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| 1 | Numerical study of pollutant movement in waves and wave-induced long-shore currents in surf zone显示文摘Water waves,wave-induced long-shore currents and movement of pollutants in waves and currents have been numerically studied based on the hyperbolic mild-slope equation,the shallow water equation,as well as the pollutant movement equation,and the numerical results have also been validated by experimental data. It is shown that the long-shore current velocity and wave set-up increase with the increasing incident wave amplitude and slope steepness of the shore plane; the wave set-up increases with the increasing incident wave period;and the pollutant morement proceeds more quiekly with the increasing incident wave amplitude and slope steepness of the shore palane. In surf zones,the long-shore currents induced by the inclined incident waves have effectively affected the pollutant movement. | TANG Jun SHEN Yongming QIU Dahong | 2008 | Acta Oceanologica Sinica2008，27，1： | 13 |
| 2 | Pharmacokinetic and pharmacodynamic study of triptolide-loaded liposome hydrogel patch under microneedles on rats with collagen-induced arthritis显示文摘Triptolide(TP),a major active component of Tripterygium wilfordii Hook.F.(TWHF),is used to treat rheumatoid arthritis(RA).However,it has a narrow therapeutic window due to its serious toxicities.To increase the therapeutic index,a new triptolide-loaded transdermal delivery system,named triptolide-loaded liposome hydrogel patch(TP-LHP),has been developed.In this paper,we used a micro-needle array to deliver TP-LHP to promote transdermal absorption and evaluated this treatment on the pharmacokinetics and pharmacodynamics of TP-LHP in a rat model of collagen-induced arthritis(CIA).The pharmacokinetic results showed that transdermal delivery of microneedle TP-LHP yielded plasma drug levels which fit a onecompartment open model.The relationship equation between plasma concentration and time was C=303.59(e 0.064 t e 0.287t).The results of pharmacodynamic study demonstrated that TP-LHP treatment mitigated the degree of joint swelling and suppressed the expressions of fetal liver kinase-1,fetal liver tyrosine kinase-4 and hypoxia-inducible factor-1α in synovium.Other indicators were also reduced by TP-LHP,including hyperfunction of immune,interleukin-1β and interleukin-6 levels in serum.The therapeutic mechanism of TP-LHP might be regulation of the balance between Th1 and Th2,as well as inhibition of the expression and biological effects of vascular endothelial growth factor. | Gui Chen Baohua Hao Dahong Ju Meijie Liu Hongyan Zhao Zhongping Du Jizi Xia | 2015 | Acta Pharmaceutica Sinica B2015，5，6： | 10 |
| 3 | Mechanisms of "kidney governing bones" theory in traditional Chinese medicine显示文摘我们的组在在繁体中文药(TCM ) 管理骨头理论的肾的机制上进行的研究在这篇论文被考察。结论能如下被总结。(1 )Neuroendocrine 免疫者网络(NIN ) 骨破折规章的小径 OPG-RANKL-RANK 是肾管理的机制之一骨头。尽管增强肾的治疗被认为是身体的整体的规章的机制之一,在 TCM 的典型整体的规定能在肾加强治疗期间通过 NIN 的 nonselective 规定被反映,它能被用来在骨头髓的微型环境通过 microadjustments 对待骨质疏松症。(2 ) 在 TCM 的髓疲劳,而另外的房间减少,是在骨头髓的脂肪细胞增加的状态,用作管理骨头的肾的失败引起的骨质疏松症的致病。(3 ) 在 TCM 的肾能被认为是在身体包括多重功能的单位的一个复杂系统,包括管理骨头的单位。肾缺乏以仅仅肾系统和并非全部的至少一个单位指缺乏系统本身,它解释许多植物的增强肾的效果;一些植物能对待骨质疏松症,而是一些不能。尽管两个都作为增强肾的代理人分类,前者能解决当后者在肾系统调整另外的单位的失败时,管理联合起来的骨头的肾的失败。尽管有管理骨头理论的肾上的当前的理解,管理骨头的肾的机制仍然保持复杂、未解决。因此,在这个区域的进一步的研究被保证。 | Dahong Ju Meijie Liu Hongyan Zhao Jun Wang | 2014 | Frontiers of Medicine2014，8，3： | 7 |
| 4 | Changes and correlation of microorganism and flavor substances during persimmon vinegar fermentation显示文摘To investigate the microbial diversity and the change of the flavor substances during the traditional natural persimmon vinegar fermentation,two group samples from alcohol fermentation stage(A)and acetic acid fermentation stage(B)were analyzed.The results showed that Burkholderia,Lactobacillus,Acetobacter,Komagataeibacter were the main bacteria,and the major fungi were Saccharomyces,Hanseniaspora,Hortaea,and Cladosporium at the genus level.The contents of flavonoids and polyphenols in B increased by 17.91%and 26.59%compared with A,respectively.The superoxide anion scavenging activity significantly increased by 20.15%.The contents of total free amino acids were 5709.99±410.36 mg/L and 5736.16±472.02 mg/L,and the total contents of 9 organic acids were 19.89±1.20 g/L and 33.77±2.49 g/L in samples A and B,respectively.Pearson correlation analysis showed that 11 flavor compounds were related to Lactobacillus and Leuconostoc;8 and 10 compounds were respectively related to Komagataeibacter and Acetobacter;13 and 19 flavor compounds were respectively associated with Saccharomyces and Monascus.Orthogonal Partial Least Square(OPLS)model showed that the contents of Leu,Lys,and lactic acid were mainly associated with fungi,andγ-aminobutyric acid(GABA)content was correlated with Lactobacillus,Acetobacter,Leuconostoc,and Saccharomyces.This study revealed the relationship between microbial diversity and flavor compounds in persimmon vinegar produced by spontaneous fermentation.The results can provide a theoretical support for the safety and health assessment of persimmon vinegar. | Dahong Wang Mengyang Wang Luwei Cao Xiaotong Wang Jianrui Sun Jiangfeng Yuan Shaobin Gu | 2022 | Food Bioscience2022，46，2： | 4 |
| 5 | New possible silver lining for pancreatic cancer therapy:Hydrogen sulfide and its donors显示文摘As one of the most lethal diseases,pancreatic cancer shows a dismal overall prognosis and high resistance to most treatment modalities.Furthermore,pancreatic cancer escapes early detection during the curable period because early symptoms rarely emerge and specific markers for this disease have not been found.Although combinations of new drugs,multimodal therapies,and adjuvants prolong survival,most patients still relapse after surgery and eventually die.Consequently,the search for more effective treatments for pancreatic cancer is highly relevant and justified.As a newly re-discovered mediator of gasotransmission,hydrogen sulfide(H2S)undertakes essential functions,encompassing various signaling complexes that occupy key processes in human biology.Accumulating evidence indicates that H2S exhibits bimodal modulation of cancer development.Thus,endogenous or low levels of exogenous H2S are thought to promote cancer,whereas high doses of exogenous H2S suppress tumor proliferation.Similarly,inhibition of endogenous H2S production also suppresses tumor proliferation.Accordingly,H2S biosynthesis inhibitors and H2S supplementation(H2S donors)are two distinct strategies for the treatment of cancer.Unfortunately,modulation of endogenous H2S on pancreatic cancer has not been studied so far.However,H2S donors and their derivatives have been extensively studied as potential therapeutic agents for pancreatic cancer therapy by inhibiting cell proliferation,inducing apoptosis,arresting cell cycle,and suppressing invasion and migration through exploiting multiple signaling pathways.As far as we know,there is no review of the effects of H2S donors on pancreatic cancer.Based on these concerns,the therapeutic effects of some H2S donors and NO-H2S dual donors on pancreatic cancer were summarized in this paper.Exogenous H2S donors may be promising compounds for pancreatic cancer treatment. | Xu Hua Yan Xiao Jianan Sun Bao Ji Shanshan Luo Bo Wu Chao Zheng Peng Wang Fanxing Xu Keguang Cheng Huiming Hua Dahong Li | 2021 | Acta Pharmaceutica Sinica B2021，11，5： | 4 |
| 6 | The application of Hartley transform to ocean engineering显示文摘The Hartley transform is a real integral transform based on harmonic functions and hassome characteristics similar to the Fourier transform. Most applications in ocean engineering requiringthe Fourier transform can also be performed by the Hartley transform. The fast Hartley transform istwice faster and more convenient to handle than the corresponding fast Fourier transform, so it is a realvalued alternative to the complex Fourier transform in many applications. The use of the Hartley trans-form in ocean engineering is presented in detail in this paper, including wave spectral analysis, separationof waves, cross-correlation in PIV technique and expression of equation in the Hartley domain. The ex-amples in the paper show deeply the advantage and efficiency of the Hartley transform over the Fouriertransform. | Hequan Sun, Dahong Qiu, Yongxue Wang State Key Laboratory of Coastal and Offshore Engineering, Dalian University of Technology, Dalian 116023, China + Corresponding author: Fax: +86-411-4708526, E-mail:hqsun@dlut. edu.cn | 2003 | Acta Oceanologica Sinica2003，22，3： | 2 |
| 7 | Synthesis of selective PAK4 inhibitors for lung metastasis of lung cancer and melanoma cells显示文摘The p21 activated kinase 4(PAK4) is serine/threonine protein kinase that is critical for cancer progression.Guided by X-ray crystallography and structure-based optimization,we report a novel subseries of C-3-substituted 6-ethynyl-1 H-indole derivatives that display high potential and specificity towards group Ⅱ PAKs.Among these inhibitors,compound 55 exhibited excellent inhibitory activity and kinase selectivity,displayed superior anti-migratory and anti-invasive properties against the lung cancer cell line A549 and the melanoma cell line B16.Compound 55 exhibited potent in vivo antitumor metastatic efficacy,with over 80% and 90% inhibition of lung metastasis in A549 or B16-BL6 lung metastasis models,respectively.Further mechanistic studies demonstrated that compound 55 mitigated TGF-β1-induced epithelial-mesenchymal transition(EMT). | Peilu Song Fan Zhao Dahong Li Jiqiang Qu Miao Yao Yuan Su Hanxun Wang Miaomiao Zhou Yujie Wang Yinli Gao Feng Li Dongmei Zhao Fengjiao Zhang Yu Rao Mingyu Xia Haitao Li Jian Wang Maosheng Cheng | 2022 | Acta Pharmaceutica Sinica B2022，12，6： | 2 |
| 8 | Correlation between cold and hot pattern in traditional Chinese medicine and gene expression profiles in rheumatoid arthritis显示文摘Clinical manifestations of rheumatoid arthritis(RA)are diversified,and based on the manifestations,the patients with RA could be classified into different patterns under traditional Chinese medicine.These patterns decide the selection of herbal prescription,and thus they can help find a subset of rheumatoid arthritis patients for a type of therapy.In the present study,we combine genome-wide expression analysis with methods of systems biology to identify the functional gene networks for the sets of clinical symptoms that comprise the major information for pattern classification.Clinical manifestations in rheumatoid arthritis were clustered with factor analysis,and two factors(similar to cold and hot patterns in traditional Chinese medicine)were found.Microarray technology was used to reveal gene expression profiles in CD4^(+)T cells from 21 rheumatoid arthritis patients.Protein-protein interaction information for these genes from databases and literature data was searched.The highly-connected regions were detected to infer significant complexes or pathways in this protein-protein interaction network.The significant pathways and function were extracted from these subnetworks using the Biological Network Gene Ontology tool.The genes significantly related to hot and cold patterns were identified by correlations analysis.MAPK signalling pathway,Wnt signaling pathway,and insulin signaling pathway were found to be related to hot pattern.Purine metabolism was related to both hot and cold patterns.Alanine,aspartate,and tyrosine metabolism were related to cold pattern,and histindine metabolism and lysine degradation were related to hot pattern.The results suggest that cold and hot patterns in traditional Chinese medicine were related to different pathways,and the network analysis might be used for identifying the pattern classification in other diseases. | Miao Jiang Cheng Xiao Gao Chen Cheng Lu Qinglin Zha Xiaoping Yan Weiping Kong Shijie Xu Dahong Ju Pu Xu Youwen Zou Aiping Lu | 2011 | Frontiers of Medicine2011，5，2： | 2 |
| 9 | Novel Graphene Biosensor Based on the Functionalization of Multifunctional Nano-bovine Serum Albumin for the Highly Sensitive Detection of Cancer Biomarkers显示文摘A simple,convenient,and highly sensitive bio-interface for graphene field-effect transistors(GFETs) based on multifunctional nano-denatured bovine serum albumin(nano-dBSA) functionalization was developed to target cancer bio-markers.The novel graphene–protein bioelectronic interface was constructed by heating to denature native BSA on the graphene substrate surface.The formed nano-d BSA film served as the cross-linker to immobilize monoclonal antibody against car-cinoembryonic antigen(anti-CEA mAb) on the graphene channel activated by EDC and Sulfo-NHS.The nano-dBSA film worked as a self-protecting layer of graphene to prevent surface contamination by lithographic processing.The improved GFETbiosensor exhibited good specificity and high sensitivity toward the target at an ultralow concentration of 337.58 fg mL-1.The electrical detection of the binding of CEA followed the Hill model for ligand–receptor interaction,indicating the negative binding cooperativity between CEA and anti-CEA mAb with a dissociation constant of 6.82×10-10M.The multifunctional nano-dBSA functionalization can confer a new function to graphene-like 2D nanomaterials and provide a promising bio-functionalization method for clinical application in biosensing,nanomedicine,and drug delivery. | Lin Zhou Kun Wang Hao Sun Simin Zhao Xianfeng Chen Dahong Qian Hongju Mao Jianlong Zhao | 2019 | Nano-Micro Letters2019，11，2： | 1 |
| 10 | Structure of activated sludge flocs显示文摘 | LI Dahong GANCZARCZYK J J | 1990 | Biotechnology and Bioengineering1990，35，1： | 1 |
| 11 | Telmisartan inhibitsboth oxidative stress and renal fibrosis after unilateral ureteral ob-struction in acatalasemic mice显示文摘 | Sugiyamal H Kobayashil M Dahong W | 2005 | Nephrol Dial Transplant2005，20，： | 1 |
| 12 | Effect of amlodipive on the growth of vascular smooth muscle cells of spontaneously hypertensive rats显示文摘 | Tang Jiarong Liu Zhengxiang Ren Dahong | 1997 | J Tongji Med University1997，17，3： | 1 |
| 13 | Cadmium( II) Removal by Modified Zeolitefrom Micro-polluted Water显示文摘 | Li Mingyu Zhu Xiaoqiang Lin Dahong Chen Weiling andRen Gang | 2011 | Environmental EngineeringScience2011，28，10： | 1 |
| 14 | Thermoluminescence and fission track impact features of rocks显示文摘Results of thermoluminescence (TL) measurement of quartz sandstone before and after impact using a two-stage light gas gun pressure apparatus indicate that, the TL of quartz sandstone decreases as the impact pressure increases, there exists a TL gradient from the outside to the inside around the impacted area, and the induced TL at the same location also has a TL gradient. Impact experiments were conducted under pressures of 12.4, 28.9, 37.8, 51.8, 64.6 and 77.6 GPa, respectively, and fission track density and fission track length before and after the impact were measured. Results demonstrate that the fission track density is decreased and the fission track length is shortened as the impact pressure is increased. | LIU Jingfa LI Dahong YU Chiling SHI Manquan | 2000 | Chinese Science Bulletin2000，45，12： | 1 |
| 15 | Effect of incisor position on the self-perceived psychosocial impacts of malocclusion among Chi- nese young adults 显示文摘 | Dahong X Xiangrong C Ying L | 2013 | Angle Orthod2013，83，4： | 1 |
| 16 | Photoinitiated crosslinking of ethylene-vinyl acetate copolymers and charac- terization of related properties 显示文摘 | YAO Dahong QU Baojun WU Qianghua | 2007 | Polym Eng Sci2007，，10： | 1 |
| 17 | Effect of esculetin on bone metabolism in ovariectomized rats显示文摘OBJECTIVE: To determine the effect of an esculetin formulation(at 97.4% purity) on osteoporosis, and to investigate the potential underlying molecular mechanism(s).METHODS: Sixty specific pathogen free-grade female Wistar rats were randomly assigned to three groups: blank control(n = 12), sham(n = 12), and model(n = 36). The model group were bilaterally ovariectomized. The sham group had the tissue surrounding the ovaries removed, while the ovaries were retained. After 3 months, the model group was randomly divided into three subgroups: OVX(n = 12), positive control(n = 12), and esculetin(n =12). The positive control group and the esculetin group were intragastrically administered diethylstilbestrol(0.046 mgkd^(-1)), respec·kg^(-1)tively,·d^(-1)) or esculetin(384 mgg^(-1) once per day for 6 consecu··-tive days; medication administration was then stopped for 1 d, before being administered for another 6 consecutive days. All rats were treated for 3months. Samples were collected at the end of the treatment period. An Osteocore3 Digital 2D bone densitometer was used to test the bone mineral density, and histomorphometric analysis was performed to measure bone mass, bone formation,and bone resorption. Enzyme-linked immunosorbent assay analysis was used to measure the serum concentrations of interleukin-6(IL-6), osteoprotegerin(OPG), and receptor activator of nuclear factor-kappa B ligand(RANKL). Immunohistochemistry and in situ hybridization were performed to detect the protein and mRNA expressions of OPG and RANKL in osteoblasts and bone marrow stromal cells.RESULTS: Compared with the OVX group, the esculetin group had significantly greater femoral bone mineral density and tibial trabecular bone volume,and significantly smaller trabecular resorption surface. The percentage of trabecular formation surface, average osteoid width, trabecular bone mineralization rate, and cortical bone mineralization rate did not significantly differ between groups. Compared with the sham group, the esculetin group had significantly decreased serum levels of IL-6and RANKL, and significant downregulation of RANKL protein and mRNA expression levels in osteoblasts and bone marrow stromal cells; however, there was no significant difference between groups in OPG.CONCLUSION: Esculetin can increase bone mass by upregulating RANKL expression in osteoblasts and bone marrow stromal cells, and decreasing serum IL-6 concentration. This indicates that the therapeutic effect of esculetin on osteoporosis occurs via decreased bone resorption. | Liu Meijie Wang Ruihai Li Yan Bai Dong Pan Jinghua Liu Hong Wang Shaojun Wu Jiaying Sun Gang Miao Qing Ju Dahong Liu Limei | 2018 | Journal of Traditional Chinese Medicine2018，38，6： | 1 |
| 18 | Enmein-type diterpenoid analogs from natural kaurene-type oridonin: Synthesis and their antitumor biological evaluation显示文摘 | Dahong Li Shengtao Xu Hao Cai Lingling Pei Hengyuan Zhang Lei Wang Hequan Yao Xiaoming Wu Jieyun Jiang Yijun Sun Jinyi Xu | 2013 | European Journal of Medicinal Chemistry2013，，： | 1 |
| 19 | Tum or Necrosis Factor Expression in ArterialWallsof Diabetic Rats显示文摘Immunohistochemistry was used to detect tumor necrosis factor (TNF α) expression in arterial wall of diabetic rats. It was found that endothelial cells were swollen and markedly proliferative in these vessels and accordingly TNF α showed strong positive immunohistochemical reaction in endothelial cells or extracellular intimal matrix of such vessels, which might be caused by the expression and release of TNF α from monocytes and arterial wall cells stimulated by AGEs. These findings suggested that increased TNF α expression might be associated with vascular damage and remodeling in diabetes. | ZHANG Muxun, REN Dahong LI Xu ZHANG Jianhua Department of Endocrinology, Tongji Hospital, Tongji Medical University, Wuhan 430030 * Department of Pathology, School of Basic Medical Sciences, Tongji Medical University, Wuhan 430030 | 1999 | Journal of Huazhong University of Science and Technology(Medical Sciences)1999，19，3： | 1 |
| 20 | Glacier changes in the Qaidam Basin from 1977 to 2018显示文摘Based on Landsat MSS/TM/OLI remote sensing images,glaciers vector data in the Qaidam Basin were extracted for 1977,2002,and 2018,and their spatial-temporal variations were analyzed.Results show that there were 2,050 glaciers covering an area of 1,693.54±40.96 km2 and having an ice volume of 108.65±2.43 km^3 in the Qaidam Basin in 2018.Glaciers with areas<1.0 km2 accounted for the largest number,while glaciers with areas of 1.0−5.0 km2 accounted for the most glacierized area.In the past 50 years,the number of glaciers decreased by 177,and the glacier area and volume reduced by 338.08 km2(−8.12 km^2/a)and 19.92 km3(−0.48 km^3/a),respectively.Retreat altitudes of glaciers were concentrated at 4,900−5,600 m,4,700−5,200 m,and 5,000−5,600 m and reduced areas accounted for 95.53%,77.80%,and 69.19%in the Kunlun,Qilian,and Altun mountains,respectively.The area of north-oriented glaciers decreased the most(−125.43 km^2),but the west-and east-oriented glaciers retreated at the fastest rate(i.e.,−27.11%and−27.10%).All glaciers showed a decreasing trend in sub-regions of the Qaidam Basin from 1977 to 2018.The decreasing trend was accelerated gradually from northwest to southeast in the northern part of the basin,while glacier change was the smallest in the middle section and gradually accelerated towards both ends of the basin's southern part.The temperature had continued to rise,and the precipitation had increased slowly in the Qaidam Basin during the past 50 years.The continuous rise in air temperature was the main reason for the retreat of glaciers. | SuGang Zhou XiaoJun Yao Yuan Zhang DaHong Zhang Juan Liu HongYu Duan | 2020 | Research in Cold and Arid Regions2020，12，6： | 1 |
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