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| 1 | Sintilimab versus docetaxel as second-line treatment in advanced or metastatic squamous non-small-cell lung cancer:an open-label,randomized controlled phase 3 trial(ORIENT-3)显示文摘Background:Treatment options for Chinese patients with locally advanced or metastatic squamous-cell non-small-cell lung cancer(sqNSCLC)after failure of first-line chemotherapy are limited.This study(ORIENT-3)aimed to evaluate the efficacy and safety of sintilimab versus docetaxel as second-line treatment in patients with locally advanced or metastatic sqNSCLC.Methods:ORIENT-3 was an open-label,multicenter,randomized controlled phase 3 trial that recruited patients with stage IIIB/IIIC/IV sqNSCLC after failure with first-line platinum-based chemotherapy.Patients were randomized in a 1:1 ratio to receive either 200 mg of sintilimab or 75 mg/m^(2) of docetaxel intravenously every 3 weeks,stratified by the Eastern Cooperative Oncology Group performance status.The primary endpoint was overall survival(OS)in the full analysis set(FAS).Secondary endpoints included progression-free survival(PFS),objective response rate(ORR),disease control rate(DCR),duration of response(DoR)and safety.Results:Between August 25,2017,and November 7,2018,290 patients were randomized.For FAS,10 patients fromthe docetaxel armwere excluded.Themedian OS was 11.79(n=145;95%confidence interval[CI],10.28-15.57)months with sintilimab versus 8.25(n=135;95%CI,6.47-9.82)months with docetaxel(hazard ratio[HR]:0.74;95%CI,0.56-0.96;P=0.025).Sintilimab treatment significantly prolonged PFS(median 4.30 vs.2.79 months;HR:0.52;95%CI,0.39-0.68;P<0.001)and showed higher ORR(25.50%vs.2.20%,P<0.001)and DCR(65.50%vs.37.80%,P<0.001)than the docetaxel arm.The median DoRwas 12.45(95%CI,4.86-25.33)months in the sintilimab arm and 4.14(95%CI,1.41-7.23)months in the docetaxel arm(P=0.045).Treatment-related adverse events of grade≥3were reported in 26(18.1%)patients in the sintilimab arm and 47(36.2%)patients in the docetaxel arm.Exploratory biomarker analysis showed potential predictive values of expression levels of two transcription factors,including OVOL2(HR:0.35;P<0.001)and CTCF(HR:3.50;P<0.001),for sintilimab treatment.Conclusions:Compared with docetaxel,sintilimab significantly improved the OS,PFS,and ORR of Chinese patients with previously treated locally advanced or metastatic sqNSCLC. | Yuankai Shi Lin Wu Xinmin Yu Puyuan Xing Yan Wang Jianying Zhou Airong Wang Jianhua Shi Yi Hu Ziping Wang Guangyu An Yong Fang Sanyuan Sun Caicun Zhou Changli Wang Feng Ye Xingya Li Junye Wang Mengzhao Wang Yunpeng Liu Yanqiu Zhao Ying Yuan Jifeng Feng Zhendong Chen Jindong Shi Tao Sun Gang Wu Yongqian Shu Qisen Guo Yi Zhang Yong Song Shucai Zhang Yuan Chen Wei Li Hongrui Niu Wenwei Hu Lijun Wang Jianan Huang Yang Zhang Ying Cheng Zhengdong Wu Bo Peng Jiya Sun Christoph Mancao Yanqi Wang Luyao Sun | 2022 | Cancer Communications2022，42，12： | 8 |
| 2 | Strip rotary tillage with subsoiling increases winter wheat yield by alleviating leaf senescence and increasing grain filling显示文摘Sustainable agriculture in the Huang–Huai–Hai Plain of China is threatened by subsoil compaction and the decline of winter wheat productivity induced by inappropriate tillage regimes. We investigated the effects of optimizing the tillage regime on grain filling and its relationship with flag leaf senescence post-anthesis in winter wheat. Four treatments were compared: rotary tillage, strip rotary tillage, strip rotary tillage with a 2-year subsoiling interval(STS), and conventional plowing tillage. STS produced higher chlorophyll content and leaf area indexes than other treatments, resulting in a greater photosynthetically active radiation capture ratio. The net photosynthesis rate of flag leaves from 14 to 28 days after anthesis and dry matter accumulation at maturity were higher in STS than in other treatments. Sucrose content and sucrose phosphate synthase activity of flag leaves first increased and then decreased during grain filling and were highest in STS. STS increased superoxide dismutase activity, increased soluble protein content, and reduced malondialdehyde concentrations in flag leaves after the middle grain-filling stages,resulting in reduced premature senescence. This consequence extended the active grain filling period and increased grain weight. The highest yields were observed in STS, reaching10,451 kg ha-1 in 2014–2015 and 10,074 kg ha-1 in 2015–2016, owing to increased spike numbers and 1000-kernel weight. Overall, our study suggested that STS could substantially increase photosynthetic capacity and delay leaf senescence, thus promoting grain filling rate and increasing winter wheat yields. | Jianning He Yu Shi Junye Zhao Zhenwen Yu | 2020 | The Crop Journal2020，8，2： | 7 |
| 3 | Efficacy and safety of high-dose esomeprazole–amoxicillin dual therapy for Helicobacter pylori rescue treatment:a multicenter,prospective,randomized,controlled trial显示文摘Background:High-dose dual therapy(HDDT)with proton pump inhibitors(PPIs)and amoxicillin has attracted widespread attention due to its favorable efficacy in eradicating Helicobacter pylori(H.pylori).This study aimed to compare the efficacy and safety of high-dose PPI-amoxicillin dual therapy and bismuth-containing quadruple therapy for H.pylori rescue treatment.Methods:This was a prospective,randomized,multicenter,non-inferiority trial.Patients recruited from eight centers who had failed previous treatment were randomly(1:1)allocated to two eradication groups:HDDT(esomeprazole 40 mg and amoxicillin 1000 mg three times daily;theHDDTgroup)and bismuth-containing quadruple therapy(esomeprazole 40 mg,bismuth potassium citrate 220 mg,and furazolidone 100 mg twice daily,combined with tetracycline 500 mg three times daily;the tetracycline,furazolidone,esomeprazole,and bismuth[TFEB]group)for 14 days.The primary endpoint was the H.pylori eradication rate.The secondary endpoints were adverse effects,symptom improvement rates,and patient compliance.Results:A total of 658 patients who met the criteria were enrolled in this study.The HDDT group achieved eradication rates of 75.4%(248/329),81.0%(248/306),and 81.3%(248/305)asdetermined by the intention-to-treat(ITT),modified intention-totreat(MITT),and per-protocol(PP)analyses,respectively.The eradication rates were similar to those in the TFEB group:78.1%(257/329),84.2%(257/305),and 85.1%(257/302).The lower 95%confidence interval boundary(9.19%in the ITT analysis,9.21%in the MITT analysis,and9.73%in the PP analysis)was greater than the predefined non-inferiority margin of10%,establishing a non-inferiority of the HDDT group vs.the TFEB group.The incidence of adverse events in the HDDT group was significantly lower than that in the TFEB group(11.1%vs.26.8%,P<0.001).Symptom improvement rates and patients’compliance were similar between the two groups.Conclusions:Fourteen-day HDDT is non-inferior to bismuth-containing quadruple therapy,with fewer adverse effects and good treatment compliance,suggesting HDDT as an alternative for H.pylori rescue treatment in the local region.Trial registration:Clinicaltrials.gov,NCT04678492. | Hanxin Bi Xingxing Chen Yuxin Chen Xin Zhao Shasha Wang Jiehong Wang Ting Lyu Shuang Han Tao Lin Mingquan Li Donghong Yuan Junye Liu Yongquan Shi | 2022 | Chinese Medical Journal2022，，14： | 3 |
| 4 | Effects of design parameters on flow and temperature fields of a cold store by CFD simulation 显示文摘 | Xie Jing Qu Xiaohua Shi Junye | 2006 | Journal of Food Engineering2006，77，： | 1 |
| 5 | Effects of design parameters on flow and temperature fields of a cold store by CFD simulation显示文摘 | Xie Jing Qu Xiaohua Shi Junye | 2006 | Journal of Food Engineering2006，77，2： | 1 |
| 6 | Investi- gating performance of microehannel evaporators with different manifold structures 显示文摘 | Junye Shi Xiaohua Qu Zhaogang Qi | 2011 | International Journal of Refrigeration2011，34，1： | 1 |
| 7 | Numerical and experimental investigation on nozzle parameters for R410A ejector air conditioning system 显示文摘 | Hu Jichao Shi Junye Liang Yuanyuan | 2014 | International Journal of Refrigeration2014，，40： | 1 |
| 8 | Effect of inlet manifold structure on the performance of the heater core in the automobile air-condition systems显示文摘 | Shi Junye Qu Xiaohua Qi Zhaogang | 2010 | Applied Thermal Engineering2010，30，89： | 1 |
| 9 | Investigating performance of microchannel evaporators with different manifold structures显示文摘 | Shi Junye Qu Xiaohua Qi Zhaogang | 2011 | International Journal of Refrigeration2011，34，1： | 1 |
| 10 | Investigating performance of microchannel evaporators with different manifold structures 显示文摘 | Shi Junye Qu Xiaohua Qi Zhaogang | 2011 | International Journal of Refrigeration2011，34，1： | 1 |
| 11 | Investi- gating performance of microchannel evaporators with different manifold structures显示文摘 | Shi Junye Qu Xiaohua Qi Zhaogang | 2011 | International Jour- nal of Refrigeration2011，34，1： | 1 |
| 12 | Investigating performance of microchannel evaporators with different manifold structures显示文摘 | Junye Shi Xiaohua Qu Zhaogang Qi Jiangping Chen | 2010 | International Journal of Refrigeration2010，，1： | 1 |
| 13 | Investigating performance of microchannel evaporators with different manifold structures 显示文摘 | Junye Shi Xiaohua Qu Zhaogang Qi | 2011 | International Journal of Refrigera- tion2011，34，1： | 1 |
| 14 | Effects of design parameters on flow and temperature fields of a cold store by CFD simulation显示文摘 | Jing Xie Qu Xiaohua Shi Junye | 2006 | Journal of Food Engineering2006，77，2： | 1 |
| 15 | Investigating performance of microchannel evaporators with different manifold structures显示文摘 | Junye Shi Xiaohua Qu Zhaogang Qi Jiangping Chen | 2010 | International Journal of Refrigeration2010，，1： | 1 |
| 16 | Investigating performance of microchannel evaporators with different manifold structures 显示文摘 | Shi Junye Qu Xiaohua Qi Zhaogang Chen Jiangping | 2011 | International Journal of Refrigeration2011，34，1： | 1 |
| 17 | Polymeric nanocomposites for electrocaloric refrigeration显示文摘Electrocaloric refrigeration represents an alternative solid-state cooling technology that has the potential to reach the ultimate goal of achieving zero-global-warming potential,highly efficient refrigeration,and heat pumps.To date,both polymeric and inorganic oxides have demonstrated giant electrocaloric effect as well as respective cooling devices.Although both polymeric and inorganic oxides have been identified as promising cooling methods that are distinguishable from the traditional ones,they still pose many challenges to more practical applications.From an electrocaloric material point of view,electrocaloric nanocomposites may provide a solution to combine the beneficial effects of both organic and inorganic electrocaloric materials.This article reviews the recent advancements in polymer-based electrocaloric composites and the state-of-the-art cooling devices operating these nanocomposites.From a device point of view,it discusses the existing challenges and potential opportunities of electrocaloric nanocomposites. | Yu CAI Qiang LI Feihong DU Jiawang FENG Donglin HAN Shanyu ZHENG Shihao YANG Yingjing ZHANG Binbin YU Junye SHI Xiaoshi QIAN | 2023 | Frontiers in Energy2023，17，4： | 0 |
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