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| 1 | Perfusion magnetic resonance imaging of the liver显示文摘Perfusion magnetic resonance imaging (MRI) studies quantify the microcirculatory status of liver parenchyma and liver lesions, and can be used for the detection of liver metastases, assessing the effectiveness of antiangiogenic therapy, evaluating tumor viability after anticancer therapy or ablation, and diagnosis of liver cirrhosis and its severity. In this review, we discuss the basic concepts of perfusion MRI using tracer kinetic modeling, the common kinetic models applied for analyses, the MR scanning techniques, methods of data processing, and evidence that supports its use from published clinical and research studies. Technical standardization and further studies will help to establish and validate perfusion MRI as a clinical imaging modality. | Choon Hua Thng Tong San Koh David J Collins Dow Mu Koh | 2010 | World Journal of Gastroenterology2010，16，13： | 15 |
| 2 | Nature:揭示干细胞惊人异质性显示文摘论文作者George Daley教授说:"这是一项非常基础的研究,但它阐明了多能性状态广泛性。我们捕获了干细胞不同状态的详细分子谱。"研究人员通过采用多种变量如不同的化学物质、培养环境和遗传敲除来扰乱多能干细胞,研究人员探究了它们的发育景观。随后,他们分析了每个细胞的遗传组成,观察了每个细胞多能状态的微小波动。他们发现内部、化学和环境信号影响干细胞方式的许多细微差异,揭示出了复杂的发育调控因子"决策"回路。 | Roshan M.Kumar Patrick Cahan Alex K.Shalek Rahul Satija A.Jay Daley Keyser Hu Li Jin Zhang Keith Pardee David Gennert John J.Trombetta Thomas C.Ferrante Aviv Regev George Q.Daley James J. Collins | 2014 | 岭南现代临床外科2014，14，6： | 10 |
| 3 | 针对患者利益的机器学习和人工智能研究:在透明性、可重复性、伦理和有效性等方面的20个关键问题显示文摘机器学习(ML)、人工智能(AI)和其他现代统计方法正为利用先前尚未开发且极速增长的数据资源提供新的机会,以期让患者获益。尽管目前正在进行许多有前景的研究,特别是在图像方面,但就文献整体而言还缺乏透明度、对可重复性清晰的阐述、对潜在伦理问题的探究,以及对有效性的明确验证。这些问题的存在有许多原因,其中最重要的一点(为此我们提供了初步解决方案)就是当前缺乏针对ML和AI的最佳实践指南。我们认为从事研究的跨学科团队和应用ML/AI影响健康的项目,将因解决有关透明度、可重复性、伦理和有效性(TREE)的一系列问题而受益。这里提出的20个关键问题为研究团队提供了一个研究设计、实施和报告框架;帮助编辑和同行评审专家评估文献的贡献;让患者、临床医生和政策制定者评估新发现可能会给患者带来的获益。 | Sebastian Vollmer Bilal A Mateen Gergo Bohner Franz J Kirdly Rayid Ghani Pall Jonsson Sarah Cumbers Adrian Jonas Katherine S L McAllister Puja Myles David Granger Mark Birse Richard Branson Karel G M Moons Gary S Collins John P A Chris Holmes Harry Hemingwayp 李峰(译) 徐磊(校) 赵邑(校) | 2020 | 英国医学杂志中文版2020，23，9： | 5 |
| 4 | FK506对实验性卒中疗效的系统评价和Meta分析显示文摘FK506是治疗急性卒中的一种候选用药。决定一种药物是否可以用于临床试验,应当以全面的、无偏倚的动物实验数据的评估为依据,同时还应考虑到这些数据的局限性。这种评估不但应包括药物疗效,而且也应包括药效在体内的特征和局限性。本研究应用系统评价和Meta分析的方法对FK506在卒中动物模型中保护作用的证据进行评价。总共纳入了29个描述了实验步骤的研究,包括1759只动物。结果显示,FK506疗效的点估计值(结局指标的改善)是31.3%[95%CI(0.272-0.354)]。在采用氯胺酮麻醉和短暂性脑缺血的动物实验中,FK506的疗效更高,在使用大鼠,合并其他疾病的动物及仅以梗死面积为疗效指标的实验中,FK506疗效较低。已发表的实验研究质量均接近临床试验标准,但在高质量的研究中,FK506的疗效较低。FK506在实验性脑卒中的研究中,虽然显示出有明显的疗效,但是应注意由于研究质量和可能的发表偏倚等冈素的影响,FK506的疗效可能被过高估计。 | Malcolm R Macleod Tori O’Collins Laura L Horky David W Howells Geoffrey A Donnan 段建钢 | 2006 | 中国循证医学杂志2006，6，6： | 3 |
| 5 | Eosinophilic esophagitis: Updated consensus recommendations for children and adults显示文摘 | Chris A. Liacouras Glenn T. Furuta Ikuo Hirano Dan Atkins Stephen E. Attwood Peter A. Bonis A. Wesley Burks Mirna Chehade Margaret H. Collins Evan S. Dellon Ranjan Dohil Gary W. Falk Nirmala Gonsalves Sandeep K. Gupta David A. Katzka Alfredo J. Lucendo Jo | 2011 | The Journal of Allergy and Clinical Immunology2011，，1： | 3 |
| 6 | Lrig1 Expression Defines a Distinct Multipotent Stem Cell Population in Mammalian Epidermis显示文摘 | Kim B. Jensen Charlotte A. Collins Elisabete Nascimento David W. Tan Michaela Frye Satoshi Itami Fiona M. Watt | 2009 | Cell Stem Cell2009，，5： | 2 |
| 7 | Next Generation Transcriptome Sequencing and Quantitative Real-Time PCR Technologies for Characterisation of the Bemisia tabaci Asia 1 mtCOI Phylogenetic Clade显示文摘A programme of functional genomics research is underway at the University of Greenwich,UK,to develop and apply genomics technologies to characterise an economically-important but under-researched Bemisia tabaci(Hemiptera:Aleyrodidae),the Asia 1 mtCOI phylogenetic group.A comparison of this putative species from India with other important B.tabaci populations and insect species may provide targets for the development of more effective whitefly control strategies.As a first step,next-generation sequencing(NGS)has been used to survey the transcriptome of adult female whitefly,with high quality RNA preparations being used to generate cDNA libraries for NGS using the Roche 454 Titanium DNA sequencing platform.Contig assemblies constructed from the resultant sequences(301 094 reads)using the software program CLC Genomics Workbench generated 3 821 core contigs.Comparison of a selection of these contigs with related sequences from other B.tabaci genetic groups has revealed good alignment for some genes(e.g.,HSP90)but misassemblies in other datasets(e.g.,the vitellogenin gene family),highlighting the need for manual curation as well as collaborative international efforts to obtain accurate assemblies from the existing next generation sequence datasets.Nevertheless,data emerging from the NGS has facilitated the development of accurate and reliable methods for analysing gene expression based on quantitative real-time RT-PCR,illustrating the power of this approach to enable rapid expression analyses in an organism for which a complete genome sequence is currently lacking. | Susan Seal Mitulkumar V Patel Carl Collins John Colvin David Bailey | 2012 | Journal of Integrative Agriculture2012，11，2： | 2 |
| 8 | Diffusion-weighted MIR in the Body: Applications and Challenges in Oncology显示文摘 | Dow-Mu Koh David Collins | 2007 | AJR2007，188，6： | 1 |
| 9 | Age of the Living Dead: Personality Rights of Deceased Celebrities显示文摘 | David Collins | 2002 | 39 Alberta Law Review2002，，： | 1 |
| 10 | Eosinophilic esophagitis: Updated consensus recommendations for children and adults显示文摘 | Chris A. Liacouras Glenn T. Furuta Ikuo Hirano Dan Atkins Stephen E. Attwood Peter A. Bonis A. Wesley Burks Mirna Chehade Margaret H. Collins Evan S. Dellon Ranjan Dohil Gary W. Falk Nirmala Gonsalves Sandeep K. Gupta David A. Katzka Alfredo J. Lucendo Jo | 2011 | The Journal of Allergy and Clinical Immunology2011，，1： | 1 |
| 11 | ADAPTORS FOR CLATHRIN COATS: Structure and Function显示文摘 | David J. Owen Brett M. Collins Philip R. Evans | 2004 | Annual Review of Cell and Developmental Biology2004，，： | 1 |
| 12 | The FBP Interacting Repressor Targets TFIIH to Inhibit Activated Transcription显示文摘 | Juhong Liu Liusheng He Irene Collins Hui Ge Daniel Libutti Junfa Li Jean-Marc Egly David Levens | 2000 | Molecular Cell2000，，2： | 1 |
| 13 | Comparative protein accumulation patterns in soybean somatic and zygotic embryos显示文摘 | Mark L. Dahmer David F. Hildebrand Glenn B. Collins | 1992 | In Vitro – Plant1992，，2： | 1 |
| 14 | Application of the CALIOP layer product to evaluate the vertical distribution of aerosols estimated by global models: AeroCom phase I results显示文摘 | Koffi Brigitte Schulz Michael Bréon Francois-Marie Griesfeller Jan Winker David Balkanski Yves Bauer Susanne Berntsen Terje Chin Mian Collins William D. Dentener Frank Diehl Thomas Easter Richard Ghan Steven Ginoux Paul Gong Sunling Horowi | 2012 | EN2012，，1： | 1 |
| 15 | US Renal Data System 2011 Annual Data Report显示文摘 | Allan J. Collins Robert N. Foley Blanche Chavers David Gilbertson Charles Herzog Kirsten Johansen Bertram Kasiske Nancy Kutner Jiannong Liu Wendy St. Peter Haifeng Guo Sally Gustafson Brooke Heubner Kenneth Lamb Shuling Li Suying Li Yi Peng Yang Qiu Trici | 2011 | American Journal of Kidney Diseases2011，，1： | 1 |
| 16 | US Renal Data System 2010 Annual Data Report显示文摘 | Allan J. Collins Robert N. Foley Charles Herzog Blanche Chavers David Gilbertson Areef Ishani Bertram Kasiske Jiannong Liu Lih-Wen Mau Marshall McBean Anne Murray Wendy St. Peter Haifeng Guo Sally Gustafson Qi Li ShuLing Li Suying Li Yi Peng Yang Qiu Tric | 2010 | American Journal of Kidney Diseases2010，，1： | 1 |
| 17 | Transport impacts on atmosphere and climate: Shipping显示文摘 | Veronika Eyring Ivar S.A. Isaksen Terje Berntsen William J. Collins James J. Corbett Oyvind Endresen Roy G. Grainger Jana Moldanova Hans Schlager David S. Stevenson | 2009 | Atmospheric Environment2009，，37： | 1 |
| 18 | A 10-y Monthly Lightning C1imate Florida: 1986-95显示文摘 | David Sharp Waylon Collins | 1997 | Weather and Forecasting1997，12，3： | 1 |
| 19 | Ruptured synthetic expanded polytertrafluoroethylene chordae tendinae 显示文摘 | Butany J Collins MJ David TE | 2004 | Cardiovasc Pathol2004，13，3： | 1 |
| 20 | US Renal Data System 2010 Annual Data Report显示文摘 | Allan J. Collins Robert N. Foley Charles Herzog Blanche Chavers David Gilbertson Areef Ishani Bertram Kasiske Jiannong Liu Lih-Wen Mau Marshall McBean Anne Murray Wendy St. Peter Haifeng Guo Sally Gustafson Qi Li ShuLing Li Suying Li Yi Peng Yang Qiu Tric | 2010 | American Journal of Kidney Diseases2010，，1： | 1 |
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