ones,they still pose many challenges to more practical applications.From an electrocaloric material point of view,electrocaloric nanocomposites may provide a solution to combine the beneficial effects of both organic and inorganic electrocaloric materials.This article reviews the recent advancements in polymer-based electrocaloric composites and the state-of-the-art cooling devices operating these nanocomposites.From a device point of view,it discusses the existing challenges and potential opportunities of electrocaloric nanocomposites. | Yu CAI Qiang LI Feihong DU Jiawang FENG Donglin HAN Shanyu ZHENG Shihao YANG Yingjing ZHANG Binbin YU Junye SHI Xiaoshi QIAN | 2023 | Frontiers in Energy2023，17，4： | 0 |
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