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| 1 | Reactive capillary hemangiomas: a novel dermatologic toxicity following anti-PD-1 treatment with SHR-1210显示文摘Objective: SHR-1210 is a new and promising anti-PD-1 agent for solid tumors. During the phase I study of SHR-1210, we encountered a novel but prevalent immune-related dermatologic toxicity: reactive capillary hemangiomas(RCHs). Thus we tried to summarize the features of RCHs and estimate their relationship with tumor response.Methods: This prospective observational study systematically enrolled 98 patients with advanced solid tumors from April 27th,2016 to June 8th, 2017 in the context of the phase I clinical study of SHR-1210. This report focused on the skin toxicities. Patients underwent entire skin inspection every two weeks while taking medication. The clinical course of RCHs was recorded and their association with tumor response was estimated. The data cut-off date was November 15th, 2017.Results: After a median follow-up of 242(range, 29–567) days, RCHs were observed in 85.7%(84/98) of patients on cutaneous/mucosal surfaces; 84.5%(71/84) of the RCHs were evaluated as grade 1 adverse events. No grade 3 or 4 RCHs were observed. The time of onset of RCHs was dose dependent and shortest in the 400 mg-dose cohort(P < 0.001). Spontaneous and complete regression of RCHs was observed both during and after treatment. The objective response rate of tumors for patients with RCHs was 28.9%(24/83). However, no responders were observed among the patients without RCHs.Conclusions: RCHs were prevalent but manageable during treatment with SHR-1210. It might add to the expanding literature regarding immune-related dermatologic adverse events. | Xuelian Chen Lanying Ma Xi Wang Hongnan Mo Dawei Wu Bo Lan Dong Qu Hongtu Zhang Jing Huang Binghe Xu | 2019 | Cancer Biology & Medicine2019，16，1： | 53 |
| 2 | Geochronologic Constraints on the Magmatic Underplating of the Gangdisê Belt in the India-Eurasia Collision: Evidence of SHRIMP II Zircon U-Pb Dating显示文摘丰富的小 mafic 侵入发生沿着 theGangdise magmatic 与 granitoids 联系了带。除了在 granitoid plutons 以内的许多分离斑粝岩身体, agabbro 辉岩地区沿着 Gangdise 带的南部的边缘发生到 theYarlung Zangbo 缝术的北方。mafic 侵入地区空间地对应于一个强壮的空中地磁学的异例,它扩大约 1400 km。mafic 侵入由斑粝岩和粗玄岩的间歇地分布式的小身体和堤组成与辉岩,橄榄石辉岩, pegmatitic 辉岩和角闪岩积累。许多证据显示 Gangdise gabbro-pyroxeniteassemblage 是最可能的结果在导出披风的岩浆的 plating 下面。详细的地调查和 mafic 岩石的系统的采样在六个地点被进行,沿着 mafic intrusive 地区的 theLhasa-Xigaze 片断,并且被标明日期的锆石虾 II U-Pb 跟随。除了二岁,样品以前出版了(47.0 +- 1 个妈和 48.9 +- 1.1 妈) ,四斑粝岩取样的留下的同位素年龄是 51.6 +- 1.3Ma, 52.5 +- 3.0 妈, 50.2 +-第 4.2Maa 49.9 +- 1.1Ma。年龄(47-52.5 妈) 提供的这些的范围在 Gangdise 下面在 plating 下面岩浆预定的 Eocene 上的 geochronologic 限制在 ca 系上带子。50 妈。这在 plating 下面 eventpost 过时到 1500 万年的印度欧亚大陆大陆碰撞的开始并且与岩浆混合的一个过程是同时期的。虾 II U-Pb 同位素分析也从一些锆石谷物发现几老年,主要在 479-526 妈的一个范围(加权的平均年龄 503+- 10 妈) ,当时,因此关于先存在的下地壳产出信息在 maficmagma 的 plating 下面发生。在 plating 下面的岩浆在印度欧亚大陆的碰撞期间是为外壳的生长的主要机制之一,这被相信,可能相应及时到 the14-16 的形成 km 厚“外壳披风过渡地区”由 Vp = 6.85-6.9 km/s 描绘了。 | DONG Guochen MO Xuanxue ZHAO Zhidan GUO Tieying WANG Liangliang CHEN Tao | 2005 | Acta Geologica Sinica(English Edition)2005，79，6： | 50 |
| 3 | Asymptotically Optimal Scenario Analysis and Wait-and-See Model for Optimal Power Flow With Wind Power显示文摘精确模拟风功率分布的场景,有效求解反映风电随机性的最优潮流模型,对大规模风电并网的经济调度、质量控制及安全运行均具有重要意义。引入风电随机变量,建立最优潮流的"wait-and-see"(WS-OPF)模型;采用优于其他指标的瓦瑟斯坦(Wasserstein)距离为衡量指标,形成与风功率概率分布最优近似的场景模型,生成渐近最优场景,获得潮流分布及机组最优出力等指导调度安全经济运行的重要信息。最后,以IEEE 30和IEEE 300系统为例,对比各种距离指标的模拟精度,验证Wasserstein距离的优良性;同时,与不考虑风电随机性的模型相比,WS-OPF模型能更好地模拟风功率随机特性,提供与实际发生的风功率相近的调度方案,从而合理地规避风电接入电网的风险,提高风电的消纳能力。 | LI Jinghua WEI Hua MO Dong | 2012 | 中国电机工程学报2012，32，22： | 27 |
| 4 | Selective catalytic methanation of CO in hydrogen-rich gases over Ni/ZrO_2 catalyst显示文摘Ni/ZrO2 catalysts were prepared by the incipient-wetness impregnation method and were investigated in activity and selectivity for the selective catalytic methanation of CO in hydrogen-rich gases with more than 20 vol% CO2. The result showed that Ni loadings significantly influenced the performance of Ni/ZrO2 catalyst. The 1.6 wt% Ni loading catalyst exhibited the highest catalytic activity among all the catalysts in the selective methanation of CO in hydrogen-rich gas. The outlet concentration of CO was less than 20 ppm with the hydrogen consumption below 7%, at a gas-hourly-space velocity as high as 10000 h-1 and a temperature range of 260 °C to 280 °C. The X-ray diffraction (XRD) and temperature programmed reduction (TPR) measurements showed that NiO was dispersed thoroughly on the surface of ZrO2 support if Ni loading was under 1.6 wt%. When Ni loading was increased to 3 wt% or above, the free bulk NiO species began to assemble, which was not favorable to increase the selectivity of the catalyst. | Qihai Liu Xinfa Dong Xinman Mo Weiming Lin | 2008 | Journal of Natural Gas Chemistry2008，17，3： | 22 |
| 5 | Constructed wetlands for wastewater treatment in cold climate--A review显示文摘Constructed wetlands(CWs) have been successfully used for treating various wastewaters for decades and have been identified as a sustainable wastewater management option worldwide.However,the application of CW for wastewater treatment in frigid climate presents special challenges.Wetland treatment of wastewater relies largely on biological processes,and reliable treatment is often a function of climate conditions.To date,the rate of adoption of wetland technology for wastewater treatment in cold regions has been slow and there are relatively few published reports on CW applications in cold climate.This paper therefore highlights the practice and applications of treatment wetlands in cold climate.A comprehensive review of the effectiveness of contaminant removal in different wetland systems including:(1) free water surface(FWS) CWs;(2) subsurface flow(SSF) CWs;and(3) hybrid wetland systems,is presented.The emphasis of this review is also placed on the influence of cold weather conditions on the removal efficacies of different contaminants.The strategies of wetland design and operation for performance intensification,such as the presence of plant,operational mode,effluent recirculation,artificial aeration and in-series design,which are crucial to achieve the sustainable treatment performance in cold climate,are also discussed.This study is conducive to further research for the understanding of CW design and treatment performance in cold climate. | Mo Wang Dong Qing Zhang Jian Wen Dong Soon Keat Tan | 2017 | Journal of Environmental Sciences2017，29，7： | 19 |
| 6 | Patients Aged 80 Years or Older are Encountered More Potentially Inappropriate Medication Use显示文摘 | Li Mo Ding Ding Shi-Yun Pu Qin-Hui Liu Hong Li Bi-Rong Dong Xiao-Yan Yang Jin-Han He | 2016 | Chinese Medical Journal2016，，1： | 16 |
| 7 | Major advances in studies of the physical geography and living environment of China during the past 70 years and future prospects显示文摘The natural environment provides material essentials for human survival and development. The characteristics,processes, regional differentiation and forcing mechanisms of the elements of the natural environment(e.g. geomorphology,climate, hydrology, soil, etc.) are the main objects of research in physical geography. China has a complex natural environment and huge regional differentiation and therefore it provides outstanding reserach opportunities in physical geography. This review summarizes the most important developments and the main contributions of research in the physical geography and human living environment in China during the past 70 years. The major topics addressed are the uplift of the Tibetan Plateau and the evolution of its cryosphere, the development of fluvial systems, the acidification of the vast arid region of the Asian interior, variations in the monsoon and westerly climate systems on multiple timescales, the development of lakes and wetlands, the watershed system model, soil erosion, past human-environment interactions, biogeography, and physical geographic zonality. After briefly introducing international research developments, we review the history of research in physical geography in China, focusing on the major achievements and major academic debates, and finally we summarize the status of current research and the future prospects. We propose that in the context of the national demand for the construction of an ecological civilization, we should make full use of the research findings of physical geography, and determine the patterns and mechanisms of natural environmental processes in order to continue to promote the continued contribution of physical geography to national development strategies, and to further contribute to the theory of physical geography from a global perspective. | Fahu CHEN Bojie FU Jun XIA Duo WU Shaohong WU Yili ZHANG Hang SUN Yu LIU Xiaomin FANG Boqiang QIN Xin LI Tingjun ZHANG Baoyuan LIU Zhibao DONG Shugui HOU Lide TIAN Baiqing XU Guanghui DONG Jingyun ZHENG Wei YANG Xin WANG Zaijun LI Fei Wang Zhenbo HU Jie WANG Jianbao LIU Jianhui CHEN Wei HUANG Juzhi HOU Qiufang CAI Hao LONG Ming JIANG Yaxian HU Xiaoming FENG Xingguo MO Xiaoyan YANG Dongju ZHANG Xiuhong WANG Yunhe YIN Xiaochen LIU | 2019 | Science China Earth Sciences2019，62，11： | 11 |
| 8 | Petrogenesis and tectonic implications of early Paleozoic granitoids in East Kunlun belt: Evidences from geochronology, geochemistry and isotopes显示文摘The East Kunlun Orogenic Belt(EKOB) provides an important link to reconstruct the evolution of the Proto-Tethys and Paleo-Tethys realm. The EKOB is marked by widespread Early Paleozoic magmatism.Here we report the petrology, bulk geochemistry, zircon Ue Pb dating and, Lue Hf and SreN d isotopic data of the Early Paleozoic granitic rocks in Zhiyu area of the southern EKOB. Based on the zircon U-Pb dating, these granitoids, consisting of diorite, granodiorite and monzogranite, were formed during 450 -430 Ma the Late Ordovician to Middle Silurian. The diorite and granodiorite are high Sr/Y ratio as adakitic affinities, and the monzogranite belongs to highly fractionated I-type. Their(^(87)Sr/^(86)Sr)ivalues range from 0.7059 to 0.7085, εNd(t) values from -1.6 to -6.0 and the zircon εHf(t) values show large variations from +9.1 to -8.6 with Hf model ages(T_(DM2)) about 848 Ma and 1970 Ma. The large variations of whole-rock Nd and zircon Hf isotopes demonstrate strong isotopic heterogeneity of the source regions which probably resulted from multi-phase underplating of mantle-derived magmas. Geochemical and isotopic studies proved that the diorite and granodiorite had been derived from partial melting of heterogeneous crustal source with variable contributions from ancient continental crust and juvenile components, and the monzogranites were representing fractional crystallization and crustal contamination for arc magma. The Early Paleozoic adakitic rocks and high-K calc-alkaline granitoids in the southern EKOB were likely emplaced in a continental marginal arc setting possibly linked to the southwards subduction of the Paleo Kunlun Ocean and the magma generation is linked to partial melting of thickened continental crust induced by underplating of mantle-derived magmas. | Guochen Dong Mingfei Luo Xuanxue Mo Zhidan Zhao Liangqiong Dong Xuehui Yu Xin Wang Xiaowei Li Xiongfei Huang Yanbin Liu | 2018 | Geoscience Frontiers2018，9，5： | 10 |
| 9 | Onset of Coronary Heart Disease is Associated with HCMV Infection and Increased CD14^+CD16^+Monocytes in a Population of Weifang,China显示文摘Objective To investigate the relationship between human cytomegalovirus(HCMV)infection and peripheral blood CD14+CD16+monocytes in the pathogenesis of coronary heart disease(CHD),and to elucidate the mechanism of pathogenesis in CHD by analyzing the correlation between infection,inflammation,and CHD,to provide a basis for the prevention,evaluation,and treatment of the disease.Methods In total,192 patients with CHD were divided into three groups:latent CHD,angina pectoris,and myocardial infarction.HCMV-IgM and-IgG antibodies were assessed using ELISA;CD14+CD16+monocytes were counted using a five-type automated hematology analyzer;mononuclear cells were assessed using fluorescence-activated cell sorting;and an automatic biochemical analyzer was used to measure the levels of triglyceride,cholesterol,high-and low-density lipoprotein cholesterols,lipoprotein,hs-CRp and Hcy.Results The positive rates of HCMV-IgM and-IgG were significantly higher in the CHD groups than in the control group.HCMV infection affects lipid metabolism to promote immune and inflammatory responses.Conclusion HCMV infection has a specific correlation with the occurrence and development of CHD.The expression of CD14+CD16+mononuclear cells in the CHD group was increased accordingly and correlated with acute HCMV infection.Thus,HCMV antibody as well as peripheral blood CD14+CD16+mononuclear cells can be used to monitor the occurrence and development of CHD. | LI Hong Zheng WANG Qin ZHANG Yi Yuan WANG Jin Dong WU Hong Juan ZHANG Mo Gen LI Ji Chen LIU Zhi Jun | 2020 | Biomedical and Environmental Sciences2020，33，8： | 8 |
| 10 | Association of Overlapped and Un-overlapped Comorbidities with COVID-19 Severity and Treatment Outcomes: A Retrospective Cohort Study from Nine Provinces in China显示文摘Objective Several COVID-19 patients have overlapping comorbidities. The independent role of each component contributing to the risk of COVID-19 is unknown, and how some non-cardiometabolic comorbidities affect the risk of COVID-19 remains unclear.Methods A retrospective follow-up design was adopted. A total of 1,160 laboratory-confirmed patients were enrolled from nine provinces in China. Data on comorbidities were obtained from the patients’ medical records. Multivariable logistic regression models were used to estimate the odds ratio(OR) and 95% confidence interval(95% CI) of the associations between comorbidities(cardiometabolic or non-cardiometabolic diseases), clinical severity, and treatment outcomes of COVID-19.Results Overall, 158(13.6%) patients were diagnosed with severe illness and 32(2.7%) had unfavorable outcomes. Hypertension(2.87, 1.30–6.32), type 2 diabetes(T2 DM)(3.57, 2.32–5.49),cardiovascular disease(CVD)(3.78, 1.81–7.89), fatty liver disease(7.53, 1.96–28.96), hyperlipidemia(2.15, 1.26–3.67), other lung diseases(6.00, 3.01–11.96), and electrolyte imbalance(10.40, 3.00–26.10)were independently linked to increased odds of being severely ill. T2 DM(6.07, 2.89–12.75), CVD(8.47,6.03–11.89), and electrolyte imbalance(19.44, 11.47–32.96) were also strong predictors of unfavorable outcomes. Women with comorbidities were more likely to have severe disease on admission(5.46,3.25–9.19), while men with comorbidities were more likely to have unfavorable treatment outcomes(6.58, 1.46–29.64) within two weeks.Conclusion Besides hypertension, diabetes, and CVD, fatty liver disease, hyperlipidemia, other lung diseases, and electrolyte imbalance were independent risk factors for COVID-19 severity and poor treatment outcome. Women with comorbidities were more likely to have severe disease, while men with comorbidities were more likely to have unfavorable treatment outcomes. | MA Yan ZHU Dong Shan CHEN Ren Bo SHI Nan Nan LIU Si Hong FAN Yi Pin WU Gui Hui YANG Pu Ye BAI Jiang Feng CHEN Hong CHEN Li Ying FENG Qiao GUO Tuan Mao HOU Yong HU Gui Fen HU Xiao Mei HU Yun Hong HUANG Jin HUANG Qiu Hua HUANG Shao Zhen JI Liang JIN Hai Hao LEI Xiao LI Chun Yan LI Min Qing LI Qun Tang LI Xian Yong LIU Hong De LIU Jin Ping LIU Zhang MA Yu Ting MAO Ya MO Liu Fen NA Hui WANG Jing Wei SONG Fang Li SUN Sheng WANG Dong Ting WANG Ming Xuan WANG Xiao Yan WANG Yin Zhen WANG Yu Dong WU Wei WU Lan Ping XIAO Yan Hua XIE Hai Jun XU Hong Ming XU Shou Fang XUE Rui Xia YANG Chun YANG Kai Jun YUAN Sheng Li ZHANG Gong Qi ZHANG Jin Bo ZHANG Lin Song ZHAO Shu Sen ZHAO Wan Ying ZHENG Kai ZHOU Ying Chun ZHU Jun Teng ZHU Tian Qing ZHANG Hua Min WANG Yan Ping WANG Yong Yan 无 | 2020 | Biomedical and Environmental Sciences2020，33，12： | 8 |
| 11 | Super-resolution fluorescence-assisted diffraction computational tomography reveals the threedimensional landscape of the cellular organelle interactome显示文摘The emergence of super-resolution(SR)fluorescence microscopy has rejuvenated the search for new cellular substructures.However,SR fluorescence microscopy achieves high contrast at the expense of a holistic view of the interacting partners and surrounding environment.Thus,we developed SR fluorescence-assisted diffraction computational tomography(SR-FACT),which combines label-free three-dimensional optical diffraction tomography(ODT)with two-dimensional fluorescence Hessian structured illumination microscopy.The ODT module is capable of resolving the mitochondria,lipid droplets,the nuclear membrane,chromosomes,the tubular endoplasmic reticulum,and lysosomes.Using dual-mode correlated live-cell imaging for a prolonged period of time,we observed novel subcellular structures named dark-vacuole bodies,the majority of which originate from densely populated perinuclear regions,and intensively interact with organelles such as the mitochondria and the nuclear membrane before ultimately collapsing into the plasma membrane.This work demonstrates the unique capabilities of SR-FACT,which suggests its wide applicability in cell biology in general. | Dashan Dong Xiaoshuai Huang Liuju Li Heng Mao Yanquan Mo Guangyi Zhang Zhe Zhang Jiayu Shen Wei Liu Zeming Wu Guanghui Liu Yanmei Liu Hong Yang Qihuang Gong Kebin Shi Liangyi Chen | 2020 | Light(Science & Applications)2020，9，1： | 7 |
| 12 | The combination of PD-1 blockade with interferon-αhas a synergistic effect on hepatocellular carcinoma显示文摘Background The efficacy of immune checkpoint inhibitors(ICIs),such as programmed cell death protein-1(PD-1)or its ligand 1(PD-L1)antibody,in hepatocellular carcinoma(HCC)is limited,and it is recommended that they be combined with other therapies.We evaluated the combination of pegylated interferon-α(Peg-IFNα)with PD-1 blockade in HCC mouse models.Methods We analyzed the effects of Peg-IFNαon tumor-infiltrating immune cells and PD-1 expression in the HCC immune microenvironment and examined the underlying mechanism of its unique effect on the PD-1 pathway.The in vivo efficacy of anti-PD-1 and Peg-IFNαwas evaluated in both subcutaneous and orthotopic mouse models of HCC.Results The combination of Peg-IFNαwith PD-1 blockade dramatically enhanced T-cell infiltration,improved the efficacy of PD-1 antibody and prolonged mouse survival compared with PD-1 antibody monotherapy.Mechanistically,Peg-IFNαcould recruit cytotoxic CD8+T cells to infiltrate the HCC microenvironment by inducing tumor cells to secrete the chemokine CCL4.Nevertheless,the HCC microenvironment quickly overcame the immune responses by upregulating PD-1 expression in CD8+T cells via the IFNα-IFNAR1-JAK1-STAT3 signaling pathway.The combination of PD-1 blockade with Peg-IFNαcould restore the cytotoxic capacity of CD8+T cells and exerted a significant synergistic effect on HCC.Conclusion These results indicate that in addition to initiating the antitumor immune response itself,Peg-IFNαcan also generate a microenvironment favoring PD-1 blockade.Thus,the combination of Peg-IFNαand PD-1 blockade can be a promising strategy for HCC. | Ying Zhu Mo Chen Da Xu Tian-En Li Ze Zhang Jian-Hua Li Xiang-Yu Wang Xin Yang Lu Lu Hu-Liang Jia Qiong-Zhu Dong Lun-Xiu Qin | 2022 | Cellular & Molecular Immunology2022，19，6： | 6 |
| 13 | Assessment of scoring systems for acute-on-chronic liver failure at predicting short-term mortality in patients with alcoholic hepatitis显示文摘AIM To assess the performance of proposed scores specific for acute-on-chronic liver failure in predicting shortterm mortality among patients with alcoholic hepatitis.METHODS We retrospectively collected data from 264 patients with clinically diagnosed alcoholic hepatitis from January to December 2013 at 21 academic hospitals in Korea. The performance for predicting short-term mortality was calculated for Chronic Liver FailureSequential Organ Failure Assessment(CLIF-SOFA), CLIF Consortium Organ Failure score(CLIF-C OFs), Maddrey'sdiscriminant function(DF), age, bilirubin, international normalized ratio and creatinine score(ABIC), Glasgow Alcoholic Hepatitis Score(GAHS), model for end-stage liver disease(MELD), and MELD-Na.RESULTS Of 264 patients, 32(12%) patients died within 28 d. The area under receiver operating characteristic curve of CLIF-SOFA, CLIF-C OFs, DF, ABIC, GAHS, MELD, and MELD-Na was 0.86(0.81-0.90), 0.89(0.84-0.92), 0.79(0.74-0.84), 0.78(0.72-0.83), 0.81(0.76-0.86), 0.83(0.78-0.88), and 0.83(0.78-0.88), respectively, for 28-d mortality. The performance of CLIF-SOFA had no statistically significant differences for 28-d mortality. The performance of CLIF-C OFs was superior to that of DF, ABIC, and GAHS, while comparable to that of MELD and MELD-Na in predicting 28-d mortality. A CLIF-SOFA score of 8 had 78.1% sensitivity and 79.7% specificity, and CLIF-C OFs of 10 had 68.8% sensitivity and 91.4% specificity for predicting 28-d mortality.CONCLUSION CLIF-SOFA and CLIF-C OF scores performed well, with comparable predictive ability for short-term mortality compared to the commonly used scoring systems in patients with alcoholic hepatitis. | Hee Yeon Kim Chang Wook Kim Tae Yeob Kim Do Seon Song Dong Hyun Sinn Eileen L Yoon Young Kul Jung Ki Tae Suk Sang Soo Lee Chang Hyeong Lee Tae Hun Kim Jeong Han Kim Hyung Joon Yim Sung Eun Kim Soon Koo Baik Byung Seok Lee Jae Young Jang Young Seok Kim Sang Gyune Kim Jin Mo Yang Joo Hyun Sohn Heon Ju Lee Seung Ha Park Eun Hee Choi Dong Joon Kim Korean Acute-on-Chronic Liver Failure Study Group | 2016 | World Journal of Gastroenterology2016，22，41： | 5 |
| 14 | Integrated genomic analysis identifies deregulated JAK/STAT-MYC-biosynthesis axis in aggressive NK-cell leukemia显示文摘好攻击的 NK 房间白血病(ANKL ) 是在从亚洲的人之中是更流行的 NK 房间瘤的一种稀罕形式并且中央并且南美洲。病人们通常在天以内死到月,甚至在收到迅速的治疗学的管理以后。这里,我们由集成整个染色体执行了 ANKL 的第一全面研究, transcriptome 并且定序指向,象功能的试金一样的 cytokine 数组。在 JAK-STAT 小径的变化在 48% 被识别(14/29 ) ANKL 病人,当细胞外的 STAT3 激发器 IL10 被 56 褶层的一般水准提高时(P < 0.0001 ) 在检查的所有病人的血浆。另外的经常变异的基因包括的 TP53 (34%) , TET2 (28%) , CREBBP (21%) 和 MLL2 (21%) 。耐心的 NK 白血病房间在多重新陈代谢的小径显示出 STAT3 phosphorylation, MYC 表示和 transcriptional 活动的突出的激活。机能上地, STAT3 激活和 MYC 表示为 ANKL 房间的增长和幸存是批评的。发信号的 STAT 调整了发信号的 MYC 抄写节目,和两 STAT, MYC 抄写被要求维持核苷酸合成和 glycolysis 的激活。一起, JAK-STAT 小径在 ANKL 为 genomic 改变和 IL10 刺激代表一个主要目标。这最新发现的 JAK/STAT-MYC-biosynthesis 轴可以在对待白血病的这种子类型为新奇治疗学的策略的发展提供机会。 | Liang Huang Dan Liu Na Wang Shaoping Ling Yuting Tang Jun Wu Lingtong Hao Hui Luo Xuelian Hu Lingshuang Sheng Lijun Zhu Di Wang Yi Luo Zhen Shang Min Xiao Xia Mao Kuangguo Zhou Lihua Cao Lili Dong Xinchang Zheng Pinpin Sui Jianlin He Shanlan Mo Jin Yan Qilin Ao Lugui Qiu Hongsheng Zhou Qifa Liu Hongyu Zhang Jianyong Li Jie Jin Li Fu Weili Zhao Jieping Chen Xin Du Guoliang Qing Hudan Liu Xin Liu Gang Huang Ding Ma Jianfeng Zhou Qian-fei Wang | 2018 | Cell Research2018，28，2： | 5 |
| 15 | Rapid synthesis of biodegradable poly(epsilon-caprolactone-co-p-dioxanone) random copolymers under microwave irradiation显示文摘Biodegradable poly(epsilon-caprolactone-co-p-dioxanone)(PCDO) random copolymers have been synthesized by ring-opening polymerization of epsilon-caprolactone(CL) and p-dioxanone(PDO) under microwave irradiation.The effects of irradiation time and different CL/PDO molar feed ratios on the microwave-assisted ring-opening polymerization(MROP) of PCDO have been discussed.The resultant products were characterized by ~1H NMR,GPC and DSC.It was found that the polymerization was completed within 20 min at 140℃.In... | Chen, Rui Hao, Jian Yuan Xiong, Cheng Dong Deng, Xian Mo | 2010 | Chinese Chemical Letters2010，21，2： | 4 |
| 16 | Stereotactic body radiotherapy for isolated paraaortic lymph node recurrence from colorectal cancer显示文摘AIM:To evaluate the efficacy and complications of stereotactic body radiotherapy in localized paraaortic lymph node recurrence from colorectal cancer.METHODS:From 2003 to 2009,7 patients with paraaortic lymph node recurrence(1-3 lesions)from colorectal cancer were treated with stereotactic body radiotherapy.Total gross tumor volumes ranged from 4 to 40 mL.The doses were escalated from 36 Gy/patient to 51 Gy/patient and were delivered in 3 fractions.RESULTS:One and 3 year overall survival rates were 100%and 71.4%,respectively,and median survival was 37 mo.GradeⅣintestinal obstruction was reported in 1 of 7 patients.This patient received 48 Gy in 3 fractions with a maximum point dose to the intestine of 53 Gy and V45Gy=3.6 mL.However,6 patients received an intestinal maximum point dose of<51 Gy and V45Gy of<1 mL,and did not develop any severe complications.CONCLUSION:This pilot study suggests selected paraaortic lymph node recurrence(1-3 closed lesions) that failed to respond to chemotherapy can be potentially salvaged by stereotactic body radiotherapy. | Mi-Sook Kim Chul Koo Cho Kwang Mo Yang Dong Han Lee Sun Mi Moon Young Joo Shin | 2009 | World Journal of Gastroenterology2009，15，48： | 4 |
| 17 | Study of low bit rate speech codec algorithm in underwater acoustic communication显示文摘At medium or long distance(> 10 km) underwater acoustic speech communication,information transfer rate is constrained by the complicated,time varying channel and limited bandwidth.The bit rate of speech coding is required to be as low as possible.The time delay of underwater acoustic wave propagation can be used for low bit rate speech coding.After investigating the Mixed Excitation Linear Prediction(MELP) standard and taking account of the auditory perceptual features,a variable and adjustable bit rate speech codec algorithm has been proposed,whose average bit rate is about 600 bps.The average Perceptual Evaluation of Speech Quality Mean Opinion Score(PESQ MOS) of synthesized speeches is about 2.8.It has been proved by the computer simulation and sea trial that the performance of the proposed algorithm is well and robust when bit error rate is no more than 10^(-3).The synthesized speech is vivid and intelligible,and keeps main individual characteristics of speaker. | XIAO Dong MO Fuyuan CHEN Geng GUO Shengming MA Li | 2013 | Chinese Journal of Acoustics2013，32，4： | 4 |
| 18 | EYA4 inhibits hepatocellular carcinoma growth and invasion by suppressing NF-κB-dependent RAP1 transactivation显示文摘Background:Our previous studies demonstrated that eyes absent homolog 4(EYA4),a member of the eye devel-opment-related EYA family in Drosophila,is frequently methylated and silenced in hepatocellular carcinoma(HCC)specimens and associated with shorter survival.The current work aimed to explore the mechanisms through which EYA4 functions as a tumor suppressor in HCC.Methods:Stable EYA4-expressing plasmid(pEYA4)transfectants of the human HCC cell lines Huh-7 and PLC/PRF/5(PLC)were established.Xenografts tumors were established via subcutaneous injection of the stable transfectants into BALB/c nude mice.Tissue samples were obtained from 75 pathologically diagnosed HCC patients.Quantitative real-time polymerase chain reaction,Western blotting and immunohistochemistry were performed to determine the expression of EYA4 in cell lines,xenografts and clinical specimens.The cell proliferation,colony formation,invasiveness and tumor formation of stable transfectants were studied.A gene expression microarray was utilized to screen genes regulated by EYA4 expression.The effect of EYA4 on nuclear factor-κB(NF-κB)/RAS-related protein 1(RAP1)signaling was demonstrated through the co-transfection of pEYA4 and Flag-tagged RAS-related protein 1A gene-expressing plasmid(Flag-RAP1A),functional studies,chromatin immunoprecipitation,immunofluorescence staining and cellular ubiquitination assay.Results:The restoration of EYA4 expression in HCC cell lines suppressed cell proliferation,inhibited clonogenic outgrowth,reduced cell invasion and restrained xenograft tumor growth,and Flag-RAP1A reversed the suppressive effects of pEYA4 in vitro.Activation of NF-κB with tumor necrosis factor-α(TNF-α)increased the binding of p65 to the RAP1A gene promoter and up-regulated RAP1 protein expression.The inhibition of NF-κB with BAY 11-7085 and p65 siRNA successfully blocked TNF-α-induced RAP1 up-regulation.EYA4 antagonized the TNF-α-induced phosphoryla-tion and ubiquitination of inhibitor of NF-κBα(IκBα)as well as the nuclear translocation and transactivation of p65,resulting in repressed NF-κB activity and RAP1 expression.Blocking the serine/threonine phosphatase activity of EYA4 with calyculin A notably abrogated its suppressive effect on NF-κB activity.In addition,EYA4 expression was inversely correlated with IκBα/RAP1 activity in clinical HCC specimens.Conclusion:Our findings provide a functional and mechanistic basis for identifying EYA4 as a bona fide tumor sup-pressor that disrupts aberrant activation of the NF-κB/RAP1 signaling pathway and thus orchestrates a physiological impediment to HCC growth and invasion. | Shi-Jing Mo Xun Hou Xiao-Yi Hao Jian-Peng Cai Xin Liu Wei Chen Dong Chen Xiao-Yu Yin | 2018 | Cancer Communications2018，38，1： | 4 |
| 19 | Alkali-activation reactivity of chemosynthetic Al_2O_3-2SiO_2 powders and their ^(27)Al and ^(29)Si magic-angle spinning nuclear magnetic resonance spectra显示文摘Pure Al_2O_3-2SiO_2 powders were prepared by sol-gel and coprecipitation methods,and their alkaliactivation reactivities were compared.The alkali-activation reactivity of the powder prepared by the sol-gel method was higher than that of the powder prepared by the coprecipitation method.The powders were investigated by ^(27)AI and ^(29)Si magic-angle spinning nuclear magnetic resonance spectroscopy(MAS NMR) to understand the relationship between their structure and alkali-activation reactivity.The ^(27)Al MAS NMR data showed that the five-coordinate AI content of the powder prepared by the sol-gel method was higher than that of the powder prepared by coprecipitation.The higher content of five-coordinate Al corresponded to higher alkali-activation reactivity.The ^(29)Si MAS NMR data showed that for the powder prepared by the sol-gel method,silicon was replaced by aluminum at secondary coordination sites of the central Si atoms during calcination.However,for the powder prepared by single-batch coprecipitation,the main change was from a low degree of polycondensation to a high degree of polycondensation. | Guangjian Zheng Xuemin Cui Dong Huang Jinying Pang Guowei Mo Shujuan Yu Zhangfa Tong | 2015 | Particuology2015，13，5： | 3 |
| 20 | Radiotherapy Plus Transarterial Chemoembolization for Hepatocellular Carcinoma Invading the Portal Vein: Long-Term Patient Outcomes显示文摘 | Sang Min Yoon Young-Suk Lim Hyung Jin Won Jong Hoon Kim Kang Mo Kim Han Chu Lee Young-Hwa Chung Yung Sang Lee Sung Gyu Lee Jin-hong Park Dong Jin Suh | 2012 | International Journal of Radiation Oncology, Biology, Physics2012，，5： | 3 |
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