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| 1 | 胆固醇酯转移蛋白基因的蛋白质截断型变异体与冠状动脉性心脏病风险的关系显示文摘随机对照试验结果表明,抑制胆固醇酯转运蛋白(cholesteryl ester transfer protein,CETP)的疗法并不能降低冠状动脉性心脏病(coronary heart disease,CHD)的发生风险。研究失败的可能原因包括靶目标无效、靶目标外小分子的不良反应和随机对照设计因素影响等。在编码药物靶点的基因中具有天然存在的遗传变异,以此为基础,人类研究可以深入了解针对基因产物的治疗的潜在功效和安全性。 | Nomura A Won HH Khera AV Takeuchi F Ito K McCarthy S Emdin CA Klarin D Natarajan P Zekavat SM Gupta N Peloso GM Borecki IB Teslovich TM Asselta R Duga S Merlini PA Correa A Kessler T Wilson JG Bown MJ Hall AS Braund PS Carey DJ Murray MF Kirchner HL Leader JB Lavage DR Manus JN Hartze DN Samani NJ Schunkert H Marrugat J Elosua R McPherson R Farrall M Watkins H Juang JJ Hsiung CA Lin SY Wang JS Tada H Kawashiri MA Inazu A Yamagishi M Katsuya T Nakashima E Nakatochi M Yamamoto K Yokota M Momozawa Y Rotter JI Lander ES Rader DJ Danesh J Ardissino D Gabriel S Willer CJ Abecasis GR Saleheen D Kubo M Kato N Ida Chen YD Dewey FE Kathiresan S 刘莉 叶鹏 | 2017 | 中华高血压杂志2017，25，9： | 2 |
| 2 | Chronic infection with Helicobacter pylori, Chlamydia pneumoniae, cytomegalovirus: population based study of coronary heart disease显示文摘 | Danesh J Wong Y Ward M | 1999 | Heart1999，81，3： | 1 |
| 3 | Risk factors for coro- nary heart disease and acute-phase proteins-a population-based study显示文摘 | DANESH J MUIR J WONG Y K eta1 | 1999 | Eur Heart J1999，20，13： | 1 |
| 4 | Chronic infectionwith helicobacter pylori,chlamydia pneumoniae,orcytomegalovirus:population based study of coronary heartdisease显示文摘 | Danesh J Wong Y Ward M | 1999 | Heart1999，81，3： | 1 |
| 5 | Chronic infection with Helicobacter pylori, Chlamydia pneumon ae,or cytomegalovirus: population based study of coronary heart disease 显示文摘 | Danesh J Wong Y Ward M | 1999 | Heart1999，81，3： | 1 |
| 6 | Targeting of RhoA/ROCK signaling ameliorates progres-sion of diabetic nephropathy independent of glucose con-trol显示文摘 | Kolavennu V Zeng L Peng H Wang Y Danesh FR | 2008 | Diabetes2008，57，3： | 1 |
| 7 | The expression and the regulatory role of OX40 and 4-1BB heterodimer in activated human T cells显示文摘 | Ma B Y Mikolajczak S A Danesh A | 2005 | Blood2005，106，： | 1 |
| 8 | Chronic infection with helicobacter pylori,chlamydia pneumoniae,or cytomegalovirouc:population based study of coronary heart disease显示文摘 | Wong Y Ward M | 1999 | Heart1999，，： | 1 |
| 9 | Modulatory effects of HMG-CoA reductase inhibitors in diabetic mieroangiopathy 显示文摘 | Danesh F R Kanwar Y S | 2004 | FASEB J2004，18，7： | 1 |
| 10 | DNA-demethylating agents target colorectal cancer cells by inducing viral mimic- 3' by endogenous transcripts显示文摘 | Roulois D Wang Y Danesh A | 2015 | Cell2015，5，： | 1 |
| 11 | Lupus membranous glomerulonephritis mimicking hepatitis C-associated nephropathy显示文摘 | Lynch P Kanwar Y S | 2002 | Am J Kidney Dis2002，39，3： | 1 |
| 12 | Targeting of RhoA/ROCK signaling ameliorates progression of diabetic nephropathy independent of glucose control显示文摘 | Kolavennu V Zeng L Peng H Wang Y Danesh FR | 2008 | Diabetes2008，57，3： | 1 |
| 13 | Modulatory effects of HMG-CoA reductase inhibitors in diabetic microangiopathy 显示文摘 | Danesh F R Kanwar Y S | 2004 | FASEB Journal2004，18，7： | 1 |
| 14 | Wax phase equilib-ria :developing a thermo dynamic model using a systematicapproach显示文摘 | JI H Y TOHIDI B DANESH A | 2004 | Fluid Phase Equilibria2004，216，： | 1 |
| 15 | Wax phase equilibria:developing a thermodynamic model using a systematic approach显示文摘 | Ji H Y Tohidi B Danesh A | 2004 | Fluid Phase Equilibria2004，216，： | 1 |
| 16 | Biology and mo- lecular approaches in genetic improvement of cultivated button mushroom (Agaricus bisporus ) 显示文摘 | Goltapeh E M Danesh Y Kamal S | 2009 | Symbiotic Fungi Berlin Heidelberg Germany: Springer2009，2009，： | 1 |
| 17 | Modulatory effects of HMG- CoA reductase inhibitors in diabetic microangiopathy 显示文摘 | DANESH F R KANWAR Y S | 2004 | FASEB J2004，18，7： | 1 |
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