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| 1 | AN ANISOTROPIC NONCONFORMING FINITE ELEMENT METHOD FOR APPROXIMATING A CLASS OF NONLINEAR SOBOLEV EQUATIONS显示文摘各向异性的 nonconforming 有限元素方法为非线性的 Sobolev 方程的一个班被介绍。最佳的错误估计和 supercloseness 为半分离、充分分离的近似计划被获得,它与传统的有限元素方法一样。另外,全球 superconvergence 通过 postprocessing 技术被导出。数字实验被包括说明建议方法的可行性。[从作者抽象] | Dongyang Shi Haihong Wang Yuepeng Du | 2009 | Journal of Computational Mathematics2009，27，2： | 49 |
| 2 | The Inhibitory Effect of Oridonin on the Growth of Fifteen Human Cancer Cell Lines显示文摘OBJECTIVE To study the inhibitory effect of oridonin on the growth of cancer cells. METHODS Fifteen human cancer cell lines were subjected to various concentrations of oridonin in culture medium. The inhibitory rate of cell growth was measured by the MTT assay, and compared with a negative con- trol and 5-Fu-positive control. RESULTS The 50% inhibiting concentration (IC50) and maximal inhibition (Imax) of oridonin shown by studying the growth of the cancer cell lines were as follows: leukemias (HL60 cells: 3.9 μg/ml and 73.8%, K562 cells: 4.3 μg/ml and 76.2%); esophageal cancers(SHEEC cells: 15.4 μg/ml and 99.2%, Eca109 cells: 15.1 μg/ml and 84.6%, TE1 cells: 4.0 μg/ml and 70.2%); gastric cancers (BGC823 cells: 7.6 μg/ml and 98.7%, SGC7901 cells: 12.3 μg/ml and 85.7%); colon cancers (HT29 cells: 13.6 μg/ml and 97.2%, HCT cells: 14.5 μg/ml and 96.5%); liver cancers (Bel7402 cells: 15.2 μg/ml and 89.2%, HepG2 cells: 7.1 μg/ml and 88.3%); pancreatic cancer (PC3 cells: 11.3 μg/ml and 68.4%); lung cancer (A549 cells: 18.6 μg/ml and 98.0% ); breast cancer (MCF7 cells: 18.4 μg/ml and 84.7%); uterine cervix cancer (Hela cells: 13.7 μg/ml and 98.5%). CONCLUSION Oridonin had a relatively wide anti-tumor spectrum, and a relatively strong inhibitory effect on the growth of the 15 human cancer cells. Inhibitory effects were concentration dependent. | Junhui Chen Shaobin Wang Dongyang Chen Guisheng Chang Qingfeng Xin Shoujun Yuan Zhongying Shen | 2007 | Chinese Journal of Clinical Oncology2007，4，1： | 32 |
| 3 | Stage-progressive distribution pattern of the Lungmachi black graptolitic shales from Guizhou to Chongqing, Central China显示文摘The Lungmachi Formation is widely distributed in Guizhou, Chongqing and the adjacent area. It is important for the study of Silurian biostratigraphy and shale-gas investigation. Based on those biostratigraphically well-studied sections from Guiyang to Huayingshan, we reveal the stage-progressive distribution pattern of the Lungmachi black shales. The distribution of the Lungmachi black shales in the studying area can be subdivided into four geographic belts from the south to the north,reflecting the joint effect of regional and global environmental changes. The graptolite depth zonation model was adopted herein to infer the water depth of major graptolite assemblages from the black shales. The changes in the water depth indicate two major stages. The first stage is named the transgressive distribution stage which ranged from the Persculptograptus persculptus Biozone(LM1, upper Hirnantian) to the Coronograptus cyphus Biozone(LM5, upper Rhuddanian), an interval mostly controlled by global sea-level rise. The second stage, ranging from the Demirastrites triangulatus Biozone(LM6, lower Aeronian) to the Spirograptus guerichi Biozone(LM9, lower Telychian), is named the regressive shrinking stage, during which the black shales were gradually replaced by mixed-facies or carbonate sediments from the south to the north, representing the effects of the persistent uplifting of the Central Guizhou Oldland. | CHEN Xu FAN JunXuan WANG WenHui WANG HongYan NIE HaiKuan SHI XueWen WEN ZhiDong CHEN DongYang LI WenJie | 2017 | Science China Earth Sciences2017，60，6： | 23 |
| 4 | A review on China's constructed wetlands in recent three decades:Application and practice显示文摘Constructed wetlands(CWs)have been introduced to and developed in China for environmental engineering over the most prosperous three decades(1990–2020).To study the origin,development process,and future trend of CWs,this review summarized a wide range of literatures between 1990 and 2020 by Chinese authors.Firstly,the publication number over years,research highlights,and the author contributions with the most published papers in this field were conducted through bibliometric analysis.Secondly,the most principal components of CWs,substrates and macrophytes were summarized and analyzed.Thirdly,the typical application cases from traditional CWs,pond systems to combined pond-wetland systems were presented.In China,CWs were predominately distributed in the east of the so-called'Hu Huanyong Line'.Therefore CWs were limited by the socio-economic level and climatic conditions.It is unquestionable that the overall level of China's CWs has improved significantly,and one of the most prominent features has started towards the plural pattern development.There has been a trend of large-scale or low-cost CW application in the recent years.However,lifecycle research and management are required for better strategies in the future. | Hong Zhang Wenzhong Tang Weidong Wang Wei Yin Honglei Liu Xiaomin Ma Yiqi Zhou Pei Lei Dongyang Wei Litian Zhang Cao Liu Jinmiao Zha | 2021 | Journal of Environmental Sciences2021，33，6： | 13 |
| 5 | Study on seepage and deformation characteristics of coal microstructure by 3D reconstruction of CT images at high temperatures显示文摘To study the seepage and deformation characteristics of coal at high temperatures,coal samples from six different regions were selected and subjected to computed tomography(CT)scanning studies.In conjunction with ANSYS software,3 D reconstruction of CT images was used for the establishment of fluidsolid conjugate heat transfer model and coal thermal deformation model based on the microstructures of coal.In addition,the structure of coal was studied in 2 D and 3 D perspectives,followed by the analysis of seepage and deformation characteristics of coal at high temperatures.The results of this study indicated that porosity positively correlated with the fractal dimension,and the connectivity and seepage performances were roughly identical from 2 D and 3 D perspectives.As the porosity increased,the fractal dimension of coal samples became larger and the pore-fracture structures became more complex.As a result,the permeability of coal samples decreased.In the meantime,fluid was fully heated,generating high-temperature water at outlet.However,when the porosity was low,the outlet temperature was very high.The average deformation of coal skeleton with different pore-fracture structures at high temperatures showed a trend of initial increase and subsequent decrease with the increase of porosity and fractal dimension.The maximum deformation of coal skeleton positively correlated with connectivity but negatively correlated with the fractal dimension. | Gang Wang Xiangjie Qin Dongyang Han Zhiyuan Liu | 2021 | International Journal of Mining Science and Technology2021，31，2： | 11 |
| 6 | Seismic wave input method for three-dimensional soil-structure dynamic interaction analysis based on the substructure of artificial boundaries显示文摘The method of inputting the seismic wave determines the accuracy of the simulation of soil-structure dynamic interaction. The wave method is a commonly used approach for seismic wave input, which converts the incident wave into equivalent loads on the cutoff boundaries. The wave method has high precision, but the implementation is complicated, especially for three-dimensional models. By deducing another form of equivalent input seismic loads in the fi nite element model, a new seismic wave input method is proposed. In the new method, by imposing the displacements of the free wave fi eld on the nodes of the substructure composed of elements that contain artifi cial boundaries, the equivalent input seismic loads are obtained through dynamic analysis of the substructure. Subsequently, the equivalent input seismic loads are imposed on the artifi cial boundary nodes to complete the seismic wave input and perform seismic analysis of the soil-structure dynamic interaction model. Compared with the wave method, the new method is simplifi ed by avoiding the complex processes of calculating the equivalent input seismic loads. The validity of the new method is verifi ed by the dynamic analysis numerical examples of the homogeneous and layered half space under vertical and oblique incident seismic waves. | Liu Jingbo Tan Hui Bao Xin Wang Dongyang Li Shutao | 2019 | Earthquake Engineering and Engineering Vibration2019，18，4： | 11 |
| 7 | AN ANISOTROPIC NONCONFORMING FINITE ELEMENT SCHEME WITH MOVING GRIDS FOR PARABOLIC INTEGRO-DIFFERENTIAL EQUATIONS显示文摘一个 Crank-Nicolson 计划基于 nonconforming,有动人的格子的有限元素在各向异性的网孔下面为寓言的 integro 微分的方程的一个班被讨论。相应集中分析被介绍,错误估计被使用插值操作员而不是是在在以前的文学的传统的有限元素方法的集中分析的一个不可缺少的工具的常规椭圆形的设计获得。 | Dongyang SHI Lin WANG | 2011 | Journal of Systems Science & Complexity2011，24，5： | 8 |
| 8 | Research and application of methods for effectiveness evaluation of mine cooling system显示文摘Regarding the complexity and inconsistency of results in existing evaluation methods of mine cooling system, this paper clarifies the advantages, disadvantages and application of various mine cooling systems through principle analysis, and divides all the cooling systems into air-cooling, ice-cooling and water-cooling according to the transportation of cold energy. On this basis, the paper proposes a simple and efficient evaluation method for mine cooling system. The first index of this method is the air temperature at point C which is 15 m away from the return wind corner at working face. A cooling system will be judged ineligible if the air temperature at point C is above 30 °C during operation, because in this case, the combustible gases in coal will sharply overflow, inducing gas incidents. Based on the preliminary judgment of the first index, another two evaluation indexes are proposed based on the cooling ability and dehumidification of an airflow volume of 1000 m3/min at point C to evaluate the investment and operation cost of mine cooling system. This evaluation method has already been successfully applied in the cooling system design of Zhangshuanglou coal mine. | Guo Pingye Wang Yanwei Duan Mengmeng Pang Dongyang Li Nan | 2015 | International Journal of Mining Science and Technology2015，25，4： | 7 |
| 9 | Transformative hyaluronic acid-based active targeting supramolecular nanoplatform improves long circulation and enhances cellular uptake in cancer therapy显示文摘Hyaluronic acid(HA) is a natural ligand of tumor-targeted drug delivery systems(DDS) due to the relevant CD44 receptor overexpressed on tumor cell membranes. However, other HA receptors(HARE and LYVE-1) are also overexpressing in the reticuloendothelial system(RES). Therefore,polyethylene glycol(PEG) modification of HA-based DDS is necessary to reduce RES capture.Unfortunately, pegylation remarkably inhibits tumor cellular uptake and endosomal escapement,significantly compromising the in vivo antitumor efficacy. Herein, we developed a Dox-loaded HA-based transformable supramolecular nanoplatform(Dox/HCVBP) to overcome this dilemma. Dox/HCVBP contains a tumor extracellular acidity-sensitive detachable PEG shell achieved by a benzoic imine linkage.The in vitro and in vivo investigations further demonstrated that Dox/HCVBP could be in a 'stealth' state at blood stream for a long circulation time due to the buried HA ligands and the minimized nonspecific interaction by PEG shell. However, it could transform into a 'recognition' state under the tumor acidic microenvironment for efficient tumor cellular uptake due to the direct exposure of active targeting ligand HA following PEG shell detachment. Such a transformative concept provides a promising strategy to resolve the dilemma of natural ligand-based DDS with conflicting two processes of tumor cellular uptake and in vivo nonspecific biodistribution. | Lu Zhong Lu Xu Yanying Liu Qingsong Li Dongyang Zhao Zhenbao Li Huicong Zhang Haotian Zhang Qiming Kan Yongjun Wang Jin Sun Zhonggui He | 2019 | Acta Pharmaceutica Sinica B2019，9，2： | 7 |
| 10 | SUPERCONVERGENCE ANALYSIS OF A NONCONFORMING TRIANGULAR ELEMENT ON ANISOTROPIC MESHES显示文摘我们构思的各向异性的网孔的班放弃常规假设。凯里的元素的一些不同性质被用来为二维的秒顺序的一个班处理超级集中各向异性的网孔上的椭圆形的边界价值问题。最佳的结果被获得;数字例子被给证实我们的理论分析。 | Dongyang SHI Hui LIANG Caixia WANG | 2007 | Journal of Systems Science & Complexity2007，20，4： | 7 |
| 11 | Surface-ligand protected reduction on plasmonic tuning of one-dimensional MoO_(3−x)nanobelts for solar steam generation显示文摘Sub-stoichiometric MoO_(3−x)nanostructures with plasmonic absorption via creating oxygen vacancies have attracted extensive attentions for many intriguing applications.However,the synthesis of one-dimensional(1D)plasmonic MoO_(3−x)nanostructures with widely tunable plasmonic absorption has remained a significant challenge because of their serious morphological destruction and phase change with increasing the concentration of oxygen vacancies.Here we demonstrate a surface-ligand protected reduction strategy for the synthesis of 1D MoO_(3−x)nanobelts with tunable plasmonic absorption in a wide wavelength range from 200 to 2,500 nm.Polyethylene glycol(PEG-400)is used as both the reductant to produce oxygen vacancies and the surface protected ligands to maintain 1D morphology during the formation process of MoO_(3−x)nanobelts,enabling the widely tunable plasmonic absorption.Owing to their broad plasmonic absorption and unique 1D nanostructure,we further demonstrate the application of 1D MoO_(3−x)nanobelts as photothermal film for interfacial solar evaporator.The surface-ligand protected reduction strategy provides a new avenue for the developing plasmonic semiconductor oxides with maintained particle morphology and thus enriching their wide applications. | Xindian Li Dongyang Wang Yun Zhang Luntao Liu Wenshou Wang | 2020 | Nano Research2020，13，11： | 4 |
| 12 | Intestinal OCTN2-and MCT1-targeted drug delivery to improve oral bioavailability显示文摘Various drug transporters are widely expressed throughout the intestine and play important roles in absorbing nutrients and drugs,thus providing high quality targets for the design of prodrugs or nanoparticles to facilitate oral drug delivery.In particular,intestinal carnitine/organic cation transporter 2(OCTN2)and mono-carboxylate transporter protein 1(MCT1)possess high transport capacities and complementary distributions.Therefore,we outline recent developments in transporter-targeted oral drug delivery with regard to the OCTN2 and MCT1 proteins in this review.First,basic information of the two transporters is reviewed,including their topological structures,characteristics and functions,expression and key features of their substrates.Furthermore,progress in transporter-targeting prodrugs and nanoparticles to increase oral drug delivery is discussed,including improvements in the oral absorption of anti-inflammatory drugs,antiepileptic drugs and anticancer drugs.Finally,the potential of a dual transporter-targeting strategy is discussed. | Gang Wang Lichun Zhao Qikun jiang Yixin Sun Dongyang Zhao Mengchi Sun Zhonggui He Jin sun Yang Wang | 2020 | Asian Journal of Pharmaceutical Sciences2020，15，2： | 3 |
| 13 | Insight into selective removal of copper from high-concentration nickel solutions with XPS and DFT:New technique to prepare 5N-nickel with chelating resin显示文摘An efficient and profitable separation process was proposed to prepare 5N(the purity of the metal solution reaches 99.999%) high-purity nickel from 3N nickel-solutions using Purolite S984. The adsorption performance of this superior resin, especially its selectivity for metal ions,was explored quantitatively. The maximum adsorption capacity for copper was 2.286 mmol/g calculated by the Langmuir model, which was twice as large as that for nickel. In the binary systems, the adsorption capacity for nickel was decreased by 45%, indicating direct competition for the active sites. The infinite separation factor for copper versus nickel exceeded 300, revealing the feasibility of preparing5N-level high-purity nickel solutions, which was further verified using the 800 BV(bed volume) effluent in the column dynamic process.According to the cost–benefit analysis, purification contributed to a profit of approximately 60,000 USD per cycle, and the investment return period was less than 1/3 years. Density functional theory analysis confirmed that four nitrogen atoms would be involved in the coordination complex and thus a structure involving two five-membered rings could be achieved. The X-ray photoelectron spectra confirmed the involvement of nitrogen atoms,implying a coordination ratio of approximately 1:1. | Xuewen Tao Fuqiang Liu Zhiping Bai Dongyang Wei Xiaopeng Zhang Junfei Wang Jie Gao Xiaowen Sun Baohua Li Chenghui Li Aimin Li | 2016 | Journal of Environmental Sciences2016，28，10： | 3 |
| 14 | In-situ construction of Z-scheme g-C_(3)N_(4)/WO_(3) composite with enhanced visible-light responsive performance for nitenpyram degradation显示文摘Developing an excellent photocatalysis system to remove pesticides from water is an urgent problem in current environment purification field.Herein,a Z-scheme WO_(3)/g-C_(3)N_(4) photocatalyst was prepared by a facile in-situ calcination method,and the photocatalytic activity was investigated for degradation of nitenpyram(NTP)under visible light.The optimal Z-scheme WO_(3)/g-C_(3)N_(4) photocatalyst displayed the highest rate constant(0.036 min-1),which is about 1.7 and 25 times higher than that of pure g-C_(3)N_(4) and WO_(3),respectively.The improvement of photocatalytic performance is attributed to fast transfer of photogene rated carriers in the Z-scheme structure,which are testified by electron spin resonance(ESR)experiments,photocurrent and electrochemical impedance spectra(EIS)measurements.Moreover,the effects of typical water environmental factors on the degradation NTP were systematically studied.And the possible degradation pathways of NTP were deduced by the intermediates detected by highperformance liquid chro matography-mass spectrometry(HPLC-MS).This work will not only contribute to understand the degradation mechanism of pesticides in real water environmental condition,but also promote the development of new technologies for pesticide pollution control as well as environmental remediation. | Shiqiao Zhou Ye Wang Kun Zhou Dongyang Ba Yanhui Ao Peifang Wang | 2021 | Chinese Chemical Letters2021，32，7： | 3 |
| 15 | Experimental study on ageing characteristics of electric locomotive ethylene propylene rubber cable under mechanical-thermal combined action显示文摘The train-mounted ethylene propylene rubber(EPR)cables of electric locomotive are partly restricted by the body structure and spatial layout and are in a combined envi-ronment of strong mechanical bending and thermal ageing.The degradation character-istics of the insulation layer have not yet received sufficient attention.In order to study the ageing characteristics of EPR cables of electric locomotive under the combined action of machine and thermal,this paper designs a bending-thermal combined ageing test platform for cables with a temperature of 135°C,bending diameter of 393.52 mm,590.28 mm and unbending cables,and tests after ageing.The product has been tested by infrared spectroscopy,scanning electron microscopy,elongation at break and broadband dielectric spectroscopy.The research results show that the bending outer part of the train-mounted EPR cable is a pain point.Under the combined action of bending and thermal,whether it is microstructure or macro performance,the degradation rate and degree of the bending of outer insulation layer are greater than the value under a single thermal ageing condition.Mechanical bending has an accelerating effect on the ageing of the EPR insulation layer.The research results can provide a reference for the ageing characteristics of the train-mounted EPR cable under the bending-thermal synergy and the evaluation of operating state of the train-mounted EPR cable under bending-thermal operating conditions. | Lijun Zhou Cong Liu Shengwei Quan Xiangyu Zhang Dongyang Wang | 2022 | High Voltage2022，7，4： | 3 |
| 16 | A scientometric review of biochar preparation research from 2006 to 2019显示文摘Biochar is the carbon-rich product obtained from the thermochemical conversion of biomass under oxygen-limited condi-tions.Preparation methods contribute to biochar properties,which are widely concerned in the agronomic and environmental benefits of agro-ecosystems.This research aims to use bibliometrics methods to comprehensively and objectively analyze the research trends in the global biochar production field from 2006 to 2019 based on the Web of Science Core Collection database.The results showed that 1434 papers related to biochar preparation were published,which gradually increased each year.The research topics were diversified,which were mainly divided into“Environmental Sciences and Ecology,”“Engineering”and“Agriculture”.Moreover,Bioresource Technology was the most published journal contained biochar preparation.Authors from China had the most publications,followed by the US,Australia and the UK.Meanwhile,Yong Sik Ok from Korea University contributed most of the publications and had the highest H-index.Keywords analysis indicated that biochar preparation by pyrolysis was a current hotspot,of which microwave and hydrothermal were a future research trend.Besides,gasification would be used to develop new biomass energy.Biochar has the characteristics of high pH,high specific surface area,high carbon content,and rich functional groups.It is mainly used in soil improvement,water pollutant adsorption,carbon sequestration and emission reduction,and energy storage materials,etc.Furthermore,raw materials,pyrolysis temperature and pyrolysis time will also affect its characteristics and applications.It is expected that this study may provide insight into the future research interests regarding biochar preparation. | Yuxin Jiao Dongyang Li Ming Wang Tiancheng Gong Mengyang Sun Tianxue Yang | 2021 | Biochar2021，3，3： | 3 |
| 17 | Deep Analysis of Power Equipment Defects Based on Semantic Framework Text Mining Technology显示文摘Defect factors and their relevant rules can be analyzed in depth by processing defect records which are often expressed in the form of text data.However,considering that defect text consists of both structured and unstructured data,it is necessary to excavate structured information from unstructured data.In this paper,a text mining method based on semantic framework technology is introduced to transform unstructured defect description into structured information such as components and defect attributes.Then,a deep analyzing model of a power equipment defect is established,which provides a scheme of defect mining based on historical defect texts.Case studies prove that the proposed deep analysis method has a guiding significance for equipment upgrading,selection and maintenance. | Huifang Wang Jing Cao Dongyang Lin | 2022 | CSEE Journal of Power and Energy Systems2022，8，4： | 2 |
| 18 | A Hg(Ⅱ)-specific probe for imaging application in living systems and quantitative analysis in environmental/food samples显示文摘Mercury ions are highly toxic and can accumulate along food chains in water,soil,crops and animals.Effective detection of mercury ions in various media is of great significance for maintaining the ecological environment and protecting people's health.In this work,a mercury ions specific fluorescent probe was developed by a simple one-step reaction of commercial substrates of 4-chloro-7-nitro-2,1,3-benzoxadiazole and 1-(2-aminoethyl)-4-methylpiperazine.Investigation on sensing behavior showed that this probe had high sensitivity and selectivity towards mercury ions.Furthermore,this probe could be used as a tool to track the level of mercury ions in living system.In living cells,the probe with green emission emitted a bright red fluorescence when it was bound to mercury ions.In Arabidopsis thaliana,similar red emission could be detected from the root tip and stalk when A.thaliana was grown in culture medium containing mercury ions.The imaging in zebrafish showed that mercury ions were mainly concentrated in the stomach and head of zebrafish.Especially,this probe could be applied in quantitative analysis of mercury ions in tap water,green tea,sea shrimp and soil.This work provided a practical tool for the detection of mercury ions in living systems and quantitative analysis in real samples. | Guangjin Li Jiali Wang Dongyang Li Shenghua Liu Jun Yin Zhibing Lai Guangfu Yang | 2021 | Chinese Chemical Letters2021，32，4： | 2 |
| 19 | Towards win-win: weighted-Voronoi-diagram based channel quantization for security enhancement in downlink cloud-RAN with limited CSI feedback显示文摘Physical layer(PHY) security is recently proved to enable improving the security of wireless communication networks. In downlink frequency division duplex(FDD) cloud radio access network(C-RAN), the performance of PHY security highly relies on the channel state information(CSI) which is usually acquired through the codebook-quantization-based technique at the transceiver. However, the conventional quantization method aggravates the leakage of privacy information in C-RAN under the eavesdropping environment. In this paper, a novel channel quantization method is investigated to improve the secrecy-rate performance of C-RAN by exploiting the high-dimension space geometry. Based on this method, it is proved that when the statistical distribution of the channel matrices of both the legitimate user and the eavesdropper is exploited, a win-win situation can be created where secrecy-rate gains are improved without sacrificing beamforming gains from the point of view of ergodic rate. Particularly, a secrecy-oriented criterion is devised to implement the proposed method for generating codebooks. Then a weighted Voronoi diagram(WVD) is formulated on the complex Grassmann manifold and finally, a vector quantization based algorithm is proposed to build up novel quantization codebooks iteratively. Simulation results further validate the superiority of our proposed codebooks over conventional codebooks in C-RAN systems. | Dongyang XU Pinyi REN Qinghe DU Li SUN Yichen WANG | 2017 | Science China(Information Sciences)2017，60，4： | 2 |
| 20 | Efficacy,safety and immunogenicity of hexavalent rotavirus vaccine in Chinese infants显示文摘A randomized,double-blind,placebo-controlled multicenter trial was conducted in healthy Chinese infants to assess the efficacy and safety of a hexavalent live human-bovine reassortant rotavirus vaccine(HRV)against rotavirus gastroenteritis(RVGE).A total of 6400 participants aged 6-12 weeks were enrolled and randomly assigned to either HRV(n?3200)or placebo(n?3200)group.All the subjects received three oral doses of vaccine four weeks apart.The vaccine efficacy(VE)against RVGE caused by rotavirus serotypes contained in HRV was evaluated from 14 days after three doses of administration up until the end of the second rotavirus season.VE against severe RVGE,VE against RVGE hospitalization caused by serotypes contained in HRV,and VE against RVGE,severe RVGE,and RVGE hospitalization caused by natural infection of any serotype of rotavirus were also investigated.All adverse events(AEs)were collected for 30 days after each dose.Serious AEs(SAEs)and intussusception cases were collected during the entire study.Our data showed that VE against RVGE caused by serotypes contained in HRV was 69.21%(95%CI:53.31-79.69).VE against severe RVGE and RVGE hospitalization caused by serotypes contained in HRV were 91.36%(95%CI:78.45-96.53)and 89.21%(95%CI:64.51-96.72)respectively.VE against RVGE,severe RVGE,and RVGE hospitalization caused by natural infection of any serotype of rotavirus were 62.88%(95%CI:49.11-72.92),85.51%(95%CI:72.74-92.30)and 83.68%(95%CI:61.34-93.11).Incidences of AEs from the first dose to one month post the third dose in HRV and placebo groups were comparable.There was no significant difference in incidences of SAEs in HRV and placebo groups.This study shows that this hexavalent reassortant rotavirus vaccine is an effective,well-tolerated,and safe vaccine for Chinese infants. | Zhiwei Wu Qingliang Li Yan Liu Huakun Lv Zhaojun Mo Fangjun Li Qingchuan Yu Fei Jin Wei Chen Yong Zhang Teng Huang Xiaosong Hu Wei Xia Jiamei Gao Haisong Zhou Xuan Bai Yueyue Liu Zhenzhen Liang Zhijun Jiang Yingping Chen Jiuwei Zhang Jialiang Du Biao Yang Bo Xing Yantao Xing Ben Dong Qinghai Yang Chen Shi Tingdong Yan Bo Ruan Haiyun Shi Xingliang Fan Dongyang Feng Weigang Lv Dong Zhang Xiangchu Kong Liuyifan Zhou Dinghong Que Hong Chen Zhongbing Chen Xiang Guo Weiwei Zhou Cong Wu Qingrong Zhou Yuqing Liu Jian Qiao Ying Wang Xinguo Li Kai Duan Yuliang Zhao Gelin Xu Xiaoming Yang | 2022 | Virologica Sinica2022，37，5： | 2 |
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