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| 1 | Survivin isoforms and clinicopathological characteristics in colorectal adenocarcinomas using real-time qPCR显示文摘AIM:To investigate three isoforms of survivin in colorectal adenocarcinomas.METHODS:We used the LightCycler Technology(Roche),along with a common forward primer and reverse primers specific for the splice variants and two common hybridization probes labeled with fluorescein and LightCycler-Red fluorophore(LC-Red 640).Real time quantitative polymerase chain reaction(PCR) was performed on cDNAs from 52 tumor specimens from colorectal cancer patients and 10 unrelated normal colorectal tissues.In the patients group,carcinoembryonic antigen(CEA) and CA19-9 tumor markers were also measured immunochemically.RESULTS:Wild type survivin mRNA isoform was expressed in 48%of the 52 tumor samples,survivin-2b in 38%and survivin-ΔΕx3 in 29%,while no expression was found in normal tissues.The mRNA expression of wild type survivin presented a significant correlation with the expression of the ratio of survivin-2b,survivin-ΔΕx3,survivin-2b/wild type survivin and survivin-ΔΕx3/wild type survivin(P<0.001).The mRNA expression of wildsurvivin and survivin-ΔΕx3 was related with tumor size and invasion(P=0.006 and P<0.005,respectively).A significant difference was found between survivin-2b and morphologic cancer type.Also,the ratio of survivin-ΔEx3/ wild-survivin was significantly associated with prognosis.No association was observed between the three isoforms and grade,metastasis,Dukes stage and gender.The three isoforms were not correlated with CEA and CA19-9.CONCLUSION:Survivin isoforms may play a role in cell apoptosis and their quantification could provide information about clinical management of patients suffering from colorectal cancer. | Anastasia Pavlidou Maria Dalamaga Christos Kroupis George Konstantoudakis Maria Belimezi George Athanasas Kleanthi Dimas | 2011 | World Journal of Gastroenterology2011，17，12： | 9 |
| 2 | Obesity, insulin resistance, adipocytokines and breast cancer: New biomarkers and attractive therapeutic targets显示文摘Worldwide, breast cancer(BC) represents the most common type of non-skin human malignancy and the second leading cause of cancer-related deaths amid women in Western countries. Obesity and its metabolic complications have rapidly become major global health issues and are associated with increased risk for cancer, especially BC in postmenopausal women. Adipose tissue is considered as a genuine endocrine organ secreting a variety of bioactive adipokines, such as leptin, adiponectin, resistin and nicotinamide phosphoribosyltransferase/visfatin. Recent evidence has indicated that the constellation of obesity, insulin resistance and adipokines is associated with the risk and prognosis of postmenopausal BC. Direct evidence is growing rapidly supporting the stimulating and/or inhibiting role of adipokines in the process of development and progression of BC. Adipokines could exert their effects on the normal and neoplastic mammary tissue by endocrine, paracrine and autocrine mechanisms. Recent studies support a role of adipokines as novel risk factors and potential diagnostic and prognostic biomarkers in BC. This editorial aims at providing important insights into the potential pathophysiological mechanisms linking adipokines to the etiopathogenesis of BC in the context of a dysfunctionaladipose tissue and insulin resistance in obesity. A better understanding of these mechanisms may be important for the development of attractive preventive and therapeutic strategies against obesity-related breast malignancy. | Maria Dalamaga | 2013 | World Journal of Experimental Medicine2013，3，3： | 4 |
| 3 | Micro-RNAs as clinical biomarkers and therapeutic targets in breast cancer:Quo vadis?显示文摘Breast cancer(BC) is the most frequent type of non skin cancer among women and a major leading cause of cancer-related deaths in Western countries. It is substantial to discover novel biomarkers with diagnostic, prognostic or predictive usefulness as well as therapeutic value for BC. Micro-RNAs(miR NAs) belong to a novel class of endogenous interfering RNAs that play a crucial role in post transcriptional gene silencing through m RNA targeting and, thus, are involved in many biological processes encompassing apoptosis,cell-cycle control, cell proliferation, DNA repair, immunity, metabolism, stress, aging, etc. Mi RNAs exert their action mainly in a tumor suppressive or oncogenic manner. The specific aberrant expression patterns of miR NAs in BC that are detected with the use of highthroughput technologies reflect their key role in cancer initiation, progression, migration, invasion and metastasis. The detection of circulating extracellular miR NAs in plasma of BC patients may provide novel, non-invasive biomarkers in favor of BC diagnosis and prognosis and,at the same time, accumulating evidence has underscored the possible contribution of miR NAs as valuable biomarkers to predict response to chemotherapy or radiotherapy. Data from in vitro and in vivo studies on BC have revealed promising therapeutic approaches via mi RNA delivery and mi RNA inhibition. The purpose of this review is to explore the ontological role of miR NAs in BC etiopathogenesis as well as to highlight their potential, not only as non-invasive circulating biomarkers with diagnostic and prognostic significance, but also as treatment response predictors and therapeutic targets aiding BC management. | Gerasimos Socrates Christodoulatos Maria Dalamaga | 2014 | World Journal of Clinical Oncology2014，5，2： | 4 |
| 4 | Pancreatic cancer expresses adiponectin receptors and is associated with hypoleptinemia and hyperadiponectinemia: a case–control study显示文摘 | Maria Dalamaga Ilias Migdalis Jessica L. Fargnoli Evangelia Papadavid Erica Bloom Nicholas Mitsiades Konstantinos Karmaniolas Nicolaos Pelecanos Sofia Tseleni-Balafouta Amalia Dionyssiou-Asteriou Christos S. Mantzoros | 2009 | Cancer Causes & Control2009，，5： | 3 |
| 5 | The Role of Adiponectin in Cancer: A Review of Current Evidence显示文摘 | Maria Dalamaga Kalliope N. Diakopoulos Christos S. Mantzoros | 2012 | Endocrine Reviews2012，，4： | 2 |
| 6 | Interplay of adipokines and myokines in cancer pathophysiology: Emerging therapeutic implications显示文摘Excess body weight constitutes a worldwide health problem with epidemic proportions impacting on the risk and prognosis of several disease states including malignancies. It is believed that the metabolic changes associated with weight gain, particularly visceral obesity, and physical inactivity could lead to dysfunctional adipose and muscle tissues causing insulin resistance, low-grade chronic inflammation and abnormal secretion of adipokines and myokines. The complex paracrine and endocrine interconnection between adipokines and myokines reflects a yin-yang balance with important implications in processes such as lipolysis control, insulin sensitivity and prevention from obesity-driven chronic low-grade inflammation and cancer promotion through anti-inflammatory adipokines and myokines. Furthermore, the complex pathophysiology of cancer cachexia is based on the interplay between muscle and adipose tissue mediated by free fatty acids, various adipokines and myokines. The purpose of this editorial is to explore the role of the adipose and muscle tissue interplay in carcinogenesis, cancer progression and cachexia, and to examine the mechanisms underpinning their association with malignancy. Understanding ofthe mechanisms connecting the interplay of adipokines and myokines with cancer pathophysiology is expected to be of importance in the development of therapeutic strategies against cancer cachexia. Advances in the field of translational investigation may lead to tangible benefits to obese and inactive persons who are at increased risk of cancer as well as to cancer patients with cachexia. | Maria Dalamaga | 2013 | World Journal of Experimental Medicine2013，3，3： | 2 |
| 7 | The Role of Adiponectin in Cancer: A Review of Current Evidence显示文摘 | Maria Dalamaga Kalliope N. Diakopoulos Christos S. Mantzoros | 2012 | Endocrine Reviews2012，，4： | 2 |
| 8 | Ischemia modified albumin, high-sensitivity c-reactive protein and natriuretic peptide in patients with coronary atherosclerosis显示文摘 | Konstantinos Kazanis Maria Dalamaga Charalampos Nounopoulos Antonios S. Manolis Nikolaos Sakellaris Gerard Jullien Amalia Dionyssiou-Asteriou | 2009 | Clinica Chimica Acta2009，，1： | 1 |
| 9 | Diakopoulos,The Role of Adiponectin in Cancer:A Review of Current Evidence显示文摘 | Maria Dalamaga Kalliope N | 2012 | Endocrine Reviews2012，33，54： | 1 |
| 10 | Ischemia modified albumin,high-sensitivity c-reactive protein and natriuretic peptide in patients with coronary atherosclerosis显示文摘 | Konstantinos Kazanis Maria Dalamaga Charal ampos Nounopoulos | 2009 | Clinica Chimica Acta2009，408，1： | 1 |
| 11 | Serum resistin: A biomarker of breast cancer in postmenopausal women? Association with clinicopathological characteristics, tumor markers, inflammatory and metabolic parameters显示文摘 | Maria Dalamaga George Sotiropoulos Konstantinos Karmaniolas Nicolaos Pelekanos Evangelia Papadavid Antigoni Lekka | 2013 | Clinical Biochemistry2013，，： | 1 |
| 12 | Adipocytokines and psoriasis: Insights into mechanisms linking obesity and inflammation to psoriasis显示文摘Psoriasis has been lately seen as a potential systemic inflammatory disease associated with a range of comorbidities exhibiting an overlapping pathology and presenting a great social health impact such as cardiovascular disease and metabolic diseases,including obesity.Adipose tissue is considered a genuine endocrine organ producing a variety of bioactive adipocytokines,like leptin,adiponectin,resistin and visfatin,participating in physiological and pathological processes,such as energy balance,insulin sensitivity and resistance,immunity,inflammation,hematopoiesis and angiogenesis.Adipocytokines could serve as a missing link in the association between psoriasis,obesity and metabolic co-morbidities.In chronic inflammatory disease states such as psoriasis,adipocytokines may be implicated in psoriasis onset,progression,severity as well as in the pathogenesis of co-morbidities.Measuring serum adipocytokine levels in the future may be useful in predicting psoriasis severity,progression,treatment outcome and risk of any co-mor-bidities.Interventions to decrease pro-inflammatory adipocytokine levels could offer preventive and therapeutic options for improving psoriasis severity and protecting against its co-morbidities.Candidate strategic interventions incorporate increased physical activity,weight control and pharmacologic approaches such as metformin.However,the mechanisms underlying the actions of adipocytokines in psoriasis as well as their potential diagnostic,prognostic and/or therapeutic utility require further investigation with larger prospective,longitudinal and mechanistic studies. | Maria Dalamaga Evangelia Papadavid | 2013 | World Journal of Dermatology2013，2，4： | 1 |
| 13 | Metabolic co-morbidities and psoriasis: The chicken or the egg?显示文摘Accumulating evidence supports that psoriasis may be a potential multisystem inflammatory disease associated with a range of co-morbidities showing an overlapping pathology and an important health impact such as metabolic diseases.Psoriasis is associated with an increased risk of obesity,metabolic syndrome(Mets)and diabetes mellitus type 2,following a'dose-response'relationship from mild to severe psoriasis.Conversely,recent evidence from large prospective studies suggests that obesity constitutes a risk factor for psoriasis and psoriatic arthritis.Also,a dyslipidemic profile may precede psoriasis onset.Both obesity,Mets and psoriasis,characterized as chronic inflammatory states,stem from a shared underlying pathophysiology exhibiting common genetic predisposition and risk factors such as high caloric intake,physical inactivity and psychological stress.Excess weight may potentiate the inflammation of psoriasis through the deregulation of adipocytokines while,at the same time,it may help the development of Mets.Interestingly,recent translational data has shown that psoriasis,through increased T-helper inflammatory cytokines in skin and sera,may exert a plethora of effects on insulin regulation and lipid metabolism.Largerpopulation-based prospective cohort and longitudinal studies are needed to unravel the association between psoriasis and metabolic co-morbidities.The recognition of the intricate complex interplay between psoriasis and metabolic co-morbidities may help dermatologists to be aware of associated metabolic co-morbidities in order to screen for metabolic diseases and manage holistically and effectively the psoriatic patient. | Maria Dalamaga Evangelia Papadavid | 2013 | World Journal of Dermatology2013，2，4： | 0 |
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