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| 1 | MicroRNA-125b-5p inhibits proliferation and promotes adipogenic differentiation in 3T3-L1 preadipocytes显示文摘以前的证据显示了 microRNA-125b (miR-125b ) 家庭戏在癌症房间生长,开发,区别,和 apoptosis 的规定的重要角色。然而,他们是否贡献 adipocyte 区别的过程,仍然保持不清楚。在现在的学习,我们表明表示 miR-125b-5p 铺平, miR-125b 家庭的一个成员,在进成熟 adipocyte 的 3T3-L1 preadipocyte 的区别期间是戏剧性地起来调整的。进 3T3-L1 房间的 miR-125b-5p 的补充支持了由增加的类脂化合物微滴和 adipocyte 特定的分子的标记的 mRNA 层次证实了的 adipogenic 区别,包括 peroxisome 激活 proliferators 的受体, CCAAT/enhancer-binding 蛋白质,丰满的酸绑定的蛋白质 4,并且脂蛋白脂肪分解酵素,并且由 triglyceride 累积。CCK-8 试金证明 miR-125b-5p 补充显著地禁止了房间增长。流动 cytometry 分析证明 miR-125b-5p 象 mRNA 和 G1/S-related 基因的蛋白质表示一样损害了 G1/S 阶段转变,例如 Cyclin D2, Cyclin D3,和 CDK4。不过,它没在 apoptosis 上有效果。由目标基因预言,另外,我们证明 smad4 可以是在鼠标 3T3-L1 preadipocytes 的 miR-125b-5p 的一个潜在的目标,为一些 miR-125b-5p 的函数的财务。一起拿,这些数据显示 miR-125b-5p 可以在 adipocyte 区别用作一个重要积极管理者,至少部分通过下面调整的 smad4。 | Dan Ouyang Yaqiong Ye Dongguang Guo Xiaofang Yu Jian Chen Junjie Qi Xiaotong Tan Yuan Zhang Yongjiang Ma Yugu Li | 2015 | Acta Biochimica et Biophysica Sinica2015，47，5： | 9 |
| 2 | MiR-181a-5p regulates 3T3-L1 cell adipogenesis by targeting Smad7 and Tcf7I2显示文摘 | Dan Ouyang Lifeng Xu Lihua zhang Dongguang Guo Xiaotong Tan Xiaofang Yu Junjie Qi Yaqiong Ye Qihong Liu Yongjiang Ma Yugu Li | 2016 | Acta Biochimica et Biophysica Sinica2016，48，11： | 9 |
| 3 | New innovations in pavement materials and engineering:A review on pavement engineering research 2021显示文摘Sustainable and resilient pavement infrastructure is critical for current economic and environmental challenges.In the past 10 years,the pavement infrastructure strongly supports the rapid development of the global social economy.New theories,new methods,new technologies and new materials related to pavement engineering are emerging.Deterioration of pavement infrastructure is a typical multi-physics problem.Because of actual coupled behaviors of traffic and environmental conditions,predictions of pavement service life become more and more complicated and require a deep knowledge of pavement material analysis.In order to summarize the current and determine the future research of pavement engineering,Journal of Traffic and Transportation Engineering(English Edition)has launched a review paper on the topic of'New innovations in pavement materials and engineering:A review on pavement engineering research 2021'.Based on the joint-effort of 43 scholars from 24 well-known universities in highway engineering,this review paper systematically analyzes the research status and future development direction of 5 major fields of pavement engineering in the world.The content includes asphalt binder performance and modeling,mixture performance and modeling of pavement materials,multi-scale mechanics,green and sustainable pavement,and intelligent pavement.Overall,this review paper is able to provide references and insights for researchers and engineers in the field of pavement engineering. | JTTE Editorial Office Jiaqi Chen Hancheng Dan Yongjie Ding Yangming Gao Meng Guo Shuaicheng Guo Bingye Han Bin Hong Yue Hou Chichun Hu Jing Hu Ju Huyan Jiwang Jiang Wei Jiang Cheng Li Pengfei Liu Yu Liu Zhuangzhuang Liu Guoyang Lu Jian Ouyang Xin Qu Dongya Ren Chao Wang Chaohui Wang Dawei Wang Di Wang Hainian Wang Haopeng Wang Yue Xiao Chao Xing Huining Xu Yu Yan Xu Yang Lingyun You Zhanping You Bin Yu Huayang Yu Huanan Yu Henglong Zhang Jizhe Zhang Changhong Zhou Changjun Zhou Xingyi Zhu | 2021 | Journal of Traffic and Transportation Engineering(English Edition)2021，8，6： | 7 |
| 4 | Transition metal oxides as hole-transporting materials in organic semiconductor and hybrid perovskite based solar cells显示文摘Organic polymer solar cells(OSCs) and organic-inorganic hybrid perovskite solar cells(PSCs) have achieved notable progress over the past several years.A central topic in these fields is exploring electronically efficient,stable and effective hole-transporting layer(HTL) materials.The goal is to enhance hole-collection ability,reduce charge recombination,increase built-in voltage,and hence improve the performance as well as the device stability.Transition metal oxides(TMOs) semiconductors such as NiO_x,CuO_x,CrO_x,MoO_x,WO_3,and V_2O_5,have been widely used as HTLs in OSCs.These TMOs are naturally adopted into PSC as HTLs and shows their importance.There are similarities,and also differences in applying TMOs in these two types of main solution processed solar cells.This concise review is on the recent developments of transition metal oxide HTL in OSCs and PSCs.The paper starts from the discussion of the cation valence and electronic structure of the transition metal oxide materials,followed by analyzing the structure-property relationships of these HTLs,which we attempt to give a systematic introduction about the influences of their cation valence,electronic structure,work function and film property on device performance. | Pingli Qin Qin He Dan Ouyang Guojia Fang Wallace C.H. Choy Gang Li | 2017 | Science China Chemistry2017，60，4： | 6 |
| 5 | Transport Accessibility and Spatial Connections of Cities in the Guangdong-Hong Kong-Macao Greater Bay Area显示文摘Based on geographic information system(GIS) spatial analysis technology, the spatial pattern of raster grid transport accessibility for the Guangdong-Hong Kong-Macao Greater Bay area was studied and the states of spatial connectedness were simulated using highway passenger transport, railway passenger transport, port passenger transport and aviation passenger transport data. The result shows that transport accessibility within the Guangdong-Hong Kong-Macao Greater Bay area costs ‘one hour’ and the spatial distribution of accessibility in the area presents clear ‘core-periphery’ spatial characteristics, with Guangzhou, Foshan, Shenzhen constituting the core. The transport accessibility of Guangdong-Hong Kong-Macao is high. Average accessibility of urban nodes as measured by travel time is 0.99 h, and the areas accessible within 1.42 h occupy 79.14% of the total area. Most of the areas with the lowest accessibility are found in the peripheral area, with the worst accessibility being 4.73 h. Compared with the west-side cities, the economically developed east-side cities of the Guangdong-Hong Kong-Macao Greater Bay area have higher connectivity with roads, railways, ports, and aviation transport. Guangzhou, Foshan, Zhuhai, Shenzhen, Hong Kong and Macao are closely linked. The higher the accessibility, the closer the intercity connectedness. | CAO Xiaoshu OUYANG Shishu YANG Wenyue LUO Yi LI Baochao LIU Dan | 2019 | Chinese Geographical Science2019，29，5： | 6 |
| 6 | Hydrochlorination of acetylene using expanded multilayered vermiculite(EML-VMT)-supported catalysts显示文摘Catalyst supports have very important effects on catalyst performance.A novel expanded multilayered vermiculite(EML-VMT) is successfully used as the catalyst support for the acetylene hydrochlorination.By mixing carbon on the surface of EML-VMT[i.e.,EML-VMT-C),the HgCl_2/EML-VMT-C achieved a high acetylene conversion of 97.3%,a vinyl chloride selectivity of 100%and a turn over frequency(TOF) value of 8.83 × 10^(-3)s^(-1) at a temperature of 140 C,an acetylene gas hourly space velocity(GHSV) of 108 h^(-1)',and a feed volume ratio V(HC1)/V(C_2H_2) of 1.15.Moreover,the HgCl_2/EML-VMT-C shows good stability.The EML-VMT also shows potential in the preparation of other EML-VMT-supported catalysts. | Xin-Huang Feng Yu Ming-Yuan Zhu Fei-Hong Ouyang Bin Dai Jian-Ming Dan | 2015 | Chinese Chemical Letters2015，26，9： | 6 |
| 7 | Coupling Effect of Heat Transfer and Flow Resistance in the Rifled Tube Water Wall of a Ultra-Supercritical CFB Boiler显示文摘The coupling factor is used in this study to characterise the combined effect of the heat transfer and resistance characteristics of a rifled tube. Boundary layer theory is utilised to investigate the relationship between the comprehensive coefficient and Reynolds number in two regions, namely, higher and lower than pseudo-critical enthalpy. Results indicate that mass flux exerts a decisive negative influence on the coupling effect, and the impacts of pressure and heat flux are weak. The overall effect decreases rapidly as the mass flux increases, but it increases in the area behind the quasi-critical enthalpy. The coupling effect is also affected by specific heat ratio, thermal acceleration and buoyancy. The correlations of heat transfer and friction resistance are deduced with high precision according to experimental data. | LI Yaode YANG Dong OUYANG Shijie LIU Dan WANG Wenyu | 2019 | Journal of Thermal Science2019，28，5： | 5 |
| 8 | Niacin alters the ruminal microbial composition of cattle under high-concentrate condition显示文摘To understand the effects of niacin on the ruminal microbial ecology of cattle under high-concentrate diet condition, Illumina MiSeq sequencing technology was used. Three cattle with rumen cannula were used in a 3 x 3 Latin-square design trial. Three diets were fed to these cattle during 3 periods for 3 days, respectively: high-forage diet(HF; forage-to-concentrate ratio = 80:20), high-concentrate diet(HC;forage-to-concentrate ratio=20:80), and HC supplemented with 800 mg/kg niacin(HCN). Ruminal pH was measured before feeding and every 2 h after initiating feeding. Ruminal fluid was sampled at the end of each period for microbial DNA extraction. Overall, our findings revealed that subacute ruminal acidosis(SARA) was induced and the a-diversity of ruminal bacterial community decreased in the cattle of HC group. Adding niacin in HC could relieve the symptoms of SARA in the cattle but the ruminal pH value and the Shannon index of ruminal bacterial community of HCN group were still lower than those of HF group. Whatever the diet was, the ruminal bacterial community of cattle was dominated by Bacteroidetes,Firmicutes and Proteobacteria. High-concentrate diet significantly increased the abundance of Prevotella,and decreased the abundance of Paraprevotella, Sporobacter, Ruminococcus and Treponema than HF.Compared with HC, HCN had a trend to decrease the percentage of Prevotella, and to increase the abundance of Succiniclasticum, Acetivibrio and Treponema. Increasing concentrate ratio could decrease ruminal pH value, and change the ruminal microbial composition. Adding niacin in HC could increase the ruminal pH value, alter the ruminal microbial composition. | Dan Luo Yufei Gao Youyou Lu Mingren Qu Xiaowen Xiong Lanjiao Xu Xianghui Zhao Ke Pan Kehui Ouyang | 2017 | Animal Nutrition2017，，2： | 4 |
| 9 | Effective and precise adenine base editing n mouse zygotes显示文摘 | Puping Liang Hongwei Sun Xiya Zhang Xiaowei Xie Jinran Zhang Yaofu Bai Xueling Ouyang Shengyao Zhi Yuanyan Xiong Wenbin Ma Dan Liu Junjiu Huang Zhou Songyang | 2018 | Protein & Cell2018，9，9： | 4 |
| 10 | Therapeutic effects of dental pulp stem cells on vascular dementia in rat models显示文摘Dental pulp stem cells are a type of adult stem cells with strong proliferative ability and multi-differentiation potential. There are no studies on treatment of vascular dementia with dental pulp stem cells. In the present study, rat models of vascular dementia were established by two-vessel occlusion, and 30 days later, rats were injected with 2 × 10^(7) dental pulp stem cells via the tail vein. At 70 days after vascular dementia induction, dental pulp stem cells had migrated to the brain tissue of rat vascular dementia models and differentiated into neuronlike cells. At the same time, doublecortin, neurofilament 200, and Neu N m RNA and protein expression levels in the brain tissue were increased, and glial fibrillary acidic protein m RNA and protein expression levels were decreased. Behavioral testing also revealed that dental pulp stem cell transplantation improved the cognitive function of rat vascular dementia models. These findings suggest that dental pulp stem cell transplantation is effective in treating vascular dementia possibly through a paracrine mechanism. The study was approved by the Animal Ethics Committee of Harbin Medical University(approval No. KY2017-132) in 2017. | Xue-Mei Zhang Yang Sun Ying-Lian Zhou Zhuo-Min Jiao Dan Yang Yuan-Jiao Ouyang Mei-Yu Yu Jin-Yue Li Wei Li Duo Wang Hui Yue Jin Fu | 2021 | Neural Regeneration Research2021，16，8： | 3 |
| 11 | Therapeutic potential of dental pulp stem cell transplantation in a rat model of Alzheimer’s disease显示文摘Dental pulp stem cells are dental pulp-derived mesenchymal stem cells that originate from the neural crest.They exhibit greater potential for the treatment of nervous system diseases than other types of stem cells because of their neurogenic differentiation capability and their ability to secrete multiple neurotrophic factors.Few studies have reported Alzheimer’s disease treatment using dental pulp stem cells.Rat models of Alzheimer’s disease were established by injecting amyloid-β1–42 into the hippocampus.Fourteen days later,5×106 dental pulp stem cells were injected into the hippocampus.Immunohistochemistry and western blot assays showed that dental pulp stem cell transplantation increased the expression of neuron-related doublecortin,NeuN,and neurofilament 200 in the hippocampus,while the expression of amyloid-βwas decreased.Moreover,cognitive and behavioral abilities were improved.These findings indicate that dental pulp stem cell transplantation in rats can improve cognitive function by regulating the secretion of neuron-related proteins,which indicates a potential therapeutic effect for Alzheimer’s disease.This study was approved by the Animal Ethics Committee of Harbin Medical University,China(approval No.KY2017-132)on February 21,2017. | Xue-Mei Zhang Yuan-Jiao Ouyang Bing-Qian Yu Wei Li Mei-Yu Yu Jin-Yue Li Zhuo-Min Jiao Dan Yang Na Li Ying Shi Yun-Yun Xu Zhi-Jun He Duo Wang Hui Yue Jin Fu | 2021 | Neural Regeneration Research2021，16，5： | 3 |
| 12 | PPARγ配体罗格列酮及其激动剂GW9662对脂肪细胞因子表达的影响(英文)显示文摘目的:脂肪组织是一个内分泌器官已逐渐得到了肯定,它能分泌多种信号分子如:脂联素和抵抗素。过氧化物酶体增殖物激活受体(peroxisome pro-liferator activated receptorγ,PPARγ)在脂肪组织高水平表达,胰岛素增敏剂-噻唑烷二酮类药物是它的选择性激动剂,噻唑烷二酮类药物如罗格列酮的胰岛素增敏作用部分是通过激活PPARγ调节脂联素(胰岛素增敏分子)和抵抗素(涉及胰岛素抵抗)表达介导的。但现在不同研究发现PPARγ激动剂对抵抗素的表达调控方向存在矛盾,我们的问题是当抵抗素表达增加的情况下脂联素的表达还能否上调。方法:用3T3-L1细胞株作为研究模型,分别用溶媒对照、罗格列酮(10μmol/L)、GW9662(5μmol/L)或罗格列酮+GW9662作用细胞,然后检测脂联素和抵抗素 mRNA表达变化情况。结果:与对照组相比,罗格列酮分别增加脂联素和抵抗素 mRNA水平1.77和1.66倍,其差异具有统计学意义(P<0.05) ;重要的是GW9662也增加脂联素水平(1.57倍,P<0.05)但对抵抗素无影响。罗格列酮和GW9662两者合用时,仍上调adiponectin mRNA水平(对照组的1.87倍,P<0.05) ,抵抗素的增加与罗格列酮单用比弱下降(对照组的1.31倍,P<0.05)。结论:本研究为PPARγ激动剂(罗格列酮)和拮抗剂(GW9662)都上调脂联素的转录提供了新的证据,两者合用时GW9662不阻断罗格列酮诱导的脂联素上调作用。综合这些数据提示噻唑烷二酮类药上调脂联素的机制可能不依赖于PPARγ。并且, GW9662在增加脂联素水平的同时不上调抵抗素水平的特性进一步支持PPARγ拮抗剂用于临床治疗胰岛素抵抗的可能性。降低抵抗素表达可能不是罗格列酮胰岛素增敏作用的重要机制。我们的结果为将来研究噻唑烷二酮类药物对人脂肪细胞因子表达在剂量和时间上提供了一定的基础。 | LIU Ying-zi Vural Ozdemir OUYANG Dong-shengI LIU Zhao-qian LIU Jie LI Zhi WANG Dan ZENG Fei-yue TAN Zhi-rong HU Dong-li ZHOU Hong-hao | 2007 | 中国临床药理学与治疗学2007，12，10： | 3 |
| 13 | Unraveling the 3D Genome Architecture in Plants:Present and Future显示文摘The eukaryotic genome has a hierarchicalthree-dimensional(3D)organization with functional implications for DNA replication,DNA repair,and transcriptional regulation.Over the past decade,scientists have endeavored to elucidate the spatial characteristics and functions of plant genome architecture using high-throughput chromatin conformation capturing technologies such as Hi-C,ChlA-PET,and HiChIP.Here,we systematically review current understanding of chromatin organization in plants at multiple scales.We also discuss the emerging opinions and concepts in 3D genome research,focusing on state-of-the-art 3D genome techniques,RNA-chromatin interactions,liquid-liquid phase separation,and dynamic chromatin alterations.We propose the application of single-cell/single-molecule multi-omics,multiway(DNA-DNA,DNA-RNA,and RNA-RNA interactions)chromatin conformation capturing methods,and proximity ligation-independent 3D genome-mapping technologies to explore chromatin organization structure and function in plants.Such methods could reveal the spatial interactions between trait-related SNPs and their target genes at various spatiotemporal resolutions,and elucidate the molecular mecha-nisms of the interactions among DNA elements,RNA molecules,and protein factors during the formation of key traits in plants. | Weizhi Ouyang Dan Xiong Guoliang Li Xingwang Li | 2020 | Molecular Plant2020，13，12： | 2 |
| 14 | Radial Anisotropy in the Crust beneath the Northeastern Tibetan Plateau from Ambient Noise Tomography显示文摘Through analysis of Rayleigh wave and Love wave Green's functions estimated from ambient noise tomography, we obtain radial anisotropy and shear wave velocity structure beneath the northeastern Tibetan Plateau. With two hundred and twenty three broadband seismic stations deployed by China Earthquake Administration, a collaborative seismic experiment of northern Tibet(ACSENT) experiment and northeastern Tibet seismic(NETS) experiment provide the unprecedented opportunity to resolve the spatial distribution of the radial anisotropy within the crust of the northeastern Tibetan Plateau. Discrepancies between Love(sh) and Rayleigh(sv) wave velocities show complex anisotropic patterns associated with the dynamic processes of the collision between the Indian and Eurasian plates:(1) In the upper crust, V_(sv)>V_(sh) anisotropy is dominant throughout the study area which probably reflects fossil microcracks induced by the uplift, folding and erosion geodynamic processes;(2) in the middle crust, V_(sh)>V_(sv) observed beneath the Songpan-Ganzi terrane and the northwestern Qilian orogen correlates well with a mid-crustal low velocity zone(LVZ);(3) at depths deeper than 40 km, V_(sh)>V_(sv) is still found in the Songpan-Ganzi terrane. This anisotropy could be caused by the sub-horizontal alignment of anisotropic minerals that has followed the collision between India and Eurasia. However, the northwestern Qilian orogen is associated with V_(sv)>V_(sh) anisotropy which may be related to the vertically aligned seismic anisotropic minerals caused by the crustal thickening. | Jing Tan Hongyi Li Xinfu Li Ming Zhou Longbin Ouyang Sanjian Sun Dan Zheng | 2015 | Journal of Earth Science2015，26，6： | 2 |
| 15 | MicroRNA-19b promotes macrophage cholesterol accumulation and aortic atherosclerosis by targeting ATP-binding cassette transporter A1显示文摘 | Yun-Cheng Lv Yan-Yan Tang Juan Peng Guo-Jun Zhao Jing Yang Feng Yao Xin-Ping Ouyang Ping-Ping He Wei Xie Yu-Lin Tan Min Zhang Dan Liu Deng-Pei Tang Francisco S. Cayabyab Xi-Long Zheng Da-Wei Zhang Guo-Ping Tian Chao-Ke Tang | 2014 | Atherosclerosis2014，，1： | 2 |
| 16 | Health benefits of Grifola frondosa polysaccharide on intestinal microbiota in type 2 diabetic mice显示文摘Grifola frondosa polysaccharide(GFP)as the natural compounds have been reported to exert diverse bioactivities.The aim of this study was to investigate the regulatory effects of GFP on intestinal microbiota in type 2 diabetic mice.The changes of microbiota in faeces of the diabetic mice upon high fat diet were determined and the V3 region of the 16S rRNA was sequenced by Illumina MiSeq high-throughput sequencing platform.Eighty operational taxonomic unit were identified to be shared by all samples,and the quality and richness of sequencing were assessed via rarefaction and rank abundance curves.The diversity of gut flora was slightly improved in diabetic mice after GFP treatment.The composition and relative abundance of gut microbiota at phylum and genus levels were altered by GFP.The abundance of Robinsoniella,Flavonifractor,Anaerotruncus,and Desulfvibrio were found to concentrate on diabetic mice through LEfSe analysis.Furthermore,Alloprevotella and Burkholderia had strong relevancy with other gut flora.Based on the findings,GFP might be a desired candidate on ameliorating the intestinal unbalance in diabetes. | Xiaoxiang Gao Dan Liu Luying Gao Yuezhen Ouyang Yuxi Wen Chao Ai Yuqing Chen Chao Zhao | 2022 | Food Science and Human Wellness2022，11，1： | 2 |
| 17 | Collecting electro- spun nanofibers with patterned electrodes显示文摘 | Li Dan Ouyang Gong Mceann J T | 2005 | N ano Lett2005，5，5： | 1 |
| 18 | Recent progress of interconnecting layer for tandem organic solar cells显示文摘This paper has reviewed:(1) the two unique advantages of tandem organic solar cells(OSCs) compared to single OSCs;(2) the challengings as well as strategies to develop qualified interconnecting layer(ICL) for tandem OSCs.More specifically,firstly,the two key advantages unique to tandem OSCs as compared to single OSCs,namely minimizing sub-bandgap transmission and thermalization loss as well as realizing optical thick and electrical thin structures,have been discussed.Secondly,the ICL,as one of the most challenging issue in tandem OSCs that needs to fulfill the optical,electrical and mechanical requirements simultaneously to realize a qualified ICL has been reviewed.As one of the most challenging requirement among the three,the electrical requirement and its corresponding three different solving strategies have been discussed in detail,revealing a bright future for developing a general strategy to realizing qualified ICL composed of different hole transporting layer(HTL) and electron transporting layer(ETL). | Shunmian Lu Dan Ouyang Wallace C.H. Choy | 2017 | Science China Chemistry2017，60，4： | 1 |
| 19 | Antifouling activities of hymenialdisine and debromohymenialdisine from the sponge Axinella sp.显示文摘 | Dan qing Feng Yan Qiu Wei Wang Xiang Wang Peng gang Ouyang Cai huan Ke | 2013 | International Biodeterioration & Biodegradation2013，，： | 1 |
| 20 | Employing an the performance of auditory interfaces 显示文摘 | Xu Honglai Zhang Dan Ouyang active mental task to enhance attention -based brain-computer Minhui | 2012 | Clinical Neurophysiology2012，124，1： | 1 |
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