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| 1 | Astragalus injection inhibits c-Jun N terminal kinase mRNA expression following oxygen-glucose deprivation and reintroduction in rat hippocampal neurons显示文摘BACKGROUND:In studies concerning cell injury induced by cerebral ischemia-reperfusion,current experiments have primarily focused on altered protein levels.In addition,the apoptotic proteins Bax and Bcl-2 have been thoroughly studied with regard to initiating neuronal apoptosis. OBJECTIVE:To establish an in vitro model of oxygen-glucose deprivation and reintroduction in the rat hippocampus to simulate cerebral ischemia-reperfusion injury;to observe c-Jun N-terminal kinase 3(JNK3) mRNA expression in hippocampal neurons following Astragalus injection;and thus to determine changes in the signaling and downstream pathways of neuronal apoptosis at the cellular and molecular level. DESIGN,TIME AND SETTING:A randomized,controlled,cellular and molecular experiment was performed at the Department of Central Laboratory,Chengde Medical College from February to June 2008. MATERIALS:Astragalus injection,the main ingredient of astragaloside,was purchased from Chengdu Di'ao Jiuhong Pharmaceutical Manufactory,China.JNK3 mRNA probe and in situ hybridization kit were purchased from Tianjin Haoyang Biological Technology,China,and JNK3 RT-PCR primers were designed by Shanghai Bio-engineering,China. METHODS:Primary cultures of hippocampal neurons derived from Sprague Dawley rats,aged 1-2 days,were established.After 8 days,the hippocampal neurons were assigned to the following interventions:model group,Astragalus group,and vehicle control group,cells were subjected to oxygen-glucose reintroduction after oxygen-glucose deprivation for 30 minutes in sugar-free Earle's solution and a hypoxia device,which contained high-purity nitrogen.The normal control group was subjected to primary culture techniques and was not treated using above-mentioned interventions. In addition,the Astragalus and vehicle control groups were treated with Astragalus injection(0.5 g/L raw drug) or sterile,deionized water at 2 hours prior to oxygen-glucose deprivation,respectively. MAIN OUTCOME MEASURES:JNK3 mRNA expression was measured by in situ hybridization and RT-PCR at 0,0.5,2,6,24,72,and 120 hours after oxygen-glucose reintroduction. RESULTS:Hippocampal neuronal morphology was normal in the normal control group. Hippocampal neurons exhibited apparent apoptosis-like pathological changes in the model,as well as the vehicle control,groups.The apoptosis-like pathological changes in the hippocampal neurons were less in the Astragalus group.Results from in situ hybridization and RT-PCR showed that JNK3 mRNA expression significantly increased in hippocampal neurons from model group,as well as the vehicle control group,compared with the normal control group(P<0.05).In addition,JNK3 mRNA expression significantly decreased in hippocampal neurons of the Astragalus group,compared with the model group and vehicle control group(P<0.05). CONCLUSION:Astragalus injection inhibited apoptosis-related JNK3 mRNA expression following oxygen-glucose deprivation and reintroduction,and accordingly played a role in inhibiting hippocampal neuronal apoptosis. | Dongqing Ye Weijuan Gao Fengxia Yan Tao Qian Yali Zhang | 2009 | Neural Regeneration Research2009，4，11： | 6 |
| 2 | Bevacizumab biosimilar LY01008 compared with bevacizumab(Avastin)as first-line treatment for Chinese patients with unresectable,metastatic,or recurrent non-squamous non-small-cell lung cancer:A multicenter,randomized,double-blinded,phase Ⅲ trial显示文摘Background:Previous studies have demonstrated the preclinical pharmacological and toxicological consistency,and clinical pharmacokinetic equivalence of bevacizumab biosimilar LY01008 with reference bevacizumab(Avastin).This randomized controlled trial aimed to compare the efficacy and safety of LY01008 with Avastin in first-line treatment of Chinese patients with advanced or recurrent non-squamous non-small cell lung cancer(NSCLC).Methods:StageⅢB-ⅣNSCLC patients with evaluable lesions,good physical status,and adequate organ functions from 67 centers across China were randomized in a ratio of 1:1 to receive LY01008 or Avastin 15 mg/kg intravenously in combination with paclitaxel/carboplatin(combined treatment)for 4-6 cycles,followed by maintenance monotherapy with LY01008 until disease progression,intolerable toxicity,or death.The primary endpoint was objective response rate(ORR)in accordance with Response Evaluation Criteria in Solid Tumors(RECIST)version 1.1 confirmed by independent radiological review committees(IRRC).Secondary endpoints included disease control rate(DCR),duration of response(DoR),progression-free survival(PFS),overall survival(OS),and safety.This study was registered in Clinical Trials.gov(NCT03533127).Results:Between December 15^(th),2017,and May 15^(th),2019,a total of 649 patients were randomized to the LY01008(n=324)or Avastin(n=325)group.As of September 25th,2019 for primary endpoint analysis,589 patients received ORR evaluation,with a median number of combined treatment cycles of 5(range 1-6)andmedian duration of treatment of 3.0(range 0.0-5.1)months.ORRof responseevaluable patients in the LY01008 and Avastin groups were 48.5% and 53.0%,respectively.The stratified ORR ratio was 0.91(90%CI 0.80-1.04,within the prespecified equivalence margin of 0.75-1.33).Up to May 15^(th),2020,with a median follow-up of 13.6(range 0.8-28.4)months,no notable differences in DCR,median DoR,median PFS,median OS,and 1-year OS rate were observed between the LY01008 and Avastin groups.There were no clinically meaningful differences in safety and immunogenicity across treatment groups.Conclusions:LY01008 demonstrated similarity to Avastin in terms of efficacy and safety in Chinese patients with advanced or recurrent non-squamous NSCLC.LY01008 combined with paclitaxel/carboplatin is expected to become a new treatment option for unresectable,metastatic,LY01008 and Avastin groups.There were no clinically meaningful differences in safety and immunogenicity across treatment groups.Conclusions:LY01008 demonstrated similarity to Avastin in terms of efficacy and safety in Chinese patients with advanced or recurrent non-squamous NSCLC.LY01008 combined with paclitaxel/carboplatin is expected to become a new treatment option for unresectable,metastatic,or recurrent non-squamous NSCLC patients in the first-line setting. | Yuankai Shi Kaijian Lei Yuming Jia Bingqiang Ni Zhiyong He Minghong Bi Xicheng Wang Jianhua Shi Ming Zhou Qian Sun Guolei Wang Dongji Chen Yongqian Shu Lianke Liu Zhongliang Guo Yong Liu Junquan Yang Ke Wang Ke Xiao LinWu Tienan Yi Debin Sun Mafei Kang Tianjiang Ma Yimin Mao Jinsheng Shi Tiegang Tang Yan Wang Puyuan Xing Dongqing Lv Wangjun Liao Zhiguo Luo Bin Wang Xiaohong Wu Xiaoli Zhu Shuhua Han Qisen Guo Rongyu Liu Zhiwei Lu Jianyong Zhang Jian Fang Changlu Hu Yinghua Ji Guolong Liu Hong Lu Dedong Wu Junhong Zhang Shuyang Zhu Zheng Liu Wensheng Qiu Feng Ye Yan Yu Yanqiu Zhao Qinhong Zheng Jun Chen Zhanyu Pan Yiping Zhang Wenjuan Lian Bo Jiang Bo Qiu Guojun Zhang Hua Zhang Yanju Chen Yuan Chen Hongbing Duan Manxiang Li Shengming Liu Lijun Ma Hongming Pan Xia Yuan Xueli Yuan Yulong Zheng Emei Gao Li Zhao Shumin Wang Can Wu | 2021 | Cancer Communications2021，41，9： | 5 |
| 3 | Studies on the properties of a thermosetting epoxy modified withchain-extended ureas containing hydroxyl- terminated polybutadiene显示文摘 | Xiaodong Tian Ye Geng Dongqing Yin | 2011 | Polymer Testing2011，30，： | 1 |
| 4 | Programmed cell death 1 genotypes are associated with susceptibility to systemic lupus erythematosus among Chinese显示文摘 | Qian Wang Dongqing Ye Jing Yin Xiangpei Li Guoqing Zhang Yongqing Zhang Xuejun Zhang | 2008 | Archives of Dermatological Research2008，，： | 1 |
| 5 | Long-term follow-up of a peer-led HIV/AIDS prevention program for married women in rural China显示文摘 | Hong Hang Ji Guoping Ye Dongqing | 2009 | IntJ Gvnaecol Obstet2009，106，1： | 1 |
| 6 | Comparison of skeletal and soft tissue pericytes identifies CXCR4+ bone forming mural cells in human tissues显示文摘Human osteogenic progenitors are not precisely defined,being primarily studied as heterogeneous multipotent cell populations and termed mesenchymal stem cells(MSCs).Notably,select human pericytes can develop into bone-forming osteoblasts.Here,we sought to define the differentiation potential of CD146 f human pericytes from skeletal and soft tissue sources,with the underlying goal of defining cell surface markers that typify an osteoblastogenic pericyte.CD146+CD31~CD45_pericytes were derived by fluorescence-activated cell sorting from human periosteum,adipose,or dermal tissue.Periosteal CD146+CD31—CD45 cells retained canonical features of pericytes/MSC.Periosteal pericytes demonstrated a striking tendency to undergo osteoblastogenesis in vitro and skeletogenesis in vivo,while soft tissue pericytes did not readily.Transcriptome analysis revealed higher CXCR4 signaling among periosteal pericytes in comparison to their soft tissue counterparts,and CXCR4 chemical inhibition abrogated ectopic ossification by periosteal pericytes.Conversely,enrichment of CXCR4+pericytes or stromal cells identified an osteoblastic/non-adipocytic precursor cell.In sum,human skeletal and soft tissue pericytes differ in their basal abilities to form bone.Diversity exists in soft tissue pericytes,however,and CXCR4+pericytes represent an osteoblastogenic,non-adipocytic cell precursor.Indeed,enrichment for CXCR4-expressing stromal cells is a potential new tactic for skeletal tissue engineering. | Jiajia Xu Dongqing Li Ching-Yun Hsu Ye Tian Leititia Zhang Yiyun Wang Robert J.Tower Leslie Chang Carolyn A.Meyers Yongxing Gao Kristen Broderick Carol Morris Jody E.Hooper Sridhar Nimmagadda Bruno Peault Aaron W.James | 2020 | Bone Research2020，8，3： | 1 |
| 7 | Deciphering built form complexity of Chinese cities through plot recognition:A case study of Nanjing,China显示文摘Dramatic changes in the economic systems and land rights in the recent history of China yielded unique but complex urban forms for many cities.The complexity of urban form is mostly manifested as ambiguous relations between elements of the physical form and between the physical form and human behavior.Currently,these ambiguities become obstacles that increasingly hinder urban regeneration.However,despite the fast-growing research on the morphology of Chinese cities,our understanding of the complexity of their built form is still in its infancy.Taking the city of Nanjing as the case study,this study attempts to decipher the complexity of its built form by investigating its plot patterns.Six samples,dating back to different development periods,are selected and analyzed in terms of both a physical entity and a unit of property.The results show that the complexity of plots is largely attributable to the inconsistency between their spatial boundaries as physical entities and as units of property.Accordingly,the plots of all six samples are re-recognized and two generic types of plot sub-series,co-inflection and embeddedness,are developed as a prism to decipher the built form complexity.The findings contribute to the theory on the compositional hierarchy of urban forms and may shed light on the urban regeneration of Chinese cities as well. | Yacheng Song Ye Zhang Dongqing Han | 2022 | Frontiers of Architectural Research2022，11，5： | 0 |
| 8 | A novel perylene diimide-based ionene polymer and its mixed cathode interlayer strategy for efficient and stable inverted perovskite solar cells显示文摘Inverted(p-i-n)perovskite solar cells(PerSCs)have attracted much attention owing to their low temperature processability,less hysteresis effect and easy integration as a subunit for the tandem device.The unsatisfactory interface contacts and energy level barrier between adjacent interlayers on the cathode side are one of the key challenges for the development of p-i-n PerSCs.Herein,perylene diimidebased(PDI)ionene polymer was synthesized and developed as a cathode interlayer(CIL)to enhance interface contact,reduce the energy level barrier and prevent the migration of I-ions.The compact PNPDI CIL with high conductivity and appropriate lowest unoccupied molecular orbital(LUMO)level,resulted in a high efficiency device(20.03%),which is higher than the control device with bathophenanthroline(Bphen)(19.48%).Bphen-based CIL shows better adjusting ability of the work function of cathode metal but exhibits poor film-forming property.So,the synergistic effect of 1+1>2 can be obtained by combining Bphen and PNPDI into one CIL.As expected,the device performance was further improved by using the mixed CIL of Bphen and PNPDI,and 21.46%power conversion efficiency(PCE)was achieved.What’s more,the compact and hydrophobic mixed CIL dramatically enhanced the resistance to I-ions and moisture,which led to much enhanced device stability. | Daizhe Wang Cong Kang Tengling Ye Dongqing He Shan Jin Xiaoru Zhang Xiaochen Sun Yong Zhang | 2023 | Journal of Energy Chemistry2023，，7： | 0 |
| 9 | Short‐time wind speed prediction based on Legendre multi‐wavelet neural network显示文摘As one of the most widespread renewable energy sources,wind energy is now an important part of the power system.Accurate and appropriate wind speed forecasting has an essential impact on wind energy utilisation.However,due to the stochastic and un-certain nature of wind energy,more accurate forecasting is necessary for its more stable and safer utilisation.This paper proposes a Legendre multiwavelet‐based neural network model for non‐linear wind speed prediction.It combines the excellent properties of Legendre multi‐wavelets with the self‐learning capability of neural networks,which has rigorous mathematical theory support.It learns input‐output data pairs and shares weights within divided subintervals,which can greatly reduce computing costs.We explore the effectiveness of Legendre multi‐wavelets as an activation function.Mean-while,it is successfully being applied to wind speed prediction.In addition,the appli-cation of Legendre multi‐wavelet neural networks in a hybrid model in decomposition‐reconstruction mode to wind speed prediction problems is also discussed.Numerical results on real data sets show that the proposed model is able to achieve optimal per-formance and high prediction accuracy.In particular,the model shows a more stable performance in multi‐step prediction,illustrating its superiority. | Xiaoyang Zheng Dongqing Jia Zhihan Lv Chengyou Luo Junli Zhao Zeyu Ye | 2023 | CAAI Transactions on Intelligence Technology2023，8，3： | 0 |
| 10 | 重离子在MRAM中引起的辐照效应研究显示文摘Nonvolatile memories play a critical role for storing significant data,the programs of micro control system and scientific observation data[1].Unfortunately,conventional charge non-volatile memories,EEPROM or PROM are hardly to suitable the new missions nowadays,such as the requirements of more than 10 years on-orbit service and ultra-deep space exploration missions,etc.Representation of novel NVRAM technologies of magnetoresistive random access memories(MRAM)utilize magnetic bits of a magnetic tunnel junction(MTJ)[2]to store binary data have inherently endurance to the direct ionization induced by the charge particle.Therefore,it is an ideal candidate general-purpose memory to be used in space-borne microelectronics. | Zhao Peixiong Liu Jie Liu Tianqi Ji Qinggang Cai Chang Li Dongqing He Ze Ye Bing Mo Lihua Zhai Pengfei Sun Youmei Hou Mingdong | 2018 | IMP & HIRFL Annual Report2018，，1： | 0 |
| 11 | 抗辐射FPGA单粒子翻转敏感性研究显示文摘In our work,the presentative configuration memory(CM)with dual interlocked storage cell and(DICE)hardened in CMOS-based 65 nm FPGA were chosen for heavy-ion evaluation.CM adopting DICE hardened structure controlled the whole routing and logical resources in FPGA is the most essential parts in radiation hardened design.For basic CMOS FPGAs,the ionizing particles can momentarily generate charges and short-circuit transistor’drain to substrate,leading node transition and initial data upset.However,DICE cell indicates that energy deposition must affect the interlocked two logics and change the electrostatic potentials in two bi-stable circuits synchronously[1]. | Cai Chang Liu Jie Liu Tianqi Zhao Peixiong Li Dongqing Ye Bing Mo Lihua He Ze Sun Youmei | 2018 | IMP & HIRFL Annual Report2018，，1： | 0 |
| 12 | Effectiveness of Xiaoyao capsule(逍遥丸)on sleep disorders and mood disturbance in patients in recovery from coronavirus disease 2019:a randomized controlled trial显示文摘OBJECTIVE:To study the efficacy of Xiaoyao capsule(逍遥丸)in improving the clinical symptoms of sleep and mood disorders during recovery from coronavirus disease 2019(COVID-19).METHODS:The study cohort comprised 200 patients with sleep and mood disorders during recovery from COVID-19.Patients were randomized into the control group and the experimental group in a 1:1 ratio by blocked randomization.The patients received either Xiaoyao capsule(experimental group)or a placebo Xiaoyao capsule(control group)for 2 weeks.The improvements in the Traditional Chinese Medicine(TCM)syndrome scales,total effective rates,and disappearance rates of irritability,anxiety,and poor sleep were compared between the two groups.RESULTS:The TCM syndrome pattern scales,total effective rates,and disappearance rates of irritability,anxiety,and poor sleep did not significantly differ between the experimental group versus the control group in the full analysis set and the per protocol set after 1 and 2 weeks of treatment(P>0.05).CONCLUSIONS:Xiaoyao capsule do not significantly improve the clinical symptoms of sleep and mood disorders in patients in recovery from COVID-19. | YANG Cunqing LIAN Fengmei YANG Guiping HUANG Yufeng ZHANG Shuangbin WANG Jianghua ZHOU Jing GUO Dongqing SHEN Chuanyun YE Tiansong FU Aojie LI Xiaoli CHEN Le ZHANG Huifeng TU Qiyin WANG Ying YANG Wenzhe TONG Xiaolin BA Yuanming | 2023 | Journal of Traditional Chinese Medicine2023，43，2： | 0 |
| 13 | Interface Engineering of Inverted Perovskite Solar Cells Using a Self-doped Perylene Diimide Ionene Terpolymer as a Thickness-Independent Cathode Interlayer显示文摘Inverted perovskite solar cells(PerSCs)are a highly promising candidate in the photovoltaic field due to their low-temperature fabrication process,negligible hysteresis,and easy integration with Si-based solar cells.A cathode interlayer(CIL)is necessary in the development of inverted devices to reduce the trap density and energy barrier between the electron transport layer(ETL)and the electrode.However,most CILs are highly thickness-sensitive due to low conductivity and poor film-forming.In this study,we report on a self-doping perylene imide-based ionene polymer(PNPDIN)used as CIL material to modify electrode in inverted PerSCs.PNPDIN exhibits high conductivity and a good solubility in polar solvent,which results in an improved power conversion efficiency(PCE)from 10.05%(device without a CIL)to 16.97%.When the blend of PNPDIN and Bphen was used as a mixed CIL,the PCE of PerSCs can be further increased to 21.28%owing to the excellent morphology and matched energy level.More importantly,the PCE of the device is highly tolerant to the thickness of the mixed CIL,which benefited from the high conductivity of PNPDIN.This development is expected to provide an excellent mixed CIL material for roll-to-roll processing efficient and stable inverted PerSCs. | Daizhe Wang Tengling Ye Dongqing He Xiaochen Sun Yong Zhang | 2023 | Chinese Journal of Chemistry2023，41，23： | 0 |
| 14 | 总剂量效应对FRAM器件单粒子翻转敏感性的影响显示文摘Ferroelectric random access memory(FRAM)is a type of nonvolatile memory that possesses many advantages,such as high operation speed and low power consumption[1].In this work,the impact of total ionizing dose(TID)on single event upset(SEU)sensitivity was studied for FRAMs.The influence of different test modes and memory patterns on FRAMs was investigated.Parameters of the test devices are listed in Table 1. | Ji Qinggang Liu Jie Yin Yanan Liu Tianqi Ye Bing Zhao Peixiong Cai Chang Liu Li Mo Lihua Li Dongqing Hou Mingdong | 2017 | IMP & HIRFL Annual Report2017，，1： | 0 |
| 15 | 反熔丝PROM单粒子效应评估显示文摘1T anti-fuse PROM fabricated by 0.13m silicon epitaxial process has a fast-read speed and a high storage density[1].8 and 16 MeVbit PROMs were irradiated by swift heavy ions for single event effect(SEE)evaluation at the terminal TR5 of the HIRFL.Testing results revealed that the PROMs have strong capacity to resist single event latch-up(SEL),because of anti-fuse mechanism and guard ring structures.No SEL phenomenon occurred during the testing.Additionally,Weibull function,as given below,was used to fit heavy-ion single event upset(SEU)cross-section statistics. | Cai Chang Liu Jie Liu Tianqi Zhao Peixiong Li Dongqing Ye Bing Yin Yanan Ji Qinggang Mo Lihua Liu Li | 2017 | IMP & HIRFL Annual Report2017，，1： | 0 |
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