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| 1 | Survivin isoforms and clinicopathological characteristics in colorectal adenocarcinomas using real-time qPCR显示文摘AIM:To investigate three isoforms of survivin in colorectal adenocarcinomas.METHODS:We used the LightCycler Technology(Roche),along with a common forward primer and reverse primers specific for the splice variants and two common hybridization probes labeled with fluorescein and LightCycler-Red fluorophore(LC-Red 640).Real time quantitative polymerase chain reaction(PCR) was performed on cDNAs from 52 tumor specimens from colorectal cancer patients and 10 unrelated normal colorectal tissues.In the patients group,carcinoembryonic antigen(CEA) and CA19-9 tumor markers were also measured immunochemically.RESULTS:Wild type survivin mRNA isoform was expressed in 48%of the 52 tumor samples,survivin-2b in 38%and survivin-ΔΕx3 in 29%,while no expression was found in normal tissues.The mRNA expression of wild type survivin presented a significant correlation with the expression of the ratio of survivin-2b,survivin-ΔΕx3,survivin-2b/wild type survivin and survivin-ΔΕx3/wild type survivin(P<0.001).The mRNA expression of wildsurvivin and survivin-ΔΕx3 was related with tumor size and invasion(P=0.006 and P<0.005,respectively).A significant difference was found between survivin-2b and morphologic cancer type.Also,the ratio of survivin-ΔEx3/ wild-survivin was significantly associated with prognosis.No association was observed between the three isoforms and grade,metastasis,Dukes stage and gender.The three isoforms were not correlated with CEA and CA19-9.CONCLUSION:Survivin isoforms may play a role in cell apoptosis and their quantification could provide information about clinical management of patients suffering from colorectal cancer. | Anastasia Pavlidou Maria Dalamaga Christos Kroupis George Konstantoudakis Maria Belimezi George Athanasas Kleanthi Dimas | 2011 | World Journal of Gastroenterology2011，17，12： | 9 |
| 2 | Obesity, insulin resistance, adipocytokines and breast cancer: New biomarkers and attractive therapeutic targets显示文摘Worldwide, breast cancer(BC) represents the most common type of non-skin human malignancy and the second leading cause of cancer-related deaths amid women in Western countries. Obesity and its metabolic complications have rapidly become major global health issues and are associated with increased risk for cancer, especially BC in postmenopausal women. Adipose tissue is considered as a genuine endocrine organ secreting a variety of bioactive adipokines, such as leptin, adiponectin, resistin and nicotinamide phosphoribosyltransferase/visfatin. Recent evidence has indicated that the constellation of obesity, insulin resistance and adipokines is associated with the risk and prognosis of postmenopausal BC. Direct evidence is growing rapidly supporting the stimulating and/or inhibiting role of adipokines in the process of development and progression of BC. Adipokines could exert their effects on the normal and neoplastic mammary tissue by endocrine, paracrine and autocrine mechanisms. Recent studies support a role of adipokines as novel risk factors and potential diagnostic and prognostic biomarkers in BC. This editorial aims at providing important insights into the potential pathophysiological mechanisms linking adipokines to the etiopathogenesis of BC in the context of a dysfunctionaladipose tissue and insulin resistance in obesity. A better understanding of these mechanisms may be important for the development of attractive preventive and therapeutic strategies against obesity-related breast malignancy. | Maria Dalamaga | 2013 | World Journal of Experimental Medicine2013，3，3： | 4 |
| 3 | Micro-RNAs as clinical biomarkers and therapeutic targets in breast cancer:Quo vadis?显示文摘Breast cancer(BC) is the most frequent type of non skin cancer among women and a major leading cause of cancer-related deaths in Western countries. It is substantial to discover novel biomarkers with diagnostic, prognostic or predictive usefulness as well as therapeutic value for BC. Micro-RNAs(miR NAs) belong to a novel class of endogenous interfering RNAs that play a crucial role in post transcriptional gene silencing through m RNA targeting and, thus, are involved in many biological processes encompassing apoptosis,cell-cycle control, cell proliferation, DNA repair, immunity, metabolism, stress, aging, etc. Mi RNAs exert their action mainly in a tumor suppressive or oncogenic manner. The specific aberrant expression patterns of miR NAs in BC that are detected with the use of highthroughput technologies reflect their key role in cancer initiation, progression, migration, invasion and metastasis. The detection of circulating extracellular miR NAs in plasma of BC patients may provide novel, non-invasive biomarkers in favor of BC diagnosis and prognosis and,at the same time, accumulating evidence has underscored the possible contribution of miR NAs as valuable biomarkers to predict response to chemotherapy or radiotherapy. Data from in vitro and in vivo studies on BC have revealed promising therapeutic approaches via mi RNA delivery and mi RNA inhibition. The purpose of this review is to explore the ontological role of miR NAs in BC etiopathogenesis as well as to highlight their potential, not only as non-invasive circulating biomarkers with diagnostic and prognostic significance, but also as treatment response predictors and therapeutic targets aiding BC management. | Gerasimos Socrates Christodoulatos Maria Dalamaga | 2014 | World Journal of Clinical Oncology2014，5，2： | 4 |
| 4 | Pancreatic cancer expresses adiponectin receptors and is associated with hypoleptinemia and hyperadiponectinemia: a case–control study显示文摘 | Maria Dalamaga Ilias Migdalis Jessica L. Fargnoli Evangelia Papadavid Erica Bloom Nicholas Mitsiades Konstantinos Karmaniolas Nicolaos Pelecanos Sofia Tseleni-Balafouta Amalia Dionyssiou-Asteriou Christos S. Mantzoros | 2009 | Cancer Causes & Control2009，，5： | 3 |
| 5 | The Role of Adiponectin in Cancer: A Review of Current Evidence显示文摘 | Maria Dalamaga Kalliope N. Diakopoulos Christos S. Mantzoros | 2012 | Endocrine Reviews2012，，4： | 2 |
| 6 | Interplay of adipokines and myokines in cancer pathophysiology: Emerging therapeutic implications显示文摘Excess body weight constitutes a worldwide health problem with epidemic proportions impacting on the risk and prognosis of several disease states including malignancies. It is believed that the metabolic changes associated with weight gain, particularly visceral obesity, and physical inactivity could lead to dysfunctional adipose and muscle tissues causing insulin resistance, low-grade chronic inflammation and abnormal secretion of adipokines and myokines. The complex paracrine and endocrine interconnection between adipokines and myokines reflects a yin-yang balance with important implications in processes such as lipolysis control, insulin sensitivity and prevention from obesity-driven chronic low-grade inflammation and cancer promotion through anti-inflammatory adipokines and myokines. Furthermore, the complex pathophysiology of cancer cachexia is based on the interplay between muscle and adipose tissue mediated by free fatty acids, various adipokines and myokines. The purpose of this editorial is to explore the role of the adipose and muscle tissue interplay in carcinogenesis, cancer progression and cachexia, and to examine the mechanisms underpinning their association with malignancy. Understanding ofthe mechanisms connecting the interplay of adipokines and myokines with cancer pathophysiology is expected to be of importance in the development of therapeutic strategies against cancer cachexia. Advances in the field of translational investigation may lead to tangible benefits to obese and inactive persons who are at increased risk of cancer as well as to cancer patients with cachexia. | Maria Dalamaga | 2013 | World Journal of Experimental Medicine2013，3，3： | 2 |
| 7 | The Role of Adiponectin in Cancer: A Review of Current Evidence显示文摘 | Maria Dalamaga Kalliope N. Diakopoulos Christos S. Mantzoros | 2012 | Endocrine Reviews2012，，4： | 2 |
| 8 | Ovarian SAHA syndrome is associated with a more insulin-resistant profile and represents an independent risk factor for glucose abnormalities in women with polycystic ovary syndrome: a prospective controlled study 显示文摘 | Dalamaga M Papadavid E Basios G etal | 2013 | JAm Acad Dermatol2013，69，6： | 1 |
| 9 | The Tax Versus Debt Controversy in a Multivariate Cointegration System 显示文摘 | Dalamagas | 1994 | Applied Economics1994，26，： | 1 |
| 10 | The role of ad- iponeetin in cancer: a review of current evidence显示文摘 | Dalamaga M Diakopoulos KN Mantzoros CS | 2012 | Endocr Rev2012，33，4： | 1 |
| 11 | Leptin's role in lipodystrophic and nonlipodystrophic insulin- resistant and diabetic individuals显示文摘 | MOON HS DALAMAGA M KIM SY et ol | 2013 | Endocrine Rev2013，34，3： | 1 |
| 12 | Coexistence of primary refractory anemia with tinged sideroblasts and T cell-lymphoblastic non-Hodgkin lymphoma显示文摘 | Karmaniolas K Chavelas C | 2004 | Acta Haematol2004，111，3： | 1 |
| 13 | Captain Nemo: A Metasearch Engine with Personalized Hierarchical Search Spaces显示文摘 | Souldatos S Dalamagas T Sellis T | 2006 | Informatica2006，，30： | 1 |
| 14 | The role of adiponectin in cancer:a review of current evidence显示文摘 | Dalamaga M Diakopoulos KN Mantzoros CS | 2012 | Endocr Rev2012，33，4： | 1 |
| 15 | A cluster analysis of road traffic-related chi ldhood knee injuries显示文摘 | Iakovakis I Dessypris N Dalamaga M | 2003 | Child Care Health Dev2003，29，4： | 1 |
| 16 | Ischemia modified albumin, high-sensitivity c-reactive protein and natriuretic peptide in patients with coronary atherosclerosis显示文摘 | Konstantinos Kazanis Maria Dalamaga Charalampos Nounopoulos Antonios S. Manolis Nikolaos Sakellaris Gerard Jullien Amalia Dionyssiou-Asteriou | 2009 | Clinica Chimica Acta2009，，1： | 1 |
| 17 | Nieotinamide phosphoribosyl-transferase/visfatin: a missing link between overweight/obesity and postmenopausal breast cancer? Potential preventive and therapeutic perspectives and challenges显示文摘 | Dalamaga M | 2012 | Med Hypotheses2012，79，5： | 1 |
| 18 | Evidence on the infectious etiology of childhood leukemia: the role of low herd immunity (Greece) 显示文摘 | Petridou E Dalamaga M Mentis A | 2001 | Cancer Causes and Control2001，12，7： | 1 |
| 19 | The role of adiponec-tin in cancer:A review of current evidence显示文摘 | Dalamaga M Diakopoulos KN Mantzoros CS | | 0，，04： | 1 |
| 20 | Leptin, soluble leptinreceptor,adiponectin and resistin in relation to OGTT in overweight/ obese posmaenopausal women显示文摘 | Hroussalas G Kassi E Dalamaga M | 2008 | Maturitxs2008，59，4： | 1 |
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