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| 1 | Linking atmospheric pollution to cryospheric change in the Third Pole region: current progress and future prospects显示文摘The Tibetan Plateau and its surroundings are known as the Third Pole(TP). This region is noted for its high rates of glacier melt and the associated hydrological shifts that affect water supplies in Asia. Atmospheric pollutants contribute to climatic and cryospheric changes through their effects on solar radiation and the albedos of snow and ice surfaces; moreover, the behavior and fates within the cryosphere and environmental impacts of environmental pollutants are topics of increasing concern. In this review, we introduce a coordinated monitoring and research framework and network to link atmospheric pollution and cryospheric changes(APCC) within the TP region. We then provide an up-to-date summary of progress and achievements related to the APCC research framework, including aspects of atmospheric pollution’s composition and concentration, spatial and temporal variations, trans-boundary transport pathways and mechanisms, and effects on the warming of atmosphere and changing in Indian monsoon, as well as melting of glacier and snow cover. We highlight that exogenous air pollutants can enter into the TP’s environments and cause great impacts on regional climatic and environmental changes. At last, we propose future research priorities and map out an extended program at the global scale. The ongoing monitoring activities and research facilitate comprehensive studies of atmosphere–cryosphere interactions, represent one of China’s key research expeditions to the TP and the polar regions and contribute to the global perspective of earth system science. | Shichang Kang Qianggong Zhang Yun Qian Zhenming Ji Chaoliu Li Zhiyuan Cong Yulan Zhang Junming Guo Wentao Du Jie Huang Qinglong You Arnico K.Panday Maheswar Rupakheti Deliang Chen Orjan Gustafsson Mark H.Thiemens Dahe Qin | 2019 | National Science Review2019，6，4： | 35 |
| 2 | Lipid metabolism reprogramming and its potential targets in cancer显示文摘Reprogramming of lipid metabolism is a newly recognized hallmark of malignancy.Increased lipid uptake,storage and lipogenesis occur in a variety of cancers and contribute to rapid tumor growth.Lipids constitute the basic struc-ture of membranes and also function as signaling molecules and energy sources.Sterol regulatory element-binding proteins(SREBPs),a family of membrane-bound transcription factors in the endoplasmic reticulum,play a central role in the regulation of lipid metabolism.Recent studies have revealed that SREBPs are highly up-regulated in various cancers and promote tumor growth.SREBP cleavage-activating protein is a key transporter in the trafficking and activation of SREBPs as well as a critical glucose sensor,thus linking glucose metabolism and de novo lipid synthesis.Targeting altered lipid metabolic pathways has become a promising anti-cancer strategy.This review summarizes recent progress in our understanding of lipid metabolism regulation in malignancy,and highlights potential molecu-lar targets and their inhibitors for cancer treatment. | Chunming Cheng Feng Geng Xiang Cheng Deliang Guo | 2018 | Cancer Communications2018，38，1： | 34 |
| 3 | 脂质代谢重编程及其在癌症中潜在靶点的研究显示文摘脂质代谢的重编程是恶性肿瘤的一个新特征。在多种癌症中,脂肪摄取、储存和脂肪生成均被上调,这也促进了肿瘤的快速生长。脂质是构成膜的基本结构,并且具有信号分子和能量来源的功能。固醇调节元件结合蛋白(Sterol regulatory element-binding proteins,SREBPs)是内质网中一类膜结合转录因子,在调节脂质代谢中起着核心作用。最近的研究表明,SREBPs在各种癌症中高度上调并促进肿瘤生长。SREBP切割激活蛋白(SREBP cleavage-activating protein,SCAP)是SREBPs转运和激活的关键转运蛋白,也是一种关键的葡萄糖传感器,因此它将葡萄糖代谢与脂类从头合成联系在一起。靶向变异的脂质代谢途径已成为一种很有前景的抗癌策略。本综述总结了近年来我们所知的对恶性肿瘤中脂质代谢调节的最新研究进展,并着重介绍了癌症治疗中潜在的分子靶点及其抑制剂。 | Chunming Cheng Feng Geng Xiang Cheng Deliang Guo | 2018 | 癌症2018，37，11： | 6 |
| 4 | A novel microRNA miR-MTCO3P38 inhibits malignant progression via STAT3/PTTG1/MYC in hepatocellular carcinoma显示文摘To the Editor,Hepatocellular carcinoma(HCC)is a malignant tumor with the fourth highest incidence and the third highest mortality among all tumor sites in China.1 Finding new diagnostic markers and therapeutic molecules may be of great value in the treatment of HCC and the improvement of prognosis. | Deliang Guo Yang Gu Dong Ma Pengpeng Liu Baiyang Chen Zhisu Liu Ping Wu Quanyan Liu | 2022 | Genes & Diseases2022，9，4： | 1 |
| 5 | Effects of vanadium ion implantation on microstructure, mechanical and tribological properties of TiN coatings显示文摘 | Bin Deng Ye Tao Deliang Guo | 2012 | Applied Surface Science2012，，22： | 1 |
| 6 | Light-triggered NO-releasing nanoparticles for treating mice with liver fibrosis显示文摘Liver fibrosis, resulting from chronic liver damage and characterized by the accumulation of extracellular matrix (ECM) proteins, is a characteristic of most types of chronic liver diseases. The activation of hepatic stellate cells (HSC) is considered an essential pathological hallmark in liver fibrosis. Although nitric oxide (NO) can effectively induce HSC apoptosis, the systemic administration of NO is ineffective and may cause severe complications such as hypotension. To overcome this limitation, nanoparticles were designed to target HSCs and release NO locally under the exposure of near infrared light (NIR). To achieve this, upconversion nanoparticle (UCNP) cores were enveloped in mesoporous silica shells (UCNP@mSiO2), which were modified with hyaluronic acid (HA-UCNP@mSiO2) and Roussin’s black salt (RBS). HA molecules recognize and bind to CD44 proteins, which are overexpressed on activated HSCs. Under exposure to a 980-nm NIR laser, the UCNP cores convert the 980-nm wavelength into ultraviolet (UV) light, which then energizes the RBS (NO donors), resulting in an efficient release of NO inside of the HSCs. Once released, NO triggers HSC apoptosis and reverses the liver fibrosis. This targeted and controlled release method provides the theoretical and experimental basis for novel therapeutic approaches to treat hepatic fibrosis. | Hongxia Liang Zhenhua Li Zhigang Ren Qiaodi Jia Linna Guo Shasha Li Hongyu Zhang Shiqi Hu Dashuai Zhu Deliang Shen Zujiang Yu Ke Cheng | 2020 | Nano Research2020，13，8： | 1 |
| 7 | Extraction of 8-hydroxyquinoline by tributylphosphate in kerosene 显示文摘 | Ll Deliang GUO Yuanyuan CHANG Zhixian | 2012 | J Chern Eng Data2012，57，10： | 1 |
| 8 | Reactive extraction of 0-, m-, and p-chlorophenol from aqueous solution using tri-n-butyl phosphate in kerosene 显示文摘 | LI Deliang GUO Yuanyuan CHANG Zhixian | 2013 | J Chern Eng Data2013，58，3： | 1 |
| 9 | Electron-ion collider in China显示文摘Lepton scattering is an established ideal tool for studying inner structure of small particles such as nucleons as well as nuclei.As a future high energy nuclear physics project,an Electron-ion collider in China(EicC)has been proposed.It will be constructed based on an upgraded heavy-ion accelerator,High Intensity heavy-ion Accelerator Facility(HIAF)which is currently under construction,together with a new electron ring.The proposed collider will provide highly polarized electrons(with a po-larization of 80%)and protons(with a polarization of 70%)with variable center of mass energies from 15 to 20 GeV and the luminosity of(2–3)×1033 cm^(−2)·s^(−1).Polarized deuterons and Helium-3,as well as unpolarized ion beams from Carbon to Uranium,will be also available at the EicC.The main foci of the EicC will be precision measurements of the structure of the nucleon in the sea quark region,including 3D tomography of nucleon;the partonic structure of nuclei and the parton interaction with the nuclear environment;the exotic states,especially those with heavy flavor quark contents.In addition,issues fundamental to understanding the origin of mass could be addressed by measurements of heavy quarkonia near-threshold production at the EicC.In order to achieve the above-mentioned physics goals,a hermetical detector system will be constructed with cutting-edge technologies.This document is the result of collective contributions and valuable inputs from experts across the globe.The EicC physics program complements the ongoing scientific programs at the Jefferson Laboratory and the future EIC project in the United States.The success of this project will also advance both nuclear and particle physics as well as accelerator and detector technology in China. | Daniele PAnderle Valerio Bertone Xu Cao Lei Chang Ningbo Chang Gu Chen Xurong Chen Zhuojun Chen Zhufang Cui Lingyun Dai Weitian Deng Minghui Ding Xu Feng Chang Gong Longcheng Gui Feng-Kun Guo Chengdong Han Jun He Tie-Jiun Hou Hongxia Huang Yin Huang KrešImir KumeričKi LPKaptari Demin Li Hengne Li Minxiang Li Xueqian Li Yutie Liang Zuotang Liang Chen Liu Chuan Liu Guoming Liu Jie Liu Liuming Liu Xiang Liu Tianbo Liu Xiaofeng Luo Zhun Lyu Boqiang Ma Fu Ma Jianping Ma Yugang Ma Lijun Mao Cédric Mezrag HervéMoutarde Jialun Ping Sixue Qin Hang Ren Craig DRoberts Juan Rojo Guodong Shen Chao Shi Qintao Song Hao Sun PawełSznajder Enke Wang Fan Wang Qian Wang Rong Wang Ruiru Wang Taofeng Wang Wei Wang Xiaoyu Wang Xiaoyun Wang Jiajun Wu Xinggang Wu Lei Xia Bowen Xiao Guoqing Xiao Ju-Jun Xie Yaping Xie Hongxi Xing Hushan Xu Nu Xu Shusheng Xu Mengshi Yan Wenbiao Yan Wencheng Yan Xinhu Yan Jiancheng Yang Yi-Bo Yang Zhi Yang Deliang Yao Zhihong Ye Peilin Yin C-PYuan Wenlong Zhan Jianhui Zhang Jinlong Zhang Pengming Zhang Yifei Zhang Chao-Hsi Chang Zhenyu Zhang Hongwei Zhao Kuang-Ta Chao Qiang Zhao Yuxiang Zhao Zhengguo Zhao Liang Zheng Jian Zhou Xiang Zhou Xiaorong Zhou Bingsong Zou Liping Zou | 2021 | Frontiers of physics2021，16，6： | 1 |
| 10 | Electropolymerization of ionic liquid substituted polyphenylene as supercapacitors materials 显示文摘 | Deliang He Yanni Guo Zhou Zhou etc | 2009 | Electrochemistry Communications2009，11，8： | 1 |
| 11 | Research on the Production Performance of Multi-stage Fractured Horizontal Well in Shale Gas Reservoir显示文摘 | ZHANG DELIANG ZHANG LIEHUI’GUO JINGJING | 2015 | Journal of Natural Gas Science and Engineering2015，26，： | 1 |
| 12 | Worldwide impacts of atmospheric vapor pressure deficit on the interannual variability of terrestrial carbon sinks显示文摘Interannual variability of the terrestrial ecosystem carbon sink is substantially regulated by various environmental variables and highly dominates the interannual variation of atmospheric carbon dioxide(CO_(2))concentrations.Thus,it is necessary to determine dominating factors affecting the interannual variability of the carbon sink to improve our capability of predicting future terrestrial carbon sinks.Using global datasets derived from machine-learning methods and process-based ecosystem models,this study reveals that the inter annual variability of the atmospheric vapor pressure deficit(VPD)was significantly negatively correlated with net ecosystem production(NEP)and substantially impacted the inter annual variability of the atmospheric CO_(2)growth rate(CGR).Further analyses found widespread constraints of VPD interannual variability on terrestrial gross primary production(GPP),causing VPD to impact NEP and CGR.Partial correlation analysis confirms the persistent and widespread impacts of VPD on terrestrial carbon sinks compared to other environmental variables.Current Earth system models underestimate the interannual variability in VPD and its impacts on GPP and NEP.Our results highlight the importance of VPD for terrestrial carbon sinks in assessing ecosystems'responses to future climate conditions. | Bin He Chen Chen Shangrong Lin Wenping Yuan Hans WChen Deliang Chen Yafeng Zhang Lanlan Guo Xiang Zhao Xuebang Liu Shilong Piao Ziqian Zhong Rui Wang Rui Tang | 2022 | National Science Review2022，9，4： | 1 |
| 13 | Distribution and bioavailability of mercury in size-fractioned atmospheric particles around an ultra-low emission power plant in Southwest China显示文摘Ultra-low emission(ULE)technology retrofits significantly impact the particulate-bound mercury(Hg)emissions from coal-fired power plants(CFPPs);however,the distribution and bioavailability of Hg in size-fractioned particulate matter(PM)around the ULE-retrofitted CF-PPs are less understood.Here,total Hg and its chemical speciation in TSP(total suspended particles),PM_(10)(aerodynamic particle diameter≤10μm)and PM_(2.5)(aerodynamic particle diameter≤2.5μm)around a ULE-retrofitted CFPP in Guizhou Province were quantified.Atmospheric PM_(2.5)concentration was higher around this ULE-retrofitted CFPP than that in the intra-regional urban cities,and it had higher mass Hg concentration than other sizefractioned PM.Total Hg concentrations in PM had multifarious sources including CFPP,vehicle exhaust and biomass combustion,while they were significantly higher in autumn and winter than those in other seasons(P<0.05).Regardless of particulate size,atmospheric PM-bound Hg had lower residual fractions(<21%)while higher HCl-soluble fractions(>40%).Mass concentrations of exchangeable,HCl-soluble,elemental,and residual Hg in PM_(2.5)were higher than those in other size-fractioned PM,and were markedly elevated in autumn and winter(P<0.05).In PM_(2.5),HCl-soluble Hg presented a significantly positive relationship with elemental Hg(P<0.05),while residual Hg showed the significantly positive relationships with HCl-soluble Hg and elemental Hg(P<0.01).Overall,these results suggested that atmospheric PM-bound Hg around the ULE-retrofitted CFPP tends to accumulate in finer PM,and has higher bioavailable fractions,while has potential transformation between chemical speciation. | Wei Zhang Jinjuan Li Hao Qiu Xingqiang Guo Zhijun Fei Yi Xing Deliang Yin | 2024 | Journal of Environmental Sciences2024，，4： | 0 |
| 14 | Exposures to temperature beyond threshold disproportionately reduce vegetation growth in the northern hemisphere显示文摘In recent decades,terrestrial vegetation in the northern hemisphere(NH)has been exposed to warming and more extremely high temperatures.However,the consequences of these changes for terrestrial vegetation growth remain poorly quantifed and understood.By examining a satellite-based vegetation index,tree-ring measurements and land-surface model simulations,we discovered a consistent convex patern in the responses of vegetation growth to temperature exposure(TE)for forest,shrub and grass in both the temperate(30°-50°N)and boreal(50°-70°N)NH during the period of 1982-2012.Te response of vegetation growth to TE for the three vegetation types in both the temperate and boreal NH increased convergently with increasing temperature,until vegetation type-dependent temperature thresholds were reached.A TE beyond these temperature thresholds resulted in disproportionately weak positive or even strong negative responses.Vegetation growth in the boreal NH was more vulnerable to extremely high-temperature events than vegetation growth in the temporal NH.Te non-linear responses discovered here provide new insights into the dynamics of northern terrestrial ecosystems in a warmer world. | Xiuchen Wu Weichao Guo Hongyan Liu Xiaoyan Li Changhui Peng Craig D.Allen Cicheng Zhang Pei Wang Tingting Pei Yujun Ma Yuhong Tian Zhaoliang Song Wenquan Zhu Yang Wang Zongshan Li Deliang Chen | 2019 | National Science Review2019，6，4： | 0 |
| 15 | The influence of increasing temperatures on highland barley yields and on the maximum cultivation altitude on the Tibetan Plateau显示文摘Highland barley(Hordeum vulgare Linn.cv.nudum Hook.f.)is the principal cereal crop over the Tibetan Plateau(TP).The response of highland barely to climate change in the past decades,especially in terms of yields still remains uncertain.In this study,its responses to climate change were investigated using daily weather data and agriculture data during 1961–2018.The results showed that the annual mean air temperature over the TP increased at 0.33°C per decade during 1961–2018,and the rate of warming increased with altitude,reaching 0.41°C per decade at altitudes of 4500–4700 m.The growing degree days(GDDs)increased by 9.6%during 2011–2018 compared with the 1960s,whereas low temperature degree days(LDDs)decreased by 40.3%over the same period,indicating that the thermal conditions for highland barley cultivation have improved.A strong relationship was observed between the yield of highland barley and LDDs(−0.76,p<0.001)than GDDs(0.58,p<0.001)in Xizang,where sufficient irrigation water is available from the melting of snow cover or glaciers.In Sichuan,with abundant precipitation,significant correlations were noticed between county-level barley yield and GDDs and LDDs(0.60,p<0.001;−0.65,p<0.001).In Qinghai,the dry regions,county-level yields were influenced significantly by temperature and precipitation.These results indicated that climate warming was beneficial to highland barley yield in most region of the TP,mainly due to decreased LDDs.The potential altitude at which highland barley cultivation is feasible increased by approximately 280–484 m during 2016–2018,compared with 1981–1983.In Xizang,highland barley could be cultivated up to an altitude of 4507 m a.s.l.between 2016 and 2018,and it increased to 4179 m a.s.l.in Qinghai.These results could help local government to take actions to adapt to global warming and improve food security. | Chun-Yi WANG Yan-Ling SONG Hans W.LINDERHOLM Yong LI Bo-Ting ZHANG Jun DU Feng-Xia LI Ming-Tian WANG Run-Yuan WANG Yong ZHU Jin-Xia XU Yan-Jun GUO Deliang CHEN | 2023 | Advances in Climate Change Research2023，14，4： | 0 |
| 16 | Glutamine-released ammonia acts as an unprecedented signaling molecule activating lipid production显示文摘In healthy humans, ammonia circulates in the bloodstream at a concentration around 11–32 μmol/L. Whether ammonia plays any physiological role has been unknown until a recent report published in Nature Metabolism.1 Ammonia, long thought to be a toxic waste product of amino acid metabolism, needs to be excreted from the human body as urea. Intriguingly, in this paper, Cheng et al1 for the first time reported that ammonia is not a waste product;rather, it is an unprecedented signaling molecule tying glucose and glutamine to lipid production in human cells. This study revealed that ammonia released from glutamine triggers a cascade of cellular processes leading to the activation of lipogenesis machinery for lipid production (Fig. 1). This discovery has major implications for developing treatments for human diseases such as cancers and metabolic syndromes, as dysregulated metabolism is a hallmark of these diseases. | Chunming Cheng Scott Kelsey Deliang Guo | 2023 | Genes & Diseases2023，10，2： | 0 |
| 17 | Guidelines for the diagnosis and treatment of pancreatic cancer in China (2021)显示文摘The incidence of pancreatic cancer has been rising worldwide,and its clinical diagnosis and treatment remain a great challenge.To present the update and improvements in the clinical diagnosis and treatment of pancreatic cancer in recent years,Chinese Pancreatic Association,the Chinese Society of Surgery,Chinese Medical Association revised the Guidelines for the Diagnosis and Treatment of Pancreatic Cancer in China(2014)after reviewing evidence-based and problem-oriented literature published during 2015-2021,mainly focusing on highlight issues regarding diagnosis and surgical treatment of pancreatic cancer,conversion strategies for locally advanced pancreatic cancer,treatment of pancreatic cancer with oligo metastasis,adjuvant and neoadjuvant therapy,standardized processing of surgical specimens and evaluation of surgical margin status,systemic treatment for unresectable pancreatic cancer,genetic testing,as well as postoperative follow up of patients with pancreatic cancer.Forty recommendation items were finally proposed based on the above issues,and the quality of evidence and strength of recommendations were graded using the Grades of Recommendation,Assessment,Development,and Evaluation system.This guideline aims to standardize the clinical diagnosis and therapy,especially surgical treatment of pancreatic cancer in China,and further improve the prognosis of patients with pancreatic cancer. | Yinmo Yang Xueli Bai Dapeng Bian Shouwang Cai Rufu Chen Feng Cao Menghua Dai Chihua Fang Deliang Fu Chunlin Ge Xiaochao Guo Chunyi Hao Jihui Hao Heguang Huang Zhixiang Jian Gang Jin Fei Li Haimin Li Shengping Li Weiqin Li Yixiong Li Hongzhen Li Tingbo Liang Xubao Liu Wenhui Lou Yi Miao Yiping Mou Chenghong Peng Renyi Qin Chenghao Shao Bei Sun Guang Tan Xiaodong Tian Huaizhi Wang Lei Wang Wei Wang Weilin Wang Junmin Wei Heshui Wu Wenming Wu Zheng Wu Jingyong Xu Changqing Yan Xiaoyu Yin Xianjun Yu Chunhui Yuan Taiping Zhang Jixin Zhang Jun Zhou Yupei Zhao on behalf of the Chinese Pancreatic Surgery Association | 2021 | Journal of Pancreatology2021，4，2： | 0 |
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