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| 1 | Simulation analysis and match experiment on negative and positive pressures of pneumatic precision metering device for rapeseed显示文摘Positive and negative pressures determine the performance of pneumatic precision metering device for rapeseed.In order to investigate the relationship between positive and negative pressures of nozzles,fluid models of chamber were developed to simulate the airflow,and the k-εturbulence model was conducted to capture the pressure and velocity of nozzles.Through these efforts linear models were achieved.Meanwhile,the three-factor factorial split-split experiment was designed with negative pressure,positive pressure and the rotating speeds varying from-1000 to-4500 Pa,50 to 250 Pa and 10 to 45 r/min,respectively.The mathematical models were developed through employing the stepwise regression method.The sequence of influential factors on the quality of feed index was positive pressure,negative pressure and rotating speed.To obtain the match regulation of negative and positive pressures with“good”performance,the ratio coefficient K of negative and positive pressures was introduced to build mathematical models.Models relating ratio coefficient K with positive pressure were fitted in different rotating speeds.The results showed that the ratio coefficient was matchedГ∈[f1(x),f2(x)]from the fitting equations with the rotating speed of 10-30 r/min;while the rotating speed has greater influence when it was 35-40 r/min and the setsΛ∈[g1(x),g2(x)]were achieved,where x∈[100,250].This study could be conducted to adjust the rotating speed of the pneumatic system to optimize the ideal performance of the seeder. | Yu Jiajia Liao Yitao Cong Jinling Yang Song Liao Qingxi | 2014 | International Journal of Agricultural and Biological Engineering2014，7，3： | 21 |
| 2 | MiR-9 reduces human acyl-coenzyme A:cholesterol acyltransferase-1 to decrease THP-1 macrophage-derived foam cell formation显示文摘MicroRNAs (miRNAs ) post-transcriptionally 由指向 mRNAs 调整基因表示并且控制大量生物函数。最近的研究显示了 miRNAs 能在哺乳动物调整类脂化合物和胆固醇新陈代谢。酰辅酶 A:cholesterol acyltransferase (ACAT ) 是在细胞的胆固醇新陈代谢的关键酶。积累的 cholesteryl 酉旨被 ACAT1 主要在泡沫房间的形成期间综合,早动脉粥样硬化患者损害的一个特点。这里,我们表明 miR-9 能指向人的 ACAT1 mRNA 的 3-untranslated 区域,明确地在不同人的房间线减少人的 ACAT1 或记者萤火虫酶(Fluc ) 蛋白质然而并非他们的 mRNAs,并且机能上地减少从 THP-1-derived 巨噬细胞的泡沫房间的形成。我们的调查结果建议 miR-9 可能是在细胞的胆固醇动态平衡和减少的一个重要管理者在由减少 ACAT1 蛋白质的 vivo 的泡沫房间的形成。 | Jiajia Xu Guangjing Hu Ming Lu Ying Xiong Qin Li Catherine C.Y. Chang Baoliang Song Tayuan Chang Boliang Li | 2013 | Acta Biochimica et Biophysica Sinica2013，45，11： | 17 |
| 3 | Mapping Heterotic Loci for Yield and Agronomic Traits Using Chromosome Segment Introgression Lines in Cotton显示文摘在现在的学习,一套染色体片断基因渗入排队(CSIL ) 使用 Gossypium hirsutum L。TM-1 作为接受者父母和 G。施主父母被用来为种间的混血儿探索杂种优势的基因基础的 barbadense Hai7124。个别地从与两个父母一起交叉的 CSIL 导出的 F1 人口的二个集合被设置调查 heterotic loci (HL ) 和替换效果 loci (SL ) 。58 HL 和 39 SL 的一个总数在 3 年里被识别。一稳定的 HL, hLP-A4-3,能在所有 3 年里被检测。三 HL, hBS-A8-1, hLP-D6-1,和 hSI-D7-11,能在 2 年里被检测。四 SL, sBS-D7-1, sLP-A8-1, sLP-D7-1,和 sLP-D12-1,能在 2 年里被检测。HL 和 SL 趋于在有靠近的位置的一些 HL 富有的染色体片断分布式。与在以前的研究检测的 QTL 相比, HL 与 QTL 显示出很少重叠,显示特点显型和杂种优势可能被 loci 的不同集合控制。基因效果的所有三种形式(部分 -- ,完整 -- ,在主导上) 被识别,当在主导上的效果做了主要贡献到杂种优势时。这些结果可以帮助为在棉花澄清杂种优势的遗传机制打了基础。 | Xian Guo Yuping Guo Jun Ma Fang Wang Mizhen Sun Lijuan Gui Jiajia Zhou Xianliang Song Xuezhen Sun Tianzhen Zhang | 2013 | Journal of Integrative Plant Biology2013，55，8： | 13 |
| 4 | ACAT1 regulates the dynamics of free cholesterols in plasma membrane which leads to the APP-a-processing alteration显示文摘 | Ming Zhu Xiaonan Zhao Jia Chen Jiajia Xu Guangjing Hu Dongqing Guo Qin Li Xiaowei Zhang Catherine C.Y. Chang Baoliang Song Ying Xiong Tayuan Chang Boliang Li | 2015 | Acta Biochimica et Biophysica Sinica2015，47，12： | 7 |
| 5 | The optional long 5'-untranslated region of human ACAT1 mRNAs impairs the production of ACAT1 protein by promoting its mRNA decay显示文摘我们以前报导了人的 ACAT1 mRNAs 用 AUG13971399 开始 codon 生产 50 kDa 蛋白质,并且另外一个未成年者用在上游的在里面框架 GGC12741276 开始 codon 的 56 kDa isoform。GGC12741276 codon 在可选的长 5-untranslated 区域被定位(5-UTR, nt 11396 ) mRNAs。相应于这 5-UTR 的 DNA 序列位于二个不同染色体, 7 和 1。在当前的工作,我们报导可选的长 5-UTR 显著地损害从 AUG13971399 codon 开始的人的 ACAT1 蛋白质的生产,主要由支持它的 mRNA 腐烂。西方的污点分析显示可选的长 5-UTR potently 损害了从 AUG13971399 codon 开始的不同蛋白质的生产,意味着这损害效果没被 3-UTR 或 ACAT1 mRNA 的编码顺序影响。反向的抄写量的聚合酶链反应的结果证明这 5-UTR 戏剧性地减少了它的连接 mRNAs 的内容。到 mRNA 比率的蛋白质的分析证明这 5-UTR 主要减少了它的 mRNA 稳定性而非改变它的翻译效率。我们下次执行了 plasmid transfection 实验并且使用了放线菌素 D 禁止抄写。结果证明这 5-UTR 支持了它的 mRNA 腐烂。用在 vitro 准备的 RNA 的另外的 transfection 和 nucleofection 实验说明了那,在细胞质和房间的原子核,没有连接,可选的长 5-UTR-linked mRNAs 比那些快腐烂了。总的来说,我们的学习在抄写以后的水平把新卓见带到人的 ACAT1 基因表示的规定。 | Xiaonan Zhao Jia Chen Lei Lei Guangjing Hu Ying Xiong Jiajia Xu Qin Li Xinying Yang Catherine C.Y. Chang Baoliang Song Tayuan Chang Boliang Li | 2009 | Acta Biochimica et Biophysica Sinica2009，41，1： | 6 |
| 6 | Comparative genomic and transcriptomic analyses uncover the molecular basis of high nitrogen-use efficiency in the wheat cultivar Kenong 9204显示文摘Studying the regulatory mechanisms that drive nitrogen-use efficiency(NUE)in crops is important for sustainable agriculture and environmental protection.In this study,we generated a high-quality genome assembly for the high-NUE wheat cultivar Kenong 9204 and systematically analyzed genes related to nitrogen uptake and metabolism.By comparative analyses,we found that the high-affinity nitrate transporter gene family had expanded in Triticeae.Further studies showed that subsequent functional differentiation endowed the expanded family members with saline inducibility,providing a genetic basis for improving the adaptability of wheat to nitrogen deficiency in various habitats.To explore the genetic and molecular mechanisms of high NUE,we compared genomic and transcriptomic data from the high-NUE cultivar Kenong 9204(KN9204)and the low-NUE cultivar Jing 411 and quantified their nitrogen accumulation under high-and low-nitrogen conditions.Compared with Jing 411,KN9204 absorbed significantly more nitrogen at the reproductive stage after shooting and accumulated it in the shoots and seeds.Transcriptome data analysis revealed that nitrogen deficiency clearly suppressed the expression of genes related to cell division in the young spike of Jing 411,whereas this suppression of gene expression was much lower in KN9204.In addition,KN9204 maintained relatively high expression of NPF genes for a longer time than Jing 411 during seed maturity.Physiological and transcriptome data revealed that KN9204 was more tolerant of nitrogen deficiency than Jing 411,especially at the reproductive stage.The high NUE of KN9204 is an integrated effect controlled at different levels.Taken together,our data provide new insights into the molecular mechanisms of NUE and important gene resources for improving wheat cultivars with a higher NUE trait. | Xiaoli Shi Fa Cui Xinyin Han Yilin He Long Zhao Na Zhang Hao Zhang Haidong Zhu Zhexin Liu Bin Ma Shusong Zheng Wei Zhang Jiajia Liu Xiaoli Fan Yaoqi Si Shuiquan Tian Jianqing Niu Huilan Wu Xuemei Liu Zhuo Chen Deyuan Meng Xiaoyan Wang Liqiang Song Lijing Sun Jie Han Hui Zhao Jun Ji Zhiguo Wang Xiaoyu He Ruilin Li Xuebin Chi Chengzhi Liang Beifang Niu Jun Xiao Junming Li Hong-Qing Ling | 2022 | Molecular Plant2022，15，9： | 6 |
| 7 | Optimizing interfacial electronic coupling with metal oxide to activate inert polyaniline for superior electrocatalytic hydrogen generation显示文摘Tuning and optimization of electronic structures and related reaction energetics are critical toward the rational design of efficient electrocatalysts.Herein,experimental and theoretical calculation demonstrate the originally inert N site within polyaniline(PANI)can be activated for hydrogen evolution by proper d-πinterfacial electronic coupling with metal oxide.As a result,the assynthesized WO3 assemblies@PANI via a facile redox-induced assembly and in situ polymerization,exhibits the electrocatalytic production of hydrogen better than other control samples including W18O49@PANI and most of the reported nobel-metal-free electrocatalysts,with low overpotential of 74 mV at 10 mA·cm−2 and small Tafel slope of 46 mV·dec−1 in 0.5M H2SO4(comparable to commercial Pt/C).The general efficacy of this methodology is also validated by extension to other metal oxides such as MoO3 with similar improvements. | Zhen-Feng Huang Jiajia Song Yonghua Du Shuo Dou Libo Sun Wei Chen Kaidi Yuan Zhengfei Dai Xin Wang | 2019 | Carbon Energy2019，1，1： | 5 |
| 8 | Tropoelastin improves adhesion and migration of intra-articular injected infrapatellar fat pad MSCs and reduces osteoarthritis progression显示文摘Intra-articular injection of mesenchymal stem cells(MSCs)is a promising strategy for osteoarthritis(OA)treatment.However,more and more studies reveal that the injected MSCs have poor adhesion,migration,and survival in the joint cavity.A recent study shows that tropoelastin(TE)regulates adhesion,proliferation and phenotypic maintenance of MSCs as a soluble additive,indicating that TE could promote MSCs-homing in regenerative medicine.In this study,we used TE as injection medium,and compared it with classic media in MSCs intra-articular injection such as normal saline(NS),hyaluronic acid(HA),and platelet-rich plasma(PRP).We found that TE could effectively improve adhesion,migration,chondrogenic differentiation of infrapatellar fat pad MSCs(IPFP-MSCs)and enhance matrix synthesis of osteoarthritic chondrocytes(OACs)in indirect-coculture system.Moreover,TE could significantly enhance IPFP-MSCs adhesion via activation of integrin β1,ERK1/2 and vinculin(VCL)in vitro.In addition,intra-articular injection of TE-IPFP MSCs suspension resulted in a short-term increase in survival rate of IPFP-MSCs and better histology scores of rat joint tissues.Inhibition of integrin β1 or ERK1/2 attenuated the protective effect of TE-IPFP MSCs suspension in vivo.In conclusion,TE promotes performance of IPFP-MSCs and protects knee cartilage from damage in OA through enhancement of cell adhesion and activation of integrin β1/ERK/VCL pathway.Our findings may provide new insights in MSCs intra-articular injection for OA treatment. | Junjun Yang Xin Wang Yahan Fan Xiongbo Song Jiangyi Wu Zhenlan Fu Tao Li Yang Huang ZheXiong Tang Shuo Meng Na Liu Jiajia Chen Pingju Liu Liu Yang Xiaoyuan Gong Cheng Chen | 2022 | Bioactive Materials2022，7，4： | 4 |
| 9 | Excess TNF-α in the blood activates monocytes with the potential to directly form cholesteryl ester-laden cells显示文摘肿瘤坏死因素 --(TNF-) 并且 monocytic 房间在动脉粥样硬化的发展起一个关键作用,它是冠的心疾病(CHD ) 的主要原因。在这个工作,我们在血在单核白血球上调查了过量 TNF- 的效果并且发现从 CHD 病人的血单核白血球有潜力直接形成 cholesteryl 酉旨(CE ) 沉重的房间在下面在里面有 oxLDL 的 vitro 孵化。proinflammatory cytokines 的血浆层次例如 TNF- , interleukin 6 (IL-6 ) ,并且 C 反应蛋白质(CRP ) ,在 CHD,病人们是比在控制的那些显著地高级的健康志愿者。然而, TNF- ,然而并非 IL-6 或 CRP 的仅仅血浆水平,断然与血单核白血球的潜力被相关直接形成 CE 沉重的房间。由使用人的血单核白血球和 monocytic THP-1 房间, CE 沉重的房间的形成上的 TNF- 的激活的效果被表明,它能被 anti-TNF- 抗体明确地堵住。而且, TNF- 能由分别地提高功能的粘附分子和 scavenger 受体的表示增加粘附和单核白血球的 oxLDL 举起,这也被揭示。最后,结果在 vivo 并且在 vitro,与一个老鼠模型一起的实验证实在血的过量 TNF- 与潜力激活单核白血球直接形成 CE 沉重的房间。这些数据证明在血的过量 TNF- 是为动脉粥样硬化和 CHD 的开发的主要扳机。 | Ming Zhu Lei Lei Zhenhua Zhu Qin Li Dongqing Guo Jiajia Xu Jia Chen Huifang Sha Xiaowei Zhang Xinying Yang Baoliang Song Boliang Li Yan Yan Ying Xiong | 2015 | Acta Biochimica et Biophysica Sinica2015，47，11： | 4 |
| 10 | Controlled Synthesis and Multifunctional Properties of FePt-Au Heterostructures显示文摘在这个工作, FePt-Au heterostructured nanocrystals (HNC ) 象蝌蚪那样 -- ,哑铃 -- ,祷告 -- ,并且像项链的 nanostructures 被 Au NC 的灵巧的 heteroepitaxial 生长综合到 FePt nanorods (NR ) 上。生长机制的研究表明最后的产品的形态学控制能与氢的吸附地点被相关到 FePt NR 上,它能被增加的形成的气体(Ar/7% H2 ) 的数量操作。内在的材料的不仅光特征和磁性在产品被保留,而且 FePt-Au HNC 证明悦耳的多功能的性质源于在 Au 和 FePt 之间的相互作用。而且为甲醇氧化, FePt-Au HNC 与商业磅催化剂相比在催化剂表面上展出了提高的催化活动和公司忍耐。作为多功能的单位, FePt-Au HNC 也拥有异构的表面,是值得注意的,它能潜在地为在生物医学的应用指向或成像目的启用他们的地点特定的 functionalization。更有趣地, FePt-Au HNC 的催化性质也在 nanocatalysis 赋予这材料以申请潜力。 | Jiajia Wu Yanglong Hou Song Gao | 2011 | Nano Research2011，4，9： | 4 |
| 11 | Semi-enclosed experimental system for coal spontaneous combustion for determining regional distribution of high-temperature zone of coal fire显示文摘Temperature variation and gas generation at diferent depths and positions in the coal combustion process were studied to determine the propagation and evolution of high temperature regions in the process of coal spontaneous combustion.This study selected coal samples from Mengcun,Shaanxi Province,People’s Republic of China,and developed a semi-enclosed experimental system(furnace)for simulating coal combustion.The thermal mass loss of coal samples under various heating rates(5,10,and 15℃/min)was analyzed through thermogravimetric analysis,and the dynamic characteristics of the coal samples were analyzed;the reliability of the semi-enclosed experimental system was verifed through the equal proportional method of fuzzy response.The results reveal that the high-temperature zone is distributed nonlinearly from the middle to the front end of the furnace,and the temperatures of points in this zone decreased gradually as the layer depth increased.The apparent activation energy of the coal samples during combustion frst increased and then decreased as the conversion degree increased.Furthermore,the proportion of mass loss and the mass loss rate in the coal samples observed in the thermogravimetric experiment is consistent with that observed in the frst and second stages of the experiment conducted using the semi-enclosed system.The research fndings can provide a theoretical basis for the prevention and control of hightemperature zones in coal combustion. | Jingyu Zhao Hanqi Ming Tao Guo Yuxuan Zhang Jun Deng Jiajia Song Qiang Zeng Chi‑Min Shu | 2022 | International Journal of Coal Science & Technology2022，9，5： | 3 |
| 12 | Low intensity near-infrared light promotes bone regeneration via circadian clock protein cryptochrome 1显示文摘Bone regeneration remains a great clinical challenge. Low intensity near-infrared(NIR) light showed strong potential to promote tissue regeneration, offering a promising strategy for bone defect regeneration. However, the effect and underlying mechanism of NIR on bone regeneration remain unclear. We demonstrated that bone regeneration in the rat skull defect model was significantly accelerated with low-intensity NIR stimulation. In vitro studies showed that NIR stimulation could promote the osteoblast differentiation in bone mesenchymal stem cells(BMSCs) and MC3T3-E1 cells, which was associated with increased ubiquitination of the core circadian clock protein Cryptochrome 1(CRY1) in the nucleus. We found that the reduction of CRY1 induced by NIR light activated the bone morphogenetic protein(BMP) signaling pathways, promoting SMAD1/5/9 phosphorylation and increasing the expression levels of Runx2 and Osterix. NIR light treatment may act through sodium voltage-gated channel Scn4a, which may be a potential responder of NIR light to accelerate bone regeneration. Together, these findings suggest that low-intensity NIR light may promote in situ bone regeneration in a CRY1-dependent manner, providing a novel, efficient and non-invasive strategy to promote bone regeneration for clinical bone defects. | Jinfeng Peng Jiajia Zhao Qingming Tang Jinyu Wang Wencheng Song Xiaofeng Lu Xiaofei Huang Guangjin Chen Wenhao Zheng Luoying Zhang Yunyun Han Chunze Yan Qian Wan Lili Chen | 2022 | International Journal of Oral Science2022，14，4： | 2 |
| 13 | Hierarchical,seamless,edge-rich nanocarbon hybrid foams for highly efficient electromagnetic-interference shielding显示文摘Lightweight,flexible,ultrahigh-performance electromagnetic-interfe rence(EMI)shielding materials are urgently required in the areas of aircraft/aerospace,portable and wearable electronics.Herein,1 D carbon nanotubes(CNT)and carbon nanofibers(CNF)with 2 D edge-rich graphene(ERG)are used to form a lightweight,flexible CNT-ERG-CNF hybrid foam.This foam was fabricated through a self-sacrificial templating chemical vapor deposition process,where nanocarbons bond through covalent bonding,forming a hierarchical 3 D hybridized carbon nanostructure.Multistage conductive networks and heterogeneous interfaces were constructed using edge-rich nanocarbons to increase the induced currents and interfacial polarization which makes great contributions to achieve high absorption electromagnetic shielding effectiveness(SEA).The CNT-ERG-CNF hybrid foam exhibits EMI shielding effectiveness(SE)exceeding55.4 dB in the X-band while the specific SE(SSE,SE divided by mass density)achieves 9200 dB cm^(3)g^(-1),which surpasses that of nearly all other carbon-based composite materials.Furthermore,the structural stability and durability of the flexible CNT-ERG-CNF hybrid foams is examined by measuring EMI SE after 10000 times cyclic bending.Remarkably,this work not only provides a new idea for preparing hierarchical carbon materials for a wide range of applications,but presents some fundamental insights for achieving higher absorption losses in EMI shielding materials. | Liyuan Han Qiang Song Kezhi Li Xuemin Yin Jiajia Sun Hejun Li Fengpei Zhang Xinran Ren Xi Wang | 2021 | Journal of Materials Science & Technology2021，，13： | 2 |
| 14 | Enhancing both strength and toughness of carbon/carbon composites by heat-treated interface modification显示文摘A simple method to increase both strength and toughness of carbon/carbon(C/C) composites is presented.This method is based on the heat treatment of the pre-deposited thin carbon coating, leading to the formation of more orderly pyrolytic carbon(PyC) as a functional interlayer between fiber and matrix that could optimize the interfacial sliding strength in C/C composites. Effects of such a heat-treated PyC layers on the microstructure, tensile strength and fracture behavior of unidirectional C/C composites were investigated. Results showed that although the in-situ fiber strength was deteriorated after the introduction of interfacial layer, tensile strength of the specimen was greatly improved by 38.5% compared with pure C/C composites without any treatment. The interfacial sliding stress sharply decreased, which was interpreted from finite element analysis and verified by Raman spectra. Therefore, the fracture behavior was changed from brittle fracture to multiple-matrix cracking induced non-linear mechanical behavior.Finally, the ultimate strength can be predicted by different models according to the interfacial sliding stress. Our research would provide a meaningful way to improve both strength and toughness of C/C composites. | Jiajia Sun Hejun Li Liyuan Han Qiang Song | 2019 | Journal of Materials Science & Technology2019，35，3： | 2 |
| 15 | Fluorescent magnetic nanoparticle-labeled mesenchymal stem cells for targeted imaging and hyperthermia therapy of in vivo gastric cancer显示文摘 | Jing Ruan Jiajia Ji Hua Song Qirong Qian Kan Wang Can Wang Daxiang Cui | 2012 | Nanoscale Research Letters2012，，1： | 1 |
| 16 | Effects of Bacillus preparations on immunity and antioxidant activities in grass carp ( Ctenopharyngodon idellus )显示文摘 | Li Weifen Zhang Xiaoping Song Wenhui Deng Bin Liang Quan Fu Luoqin Zheng Jiajia Wang yue Yu Dongyou | 2012 | Fish Physiology and Biochemistry2012，，6： | 1 |
| 17 | Acidification and bubble template derived porous g-C_(3)N_(4) for efficient photodegradation and hydrogen evolution显示文摘Graphitic carbon nitride(g-C_(3)N_(4))as a metal-free candidate of photocatalyst has received worldwide attention because of its great potentials in solar light-induced degradation and hydrogen evolution,yet the industrial application is seriously hindered by the small specific surface area and rapid recombination rate of carriers.Herein,we demonstrate that porous g-C_(3)N_(4)(HCl-CNU-X)can be prepared via the copolymerization of acidified melamine and a green bubble template(urea).Transmission electron microscopy and nitrogen sorption characterization results show that the prepared HCl-CNU-X possesses an in-plane porous structure and large specific surface area,enabling the exposure of more accessible active sites.As a result,HCl-CNU-X exhibits both enhanced photocatalytic tetracycline hydrochloride degradation and higher hydrogen evolution than bulk g-C_(3)N_(4).The boosted photocatalytic performance was ascribed to the formation of the porous structure,which dramatically promotes the separation of charge-carriers and facilitates the electron transfer.This work demonstrates that the acidification of nitrogen-rich precursors combined with a bubble-template can develop a new paradigm of highly porous photocatalysts for environmental remediation and water splitting. | Yixuan Wang Fengting He Lin Chen Jie Shang Jiajia Wang Shuaijun Wang Huimin Song Jinqiang Zhang Chaocheng Zhao Shaobin Wang Hongqi Sun | 2020 | Chinese Chemical Letters2020，31，10： | 1 |
| 18 | Structural and Morphological Modulation of BiOCl Visible-light Photocatalyst Prepared via an In situ Oxidation Synthesis显示文摘 | WANG Jianmin CAO Feng DENG Ruiping HUANG Lijian LI Song CAI Jiajia LU Xin QIN Gaowu | 2016 | Chemical Research in Chinese Universities2016，32，3： | 1 |
| 19 | Global trends and regional differences in non-transport unintentional injuries mortality among children and adolescents, 1990 to 2019: results from the Global Burden of Disease 2019 study显示文摘Background::Non-transport unintentional injuries(NTUIs)are major public concerns,especially among children and adolescents in low-and middle-income countries.With environmental and cognitive changes,a recent systematic description of global trends and regional differences concerning NTUIs is urgently needed for the global agenda of relevant policy-making and intervention target findings.Methods::We used mortality,population,and socio-demographic-index(SDI)data from Global Burden of Disease 2019 to analyze the trends of NTUIs mortality.We applied the slope index of inequality(SII)and relative index of inequality(RII)to measure the absolute and relative inequality between countries and territories.The concentration curve and concentration index(CI)were also used to measure the inequality.We conducted a sensitivity analysis to make our findings credible.Results::In 2019,there were 205,000 deaths due to NTUIs among children and adolescents aged 5 to 24 years,which decreased from 375,000 in 1990.In 2019,the age-standardized mortality rate(ASMR)was 8.13 per 100,000,ranging from the lowest in the Netherlands(0.90 per 100,000)to the highest in the Solomon Islands(29.34 per 100,000).The low-middle SDI group had the highest ASMR of NTUIs,while the low SDI group had the slowest decrease.After excluding the death caused by'exposure to forces of nature'and'other unintentional injuries',drowning accounted for the most deaths in almost every SDI group,gender,and age group,but the major causes of death varied in different subgroups.For example,animal contact was a major cause in low and low-middle SDI groups but less in high SDI groups,while high and high-middle SDI groups had a higher proportion of deaths for foreign body and poisonings.The SII showed a declining trend,but the RII and CI did not,which might indicate that inequality was persistent.Similar results were found in the sensitivity analysis.Conclusions::Despite the declining trend of the mortality rate and the narrowing gap between countries,there were still a large number of children and adolescents dying from NTUIs,and those experiencing social-economic disadvantages remained at high mortality.Embedding the prevention of NTUIs into sustainable development goals might contribute to the progress of reducing death and inequalities,which ensures that no one is left behind. | Yunfei Liu Yanhui Dong Xiaojin Yan Ning Ma Jiajia Dang Jingshu Zhang Panliang Zhong Luo Li Zhiyong Zou Yi Song Jun Ma | 2022 | Chinese Medical Journal2022，135，17： | 1 |
| 20 | Monitoring casein kinase Ⅱ at subcellular level via bio-bar-code-based electrochemiluminescence biosensing method显示文摘A highly sensitive electrochemiluminescence(ECL) biosensing method was developed for monitoring casein kinase Ⅱ(CK2) at subcellular level via bio-bar-code assay.A bio-bar-code probe(h-DNA/AuNPs/pDNA) prepared by conjugating phosphorylated DNA(p-DNA) and hairpin DNA(h-DNA) onto gold nanoparticles(AuNPs) was used as a carrier for ECL signal reagent(Ru(phen)32+) while a specific peptide was used as a recognition substance.A gold ultramicroelectrode with a diameter of 400 nm was fabricated and then modified with the specific peptide via self-assembly technique to obtain peptide modified gold ultramicroelectrode.The peptide on gold ultramicroelectrode was phosphorylated in the presence of CK2 and adenosine 5’-triphosphate,and then the phosphorylated peptide was integrated with the h-DNA/AuNPs/p-DNA through a process mediated by zirconium cations(Zr4+),and finally Ru(phen)32+ was intercalated into h-DNA.A 'signal on' ECL method was developed for the detection of CK2 in the range of 0.005-0.2 U/mL with a detection limit of 0.001 U/mL.Additionally,combined efficient subcellular phosphorylation in vivo with bio-bar-code-based ECL biosensing method,the ECL method was further applied to monitor CK2 at subcellular level without tedious subcellular fractionation.It was found that the concentration of CK2 by inserting the peptide modified gold ultramicroelectrode into the nucleus was higher than that into cytoplasm of HeLa cells.A distinct heterogeneity among CK2 concentrations in single cells was observed for cellular heterogeneity assessment. | Lifen Wang Jiajia Song Xiaofei Wang Honglan Qi Qiang Gao Chengxiao Zhang | 2020 | Chinese Chemical Letters2020，31，9： | 1 |
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