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| 1 | Advances in statistical mechanics of rock masses and its engineering applications显示文摘To efficiently link the continuum mechanics for rocks with the structural statistics of rock masses,a theoretical and methodological system called the statistical mechanics of rock masses(SMRM)was developed in the past three decades.In SMRM,equivalent continuum models of stressestrain relationship,strength and failure probability for jointed rock masses were established,which were based on the geometric probability models characterising the rock mass structure.This follows the statistical physics,the continuum mechanics,the fracture mechanics and the weakest link hypothesis.A general constitutive model and complete stressestrain models under compressive and shear conditions were also developed as the derivatives of the SMRM theory.An SMRM calculation system was then developed to provide fast and precise solutions for parameter estimations of rock masses,such as full-direction rock quality designation(RQD),elastic modulus,Coulomb compressive strength,rock mass quality rating,and Poisson’s ratio and shear strength.The constitutive equations involved in SMRM were integrated into a FLAC3D based numerical module to apply for engineering rock masses.It is also capable of analysing the complete deformation of rock masses and active reinforcement of engineering rock masses.Examples of engineering applications of SMRM were presented,including a rock mass at QBT hydropower station in northwestern China,a dam slope of Zongo II hydropower station in D.R.Congo,an open-pit mine in Dexing,China,an underground powerhouse of Jinping I hydropower station in southwestern China,and a typical circular tunnel in Lanzhou-Chongqing railway,China.These applications verified the reliability of the SMRM and demonstrated its applicability to broad engineering issues associated with jointed rock masses. | Faquan Wu Jie Wu Han Bao Bo Li Zhigang Shan Deheng Kong | 2021 | Journal of Rock Mechanics and Geotechnical Engineering2021，13，1： | 8 |
| 2 | Rapid intelligent evaluation method and technology for determining engineering rock mass quality显示文摘The evaluation of engineering rock mass quality is fundamental work for the engineering activities of rock mass.The increasing scale of rock mass engineering necessitates higher intelligence,timeliness,and accuracy in engineering rock mass quality evaluation.As the core aspects of engineering rock mass quality evaluation,the structural characteristics,mechanical characteristics,and quality classification of rock mass have been innovated in recent years.The non-contact measurement technology for rock mass structure and rapid interpretation of rock mass structure information enables the intelligent extraction and analysis of rock mass structure parameters.The modular backpack laboratory system of rock mechanics provides an effective means to acquire rock mechanical parameters on-site conveniently.The theory of statistical mechanics of rock mass(SMRM)integrates various factors such as the rock mass properties,geological environment,and engineering disturbance,providing a theoretical basis for accurately evaluating the weakening and anisotropy of rock mass.The cloud computing platform established based on SMRM can provide technical support for the rapid calculation of rock mass parameters and instant evaluation of the rock mass quality.The development of intelligent evaluation method and technology is altering the conventional technical state of qualitative and semi-quantitative evaluation of engineering rock mass quality,supporting the realization of rock mass engineering construction with intellectualization and informatization. | Faquan Wu Jie Wu Han Bao Zhongxi Bai Lei Qiao Fang Zhang Bo Li Fuan Si Lei Yu Shenggong Guan Peng Sha Deheng Kong Zhenzhong Dai Kun Chen Yun Tian Changqing Liu | 2023 | Rock Mechanics Bulletin2023，2，2： | 3 |
| 3 | Histone deacetylase SIRT6 inhibits glioma cell growth through down-regulating NOTCH3 expression显示文摘Gliomas 是中央神经系统的最普通的大脑肿瘤。在这研究,我们在人的 gliomas 调查了分子的机制和 SIRT6 的生物功能。在 glioma 纸巾和房间的 SIRT6 的表示层次被 qRT-PCR 和西方的污点分析分析。CCK8 和 clonogenicity 试金被执行检测房间增长。而且, glioma 房间的迁居和侵略被 transwell 试金检验。SIRT6 的表示与正常大脑织物或 NHA 相比在人的 glioma 纸巾或房间线是显著地更低的,这被发现。起来调整的 SIRT6 显著地减少了 U87 和 U251 房间的房间增长,移植和侵略。由对比, SIRT6 击倒 U87 和 U251 房间的戏剧性地增加的房间增长,移植和侵略。而且,显著地在 NOTCH3 的表示上增加了 U87 和 U251 房间的房间增长,移植,和侵略。然而,这些效果在 SIRT6 的 overexpression 以后被废除。这些结果建议 SIRT6 可以经由在 glioma 表明小径的 NOTCH3 的抑制压制房间增长,移植,和侵略。 | Xin Chen Deheng Li Yang Gao Yiqun Cao Bin Hao | 2018 | Acta Biochimica et Biophysica Sinica2018，50，4： | 2 |
| 4 | PD monitor system for power generators显示文摘 | Zhenyuan Wang Deheng Zhu Kexiong Tan Fuqi Li | | 0，，06： | 1 |
| 5 | Early-phase clinical trials of anti-HIV Drugs——understanding and discussion显示文摘Innovative anti-HIV drugs developed by local sponsors in China have come into the stage of early-phase clinical trials.How to systemically design the clinical trials of innovative anti-HIV drugs still remains a challenge for them.This article references the literature and the experience of reviewers,to introduce general considerations concerning early-phase clinical trials of innovative anti-HIV drugs. | LI YaJie,ZHAO Ming & ZHAO DeHeng Center for Drug Evaluation,State Food and Drug Administration,Beijing 100038,China | 2009 | Science China(Life Sciences)2009，52，6： | 1 |
| 6 | Effects of the grain alignment on the coercivity and its angular dependence for NdCoFeB permanent magnets显示文摘The dependence of the macroscopic magnetism for NdCoFeB permanent magnet on the degree of grain alignment has been studied. With an increase in grain alignment degree, the coercivity of the permanent magnet decreases and the remanence increases. The decrease rate of the coercivity is smaller than the increase rate of the remanence. The coercivity H c(θ) increases with increasing angle θ between the applied field and the texture axis, and for the permanent magnets with good grain alignment the increase rate of H c(θ) is large. These experimental results can be interpreted by using the starting field theory of coercivity. | Ruwei Gao Wei Li Changguo Ji Deheng Zhang Jiancheng Zhang | 1998 | Chinese Science Bulletin1998，43，2： | 0 |
| 7 | Secreted phosphoprotein 1 promotes angiogenesis of glioblastoma through upregulating PSMA expression via transcription factor HIF1α显示文摘Glioblastoma multiforme(GBM)is a highly vascularized malignant brain tumor.Our previous study showed that prostate-specific membrane antigen(PSMA)promotes angiogenesis of GBM.However,the specific mechanism underlying GBM-induced PSMA upregulation remains unclear.In this study,we demonstrate that the GBM-secreted cytokine phosphoprotein 1(SPP1)can regulate the expression of PSMA in human umbilical vein endothelial cells(HUVECs).Our mechanistic study further reveals that SPP1 regulates the expression of PSMA through the transcription factor HIF1α.Moreover,SPP1 promotes HUVEC migration and tube formation.In addition,HIF1α knockdown reduces the expression of PSMA in HUVECs and blocks the ability of SPP1 to promote HUVEC migration and tube formation.We further confirm that SPP1 is abundantly expressed in GBM,is associated with poor prognosis,and has high clinical diagnostic value with considerable sensitivity and specificity.Collectively,our findings identify that the GBM-secreted cytokine SPP1 upregulates PSMA expression in endothelial cells via the transcription factor HIF1α,providing insight into the angiogenic process and promising candidates for targeted GBM therapy. | Wenjing Tu Hui Zheng Liangdong Li Changshuai Zhou Mingtao Feng Lei Chen Deheng Li Xin Chen Bin Hao Huaping Sun Yiqun Cao Yang Gao | 2023 | Acta Biochimica et Biophysica Sinica2023，55，3： | 0 |
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