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| 1 | Comprehensive functional annotation of susceptibility variants identifies genetic heterogeneity between lung adenocarcinoma and squamous cell carcinoma显示文摘Although genome-wide association studies have identified more than eighty genetic variants associated with non-small cell lung cancer(NSCLC)risk,biological mechanisms of these variants remain largely unknown.By integrating a large-scale genotype data of 15581 lung adenocarcinoma(AD)cases,8350 squamous cell carcinoma(SqCC)cases,and 27355 controls,as well as multiple transcriptome and epigenomic databases,we conducted histology-specific meta-analyses and functional annotations of both reported and novel susceptibility variants.We identified 3064 credible risk variants for NSCLC,which were overrepresented in enhancer-like and promoter-like histone modification peaks as well as DNase I hypersensitive sites.Transcription factor enrichment analysis revealed that USF1 was AD-specific while CREB1 was SqCC-specific.Functional annotation and genebased analysis implicated 894 target genes,including 274 specifics for AD and 123 for SqCC,which were overrepresented in somatic driver genes(ER=1.95,P=0.005).Pathway enrichment analysis and Gene-Set Enrichment Analysis revealed that AD genes were primarily involved in immune-related pathways,while SqCC genes were homologous recombination deficiency related.Our results illustrate the molecular basis of both wellstudied and new susceptibility loci of NSCLC,providing not only novel insights into the genetic heterogeneity between AD and SqCC but also a set of plausible gene targets for post-GWAS functional experiments. | Na Qin Yuancheng Li Cheng Wang Meng Zhu Juncheng Dai Tongtong Hong Demetrius Albanes Stephen Lam Adonina Tardon Chu Chen Gary Goodman Stig EBojesen Maria Teresa Landi Mattias Johansson Angela Risch H-Erich Wichmann Heike Bickeboller Gadi Rennert Susanne Arnold Paul Brennan John KField Sanjay Shete Loic Le Marchand Olle Melander Hans Brunnstrom Geoffrey Liu Rayjean JHung Angeline Andrew Lambertus AKiemeney Shan Zienolddiny Kjell Grankvist Mikael Johansson Neil Caporaso Penella Woll Philip Lazarus Matthew BSchabath Melinda CAldrich Victoria LStevens Guangfu Jin David CChristiani Zhibin Hu Christopher IAmos Hongxia Ma Hongbing Shen | 2021 | Frontiers of Medicine2021，15，2： | 3 |
| 2 | First description of cervical intradural thymoma metastasis显示文摘Thymoma and thymic carcinoma are rare epithelial tumors, which originate from the thymus gland. According to the World Health Organization there are 'organotypic'(types A, AB, B1, B2, and B3) and 'non-organotypic'(thymic carcinomas) thymomas. Type B3 thymomas are aggressive tumors, which can metastasize. Due to the rarity of these lesions, only 7 cases of extradural metastasis are described in the literature. We report the first and unique case of a man with cervical intradural B3 thymoma metastasis. A 46-year-old man underwent thymoma surgical removal. The year after the procedure he was treated for a parietal pleura metastasis. In 2006 he underwent cervical-dorsal extradural metastasis removal and C5-Th1 stabilization. Seven years after he came to our observation complaining left cervicobrachialgia and a reduction of strength of the left arm. He underwent a cervical spine magnetic resonance imaging, which showed a new lesion at the C5-C7 level. The patient underwent a surgery for the intradural B3 thymoma metastasis. Neurological symptoms improved although the removal was subtotal. He went through postoperative radiation therapy with further mass reduction. Spinal metastases are extremely rare. To date, only 7 cases of spinal extradural metastasis have been described in the literature. This is the first case of spinal intradural metastasis. Early individuation of these tumors and surgical treatment improve neurological outcome in patients with spinal cord compression. A multimodal treatment including neoadjuvant chemotherapy, surgery and postoperative radiation therapy seems to improve survival in patients with metastatic thymoma. | Nicola Marotta Cristina Mancarella Davide Colistra Alessandro Landi Demo Eugenio Dugoni Roberto Delfini | 2015 | World Journal of Clinical Cases2015，3，11： | 3 |
| 3 | Chemical characterization of volatile organic compounds near the World Trade Center: Ambient concentrations and source apportionment显示文摘 | David A. Olson Gary A. Norris Robert L. Seila Matthew S. Landis Alan F. Vette | 2007 | Atmospheric Environment2007，，27： | 1 |
| 4 | Chemical characterization of volatile organic compounds near the World Trade Center: Ambient concentrations and source apportionment显示文摘 | David A. Olson Gary A. Norris Robert L. Seila Matthew S. Landis Alan F. Vette | 2007 | Atmospheric Environment2007，，27： | 1 |
| 5 | Fenton degradation assisted by cyclodextrins of a high molecular weight polycyclic aromatic hydrocarbon benzo[a]pyrene显示文摘 | Etienne Veignie Catherine Rafin David Landy Sophie Fourmentin Gheorghe Surpateanu | 2009 | Journal of Hazardous Materials2009，，2： | 1 |
| 6 | Isolation and characterization of cellulose/arabinoxylan residual mixtures from corn fiber gum processes显示文摘 | Landis W Doner David B Johniton | 2001 | Cereal Chem2001，78，2： | 1 |
| 7 | Vertebral artery hypoplasia: A predisposing factor for posterior circulation stroke?显示文摘 | Fabienne Perren Davide Poglia Theodor Landis Roman Sztajzel | 2007 | Neurology2007，，1： | 1 |
| 8 | Cyclodextrins: A new efficient absorbent to treat waste gas streams显示文摘 | Philippe Blach Sophie Fourmentin David Landy | 2008 | Chemosphere2008，70，： | 1 |
| 9 | Intestinal dendritic cells: Their role in intestinal inflammation, manipulation by the gut microbiota and differences between mice and men显示文摘 | Elizabeth R. Mann Jonathan D. Landy David Bernardo Simon T.C. Peake Ailsa L. Hart Hafid Omar Al-Hassi Stella C. Knight | 2013 | Immunology Letters (-)2013，，1： | 1 |
| 10 | The Spiritual Dimension of North American Nature Writing 显示文摘 | Barnhill David Landis | 2006 | New York:Oxford UP2006，，： | 1 |
| 11 | The Pediatric Cardiomyopathy Registry and Heart Failure: Key Results from the First 15 Years显示文摘 | James D. Wilkinson David C. Landy Steven D. Colan Jeffrey A. Towbin Lynn A. Sleeper E. John Orav Gerald F. Cox Charles E. Canter Daphne T. Hsu Steven A. Webber Steven E. Lipshultz | 2010 | Heart Failure Clinics2010，，4： | 1 |
| 12 | A Planner's Guide to Places Rated Almanac'显示文摘 | Landis John D and David S Sawicki | 1988 | Journal of the AmericanPlanning Association1988，54，3： | 1 |
| 13 | Isolation and characterization of cellulose/arabinoxylan residual mixtures from corn fiber gum processes显示文摘 | Landis W Doner David B Johnston | 1978 | Cereal Chem1978，，2： | 1 |
| 14 | Intestinal dendritic cells: Their role in intestinal inflammation, manipulation by the gut microbiota and differences between mice and men显示文摘 | Elizabeth R. Mann Jonathan D. Landy David Bernardo Simon T.C. Peake Ailsa L. Hart Hafid Omar Al-Hassi Stella C. Knight | 2013 | Immunology Letters (-)2013，，1： | 1 |
| 15 | Dysregulated Circulating Dendritic Cell Function in Ulcerative Colitis Is Partially Restored by Probiotic Strain Lactobacillus casei Shirota显示文摘 | Elizabeth R. Mann Jialu You Verena Horneffer-van der Sluis David Bernardo Hafid Omar Al-Hassi Jon Landy Simon T. Peake Linda V. Thomas Cheng T. Tee Gui Han Lee Ailsa L. Hart Parveen Yaqoob Stella C. Knight Eduardo Arranz | 2013 | <journal-title>Mediators of Inflammation2013，，： | 1 |
| 16 | An inter-laboratory study of DNA-based identity,parentage and species testing in animal forensic genetics显示文摘The probative value of animal forensic genetic evidence relies on laboratory accuracy and reliability.Inter-laboratory comparisons allow laboratories to evaluate their performance on specific tests and analyses and to continue to monitor their output.The International Society for Animal Genetics(ISAG)administered animal forensic comparison tests(AFCTs)in 2016 and 2018 to assess the limitations and capabilities of laboratories offering forensic identification,parentage and species determination services.The AFCTs revealed that analyses of low DNA template concentrations(≤300 pg/μL)constitute a significant challenge that has prevented many laboratories from reporting correct identification and parentage results.Moreover,a lack of familiarity with species testing protocols,interpretation guidelines and representative databases prevented over a quarter of the participating laboratories from submitting correct species determination results.Several laboratories showed improvement in their genotyping accuracy over time.However,the use of forensically validated standards,such as a standard forensic short tandem repeat(STR)kit,preferably with an allelic ladder,and stricter guidelines for STR typing,may have prevented some common issues from occurring,such as genotyping inaccuracies,missing data,elevated stutter products and loading errors.The AFCTs underscore the importance of conducting routine forensic comparison tests to allow laboratories to compare results from each other.Laboratories should keep improving their scientific and technical capabilities and continuously evaluate their personnel’s proficiency in critical techniques such as low copy number(LCN)analysis and species testing.Although this is the first time that the ISAG has conducted comparison tests for forensic testing,findings from these AFCTs may serve as the foundation for continuous improvements of the overall quality of animal forensic genetic testing. | Sreetharan Kanthaswamy Torsten Brendel Luis Cancela Denise A.Andrade de Oliveira Bertram Brenig Carmen Cons Julian A.Crespi Markéta Dajbychová Andreas Feldl Tomohito Itoh Vincenzo Landi Amparo Martinez Malgorzata Natonek-Wisniewska Robert F.Oldt Anna Radko Oscar Ramírez Clementina Rodellar Manuel Ruiz-Girón David Schikorski María Elena Turba Guillermo Giovambatista | 2022 | Forensic Sciences Research2022，7，4： | 0 |
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