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| 1 | 银杏内酯类合成物F抗血小板激活因子和组织胺的实验研究显示文摘目的:研究银杏内酯类合成物F(简称药物F)同时拮抗组织胺(HA)和血小板激活因子(PAF)的作用。方法:测定离休豚鼠肺组织的收缩率以及用药物F后的致敏豚鼠肺功能的变化。结果:(1)加入药物F后离体豚鼠的气管条和肺条对HA的收缩率分别由(50.97±16.00)%和(54.2±12.17)%降至(21.69±3.85)%和(22.97±17.78)%(P<0.05);(2)药物F保护后,离体豚鼠肺条对PAF的相对收缩率由(89.49±16.00)%降至(46.21±14.23)%(P<0.05);(3)药物F保护的豚鼠致敏后,其肺功能较对照组有改善趋势。结论:药物F能同时拮抗离体豚鼠肺组织对HA和PAF的收缩反应,并有改善致敏豚鼠肺功能的趋势,可望用于支气管哮喘的治疗。 | 倪健 董竞成 吴淦桐 Godfroid JJ Heymans F 李明华 | 2000 | 中国中西医结合杂志2000，20，5： | 16 |
| 2 | Colonoscopic yield of colorectal neoplasia in daily clinical practice显示文摘AIM:To assess the prevalence and location of ad-vanced neoplasia in patients undergoing colonoscopy,and to compare the yield per indication.METHODS:In a multicenter colonoscopy survey (n = 18 hospitals) in the Amsterdam area (Northern Holland),data of all colonoscopies performed during a three month period in 2005 were analyzed. The location and the histological features of all colonic neoplasia were recorded. The prevalence and the distribution ofadvanced colorectal neoplasia and differences in yield between indication clusters were evaluated. Advanced neoplasm was defi ned as adenoma > 10 mm in size,with > 25% villous features or with high-grade dyspla-sia or cancer.RESULTS:A total of 4623 eligible patients underwent a total colonoscopy. The prevalence of advanced neo-plasia was 13%,with 281 (6%) adenocarcinomas and 342 (7%) advanced adenomas. Sixty-seven percent and 33% of advanced neoplasia were located in the distal and proximal colon,respectively. Of all patients with right-sided advanced neoplasia (n = 228),51% had a normal distal colon,whereas 27% had a syn-chronous distal adenoma. Ten percent of all colono-scopies were performed in asymptomatic patients,7% of whom had advanced neoplasia. In the respective procedure indication clusters,the prevalence of right-sided advanced neoplasia ranged from 11%-57%. CONCLUSION:One out of every 7-8 colonoscopies yielded an advanced colorectal neoplasm. Colonoscopy is warranted for the evaluation of both symptomatic and asymptomatic patients. | Jochim S Terhaar sive Droste Mike E Craanen Rene WM van der Hulst Joep F Bartelsman Dick P Bezemer Kim R Cappendijk Gerrit A Meijer Linde M Morsink Pleun Snel Hans ARE Tuynman Roy LJ van Wanrooy Eric IC Wesdorp Chris JJ Mulder | 2009 | World Journal of Gastroenterology2009，15，9： | 6 |
| 3 | 胆固醇酯转移蛋白基因的蛋白质截断型变异体与冠状动脉性心脏病风险的关系显示文摘随机对照试验结果表明,抑制胆固醇酯转运蛋白(cholesteryl ester transfer protein,CETP)的疗法并不能降低冠状动脉性心脏病(coronary heart disease,CHD)的发生风险。研究失败的可能原因包括靶目标无效、靶目标外小分子的不良反应和随机对照设计因素影响等。在编码药物靶点的基因中具有天然存在的遗传变异,以此为基础,人类研究可以深入了解针对基因产物的治疗的潜在功效和安全性。 | Nomura A Won HH Khera AV Takeuchi F Ito K McCarthy S Emdin CA Klarin D Natarajan P Zekavat SM Gupta N Peloso GM Borecki IB Teslovich TM Asselta R Duga S Merlini PA Correa A Kessler T Wilson JG Bown MJ Hall AS Braund PS Carey DJ Murray MF Kirchner HL Leader JB Lavage DR Manus JN Hartze DN Samani NJ Schunkert H Marrugat J Elosua R McPherson R Farrall M Watkins H Juang JJ Hsiung CA Lin SY Wang JS Tada H Kawashiri MA Inazu A Yamagishi M Katsuya T Nakashima E Nakatochi M Yamamoto K Yokota M Momozawa Y Rotter JI Lander ES Rader DJ Danesh J Ardissino D Gabriel S Willer CJ Abecasis GR Saleheen D Kubo M Kato N Ida Chen YD Dewey FE Kathiresan S 刘莉 叶鹏 | 2017 | 中华高血压杂志2017，25，9： | 2 |
| 4 | Mapping of a gene for long QT syndrome to chromosome 4q25-27显示文摘 | Schott JJ Charpentier F Pelter S | 1995 | Am J Hum Genet1995，57，： | 1 |
| 5 | Interleuki-1 beta stimulates human mesangial cells to synthesize and release interleukin-6 and -8显示文摘 | Abbott F Rvan JJ Ceska M | 1991 | Kidney Int1991，40，4： | 1 |
| 6 | Short-term TPN containing n-3 fatty acids ameliorate lactic induced by endotoxin in guindea pigs显示文摘 | Flores F Hirschberg Y | 1990 | Arm J Clin Nutr1990，52，： | 1 |
| 7 | Acomparison of thelectrocardiographic, cardioto xic effects of racemic bupivacaine levobupivacaine, and ropivacaine in anesthetized swine显示文摘 | Morrison SG Dominguez JJ Frascarolo F | 2000 | Anesth Analg2000，90，： | 1 |
| 8 | The management of Complex re-nal stones显示文摘 | Rassweiler JJ Renner G Eisenberger F | 2000 | BJU International2000，8，： | 1 |
| 9 | Non-Hodgkinp′s lymphoma in bone:pathologic and radiologic features with clinical correlates显示文摘 | Clayton F Butler JJ Ayala AG | 1987 | Cancer1987，60，10： | 1 |
| 10 | Surgical manage- ment of adrenal metastases 显示文摘 | Sancho JJ Triponez F Montet X | 2012 | Langenbecks Arch Surg2012，397，： | 1 |
| 11 | Evidence for the shikimate pathway in apicomplexan parasites显示文摘 | Roberts F Roberts CW Johnson JJ | 1998 | Nature1998，393，6699： | 1 |
| 12 | PIK3CA Mutations Frequently Coexist with RAS and BRAF mutations in Patients with Advanced Cancers显示文摘 | Janku F Lee JJ Tsimberidou AM | 2011 | PLoS One2011，6，22： | 1 |
| 13 | Coculture of osteoblasts and endothelial cells:optimization of culture medium and cell ratio显示文摘 | Ma J van den Beucken JJ Yang F | | 0，，03： | 1 |
| 14 | Assessment of quality of lifein patients undergoing orthognathic surgery 显示文摘 | Bock JJ Odemar F Fuhrmann RA | 2009 | J Orofac Orthop2009，70，5： | 1 |
| 15 | Vitamin D defi ciency is associated with the metabolic syndrome in morbid obesity显示文摘 | Botella-Carretero JI Alvarez-Blasco F Villafruela JJ | 2007 | Clin Nutr2007，26，5： | 1 |
| 16 | Effects of atorvastatin on pathological changes in brain tissue and plasma MMP-9 in rats with intracerebral hemorrhage 显示文摘 | Cui JJ Wang D Gao F | 2012 | Cell Biochem Biophys2012，62，1： | 1 |
| 17 | Coculture of osteoblasts and endothelial cells: optimization of culture medium and cell ratio 显示文摘 | Ma J van den Beucken JJ Yang F | 2011 | Tissue Eng Part C Methods2011，17，3： | 1 |
| 18 | Characterization of a multicomponent receptor for GDNF显示文摘 | Treanor JJ Goodman L de Sauvage F el al | 1996 | Nature1996，382，6586： | 1 |
| 19 | Selective inhibition of a cyclic nucleotide independent protein kinase (G type casein kinase) by quercetin and related polyphenols显示文摘 | Feige JJ Pirollet F | 1982 | Biochem Pharmacol1982，31，7： | 1 |
| 20 | The manage- ment of complex renal stones 显示文摘 | RASSWEILER JJ RENNER C EISENBERGER F | 2000 | BJU International2000，86，： | 1 |
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