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| 1 | Optimization of process parameters for mature landfill leachate pretreatment using MAP precipitation显示文摘 | Wei LI Xiaowen DING Min LIU Yuewen GUO Lei LIU | 2012 | Frontiers of Environmental Science & Engineering2012，6，6： | 9 |
| 2 | Regulation of the homeostasis of hepatic endoplasmic reticulum and cytochrome P450 enzymes by autophagy显示文摘The endoplasmic reticulum(ER)is an intracellular organelle consisting of a continuous network of membranes.In the liver,the ER is highly active in protein modification,lipid metabolism,and xenobiotic detoxification.Maintaining these complicated processes requires elaborate control of the ER lumen environment as well as the ER volume.Increasing evidence suggests that autophagy plays a critical role in regulating the homeostasis of hepatic ER contents and levels of cytochrome P450(CYP)enzymes via selective ER-phagy.This review will provide an overview of ER-phagy,summarizing the possible roles of recently identified ER-phagy receptor proteins in regulating the homeostasis of hepatic ER and CYP enzymes as well as outlining the various implications of ER-phagy in ER-related liver diseases. | Xiaowen Ma Clayre Parson Wen-Xing Ding | 2018 | Liver Research2018，2，3： | 3 |
| 3 | Development and test of the Export Coefficient Model in the Upper Reach of the Yangtze River显示文摘 | Xiaowen Ding Zhenyao Shen Qian Hong Zhifeng Yang Xing Wu Ruimin Liu | 2009 | Journal of Hydrology2009，，3： | 3 |
| 4 | Preparation and rheological studies on the solvent based acrylic pressure sensitive ad- hesives with different crosslinking density 显示文摘 | Zhang Xiaowen Ding Yuting Zhang Guanli | 2011 | International Journal of Adhesion and Adhesives2011，31，7： | 1 |
| 5 | Preparation and rheological studies on the solvent based acrylic pressure sensitive adhesives with different crosslinking density显示文摘 | Xiaowen Zhang Yuting Ding Guanli Zhang | 2011 | International Journal of Adhesion & Adhesives2011，31，7： | 1 |
| 6 | Occupational Mercury Exposure at a Thermometer Facility-Jiangsu Province, 2019显示文摘Summary What is already known about this topic?Mercury is still used in the manufacture of some thermometers in China.This may pose health risks if exposure is not properly prevented and controlled.What is added by this report?An onsite investigation of a workplace at a thermometer facility in Jiangsu Province in 2019 found heavily elevated airborne and urinary mercury levels among a massive number of workers exposed to mercury. | Yanqiong Xu Xiaoling Zhang Yiliang Xin Xiaowen Liu Xing Sheng Enmin Ding Jingxin Xie Lei Han Hengdong Zhang Xin Liu | 2020 | China CDC weekly2020，2，42： | 1 |
| 7 | Emodin improves lipid and glucose metabolism in high fat diet-induced obese mice through regulating SREBP pathway.显示文摘 | Jinmei Li Lili Ding Baoliang Song Xu Xiao Meng Qi Qiaoling Yang Qiming Yang Xiaowen Tang Zhengtao Wang Li Yang | 2015 | European Journal of Pharmacology2015，，： | 1 |
| 8 | Accumulation and bioavailability of copper and nickel in wheat plants grown in contaminated soils from the oasis, northwest China显示文摘 | Shengli Wang Zhongren Nan Xiaowen Liu Yuan Li Song Qin Haixia Ding | 2009 | Geoderma2009，，3： | 1 |
| 9 | Long-term variation (1960-2003) and causal factors of non-point-source nitrogen and phosphorus in the upper reach of the Yangtze River显示文摘 | SHEN Zhenyao CHEN Lei DING Xiaowen | 2013 | Journal of Hazardous Materials2013，25，： | 1 |
| 10 | Emergence of a novel reassortant avian influenza virus(H10N3) in Eastern China with high pathogenicity and respiratory droplet transmissibility to mammals显示文摘Decades have passed since the first discovery of H10-subtype avian influenza virus(AIV) in chickens in 1949,and it has been detected in many species including mammals such as minks,pigs,seals and humans.Cases of human infections with H10N8viruses identified in China in 2013 have raised widespread attention.Two novel reassortant H10N3 viruses were isolated from chickens in December 2019 in eastern China during routine surveillance for AIVs.The internal genes of these viruses were derived from genotype S(G57) H9N2 and were consistent with H5N6,H7N9 and H10N8,which cause fatal infections in humans.Their viral pathogenicity and transmissibility were further studied in different animal models.The two H10N3 isolates had low pathogenicity in chickens and were transmitted between chickens via direct contact.These viruses were highly pathogenic in mice and could be transmitted between guinea pigs via direct contact and respiratory droplets.More importantly,these viruses can bind to both human-type SAα-2,6-Gal receptors and avian-type SAα-2,3-Gal receptors.Asymptomatic shedding in chickens and good adaptability to mammals of these H10N3 isolates would make it easier to transmit to humans and pose a threat to public health. | Kaituo Liu Pingyun Ding Yuru Pei Ruyi Gao Wenwen Han Huafen Zheng Zhuxing Ji Miao Cai Jinyuan Gu Xiuli Li Min Gu Jiao Hu Xiaowen Liu Shunlin Hu Pinghu Zhang Xiaobo Wang Xiaoquan Wang Xiufan Liu | 2022 | Science China(Life Sciences)2022，65，5： | 1 |
| 11 | Long-term variation (1960-2003) and causal factors of non-point-source nitrogen and phosphorus in the upper reach of the Yangtze River 显示文摘 | SHEN Zhenyao CHEN Lei DING Xiaowen | 2013 | Journal of Hazardous Materials2013，25，： | 1 |
| 12 | Development and test of the export coefficient model in the upper reach of the yangtze river显示文摘 | Ding Xiaowen Shen Zhenyao Hong Qian | 2010 | Journal of Hydrology2010，383，： | 1 |
| 13 | Development and test of the export coefficient model in the upper reach of the Yangtze River显示文摘 | Ding Xiaowen Shen Zhenyao Hong Qian | 2010 | Journal of Hydrology2010，383，3： | 1 |
| 14 | Mitochondrial 12S rRNA variants in 1642 Han Chinese pediatric subjects with aminoglycoside-induced and nonsyndromic hearing loss显示文摘 | Jianxin Lu Zhiyuan Li Yi Zhu Aifen Yang Ronghua Li Jing Zheng Qin Cai Guanghua Peng Wuwei Zheng Xiaowen Tang Bobei Chen Jianfu Chen Zhisu Liao Li Yang Yongyan Li Junyan You Yu Ding Hong Yu Jindan Wang Dongmei Sun Jianyue Zhao Ling Xue Jiying Wang Min-Xin | 2010 | Mitochondrion2010，，4： | 1 |
| 15 | Hemodialysis to the platelet aggregation of uremia and CD41, CD61, CD42显示文摘 | Tu Xiaowen Zhang Aiping Ding RH | 2001 | Clin Inter2001，18，2： | 1 |
| 16 | Development and test of the Export Coefficient Model in the Upper Reach of the Yangtze River 显示文摘 | DING Xiaowen SHEN Zhenyao HONG Qian | 2010 | Journal of Hydrology2010，383，： | 1 |
| 17 | Fast response chlorine gas sensor based on mesoporous SnO 2显示文摘 | Ding Wang Ping Hu Jiaqiang Xu Xiaowen Dong Qingyi Pan | 2009 | Sensors & Actuators: B. Chemical2009，，： | 1 |
| 18 | Pharmacokinetics of propafenone hydrochloride sustained-release capsules in male beagle dogs显示文摘This paper describes the development and validation of a liquid chromatography–mass spectrometric assay for propafenone and its application to a pharmacokinetic study of propafenone administered as a new propafenone hydrochloride sustained-release capsule(SR-test), as an instant-release tablet(IR-reference) and as the market leader sustained-release capsule(Rythmol, SR-reference) in male beagle dogs(n ? 8). In Study A comparing SR-test with IR-reference in a crossover design T_(max) and t_(1/2) of propafenone for SR-test were significantly higher than those for IR-reference while C_(max) and AUC were lower demonstrating the sustained release properties of the new formulation. In Study B comparing SRtest with SR-reference the observed C_(max) and AUC of propafenone for SR-test(124.57140.0 ng/m L and612.07699.2 ng·h/m L, respectively) were higher than for SR-reference(78.52772.92 ng/m L and423.67431.6 ng·h/m L, respectively) although the differences were not significant. Overall, the new formulation has as good if not better sustained release characteristics to the market leader formulation. | Liping Pan Yafang Qian Minlu Cheng Pan Gu Yanna He Xiaowen Xu Li Ding | 2015 | Acta Pharmaceutica Sinica B2015，5，1： | 1 |
| 19 | Correlation between Load of HPV 16 DNA in Cervical Cancer and HPV 16 DNA in Lymph Nodes显示文摘OBJECTIVE To determine the association between viral loadof human papillomavirus 16 (HPV16) DNA in the primary focusof cervical carcinoma and HPV16 DNA in pelvic lymph nodes.METHODS The HPV16 DNA load was measured by fluorescentquantitation polymerase chain reaction (FQ-PCR) in 17 primaryfoci. HPV16 DNA was detected by polymerase chain reaction(PCR) using HPV16 type-specific primers in 296 pelvic lymphnodes which were from 17 cases of cervical cancer.RESULTS The viral load of HPV16 DNA showed statisticallysignificant differences between tumors with a diameter of < 4cm and ≥ 4 cm (P < 0.05). Seven of 17 cervical cancer cases hadHPV16 DNA positive lymph nodes, designated as the positivegroup, while the remaining 10 without positive lymph nodes wasdesignated the negative group. The average load of HPV16 DNAshowed no significant difference between the 2 groups (P > 0.05).The load of HPV16 in the primary lesion was not associated withthat in the lymph nodes. There were 38 HPV16 DNA positivenodes in the total 296 nodes. The rate of positivity of HPV16 DNAin lymph nodes showed statistically significant differences inconsideration of maximum tumor diameter, tumor differentiation,histologic type, depth of myometial infiltration and the metastaticstatus of the nodes, respectively (P < 0.05).CONCLUSION Viral load of HPV16 in the primary cancer focuscorrelated with the quantity of tumor cells in the primary focusbut not with the existence of HPV DNA positive lymph nodes.Detection of HPV DNA may help to find the early metastases thatcannot be evaluated histopathologically, but the prognostic valueof HPV positive lymph nodes needs further examination. | Shuzhen Dai Ding Ma Weidong Qu Xiaowen Xu | 2009 | Clinical oncology and cancer resexreh2009，6，6： | 0 |
| 20 | High-throughput screening of novel TFEB agonists in protecting against acetaminopheninduced liver injury in mice显示文摘Macroautophagy(referred to as autophagy hereafter)is a major intracellular lysosomal degradation pathway that is responsible for the degradation of misfolded/damaged proteins and organelles.Previous studies showed that autophagy protects against acetaminophen(APAP)-induced injury(AILI)via selective removal of damaged mitochondria and APAP protein adducts.The lysosome is a critical organelle sitting at the end stage of autophagy for autophagic degradation via fusion with autophagosomes.In the present study,we showed that transcription factor EB(TFEB),a master transcription factor for lysosomal biogenesis,was impaired by APAP resulting in decreased lysosomal biogenesis in mouse livers.Genetic loss-of and gain-of function of hepatic TFEB exacerbated or protected against AILI,respectively.Mechanistically,overexpression of TFEB increased clearance of APAP protein adducts and mitochondria biogenesis as well as SQSTM1/p62-dependent non-canonical nuclear factor erythroid 2-related factor 2(NRF2)activation to protect against AILI.We also performed an unbiased cell-based imaging high-throughput chemical screening on TFEB and identified a group of TFEB agonists.Among these agonists,salinomycin,an anticoccidial and antibacterial agent,activated TFEB and protected against AILI in mice.In conclusion,genetic and pharmacological activating TFEB may be a promising approach for protecting against AILI. | Xiaojuan Chao Mengwei Niu Shaogui Wang Xiaowen Ma Xiao Yang Hua Sun Xujia Hu Hua Wang Li Zhang Ruili Huang Menghang Xia Andrea Ballabio Hartmut Jaeschke Hong-Min Ni Wen-Xing Ding | 2024 | Acta Pharmaceutica Sinica B2024，14，1： | 0 |
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