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| 1 | Pancreatic cancer stromal biology and therapy显示文摘Pancreatic cancer is one of the most lethal malignancies.Significant progresses have been made in understanding of pancreatic cancer pathogenesis,including appreciation of precursor lesions or premalignant pancreatic intraepithelial neoplasia(PanINs),description of sequential transformation from normal pancreatic tissue to invasive pancreatic cancer and identification of major genetic and epigenetic events and the biological impact of those events on malignant behavior.However,the currently used therapeutic strategies targeting tumor epithelial cells,which are potent in cell culture and animal models,have not been successful in the clinic.Presumably,therapeutic resistance of pancreatic cancer is at least in part due to its drastic desmoplasis,which is a defining hallmark for and circumstantially contributes to pancreatic cancer development and progression.Improved understanding of the dynamic interaction between cancer cells and the stroma is important to better understanding pancreatic cancer biology and to designing effective intervention strategies.This review focuses on the origination,evolution and disruption of stromal molecular and cellular components in pancreatic cancer,and their biological effects on pancreatic cancer pathogenesis. | Dacheng Xie Keping Xie | 2015 | Genes & Diseases2015，2，2： | 9 |
| 2 | Characteristics of the mantle source region of sodium lamprophyres and petrogenetic tectonic setting in northeastern Hunan,China显示文摘A set of unique sodium lamprophyres is devel)0.1(oped in the Cenozoic intraconti)]nental extensional zone of northeastern Hunan. These lamprophyres are significantly different in major [(and trace elements and Sr, Nd isotopes from ordinary potassic lamprophyr\ es. )0(The rocks)0( )(are)( )]characterized as being enriched in Na2O and high in TiO2 and weakly enriched in Nb, Ta, Nd and LREE with no negative Eu anomaly. The trace elements and Sr, Nd isotopic compositions are typical of the mantle source region of oceanic island basalts (OIB). The average initial 87Sr/86Sr ratio is 0.705332, and the average initial 143Nd/144Nd ratio is 0.512650, with εNd(t) being[( )45.4(+3.5)(--)(+3.9, )]marking a mantle source region of unique sodium lamprophyres. The lamprophyres were formed by metasomatism of the primitive mantle at the bottom of lithosphere by vola[(tile)(-)(containing )68.2(f)(l)(u-)]ids/melts from the asthenosphere. The measured Rb-Sr isochron age of sodium lamprophyre is 136.61 Ma, representing a period in which the tectonic setting changed from compressive to extensional. [(Sodium lamprophyres were formed in a mantle plume tectonic set)0(ting characterized by mantle )]upwelling from the asthenosphere within the continent. Asthenospheric mantle upwelling is the principal geodynamic factor leading to the formation of sodium lamprophyres and constraining the [(Yanshanian i)0(n)(tracontinental extensional activity in northeast)0(ern Hunan, China.)] | JIA Dacheng HU Ruizhong LU Yan XIE Guiqing QIU Xuelin | 2004 | Science China Earth Sciences2004，47，6： | 7 |
| 3 | An inducible CRISPR-ON system for controllable gene activation in human pluripotent stem cells显示文摘 | Jianying Guo Dacheng Ma Rujin Huang Jia Ming Min Ye Kehkooi Kee Zhen Xie Jie Na | 2017 | Protein & Cell2017，8，5： | 4 |
| 4 | China Antihypertensive Trial in Acute Ischemic Stroke II (CATIS-2): rationale and design显示文摘Backgrounds Increased blood pressure(BP)for patients who had an acute ischaemic stroke is associated with poor functional outcome,however the optimal timing of antihypertensive therapy is unknown.Aims We aim to compare early antihypertensive treatment to delayed antihypertensive treatment for reducing the risk of composite major disability and mortality at 3 months in acute ischaemic stroke.Design The China Antihypertensive Trial in Acute Ischemic Stroke II(CATIS-2)trial is a multicentre,randomised,open-label,blinded-endpoints trial that will be conducted in 100 hospitals in China.The primary outcome is the composite of death and major disability(modified Rankin Scale score≥3)at 3 months of randomisation.Antihypertensive treatment will be received immediately after randomisation in the early treatment group,aimed at average systolic BP by 10%-20%reduction within the first 24 hours,and achieving an average BP level of<140/90 mm Hg within 5 days.Patients in the delayed treatment group will discontinue any antihypertension medications for the first 7 days of randomisation,and will receive antihypertensive therapy achieving a BP goal of<140/90 mm Hg after 7 days.Conclusion The CATIS-2 trial will be testing the hypotheses that early BP lowering leads to improved functional outcome without any other harms,and developing clinical guidelines of the BP management for patients who had an acute ischaemic stroke. | Liping Liu Yilong Wang Xuewei Xie Dacheng Liu Aili Wang Penglian Wang Suwen Shen Chongke Zhong Yufei Wei Tan Xu Yuesong Pan Yong Jiang Xia Meng David Wang Yonghong Zhang Jiang He Yongjun Wang | 2021 | Stroke & Vascular Neurology2021，6，2： | 3 |
| 5 | Room‐Temperature Intercalation–Deintercalation Strategy Towards VO<sub>2</sub>(B) Single Layers with Atomic Thickness显示文摘 | Liang Liu Tao Yao Xiaogang Tan Qinghua Liu Zhiqiang Wang Dacheng Shen Zhihu Sun Shiqiang Wei Yi Xie | 2012 | Small2012，，24： | 1 |
| 6 | Explore the dominant factor in prime editing via a view of DNA processing显示文摘Prime editing is a revolutionary gene-editing method that is capable of introducing insertions,deletions and base substitutions into the genome.However,the editing efficiency of Prime Editor(PE)is limited by the DNA repair process.Here,we show that overexpression of the flap structure-specific endonuclease 1(FEN1)and the DNA ligase 1(LIG1)increases the efficiency of prime editing,which is similar to the dominant negative mutL homolog 1(MLH1dn).In addition,MLH1 is still the dominant factor over FEN1 and LIG1 in prime editing.Our results help to further understand the relationship of proteins involved in prime editing and envisage future directions for the development of PE. | Zhimeng Xu Dacheng Ma Houzhen Su Xiaodong Jia Yinqing Li Yinying Lu Zhen Xie | 2023 | Synthetic and Systems Biotechnology2023，8，3： | 0 |
| 7 | The effect of applied potential on stress corrosion cracking of X80 pipeline steel in acidic soil containing sulfate-reducing bacteria显示文摘Electrochemical experiments,slow strain rate tensile testing(SSRT),and scanning electron microscopy were used to investigate the effect of various applied potentials on the stress corrosion cracking(SCC)of X80 pipeline steel in acidic soil containing sulfate-reducing bacteria(SRB).The results demonstrated that when the anodic potential was applied,X80 steel exhibited sensitivity to SCC,which was attributed to anodic dissolution.The SCC sensitivity initially decreased,but then increased with a negative shift in the applied potential.At-1200 mV,SCC was the most sensitive,which corresponded to the substantial cathodic polarisation and toxic impact of SRB,which increased the risk of hydrogen embrittlement.At-850 mV,the SCC sensitivity was the lowest because cathodic polarisation suppressed anodic dissolution.The experimental results can contribute to the prevention and management of SCC in operational pipelines. | HE JianYu XIE Fei ZHAO Yang GUO DaCheng WANG Dan LI JunChi | 2023 | Science China(Technological Sciences)2023，66，10： | 0 |
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