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| 1 | Scientific objectives of the Hot Universe Baryon Surveyor(HUBS) mission显示文摘The Hot Universe Baryon Surveyor(HUBS) is a proposed space-based X-ray telescope for detecting X-ray emissions from the hot gas content in our universe. With its unprecedented spatially-resolved high-resolution spectroscopy and large field of view,the HUBS mission will be uniquely qualified to measure the physical and chemical properties of the hot gas in the interstellar medium, the circumgalactic medium, the intergalactic medium, and the intracluster medium. These measurements will be valuable for two key scientific goals of HUBS, namely to unravel the AGN and stellar feedback physics that governs the formation and evolution of galaxies, and to probe the baryon budget and multi-phase states from galactic to cosmological scales. In addition to these two goals, the HUBS mission will also help us solve some problems in the fields of galaxy clusters, AGNs, difuse X-ray backgrounds, supernova remnants, and compact objects. This paper discusses the perspective of advancing these fields using the HUBS telescope. | Joel Bregman Renyue Cen Yang Chen Wei Cui Taotao Fang Fulai Guo Edmund Hodges-Kluck Rui Huang Luis C.Ho Li Ji Suoqing Ji Xi Kang Xiaoyu Lai Hui Li Jiangtao Li Miao Li Xiangdong Li Yuan Li Zhaosheng Li Guiyun Liang Helei Liu Wenhao Liu Fangjun Lu Junjie Mao Gabriele Ponti Zhijie Qu Chenxi Shan Lijing Shao Fangzheng Shi Xinwen Shu Lei Sun Mouyuan Sun Hao Tong Junfeng Wang Junxian Wang Q.Daniel Wang Song Wang Tinggui Wang Weiyang Wang Zhongxiang Wang Dandan Xu Haiguang Xu Heng Xu Renxin Xu Xiaojie Xu Yongquan Xue Hang Yang Feng Yuan Shuinai Zhang Yuning Zhang Zhongli Zhang Yuanyuan Zhao Enping Zhou Ping Zhou | 2023 | Science China(Physics,Mechanics & Astronomy)2023，66，9： | 1 |
| 2 | Vertex results for parametric He problems of weighted interval feedback systems 显示文摘 | An Senjian Huang Lin Wang Enping | 2000 | Systems &Control Letters2000，39，5： | 1 |
| 3 | No Association Between the Polymorphisms in Matrix Metalloproteinase-1 and Matrix Metalloproteinase-3 Promoter Regions and Colorectal Cancer in Chinese显示文摘 | Enping Xu Ph.D. Maode Lai Ph.D. Bingjian L? Ph.D. Xiaoming Xing Ph.D. Qiong Huang | 2006 | Diseases of the Colon & Rectum2006，，9： | 1 |
| 4 | GLTSCR1 coordinates alternative splicing and transcription elongation of ZO1 to regulate colorectal cancer progression显示文摘Alternative splicing(AS)and transcription elongation are vital biological processes,and their dysregulation causes multiple diseases,including tumors.However,the coregulatory mechanism of AS and transcription elongation in tumors remains unclear.This study demonstrates a novel AS pattern of tight junction protein 1(ZO1)regulated by the RNA polymerase II elongation rate in colorectal cancer(CRC).Glioma tumor suppressor candidate region gene 1(GLTSCR1)decreases the transcription elongation rate of ZO1 to provide a time window for binding of the splicing factor HuR to the specific motif in intron 22 of ZO1 and spliceosome recognition of the weak 3 and 5 splice sites in exon 23 to promote exon 23 inclusion.Since exon 23 inclusion in ZO1 suppresses migration and invasion of CRC cells,our findings suggest a novel potential therapeutic target for CRC. | Fengyan Han Beibei Yang Mingyue Zhou Qiong Huang Minglang Mai Zhaohui Huang Maode Lai Enping Xu Honghe Zhang | 2022 | Journal of Molecular Cell Biology2022，14，2： | 1 |
| 5 | Protective effect of alpha-synuclein knockdown on methamphetamine-induced neurotoxicity in dopaminergic neurons显示文摘The over-expression of α-synuclein is a major factor in the death of dopaminergic neurons in a methamphetamine-induced model of Parkinson's disease. In the present study, α-synuclein knockdown rats were created by injecting α-synuclein-shRNA lentivirus stereotaxically into the right striatum of experimental rats. At 2 weeks post-injection, the rats were injected intraper-itoneally with methamphetamine to establish the model of Parkinson's disease. Expression of α-synuclein mRNA and protein in the right striatum of the injected rats was significantly down-regulated. Food intake and body weight were greater in α-synuclein knockdown rats, and water intake and stereotyped behavior score were lower than in model rats. Striatal dopamine and tyrosine hydroxylase levels were significantly elevated in α-synuclein knockdown rats. Moreover, superoxide dismutase activity was greater in α-synuclein knockdown rat striatum, but the levels of reactive oxygen species, malondialdehyde, nitric oxide synthase and nitrogen monoxide were lower compared with model rats. We also found that α-synuclein knockdown inhibited metham-phetamine-induced neuronal apoptosis. These results suggest that α-synuclein has the capacity to reverse methamphetamine-induced apoptosis of dopaminergic neurons in the rat striatum by inhibiting oxidative stress and improving dopaminergic system function. | Yunchun Tai Ling Chen Enping Huang Chao Liu Xingyi Yang Pingming Qiu Huijun Wang | 2014 | Neural Regeneration Research2014，9，9： | 0 |
| 6 | The Quality Difference of Tobacco Leaves Between Different Flue-curing Processes in Honghe Tobacco-growing Area显示文摘[Objectives] This study was conducted to compare the effects of different curing processes,in order to optimize the local supporting intensive fluecuring process.[Methods] A comparative experiment was carried out in Mile,Luxi and Jianshui on the four-layer tobacco-packed intensive curing process(K1)and the eight-point precise and intensive curing process(K2).[Results]The results showed that according to the appearance evaluation of the tobacco leaves,K1 was higher than K2 in respective scores of color,maturity,leaf structure and defects and the total score,while K1 equaled K2 in the scores of identity,oil content,chroma and length.The differences in respective scores of the two processes were not significant.According to the results of sensory evaluation,the two tobacco enterprises got different evaluation results of unblended cigarettes made of the middle leaves due to different raw material requirements of the enterprises by different processes.K1 was higher than K2 in the sensory evaluation of China Tobacco Yunnan Industrial Co.,Ltd.,while it was lower than K2 in that of China Tobacco Zhejiang Industrial Co.,Ltd.,and the difference in the total score between the two processes was significant.From the content of chemical components,in the conventional chemical component contents including total sugar,reducing sugar,chlorine and starch,K1 was higher than K2,while in the contents of potassium,total phytonine,total nitrogen and petroleum ether extract,K1 was lower than K2,but the differences were not significant.K1 was lower than K2 in the contents of neutral aroma components including ketones,alcohols,aldehydes,heterocyclics,neophytadiene and total content,while K1 was higher than K2 in the contents of esters,phenols,but the respective differences were not significant.Except the significant difference in the total score in the sensory evaluation of China Tobacco Zhejiang Industrial Co.,Ltd.,there were no significant differences in other items in the appearance evaluation,sensory evaluation and chemical composition of tobacco leaves between K1 and K2.[Conclusions] The supporting intensive curing process can be further optimized on the basis of this study. | Lina YANG Xinwei JI Folin LI Bingbing LYU Kun HUANG Enping PU Zelin CHEN Junhong CHEN Xiaolin YANG Jungang DUAN Rui LI | 2020 | Agricultural Biotechnology2020，9，2： | 0 |
| 7 | Single‑cell sequencing reveals the reproductive variations between primiparous and multiparous Hu ewes显示文摘Background In the modern sheep production systems,the reproductive performance of ewes determines the economic profitability of farming.Revealing the genetic mechanisms underlying differences in the litter size is important for the selection and breeding of highly prolific ewes.Hu sheep,a high-quality Chinese sheep breed,is known for its high fecundity and is often used as a model to study prolificacy traits.In the current study,animals were divided into two groups according to their delivery rates in three consecutive lambing seasons(namely,the high and low reproductive groups with≥3 lambs and one lamb per season,n=3,respectively).The ewes were slaughtered within 12 h of estrus,and unilateral ovarian tissues were collected and analyzed by 10×Genomics single-cell RNA sequencing.Results A total of 5 types of somatic cells were identified and corresponding expression profiles were mapped in the ovaries of each group.Noticeably,the differences in the ovary somatic cell expression profiles between the high and low reproductive groups were mainly clustered in the granulosa cells.Furthermore,four granulosa cell subtypes were identified.GeneSwitches analysis revealed that the abundance of JPH1 expression and the reduction of LOC101112291 expression could lead to different evolutionary directions of the granulosa cells.Additionally,the expression levels of FTH1 and FTL in mural granulosa cells of the highly reproductive group were significantly higher.These genes inhibit necroptosis and ferroptosis of mural granulosa cells,which helps prevent follicular atresia.Conclusions This study provides insights into the molecular mechanisms underlying the high fecundity of Hu sheep.The differences in gene expression profiles,particularly in the granulosa cells,suggest that these cells play a critical role in female prolificacy.The findings also highlight the importance of genes such as JPH1,LOC101112291,FTH1,and FTL in regulating granulosa cell function and follicular development. | Ting Ge Yifan Wen Bo Li Xiaoyu Huang Shaohua Jiang Enping Zhang | 2024 | Journal of Animal Science and Biotechnology2024，15，2： | 0 |
| 8 | Development and Economic Effect of Farmers' Specialized Cooperatives显示文摘The paper introduces the present development of farmers' specialized cooperatives in China, points out that although the cooperatives in China develop rapidly, they are generally small and their advantages cannot be given into full play, and then analyzes the development achievements of the cooperatives, for example, they have realized scale benefits, their management system tends to more mature, the economic value of their brands is improved and they have created great economic benefits. The paper also points out the stable development path for the cooperatives, that is, the cooperatives should cooperate with local villages, and take a path of combined village and cooperative development so that the cooperative members can get a stable income; the cooperatives can also cooperate with local leading enterprises, which can help the cooperatives to manage, sell and form their products brands, thus the cooperatives can get loans easily to solve the capital bottleneck of cooperative development and improve the members' incomes. | Huide HUANG Wanzhen ZHANG Enping LIU | 2013 | Asian Agricultural Research2013，5，2： | 0 |
| 9 | Robust stabilization of the system family显示文摘The problem of robust stabilization of a system family is studied here. A sufficient condition for the existence of a robust controller is presented under the assumption that there are perturbations both in the numerator and in the denominator of the nominal system. This condition can be given by an inequality that is satisfied by the coefficient vectors of the perturbed polynomials. Based on this, the robust controller family stabilizing the system family can be obtained. Therefore, the condition has the advantages of easy computing and further satisfying other required properties. | WANG Enping HUANG Lin GENG Zhiyong | 2000 | Chinese Science Bulletin2000，45，9： | 0 |
| 10 | Study on Banana Cooperatives in Hainan Province显示文摘This paper gives an overview of the distribution,member scale,production and operation of banana cooperatives in Hainan Province,and points out the market risk and natural risk faced by the production of banana cooperatives in Hainan Province. In order to promote the banana cooperatives to form new agricultural management system integrating organization and intensification,this paper puts forth the production and operation recommendations,such as joint production of banana cooperatives,timely planting of banana,brand management,and improvement of production and operation technical level. | Huide HUANG Wanzhen ZHANG Enping LIU Xizhu ZHANG | 2013 | Asian Agricultural Research2013，5，7： | 0 |
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