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| 1 | Ten cities cross-sectional questionnaire survey of children asthma and other allergies in China显示文摘Asthma,rhinitis and eczema(allergic or non-allergic)have increased throughout the world during the last decades,especially among children.Changes in the indoor environment are suspected to be important causes.China has experienced a dramatic change in indoor environmental exposures during the past two decades.However,such changes and their associations with children’s asthma and other health aspects have not been thoroughly studied.China,Children,Homes,Health(CCHH),Phase I,was a cross-sectional questionnaire survey of 48219 children 1–8 years old in 10 Chinese cities during 2010–2012.The questionnaire includes the International Study of Asthma and Allergies in Childhood(ISAAC)core health questions and additional questions regarding housing,life habits and outdoor environment.In health analyses,children aged 3–6 years old were included.The prevalences of doctor diagnosed asthma varied from 1.7%to 9.8%(mean 6.8%),a large increase from 0.91%in 1999 and 1.50%in2000.The prevalence of wheeze,rhinitis and atopic eczema(last 12 months)varied from 13.9%to 23.7%,24.0%to 50.8%and4.8%to 15.8%,respectively.Taiyuan had the lowest prevalences of all illnesses and Shanghai the highest,except for wheezewhere the highest value was for Urumqi.We found(1)no obvious association between disease prevalences and ambient PM10concentrations and(2)higher prevalences of disease in humid climates with hot summers and cold winters,but with no centrally heated buildings.Associations between the diseases and economic status as indexed by Gross Domestic Product(GDP)requires further study. | ZHANG YinPing LI BaiZhan HUANG Chen YANG Xu QIAN Hua DENG QiHong ZHAO ZhuoHui LI AnGui ZHAO JiaNing ZHANG Xin QU Fang HU Yu YANG Qin WANG Juan ZHANG Ming WANG Fang ZHENG XiaoHong LU Chan LIU ZhiJian SUN YueXia MO JinHan ZHAO YiLi LIU Wei WANG TingTing NORBCK Dan BORNEHAG Carl-Gustaf SUNDELL Jan | 2013 | Chinese Science Bulletin2013，58，34： | 22 |
| 2 | Integrative single-cell analysis of transcriptome,DNA methylome and chromatin accessibility in mouse oocytes显示文摘Oocyte growth is a key step in forming mature eggs that are ready to be fertilized.The states and modifications of chromatin represent critical sources of information for this process.However,the dynamics and interrelations of these chromatin characteristics remain elusive.In this study,we developed an improved scCOOL-seq technique (iscCOOL-seq),which is a multiomics,single-cell and single-base resolution method with high mapping rates,and explored the chromatin accessibility landscape and its relationship to DNA methylation in growing mouse oocytes.The most dramatic change in chromatin accessibility occurs during oocyte growth initiation,accompanied with prominent transcriptome alterations and an elevated variation in DNA methylation levels among individual oocytes.Unlike CpG islands (CGIs),partially methylated domains (PMDs)are associated with a low density of nucleosome-depleted regions (NDRs)during the whole maturation period.Surprisingly,highly expressed genes are usually associated with NDRs at their transcriptional end sites (TESs).In addition,genes with de novo methylated gene bodies during oocyte maturation are already open at their promoters before oocyte growth initiation.Furthermore,epigenetic and transcription factors that might be involved in oocyte maturation are identified.Our work paves the way for dissecting the complex, yet highly coordinated,epigenetic alterations during mouse oocyte growth and the establishment of totipotency. | Chan Gu Shanling Liu Qihong Wu Lin Zhang Fan Guo | 2019 | Cell Research2019，29，2： | 14 |
| 3 | Effect of lattice distortion on solid solution strengthening of BCC high-entropy alloys显示文摘An analytical model is established to study the influence of lattice distortion and fraction of Hf on the yield strength of the BCC TiNbTaZrHfxmulti-component high entropy alloys(HEAs). Meanwhile, the mechanism of solid solution strengthening caused by lattice distortion is also discussed in the HEA. The distorted unit cell is introduced to indicate the lattice distortion effects induced by the differences of the atomic size and shear modulus by doping other elements in Ti-based metal. The results show that the calculated values of the alloying yield strength considering the path of least resistance are obtained with regard to various grain sizes for the equiatomic TiNbTaZrHf HEA, which is well in line with the experimental results. Furthermore, it is predicted that the alloying yield strength is the largest value in the case of the same grain size for the Hf atomic fraction of 0.122. The meaningful modeling could provide a theoretical method to investigate the yield strength and alloying design of other BCC HEAs in the future. | Zhipeng Wang Qihong Fang Jia Li Bin Liu Yong Liu | 2018 | Journal of Materials Science & Technology2018，34，2： | 11 |
| 4 | MiR-181a-5p regulates 3T3-L1 cell adipogenesis by targeting Smad7 and Tcf7I2显示文摘 | Dan Ouyang Lifeng Xu Lihua zhang Dongguang Guo Xiaotong Tan Xiaofang Yu Junjie Qi Yaqiong Ye Qihong Liu Yongjiang Ma Yugu Li | 2016 | Acta Biochimica et Biophysica Sinica2016，48，11： | 9 |
| 5 | Effects of ambient air pollution on allergic rhinitis among preschool children in Changsha, China显示文摘Prevalence of allergic rhinitis has rapidly increased among Chinese children,but the reasons are unclear.Recent findings have suggested that exposure to outdoor air pollutants may increase the risk of allergic rhinitis,but the results were inconsistent.This study further investigated the effect of outdoor air pollutants on allergic rhinitis among preschool children.A standardized questionnaire on health,home and environmental factors was conducted for 4988 children aged 1–8 in the city of Changsha,and the concentrations of PM10(particle diameter 10 m),sulfur dioxide(SO2)and nitrogen dioxide(NO2)during 2006–2011 were acquired from the official web of Changsha Environmental Protection Agency.Results showed that the prevalence of children’s doctor diagnosed rhinitis was 8.4%(95%confidence interval[CI]7.0%–10.0%).It was found that the prevalence of rhinitis was not associated with site-specific background concentrations of air pollutants,but significantly positively correlated with age-related accumulative personal exposure of PM10,SO2and NO2.We conclude that age-related accumulative personal exposure to ambient air pollution may play an important role in the development of rhinitis. | LU Chan DENG QiHong OU CuiYun LIU WeiWei SUNDELL Jan | 2013 | Chinese Science Bulletin2013，58，34： | 7 |
| 6 | Antigenically dominant proteins within the human liver mitochondrial proteome identified by monoclonal antibodies显示文摘Analysis of the mitochondrial proteome would provide valuable insight into the function of this important organelle, which plays key roles in energy metabolism, apoptosis, free radical production, thermogenesis, and calcium signaling. It could also increase our understanding about the mechanisms that promote mitochondrial disease. To identify proteins that are antigenically dominant in human liver mitochondria, we generated >240 hybridoma cell lines from native mitochondrial proteins after cell fusion, screening, and cloning. Antibodies that recognized mitochondrial proteins were identified by screening human liver cDNA expression libraries. In this study, we identified 6 major antigens that were recognized by at least 2 different monoclonal antibodies (mAbs). The proteins that were antigenically dominant were: acetyl-Coenzyme A acyltransferase 2 (mitochondrial 3-oxoacyl-Coenzyme A thiolase), aldehyde dehydrogenase 1 family member A1, carbamoyl phosphate synthetase 1, dihydrolipoamide S-acetyltransferase (E2 component of pyruvate dehydrogenase complex), enoyl coenzyme A hydratase 1, and hydroxysteroid (11-beta) dehydrogenase 1. We also determined the subcellular localizations of these enzymes within the mitochondria using immunohistocytochemistry. We believe that these well-characterized antibodies will provide a valuable resource for the Human Liver Proteome Project (HLPP), and will make studies aimed at investigating liver mitochondrial function far easier to perform in future. Our results provide strong evidence that, (i) depletion of dominant proteins from liver mitochondrial samples is possible and, (ii) the approaches adopted in this study can be used to explore or validate protein-protein interactions in this important organelle. | JU YanFang YANG JinJu LIU Rong LIU XiaoLan DU XueMei LIU Li CHEN ZhiCheng CHI Jun LIU ShuEr GAO Yuan GAO JianEn JIAO ShunChang HE FuChu SUN QiHong | 2011 | Science China(Life Sciences)2011，54，1： | 6 |
| 7 | Prevention of surgical site infection under different ventilation systems in operating room environment显示文摘Biological particles in the operating room(OR)air environment can cause surgical site infections(SSIs).Various ventilation systems have been employed in ORs to ensure an ultraclean environment.However,the effect of different ventilation systems on the control of bacteria-carrying particles(BCPs)released from the surgical staff during surgery is unclear.In this study,the performance of four different ventilation systems(vertical laminar airflow ventilation(VLAF),horizontal laminar airflow ventilation(HLAP),differential vertical airflow ventilation(DVAF),and temperature-controlled airflow ventilation(TAF))used in an OR was evaluated and compared based on the spatial BCP concentration.The airflow field in the OR was solved by the Renormalization Group(RNG)k-e turbulence model,and the BCP phase was calculated by Lagrangian particle tracking(LPT)and the discrete random walk(DRW)model.It was found that the TAF system was the most effective ventilation system among the four ventilation systems for ensuring air cleanliness in the operating area.This study also indicated that air cleanliness in the operating area depended not only on the airflow rate of the ventilation system but also on the airflow distribution,which was greatly affected by obstacles such as surgical lamps and surgical staff. | Zhijian Liu Haiyang Liu Hang Yin Rui Rong Guoqing Cao Qihong Deng | 2021 | Frontiers of Environmental Science & Engineering2021，15，3： | 5 |
| 8 | Surface morphology and electronic structure in stoichiometric superconductor CaKFe_(4)As_(4) robed by scanning tunneling microscopy/spectroscopy显示文摘CaKFe_(4)As_(4) is a new-type superconductor with a relatively high transition temperature of 35 K among stoichiometric iron-based superconductors. Based on scanning tunneling microscopy/spectroscopy, the surface morphology and electronic structure of CaKFe_(4)As_(4) single crystal were systematically investigated. The cleaved CaKFe_(4)As_(4) showed various morphologies, such as atomically resolved 1×1, 1×2, and √2×√2 lattices. By analyzing the geometrical correlations of these morphologies, the 1×1 and 1×2 lattices were identified as the original and reconstructed As layers, respectively, whereas the √2×√2 lattice was distinguished as the reconstructed alkaline-earth-metal or alkali-metal layer. The superconducting energy gap of 7.3 me V and bosonic mode of 12.7 me V were resolved in the scanning tunneling spectra. In addition, the superconducting energy gaps measured on different terminations were identical and consistent with the values obtained by bulk-sensitive techniques, indicating that the electronic structures of CaKFe_(4)As_(4) were insensitive to the surface reconstructions. Our study clarifies the relationships between complex surface reconstructions and surface terminations and preliminarily presents that there is no obvious effect of surface reconstructions on electronic states. | Xiaodong Yu Zhongxu Wei Zhanyi Zhao Tao Xie Chang Liu Ge He Qihong Chen Lei Shan Huiqian Luo Qing Huan Jie Yuan Kui Jin | 2021 | Science China(Physics,Mechanics & Astronomy)2021，64，12： | 5 |
| 9 | A photocleavable low molecular weight hydrogel for light-triggered drug delivery显示文摘A photocleavable low-molecular-weight hydrogelator (LMWG) was synthesized based on coumarin derivative.~1H NMR and UV spectroscopy study suggested that the gelator had good gelling ability, and the driving force for the gelation were hydrogen bonding and π-π stacking. This molecular hydrogel exhibited satisfied photocleavage at C-N bond in 7-amino coumarin with the light irradiation (365 nm,77.5 mW/cm^2). The promising photo-triggered drug release of antineoplastics cytarabine hydrochloride has been obtained, due to the photocleavage motived gel-sol transition. | Qihong Liu Hao Wang Guotao Li Miaochang Liu Jinchang Ding Xiaobo Huang Wenxia Gao Huayue Wu | 2019 | Chinese Chemical Letters2019，30，2： | 4 |
| 10 | Anal swab findings in an infant with COVID-19显示文摘Introduction: The transmission pathways of coronavirus disease 2019 (COVID-19) remain not completely clear. In this case study the test for the novel severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in pharyngeal swab and anal swab were compared.Case presentation: A 3-month-old girl was admitted to our hospital with COVID-19. Her parents had both been diagnosed with COVID-19. The results of pharyngeal swab and anal swab of the little girl were recorded and compared during the course of the disease. The oropharyngeal specimen showed negative result for SARS-CoV-2 on the 14th day after onset of the illness. However, the anal swab was still positive for SARS-CoV-2 on the 28th day after the onset of the illness.Conclusion: The possibility of fecal-oral transmission of COVID-19 should be assessed. Personal hygiene during home quarantine merits considerable attention. | Qihong Fan Yan Pan Qingcui Wu Shan Liu Xu Song Zhongguo Xie Yang Liu Liang Zhao Zhonghong Wang Yifei Zhang Zuchuang Wu Lei Guan Xiaolong Lv | 2020 | Pediatric Investigation2020，4，1： | 3 |
| 11 | Microstructural evolution and mechanical properties of FeCoCrNiCu high entropy alloys:a microstructure-based constitutive model and a molecular dynamics simulation study显示文摘High entropy alloys(HEAs)attract remarkable attention due to the excellent mechanical performance.However,the origins of their high strength and toughness compared with those of the traditional alloys are still hardly revealed.Here,using a microstructure-based constitutive model and molecular dynamics(MD)simulation,we investigate the unique mechanical behavior and microstructure evolution of FeCoCrNiCu HEAs during the indentation.Due to the interaction between the dislocation and solution,the high dislocation density in FeCoCrNiCu leads to strong work hardening.Plentiful slip systems are stimulated,leading to the good plasticity of FeCoCrNiCu.The plastic deformation of FeCoCrNiCu is basically affected by the motion of dislocation loops.The prismatic dislocation loops inside FeCoCrNiCu are formed by the dislocations with the Burgers vectors of a/6[112]and a/6[112],which interact with each other,and then emit along the<111>slip direction.In addition,the mechanical properties of FeCoCrNiCu HEA can be predicted by constructing the microstructure-based constitutive model,which is identified according to the evolution of the dislocation density and the stress-strain curve.Strong dislocation strengthening and remarkable lattice distortion strengthening occur in the deformation process of FeCoCrNiCu,and improve the strength.Therefore,the origins of high strength and high toughness in FeCoCrNiCu HEAs come from lattice distortion strengthening and the more activable slip systems compared with Cu.These results accelerate the discovery of HEAs with excellent mechanical properties,and provide a valuable reference for the industrial application of HEAs. | Gangjie LUO Li LI Qihong FANG Jia LI Yuanyuan TIAN Yong LIU Bin LIU Jing PENG P.K.LIAW | 2021 | Applied Mathematics and Mechanics(English Edition)2021，42，8： | 3 |
| 12 | A SCREW DISLOCATION IN A THREE-PHASE COMPOSITE CYLINDER MODEL WITH INTERFACIAL RIGID LINES显示文摘The problem of the elastic interaction between a screw dislocation and a threephase circular inclusion with interfacial rigid lines (anti-cracks) is investigated. An efficient and concise method for the complex multiply connected region is developed, with which explicit series form solutions of the complex potentials in the matrix, and the interphase layer and inclusion regions are derived. Based on the complex potentials, the image force on the screw dislocation is then calculated by using the Peach-Koehler formula. The equilibrium position of the dislocation is discussed in detail for various rigid line geometries, interphase layer thicknesses and material property combinations. The main results show that the interfacial rigid lines exert a significant perturbation effect on the motion of the screw dislocation near the circular inclusion surrounded by an interphase layer. | Fang Qihong Liu Youwen Jiang Chiping | 2005 | Acta Mechanica Solida Sinica2005，18，4： | 2 |
| 13 | MicroRNA-181a-5p enhances cell proliferation in medullary thymic epithelial cells via regulating TGF-β signaling显示文摘在从不同年龄的老鼠的胸腺纸巾的 miRNAs 的表示侧面在我们的以前的学习被表明了。在 miRNA 表达式侧面的综合分析以后,我们证明 miR-181a-5p 的表达式显著地在 thymic 被减少从 10- 的上皮的房间(侦探) 到 19-month-old 鼠标当与那相比在从 1-month-old 的侦探由量的反向的 transcriptase 聚合酶的鼠标锁住反应时。我们在侦探假设了那 miR-181a-5p 可能通过调整一些基因或发信号的小径与年龄相关的胸腺复杂物被联系。测试这个假设,老鼠髓的 thymic 上皮的房间(MTEC1 ) 被使用。有 miR-181a-5p 的 Transfection 模仿支持了 MTEC1 房间的增长,但是没影响 apoptosis。效果被颠倒 miR-181a-5p 的表示什么时候在 MTEC1 房间被压制。而且,转变生长因素贝它受体(Tgfbr1 ) 我被酶试金作为 miR-181a-5p 的一个直接目标证实。而且,它被发现 miR-181a-5p 的那 overexpression 下面调整 Smad3 的 phosphorylation 并且堵住了发信号的转变生长因素贝它的激活。不过,一相反地,关联在 Tgfbr1 的表示之间被观察,在侦探的 miR-181a-5p 源于不同年龄的老鼠。一起,我们提供 miR-181a-5p 可以是在侦探,和表示的增长的一个重要内长的管理者的证据在侦探的 miR-181a-5p 的层次可以与年龄相关的胸腺复杂物被联系。 | Dongguang Guo Yaqiong Ye Junjie Qi Lihua Zhang Lifeng Xu Xiaotong Tan Xiaofang Yu Qihong Liu Jilong Liu Yuan Zhang Yongjiang Ma Yugu Li | 2016 | Acta Biochimica et Biophysica Sinica2016，48，9： | 2 |
| 14 | Microstructure evolution and deformation mechanism of amorphous/crystalline high-entropy-alloy composites显示文摘High-entropy amorphous alloys present high hardness,but low tensile ductility.Here,deformation behavior of the amorphous/crystalline Fe Co Cr Ni high-entropy alloy(HEA)composite prepared by the previous experiment is investigated using atomic simulations.The result shows the partial dislocations in the crystal HEA layer,and the formation of shear bands in the amorphous HEA layer occurs after yielding.The strength of the amorphous/crystalline HEA composite reduces with increasing the thickness of the amorphous layer,agreeing with the previous experiments.The coupled interaction between the crystal plasticity and amorphous plasticity in amorphous/crystalline HEA composites results in a more homogeneous redistribution of plastic deformation to cause interface hardening,due to the complex stress field in the amorphous layer.The current findings provide the insight into the deformation behavior of the amorphous/crystalline HEA composite at the nanoscale,which are useful for optimizing the structure of the HEA composite with high strength and good plasticity. | Jia Li Haotian Chen Hui Feng Qihong Fang Yong Liu Feng Liu Hong Wu Peter K Liaw | 2020 | Journal of Materials Science & Technology2020，54，19： | 2 |
| 15 | Untangling the influence of soil moisture on root pullout property of alfafa plant显示文摘Root pullout property of plants was of key importance to the soil reinforcement and the improvement of slope stability. To investigate the influence of soil moisture on root pullout resistance and failure modes in soil reinforcement process, we conducted pullout tests on alfalfa(Medicago sativa L.) roots at five levels(40, 30, 20, 10 and 6 kPa) of soil matric suction, corresponding to respectively 7.84%, 9.66%, 13.02%, 19.35% and 27.06% gravimetric soil moisture contents. Results showed that the maximal root pullout force of M. sativa decreased in a power function with increasing soil moisture content from 7.84% to 27.06%. Root slippage rate increased and breakage rate decreased with increasing soil moisture content. At 9.66% soil moisture content, root slippage rate and breakage rate was 56.41% and 43.58%, respectively. The threshold value of soil moisture content was about 9.00% for alfalfa roots in the loess soil. The maximal pullout force of M. sativa increased with root diameter in a power function. The threshold value of root diameter was 1.15 mm, because root slipping force was greater than root breaking force when diameter >1.15 mm, while diameter ≤1.15 mm, root slipping force tended to be less than root breaking force. No significant difference in pullout forces was observed between slipping roots and breaking roots when they had similar diameters. More easily obtained root tensile force(strength) is suggested to be used in root reinforcement models under the condition that the effect of root diameter is excluded as the pullout force of breaking roots measured in pullout tests is similar to the root tensile force obtained by tensile tests. | ZHANG Chaobo LIU Yating LIU Pengchong JIANG Jing YANG Qihong | 2020 | Journal of Arid Land2020，12，4： | 2 |
| 16 | Price Discrimination in Two- Sided Markets 显示文摘 | Qihong Liu Konstantinos S | 2013 | Journal of Economies & Management Strategy2013，，4： | 1 |
| 17 | INTERACTION OF A DISLOCATION DIPOLE WITH A MODE III INTERFACE CRACK显示文摘Interaction between a screw dislocation dipole and a mode III interface crack is investigated. By using the complex variable method, the closed form solutions for complex potentials are obtained when a screw dislocation dipole lies inside a medium. The stress fields and the stress intensity factors at the tip of the interface crack produced by the screw dislocation dipole are given. The influence of the orientation, the dipole arm and the location of the screw dislocation dipole as well as the material mismatch on the stress intensity factors is discussed. The image force and the image torque acting on the screw dislocation dipole center are also calculated. The mechanical equilibrium position of the screw dislocation dipole is examined for various material property combinations and crack geometries. The results indicate that the shielding or anti-shielding effect on the stress intensity factor increases abruptly when the dislocation dipole approaches the tip of the crack. Additionally, the disturbation of the interface crack on the motion of the dislocation dipole is also significant. | Jin Bo Fang Qihong Liu Youwen | 2007 | Acta Mechanica Solida Sinica2007，20，1： | 1 |
| 18 | FEM computation of groove ridge and Monte Carlo simulation in two-body abrasive wear显示文摘 | Liang Fang Qihong Cen Kun Sun Weimin Liu Xiaofeng Zhang Zhifu Huang | 2004 | Wear2004，，1： | 1 |
| 19 | Preparation and structural characterization of nanocrystalline poly(vinyl chloride)显示文摘 | Chuanxi Xiong Tao Wang Qihong Liu | 2004 | J Appl Polym Sci2004，91，1： | 1 |
| 20 | Customer Information Sharing among Rival Firms 显示文摘 | Qihong Liu and Konstantinos Serfes | 2006 | European Economic Review2006，，01： | 1 |
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