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| 1 | Microstructures and Properties of NiCrBSi/WC Biomimetic Coatings Prepared by Plasma Spray Welding显示文摘 | Shiming Huang Daqian Sun Desheng Xu Wenquan Wang Hongyong Xu | 2015 | Journal of Bionic Engineering2015，12，4： | 7 |
| 2 | A newly discovered role ofmetabolic enzyme PCK1 as a protein kinase to promote cancer lipogenesis显示文摘Lipid metabolism,in particular fatty acid and cholesterol synthesis,is essential to convert nutrients into metabolic intermediates for membrane biosynthesis,energy storage and the generation of signaling molecules.Tumor cells maintain high level of lipid metabolism for rapid cell proliferation[1-4].Transcription of genes required for fatty acid and cholesterol synthesis and cholesterol uptake is controlled by membrane-bound transcription factor sterol regulatory element-binding proteins(SREBPs),including SREBP-1a,SREBP-1c/ADD1 and SREBP-2 isoforms[5].The function of SREBPs is mainly regulated by an escort protein(the SREBP cleavage-activating protein[SCAP])and endoplasmic reticulum(ER)anchor proteins(insulininduced genes[Insigs]),during the feedback loop of cholesterol synthesis[6-8].Under sterol-depleted conditions,SCAP and SREBPs complex is captured by COPIImediated vesicles and transported from the ER to the Golgi apparatus[7,9],where the SREBPs are proteolytically processed by Site-1 protease(S1P)and Site-2 protease(S2P)to yield active amino-terminal fragments that enter the nucleus for gene transcription[10,11].Under high intracellular sterol conditions,abundant cholesterol in the ER membrane binds to SCAP,induces its conformational change,and enables it to bind to Insigs. | Hongfei Jiang Lei Zhu Daqian Xu Zhimin Lu | 2020 | Cancer Communications2020，40，9： | 6 |
| 3 | PAQR10 and PAQR11 mediate Ras signaling in the Golgi apparatus显示文摘地岬在许多细胞的活动起一个枢轴的作用,并且它的 subcellular 区分提供空间、时间的选择。这里,我们报导由二高度相应的蛋白质 PAQR10 和孕激素和 AdipoQ 受体家庭的 PAQR11 在 Golgi 仪器发信号的地岬的空间规定的一个模式。PAQR10 和 PAQR11 在 Golgi 仪器是只局部性的。PAQR10/PAQR11 的 Overexpression 刺激基础、导致 EGF 的英皇家空军之阶级最低之兵 phosphorylation 并且以一种剂量依赖者方式增加英皇家空军之阶级最低之兵目标基因的表示。PAQR10/PAQR11 的 Overexpression 显著地提高 HRas, NRas 和 KRas4A 的 Golgi 本地化,然而并非 KRas4B。PAQR10 和 PAQR11 罐头也与 HRas, NRas 和 KRas4A 交往,然而并非 KRas4B。在由 PAQR10/PAQR11 的 overexpression 的 Golgi 仪器的增加的地岬蛋白质处于一个活跃状态。一致地, PAQR10 和 PAQR11 还原剂击倒在 Golgi 仪器的刺激 EGF 的英皇家空军之阶级最低之兵 phosphorylation 和地岬激活。有趣地, PAQR10 和 PAQR11 能与 RasGRP1,地岬的 guanine 核苷酸交换蛋白质,和 RasGRP1 的增加 Golgi 本地化交往。RasGRP1 的 C1 领域为和 PAQR10/PAQR11 的 RasGRP1 的相互作用必要、足够。由 overexpressed PAQR10/PAQR11 的英皇家空军之阶级最低之兵 phosphorylation 的模拟被 RasGRP1 的 downregulation 废除。而且, PC12 房间的区别被 PAQR10/PAQR11 的 overexpression 显著地提高。一起,这研究揭开由 PAQR10 和 PAQR11 在 Golgi 仪器发信号的地岬的空间规定的一个新范例。 | Ting Jin Qiurong Ding Heng Huang Daqian Xu Yuhui Jiang Ben Zhou Zhenghu Li Xiaomeng Jiang Jing He Weizhong Liu Yixuan Zhang Yi Pan Zhenzhen Wang Walter G Thomas Yan Chen | 2012 | Cell Research2012，22，4： | 6 |
| 4 | Effects of Alloying Elements on Microstructure and Erosion Resistance of Fe-C-Cr Weld Surfacing Layer显示文摘Effects of alloying elements on microstructure and erosion resistance of Fe-C-Cr weld surfacing layer have been studied. The experimental results show that increasing C and Cr content favors improving the erosion resistance of the layer, and the excessive C and Cr result in decreasing the erosion resistance at 90 deg. erosion. That Mo, Nb or Ti improves the erosion resistance of Fe-C-Cr weld surfacing layer is mainly attributed to increasing the amount of M7C3 and forming fine NbC or TiC in austenite matrix, but the excessive Mo, Nb or Ti is unfavorable. The addition of Mo, Nb and Ti in proper combination possesses stronger effect on improving the erosion resistance and the erosion resistance (εA) of Fe-C-Cr weld surfacing layer with fine NbC, TiC and M7C3 distributing uniformly in austenite matrix obviously increases to 2.81 at 15 deg. erosion and 2.88 at 90 deg. erosion when the layer composition is 3.05C, 20.58Cr, 1.88Mo, 2.00Nb and 1.05Ti (in wt pct). | Daqian SUN, Wenquan WANG, Zhaozhi XUAN, Yue XU and Zhenfeng ZHOUSchool of Materials Science and Engineering, Jilin University, Changchun 130025, China | 2003 | Journal of Materials Science & Technology2003，19，4： | 4 |
| 5 | Spectroscopic characterization of effective components anthraquinones in Chinese medicinal herbs binding with serum albumins显示文摘 | Shuyun Bi Daqian Song Yuhe Kan Dong Xu Yuan Tian Xin Zhou Hanqi Zhang | 2005 | Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy2005，，1： | 2 |
| 6 | Gastrin attenuates sepsis-induced myocardial dysfunction by down-regulation of TLR4 expression in macrophages显示文摘Myocardial dysfunction is the most serious complication of sepsis.Sepsis-induced myocardial dysfunction(SMD)is often associated with gastrointestinal dysfunction,but its pathophysiological significance remains unclear.The present study found that patients with SMD had higher plasma gastrin concentrations than those without SMD.In mice,knockdown of the gastrin receptor,cholecystokinin B receptor(Cckbr),aggravated lipopolysaccharide(LPS)-induced cardiac dysfunction and increased inflammation in the heart,whereas the intravenous administration of gastrin ameliorated SMD and cardiac injury.Macrophage infiltration plays a significant role in SMD because depletion of macrophages by the intravenous injection of clodronate liposomes,48 h prior to LPS administration,alleviated LPSinduced cardiac injury in Cckbr-deficient mice.The intravenous injection of bone marrow macrophages(BMMs)overexpressing Cckbr reduced LPS-induced myocardial dysfunction.Furthermore,gastrin treatment inhibited toll-like receptor 4(TLR4)expression through the peroxisome proliferator-activated receptor a(PPAR-a)signaling pathway in BMMs.Thus,our findings provide insights into the mechanism of the protective role of gastrin/CCKBR in SMD,which could be used to develop new treatment modalities for SMD. | Dandong Fang Yu Li Bo He Daqian Gu Mingming Zhang Jingwen Guo Hongmei Ren Xinyue Li Ziyue Zhang Ming Tang Xingbing Li Donghai Yang Chunmei Xu Yijie Hu Hongyong Wang Pedro AJose Yu Han Chunyu Zeng | 2023 | Acta Pharmaceutica Sinica B2023，13，9： | 1 |
| 7 | Spectroscopic characterization of effective components anthraquinones in Chinese medicinal herbs binding with serum albumins显示文摘 | Shuyun Bi Daqian Song Yuhe Kan Dong Xu Yuan Tian Xin Zhou Hanqi Zhang | 2005 | Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy2005，，1： | 1 |
| 8 | Spectroscopic characterization of effective components anthraquinones in Chinese medicinal herbs binding with serum albumins显示文摘 | Shuyun Bi Daqian Song Yuhe Kan Dong Xu Yuan Tian Xin Zhou Hanqi Zhang | 2005 | Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy2005，，1： | 1 |
| 9 | Evolution of the global polyethylene waste trade system显示文摘Introduction:China’s import bans on solid wastes starting from 2017 have challenged the global trade system of plastic wastes,which remains poorly characterized.This study chooses polyethylene(PE)as a case and aims to map out the global trade networks of PE waste(GPETN)from 1976 to 2017.Outcomes:We find that the size and complexity of the GPETN had been growing until 2016.After the mid-1990s,PE waste basically flowed from developed economies,mainly the EU and the US,to developing economies such as China.Since 2001 when admitted into the WTO,China’s PE waste import surged until 2014 when it absorbed over 60%of global export.Regulations on solid waste import following the Green Fence campaign in 2013 resulted in substantial reductions in China’s import as well as the global export of PE waste after 2014.Several other developing economies,such as Malaysia,Turkey,and Vietnam,had transitioned to net importers,but their imports were insufficient to replace China as new recycling bases for PE waste.Conclusion:The results highlight the urgent need of a joint effort for developed and developing countries to build a stronger global circular economy system with sufficient capacity to treat PE waste locally. | Wen Xu Wei-Qiang Chen Daqian Jiang Chao Zhang Zijie Ma Yan Ren Lei Shi | 2020 | Ecosystem Health and Sustainability2020，6，1： | 0 |
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