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| 1 | Study on gastric cancer blood plasma based on surface-enhanced Raman spectroscopy combined with multivariate analysis显示文摘A surface-enhanced Raman spectroscopy (SERS) method combined with multivariate analysis was developed for non-invasive gastric cancer detection. SERS measurements were performed on two groups of blood plasma samples: one group from 32 gastric patients and the other group from 33 healthy volunteers. Tentative assignments of the Raman bands in the measured SERS spectra suggest interesting cancer-specific biomolecular changes, including an increase in the relative amounts of nucleic acid, collagen, phospholipids and phenylalanine and a decrease in the percentage of amino acids and saccharide in the blood plasma of gastric cancer patients as compared with those of healthy subjects. Principal components analysis (PCA) and linear discriminant analysis (LDA) were employed to develop effective diagnostic algorithms for classification of SERS spectra between normal and cancer plasma with high sensitivity (79.5%) and specificity (91%). A receiver operating characteristic (ROC) curve was employed to assess the accuracy of diagnostic algorithms based on PCA-LDA. The results from this exploratory study demonstrate that SERS plasma analysis combined with PCA-LDA has tremendous potential for the non-invasive detection of gastric cancers. | FENG ShangYuan PAN JianJi WU YanAn LIN Duo CHEN YanPing XI GangQin LIN JuQiang CHEN Rong | 2011 | Science China(Life Sciences)2011，54，9： | 15 |
| 2 | How to identify dislocations in molecular dynamics simulations?显示文摘Dislocations are of great importance in revealing the underlying mechanisms of deformed solid crystals.With the development of computational facilities and technologies,the observations of dislocations at atomic level through numerical simulations are permitted.Molecular dynamics(MD)simulation suggests itself as a powerful tool for understanding and visualizing the creation of dislocations as well as the evolution of crystal defects.However,the numerical results from the large-scale MD simulations are not very illuminating by themselves and there exist various techniques for analyzing dislocations and the deformed crystal structures.Thus,it is a big challenge for the beginners in this community to choose a proper method to start their investigations.In this review,we summarized and discussed up to twelve existing structure characterization methods in MD simulations of deformed crystal solids.A comprehensive comparison was made between the advantages and disadvantages of these typical techniques.We also examined some of the recent advances in the dynamics of dislocations related to the hydraulic fracturing.It was found that the dislocation emission has a significant effect on the propagation and bifurcation of the crack tip in the hydraulic fracturing. | LI Duo WANG Feng Chao YANG Zhen Yu ZHAO Ya Pu | 2014 | Science China(Physics,Mechanics & Astronomy)2014，57，12： | 11 |
| 3 | Brazing of C/C composite and Ti-6Al-4V with graphene strengthened AgCuTi filler:Effects of graphene on wettability,microstructure and mechanical properties显示文摘Graphene nanosheets(GNSs) strengthened AgCuTi composite filler(AgCuTi_G) was used to braze C/C composite and Ti-6Al-4V. The effects of GNSs on the wettability of AgCuTi_G filler on the C/C composite surface and the interfacial microstructure and mechanical properties of brazed joints were investigated. The results indicate that the addition of GNSs reduced the wettability of AgCuTi_G. The interfacial microstructure of brazed joints evolved with the addition of GNSs, where Ti_3Cu_4 and TiCu_4 were converted to TiCu and the thickness of the reaction layer adjacent to the base material decreased. The maximum shear strength of joints brazed at 0.3 wt% GNSs was 23.3 MPa(880℃/10 min). Further adding GNSs deteriorated the shear strength of the joints. Fracture of the joints occurred in the C/C composite substrate and the TiC layer adjacent to C/C composite. | Duo LIU Yanyu SONG Yinghao ZHOU Xiaoguo SONG Wei FU Jicai FENG | 2018 | Chinese Journal of Aeronautics2018，31，7： | 11 |
| 4 | Major advances in studies of the physical geography and living environment of China during the past 70 years and future prospects显示文摘The natural environment provides material essentials for human survival and development. The characteristics,processes, regional differentiation and forcing mechanisms of the elements of the natural environment(e.g. geomorphology,climate, hydrology, soil, etc.) are the main objects of research in physical geography. China has a complex natural environment and huge regional differentiation and therefore it provides outstanding reserach opportunities in physical geography. This review summarizes the most important developments and the main contributions of research in the physical geography and human living environment in China during the past 70 years. The major topics addressed are the uplift of the Tibetan Plateau and the evolution of its cryosphere, the development of fluvial systems, the acidification of the vast arid region of the Asian interior, variations in the monsoon and westerly climate systems on multiple timescales, the development of lakes and wetlands, the watershed system model, soil erosion, past human-environment interactions, biogeography, and physical geographic zonality. After briefly introducing international research developments, we review the history of research in physical geography in China, focusing on the major achievements and major academic debates, and finally we summarize the status of current research and the future prospects. We propose that in the context of the national demand for the construction of an ecological civilization, we should make full use of the research findings of physical geography, and determine the patterns and mechanisms of natural environmental processes in order to continue to promote the continued contribution of physical geography to national development strategies, and to further contribute to the theory of physical geography from a global perspective. | Fahu CHEN Bojie FU Jun XIA Duo WU Shaohong WU Yili ZHANG Hang SUN Yu LIU Xiaomin FANG Boqiang QIN Xin LI Tingjun ZHANG Baoyuan LIU Zhibao DONG Shugui HOU Lide TIAN Baiqing XU Guanghui DONG Jingyun ZHENG Wei YANG Xin WANG Zaijun LI Fei Wang Zhenbo HU Jie WANG Jianbao LIU Jianhui CHEN Wei HUANG Juzhi HOU Qiufang CAI Hao LONG Ming JIANG Yaxian HU Xiaoming FENG Xingguo MO Xiaoyan YANG Dongju ZHANG Xiuhong WANG Yunhe YIN Xiaochen LIU | 2019 | Science China Earth Sciences2019，62，11： | 11 |
| 5 | Vacuum brazing of GH99 superalloy using graphene reinforced BNi-2 composite filler显示文摘A novel graphene reinforced BNi-2 composite filler was developed for brazing GH99 superalloy. The interfacial microstructure of brazed joints was analyzed by field emission scanning electron microscope and a transmission electron microscope. The effects of graphene addition on the microstructure evolution and mechanical properties of brazed joints were investigated, and the strengthening mechanism of graphene was analyzed. The results revealed that due to the addition of graphene, M23(C,B)6 compounds were synthesized in the solid solution and brittle boride precipitates near the brazing seam decreased.Graphene was effective in retarding solute atoms diffusion thus impeding the precipitation of borides.Furthermore, the low coefficient of thermal expansion(CTE) of graphene was conducive to relieve stress concentration of the brazed joints during the cooling process. The shear strengths of brazed joints were significantly improved by exerting the strengthening effect of graphene. The maximum shear strengths of the brazed joints were 410.4 MPa and 329.7 MPa at room temperature and 800?C, respectively. | Duo Liu Yanyu Song Bin Shi Qi Zhang Xiaoguo Song Hongwei Niu Jicai Feng | 2018 | Journal of Materials Science & Technology2018，34，10： | 10 |
| 6 | Research on Water-Exit and Take-off Process for Morphing Unmanned Submersible Aerial Vehicle显示文摘This paper presents a theoretic implementation method of Morphing Unmanned Submersible Aerial Vehicle(MUSAV),which can both submerge in the water and fly in the air.Two different shapes are put forward so that the vehicle can suit both submergence and flight,considering the tremendous differences between hydrodynamic configuration and aerodynamic configuration of a vehicle.The transition of the two shapes can be achieved by using morphing technology.The water-to-air process,including water-exit,morphing,take-off and steady flight,is analyzed.The hydrodynamic and aerodynamic model of the vehicle exiting the water surface obliquely and then taking off into the air has been founded.The control strategy after morphing is analyzed and the control method is given.Numerical method is used to validate the motion model of the water-exit process.Results of simulations show the validity of the proposed model and the feasibility of MUSAV in theory. | HU Jun-hua XU Bao-wei FENG Jin-fu QI Duo YANG Jian WANG Cong | 2017 | China Ocean Engineering2017，31，2： | 8 |
| 7 | H2 strain attenuated live hepatitis A vaccines:protective efficacy in a hepatitis A outbreak显示文摘AIM To investigate the protective efficacy ofH2 strain attenuated live hepatitis A vaccines(H2-strain vaccines)in hepatitis A(HA)outbreaks.METHODS With the permission of theirparents,5551 pre-school and grade 1-3 primaryschool children were inoculated with 1 dose(106.5TCID50)of H2-strain vaccines in anonrandomized,controlled trial conducted inFucheng County,Hebei Province in May 1997.Another 6485 children in the same grades andcompatible in gender and age were enrolled ascontrols.Epidemiological and serological surveywas conducted to evaluate the protectiveefficacy of the vaccines.ELISA was used todetect serum IgM anti-HAV.RESULTS HA outbreak started in early May1998,peaked in the middle of the same month,and lasted about 80 days.Overall 302 HA caseswere found,192(53.58%)were 5-9 years old.One vaccinee and 25 control cases were found tohave hepatitis A,which account for 0.28%(1/356)and 5.92%(25/422)of all vaccinees andcontrols in the 14 villages,respectively.The protective efficacy of vaccines was 95.27%(95% Cl:85.83%-104.72%).In subjects testedfor anti-HAV IgM from 13 villages,1(0.40%)overt and 11(4.06%)asymptomatic HAV caseswere found in 271 vaccinees,but 21(6.69%)ofovert and asymptomatic ones were found in 314controls.CONCLUSION H2 strain vaccines were excellent in preventing overt hepatitis A, but not so effective in preventing asymptomatic hepatitis A virus infection. A booster dose might be needed to get permanent reliable immunity. | Yu Liang Zhao Zong Da Meng Zhi Yi Xu Jun Jie Guo Shao Ai Chai Cheng Gang Duo Xuan Yi Wang Jin Feng Yao Hong Bin Liu Shun Xiang Qi Hui Bin Zhu | 2000 | World Journal of Gastroenterology2000，6，6： | 7 |
| 8 | Macrophage-activating lipopeptide-2 downregulates the expression of ATP-binding cassette transporter A1 by activating the TLR2/ NF-KB/ZNF202 pathway in THP-1 macrophages显示文摘 | Liangjie Peng Zizhen Zhang Min Zhang Xiaohua Yu Feng Yao Yulin Tan Dan Liu Duo Gong Huang Chong Xiaoyan Liu Xilong Zheng Guoping Tian Chaoke Tang | 2016 | Acta Biochimica et Biophysica Sinica2016，48，4： | 6 |
| 9 | Flow Field and Heat Transfer Analysis of Local Structure for Regenerative Cooling Panel显示文摘Local structure of cooling panel has great effects on the heat transfer in the cooling channel for the scramjet. The problems of flow dead area and mass flow rate non-uniform distribution caused by the local structure effect the cooling effectiveness in the channel seriously. Numerical simulation to the flow field of scramjet cold panel with four different fuel injection island structures respectively has been carried out using the CFD commercial software-CFX in this research. The results reveal that flow dead area has been eliminated and flow field has been improved for the optimized structure. Furthermore, local resistance loss has been decreased and the mass flow rate non-uniform distribution in the channel has been reduced. Based on the optimized results, some suggestions about the local design of cooling panel have been proposed in this research. | Yu Feng Hongyan Huang Tao Li Duo Zhang Zhongqi Wang | 2012 | Journal of Thermal Science2012，21，2： | 5 |
| 10 | Exendin-4 and linagliptin attenuate neuroinflammation in a mouse model of Parkinson's disease显示文摘Use of glucagon-like peptide-1 receptor agonist or dipeptidyl peptidase 4 inhibitor has been shown to lower the incidence of Parkinson's disease in patients with diabetes mellitus.Therefore,using these two treatments may help treat Parkinson's disease.To further investigate the mechanisms of action of these two compounds,we established a model of Parkinson's disease by treating mice with 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine and then subcutaneously injected them with the glucagon-like peptide-1 receptor agonist exendin-4 or the dipeptidyl peptidase 4 inhibitor linagliptin.We found that both exendin-4 and linagliptin reversed motor dysfunction,glial activation,and dopaminergic neuronal death in this model.In addition,both exendin-4 and linagliptin induced microglial polarization to the anti-inflammatory M2 phenotype and reduced pro-inflammatory cytokine secretion.Moreover,in vitro experiments showed that treatment with exendin-4 and linagliptin inhibited activation of the nucleotide-binding oligomerization domain-and leucine-rich-repeat-and pyrin-domaincontaining 3/caspase-1/interleukin-1βpathway and subsequent pyroptosis by decreasing the production of reactive oxygen species.These findings suggest that exendin-4 and linagliptin exert neuroprotective effects by attenuating neuroinflammation through regulation of microglial polarization and the nucleotidebinding oligomerization domain-and leucine-rich-repeat-and pyrin-domain-containing 3/caspase-1/interleukin-1βpathway in a mouse model of Parkinson's disease induced by 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine.Therefore,these two drugs may serve as novel anti-inflammatory treatments for Parkinson's disease. | Hai-Yang Yu Tong Sun Zhen Wang Hong Li Duo Xu Jing An Lu-Lu Wen Jia-Yi Li Wen Li Juan Feng | 2023 | Neural Regeneration Research2023，18，8： | 4 |
| 11 | Adiponectin receptor 1 and small ubiquitin-like modifier 4 polymorphisms are associated with risk of coronary artery disease without diabetes显示文摘编码 adiponectin 受体 1 的基因( ADIPOR1 )和小象ubiquitin一样修饰词( SUMO4 ) 4 被连接了到 anti-atherogenic 效果,但是很少对是否被知道在二基因的多型性,独立行动或交往,没有 diabetes.MethodsWe genotyped ,影响冠的动脉疾病( CAD )的风险没有糖尿病的 200 个 CAD 病人和没有 CAD 的 200 控制,它被选择基于前一个没有 diabetes.ResultsRisk 等位基因,协会也是的潜力在 ADIPOR1 (rs7539542-G, rs7514221-C 和 rs3737884-G ) 在三 SNP 在这些 SNP 和 CAD 的临床的特征之间探索了,没有糖尿病,在在 SUMO4 的 SNP rs237025 的 G 等位基因显著地增加了 CAD 的风险,与从 1.79 ~ 4.44 的 ORs。任何这四风险等位基因的搬运人出现了类似不利 ? 临床的特征。与有 CC 或 GC 遗传型的个人相比,有在 rs3737884 的 GG 遗传型的那些在影响了左前面的下降冠的动脉的 CAD 的显著地更高的风险(或:6.77, P = 0.009 ) ,恰好冠的动脉(或:4.81, P = 0.028 ) 或容器的一个相对大的数字(P = 0.04 ) 。没有糖尿病,在 SUMO4 在 SNP 象风险等位基因一样在 ADIPOR1 在三 SNP 中的至少一个带风险等位基因的个人比不带任何风险等位基因的个人在 CAD 的显著地更高的风险(或:5.82, 95% CI:1.2327.7, P = 0.013 ) 没有糖尿病,在 ADIPOR1 和 SUMO4 的 .ConclusionsSNPs 与 CAD 的提高的风险被联系,并且在二基因的 SNP 可以交往联合影响疾病风险。 | Hong LI Ze YANG Lian-Mei PU Xiang LI Yang RUAN Fan YANG Shuai MENG Duo YANG Wei YAO Hao FU Feng ZHANG Ze-Ning JIN | 2016 | Journal of Geriatric Cardiology2016，13，9： | 4 |
| 12 | Precision integration of grating-based polarizers onto focal plane arrays of near-infrared photovoltaic detectors for enhanced contrast polarimetric imaging显示文摘Polarimetric imaging enhances the ability to distinguish objects from a bright background by detecting their particular polarization status,which offers another degree of freedom in infrared remote sensing.However,to scale up by monolithically integrating grating-based polarizers onto a focal plane array(FPA)of infrared detectors,fundamental technical obstacles must be overcome,including reductions of the extinction ratio by the misalignment between the polarizer and the detector,grating line width fluctuations,the line edge roughness,etc.This paper reports the authors’latest achievements in overcoming those problems by solving key technical issues regarding the integration of large-scale polarizers onto the chips of FPAs with individual indium gallium arsenide/indium phosphide(In Ga As/In P)sensors as the basic building blocks.Polarimetric and photovoltaic chips with divisions of the focal plane of 540×4 pixels and 320×256 superpixels have been successfully manufactured.Polarimetric imaging with enhanced contrast has been demonstrated.The progress made in this work has opened up a broad avenue toward industrialization of high quality polarimetric imaging in infrared wavelengths. | Bo Feng Yifang Chen Duo Sun Zongyao Yang Bo Yang Xue Li Tao Li | 2021 | International Journal of Extreme Manufacturing2021，3，3： | 4 |
| 13 | Synthesis of MOF-derived nitrogen-doped carbon microtubules via template self-consumption显示文摘Herein,by optimizing nano-ZnO template,N-doped hollow carbon microtubules with controllable thickness are synthesized deriving from ZnO@zeolitic lmidazolate framework(ZIF-8)nanorod by template self-consumption method,and a superior structure with graphene-like layers of an average length of 5μm and diameter of 200 nm are proposed to be used as the cathode carries for Li-S batteries.Through electrochemical testing,we found that the prepared hollow carbon microtubules have higher discharge capacity and better rate performance than the ZIF-8 derived carbon,showing potential application value.Our work provides a feasible way for the preparation of monodisperse graphene-like hollow materials. | Duo Wang Ze-Yu Zhao Ping Wang Si-Miao Wang Ming Feng | 2022 | Rare Metals2022，41，8： | 3 |
| 14 | Elucidation of the sodium kinetics in layered P-type oxide cathodes显示文摘Sodium-ion intercalation oxides generally possess high compositional diversity according to their different stacking sequences.The sodium diffusion pathway in layered P-type materials used in sodium-ion batteries is open,which can increase their rate capability by directly transmitting Na+between adjacent triangular prismatic channels,rather than passing through an intermediate tetrahedral site in O-type structure.However,how the structure chemistry of the P-type oxides determines their electrochemical properties has not been fully understood yet.Herein,by comparing the crystalline structures,electrochemical behaviors,ion/electron transport dynamics of a couple of P-type intercalation cathodes,P2-Na_(2/3)Ni1/3Mn_(2/3)O_(2)and P3-Na_(2/3)Ni_(1/3)Mn_(2/3)O_(2)with the same compositions,we demonstrate experimentally and computationally that the P2 phase delivers better cycling stability and rate capability than the P3 counterpart due to the predominant contribution of the faster intrinsic Na diffusion kinetics in the P2 bulk.We also point out that it is the electronic conductivity that captures the key electrochemistry of layered P3-type materials and makes them possible to enhance the sodium storage performance.The results reveal that the correlation between stacking structure and functional properties in two typical layered P-type cathodes,providing new guidelines for preparing and designing alkali-metal layered oxide materials with improved battery performance. | Lianzheng Yu Haojie Dong Yu-Xin Chang Zhiwei Cheng Kang Xu Yi-Hu Feng Duo Si Xu Zhu Mengting Liu Bing Xiao Peng-Fei Wang Sailong Xu | 2022 | Science China Chemistry2022，65，10： | 3 |
| 15 | Crystal growth and properties of Ca3NbGa3Si2O14 single crystals显示文摘 | WANG Zeng- mei CHENG Xiu - feng YUAN Duo -rong | 2003 | J Cryst Grwoth2003，249，2： | 1 |
| 16 | Synthesis of titanium dioxide films by ion beam enhanced deposition显示文摘 | Zhang Feng Zheng Zhihong Liu Duo | 1997 | Nuclear Instruments and Methods in Physics Research B1997，132，4： | 1 |
| 17 | Effects of silkworm pupa protein on apoptosis and energy metabolism in human colon cancer DLD-1 cells显示文摘Objective:To investigate the effects of silkworm pupa(Bombyx mori) protein(SPP) on cell proliferation,apoptosis and energy metabolism in human colon cancer cells DLD-1.Methods:CCK-8 was used to detect cell proliferation rate after 72 h of cell culture for the control group(normal cultured DLD-1 cells) and SPP dose groups;Annexin-V/PI was applied to observe cell apoptosis;XFe24 Extracellular Flux Analyzer was used to detect cell mitochondrial respiratory function and glycolytic function.Results:Comparing with the control,SPP significantly inhibited the proliferation of DLD-1 cells with all the dosage tested(P <0.01);flow cytometry showed that SPP significantly promoted apoptosis(P<0.05).Additionally,SPP could significantly inhibited mitochondrial metabolism and glycolysis of DLD-1 cells and decreased cell energy metabolism in all groups treated with different doses.Conclusion:SPP can cause oxidative damage,promote apoptosis,and reduce mitochondrial respiratory and glycolysis rate in colon cancer DLD-1 cells,which reveals that SPP has the potential to serve as the anti-cancer drugs in the future,but further experimental evidence is needed. | Xiaojiao Ji Jing Wang Aijin Ma Duo Feng Yue He Wenjie Yan | 2022 | Food Science and Human Wellness2022，11，5： | 1 |
| 18 | Synthesis of titanium dioxide films by ion beam enhanced deposition显示文摘 | Feng Z Zhihong Z Duo L | 1997 | Nuclear Instr Methods Phys Res B1997，132，5： | 1 |
| 19 | Synthesis of titanium dioxide films by ion beam enhanced deposition显示文摘 | Feng Z Zhihong Z Duo L | 1997 | Nuclear Instr Methods Phys Res B1997，132，： | 1 |
| 20 | Laparoscopic Local Resection Based on Sentinel Node Evaluation for Early Gastric Cancer: A Preliminary Report显示文摘 | Lin Bo Wang Jian Guo Shen Li Feng Dong Chao Yang Xu Wen Jun Chen Shu Duo Xie Xiang Yang Song Ning Dai Xiao Ming Yuan | 2008 | Journal of Gastrointestinal Surgery2008，，8： | 1 |
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