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| 1 | Decratonic gold deposits显示文摘The North China Craton(NCC) hosts numerous gold deposits and is known as the most gold-productive region of China. The gold deposits were mostly formed within a few million years in the Early Cretaceous(130–120 Ma), coeval with widespread occurrences of bimodal magmatism, rift basins and metamorphic core complexes that marked the peak of lithospheric thinning and destruction of the NCC. Stable isotope data and geological evidence indicate that ore-forming fluids and other components were largely exsolved from cooling magma and/or derived from mantle degassing during the period of lithospheric extension. Gold mineralization in the NCC contrasts strikingly with that of other cratons where gold ore-forming fluids were sourced mostly from metamorphic devolatization in compressional or transpressional regimes. In this paper, we present a summary and discussion on time-space distribution and ore genesis of gold deposits in the NCC in the context of the timing, spatial variation, and decratonic processes. Compared with orogenic gold deposits in other cratonic blocks, the Early Cretaceous gold deposits in the NCC are quite distinct in that they were deposited from magma-derived fluids under extensional settings and associated closely with destruction of cratonic lithosphere. We argue that Early Cretaceous gold deposits in the NCC cannot be classified as orogenic gold deposits as previously suggested, rather, they are a new type of gold deposits, termed as 'decratonic gold deposits' in this study. The westward subduction of the paleo-West Pacific plate(the Izanagi plate) beneath the eastern China continent gave rise to an optimal tectonic setting for large-scale gold mineralization in the Early Cretaceous. Dehydration of the subducted and stagnant slab in the mantle transition zone led to continuous hydration and considerable metasomatism of the mantle wedge beneath the NCC. As a consequence, the refractory mantle became oxidized and highly enriched in large ion lithophile elements and chalcophile elements(e.g., Cu, Au, Ag and Te). Partial melting of such a mantle would have produced voluminous hydrous, Au- and S-bearing basaltic magma, which, together with crust-derived melts induced by underplating of basaltic magma, served as an important source for ore-forming fluids. It is suggested that the Eocene Carlin-type gold deposits in Nevada, occurring geologically in the deformed western margin of the North America Craton, are comparable with the Early Cretaceous gold deposits of the NCC because they share similar tectonic settings and auriferous fluids. The NCC gold deposits are characterized by gold-bearing quartz veins in the Archean amphibolite facies rocks, whereas the Nevada gold deposits are featured by fine-grained sulfide dissemination in Paleozoic marine sedimentary rocks. Their main differences in gold mineralization are the different host rocks, ore-controlling structures, and ore-forming depth. The similar tectonic setting and ore-forming fluid source, however, indicate that the Carlin-type gold deposits in Nevada are actually analogous to decratonic gold deposits in the NCC. Gold deposits in both the NCC and Nevada were formed in a relatively short time interval(<10 Myr) and become progressively younger toward the subduction zone. Younging of gold mineralization toward subduction zone might have been attributed to retreat of subduction zone and rollback of subducted slab. According to the ages of gold deposits on inland and marginal zones, the retreat rates of the Izanagi plate in the western Pacific in the Early Cretaceous and the Farallon plate of the eastern Pacific in the Eocene are estimated at 8.8 cm/yr and 3.3 cm/yr, respectively. | ZHU RiXiang FAN HongRui LI JianWei MENG QingRen LI ShengRong ZENG QingDong | 2015 | Science China Earth Sciences2015，58，9： | 37 |
| 2 | Coesite inclusions in zircon from gneisses identified by laser Raman microspectrometer in ultra-high pressure zone of Dabie Mountains,China显示文摘The mineral inclusions in zircon from gneisses in ultra-high pressure (UHP) zone of the Dabie Mountains were identified by using a laser Raman microspectrometer. Coesite occurs as inclusions in zircons from all types of gneiss. Other important minerals, such as jadeite, omphacite, aragonite, barite, and anhydrite were also found as inclusion minerals. These discoveries indicate that ( i) gneissic country rocks had metamorphosed at the same time as the enclosed eclogites; and (ii) SO4-2 -bearing fluids were presentin the UHP metamorphic process, which is manifested by occurrence of barite and anhydrite coexisting with coesite. | LIU Jingbo YE Kai CONG Bolin Maruyama Shegnori FAN Hongrui | 2001 | Chinese Science Bulletin2001，46，22： | 22 |
| 3 | In situ Nd isotopic measurement of natural geological materials by LA-MC-ICPMS显示文摘Using newly determined Sm isotopic abundances for correcting the isobaric interference of 144Sm on 144Nd and the established mass bias relationship between Sm and Nd, a series of in situ Nd isotopic measurements were conducted for relatively high Nd concentrations of natural geological materials, including apatite, titanite, monazite and perovskite on a Neptune multi-collector inductively coupled plasma mass spectrometry (MC-ICPMS), coupled to a 193 nm ArF excimer laser ablation system. The results show that Ce has no significant influence on the precision and accuracy of Nd isotopic analyses for LREE-enriched geological minerals and that our approach is efficient in obtaining reliable 143Nd/144Nd and 147Sm/144Nd ratios for those materials with Sm/Nd<1 (147Sm/144Nd<0.6). When combined with trace element and U-Pb isotope data, the in situ Nd isotopic data can provide important information on geological processes. | YANG YueHeng SUN JinFeng XIE LieWen FAN HongRui WU FuYuan | 2008 | Chinese Science Bulletin2008，53，7： | 18 |
| 4 | Dual origins of Xiaoqinling gold-bearing quartz veins:Fluid inclusion evidence显示文摘Fluid inclusion research in Archean metamorphic rocks, Yanshanian granite and gold-bearing quartz veins shows that regional metamorphic fluids are high temperature and high saline, Yanshanian post-granitic fluids are CO2-bearing low saline, and ore-forming fluids are also CO2-rich low saline. In gold-barren/free parts of quartz veins in gold deposits, daughter mineral-bearing high saline inclusions related with metamorphic fluids remained. This proclaims quartz veins hosting gold ores might have been formed in early metamorphism, and overlapped or mineralized by late Yanshanian gold-bearing fluids. | Hongrui Fan Yihan Xie Rui Zhao Yinglan Wang | 2000 | Chinese Science Bulletin2000，45，15： | 17 |
| 5 | Zircon U-Pb dating of basement gneisses in the super-large Bayan Obo REE-Fe-Nb deposit, Inner Mongolia显示文摘Zircon U-Pb ages have been determined for basement gneisses in the Bayan Obo REE-Fe-Nb deposit. On the U-Pb concordia diagram data of three samples yield up-per intercept ages of 1948-1917 Ma. Thus, these basement gneisses are of Paleoproterozoic. Rock association of these basement gneisses includes tonalite, syenite and paragneiss, not belonging to a sedimentary package. It is more appro-priate to consider this association as a basement complex rather than a stratigraphic 'Group'. | WANG Kaiyi FAN Hongrui XIE Yihan LI Huimin | 2002 | Chinese Science Bulletin2002，47，3： | 16 |
| 6 | Bayan Obo Carbonatites:Texture Evidence from Polyphase Intrusive and Extrusive Carbonatites显示文摘大多数所谓的 Bayan Obo 有细密纹理的白云石云石收集了从主要并且东方 orebodies 表演一块 microporphyritic 质地,也就是, microphenocrysts 被放在一个很有细密纹理的矩阵,尽管将近所有他们经历了也变丑或改变引起的再结晶。质地似乎可能坚持说原来的特征。暴烈的岩石的最典型的质地之一是斑状的质地,这被知道,并且 microporphyritic 质地是斑晶和矩阵与显微镜仅仅是可区分的一个在变化。因此,白云石云石总体上并且东方 orebodies 可能与挤出的 carbonatites 有关。另外,也在那里发生有在 Bayan Obo 的不同质地的一些 carbonatite 基石和女同性恋。因此, Bayan Obo carbonatites 是多相的恼人、挤出的 carbonatites。 | WANG Kaiyi FAN Hongrui YANG Kuifeng HU Fangfang MA Yuguang | 2010 | Acta Geologica Sinica(English Edition)2010，84，6： | 11 |
| 7 | Fluid inclusions in whiteschist in the ultrahigh-pressure metamorphic belt of Dabie Shan,China显示文摘Hualiangting whiteschist in the Dabie Shan ultrahigh-pressure eclogite complex is a specific Mg-Al-rich metamorphic rock. Its protolith was a felsic dyke, which suffered replacement by high-pressure fluids during ec-logite-facies metamorphism. Based on fluid inclusion results in whiteschist, primary high-pressure fluids are CO2-bearing aqueous solutions. Those prove that there exists CO2-H2O fluid during the ultrahigh-pressure metamorphism. Pseu-dosecondary H2O inclusions were trapped during ultra-high-pressure exhumation, whereas secondary H2O inclusions were related to the latest evolutionary stage of the ultrahigh-pressure exhumation. | Hongrui Fan Jingbo Liu Jinghui Guo Kai Ye Bolin Cong | 2002 | Chinese Science Bulletin2002，47，12： | 3 |
| 8 | Ore-forming fluids associated with granite-hosted gold mineralization at the Sanshandao deposit, Jiaodong gold province, China 显示文摘 | Fan Hongrui Zhai Mingguo Xie Yihan | 2003 | Mineralium Deposita2003，38，6： | 1 |
| 9 | lncR-GAS5 upregulates the splicing factor SRSF10 to impair endothelial autophagy,leading to atherogenesis显示文摘Long noncoding RNAs(lncRNAs)play a critical role in the regulation of atherosclerosis.Here,we investigated the role of the lncRNA growth arrest-specific 5(lncR-GAS5)in atherogenesis.We found that the enforced expression of lncR-GAS5 contributed to the development of atherosclerosis,which presented as increased plaque size and reduced collagen content.Moreover,impaired autophagy was observed,as shown by a decreased LC3II/LC3I protein ratio and an elevated P62 level in lncR-GAS5-overexpressing human aortic endothelial cells.By contrast,lncR-GAS5 knockdown promoted autophagy.Moreover,serine/arginine-rich splicing factor 10(SRSF10)knockdown increased the LC3II/LC3I ratio and decreased the P62 level,thus enhancing the formation of autophagic vacuoles,autolysosomes,and autophagosomes.Mechanistically,lncR-GAS5 regulated the downstream splicing factor SRSF10 to impair autophagy in the endothelium,which was reversed by the knockdown of SRSF10.Further results revealed that overexpression of the lncR-GAS5-targeted gene miR-193-5p promoted autophagy and autophagic vacuole accumulation by repressing its direct target gene,SRSF10.Notably,miR-193-5p overexpression decreased plaque size and increased collagen content.Altogether,these findings demonstrate that lncR-GAS5 partially contributes to atherogenesis and plaque instability by impairing endothelial autophagy.In conclusion,lncR-GAS5 overexpression arrested endothelial autophagy through the miR-193-5p/SRSF10 signaling pathway.Thus,miR-193-5p/SRSF10 may serve as a novel treatment target for atherosclerosis. | Yuhua Fan Yue Zhang Hongrui Zhao Wenfeng Liu Wanqing Xu Lintong Jiang Ranchen Xu Yue Zheng Xueqing Tang Xiaohan Li Limin Zhao Xin Liu Yang Hong Yuan Lin Hui Chen Yong Zhang | 2023 | Frontiers of Medicine2023，17，2： | 1 |
| 10 | Types, characteristics, and time–space distribution of molybdenum deposits in China显示文摘 | Qingdong Zeng Jianming Liu Kezhang Qin Hongrui Fan Shaoxiong Chu Yongbin Wang Lingli Zhou | 2013 | International Geology Review2013，，11： | 1 |
| 11 | Conditions and processes leading to large-scale gold deposition in the Jiaodong province,eastern China显示文摘The gold deposits in the Jiaodong Peninsula constitute the largest gold mineralized province in China.The mineralization shows common characteristics in their tectonic setting,ore-forming fluid and metallogenic system.Sulfidation and fluid immiscibility are two important mechanisms controlling gold precipitation,both of which consume sulfur in the oreforming fluids.The escape of H2S from the main ore-forming fluids and the decrease of total sulfur concentration not only lead to the efficient precipitation of gold,but also result in the crystallization of reducing minerals such as pyrrhotite and oxidizing minerals such as magnetite.Quartz solubility shows strong dependence on temperature,pressure,and CO2 content.The dependence of quartz solubility on pressure is weak at low temperatures,and progressively stronger at higher temperatures.Similarly,the temperature dependence of quartz solubility is relatively low at low pressures,but becomes gradually stronger at high pressures.The results of solubility modeling can constrain the dissolution and reprecipitation behavior of quartz in the oreforming veins and the formation mechanism of different types of quartz veins.The multi-stage mineralization fluid activity resulted in the complex dissolution structure of quartz in the Jiaodong gold veins.Pyrite in the main metallogenic period in the Jiaodong gold deposits shows complex microstructure characteristics at single crystal scale.The trace elements(mainly the coupling of As-and Au-rich belt)and sulfur isotope composition also display a certain regularity.The As-rich fluids might have formed by the initial pulse of ore-forming fluids through As-rich metasedimentary strata,while the As-Au oscillation zone at the margin of pyrite grains is related to the pressure fluctuation caused by fault activity and the local phase separation of fluids.There is a temporal and spatial evolution of gold fineness in the Jiaodong gold deposits.Water/rock reaction(sulfidation)was the main ore-forming mechanism of early gold mineralization,forming relatively high fineness gold,while significant pressure drop in the shallow part accompanied by fluid phase separation promoted the late gold mineralization,forming low fineness gold.Under cratonic destruction setting,dehydration of the amphibolite and granulite facies metamorphic lower-crust resulted in the formation of Au-CO2-rich ore-forming fluids,which rose along the deep fault and secondary structure,and formed the largescale fault-controlled gold deposits in Jiaodong. | Hongrui FAN Tingguang LAN Xinghui LI M.SANTOSH Kuifeng YANG Fangfang HU Kai FENG Huanlong HU Hongwei PENG Yongwen ZHANG | 2021 | Science China Earth Sciences2021，64，9： | 1 |
| 12 | Fluid unmixing/ immiscibility as an ore-forming process in the giant REE - Nb - Fe deposit, Inner Mongolian, China:Evidence from fluid inclusions显示文摘 | Fan Hongrui Hu Fangfang Yang Kuifeng | 2006 | Journal of Geochemical Exploration2006，89，13： | 1 |
| 13 | Mesoproteroz- oic carbonatitic magmatism in the Bayan Obo deposit, Inner Mongolia, North China: Constraints for the mechanism of su- per accumulation of rare earth elements显示文摘 | Yang Kuifeng Fan Hongrui Santosh M | 2011 | Ore Geology Re- views2011，40，1： | 1 |
| 14 | General Design and Thermodynamic Analysis of a Supercritical Carbon Dioxide Cannon显示文摘This paper presents a new supercritical carbon dioxide(SCO_(2))cannon based on the carbon dioxide(CO_(2))’s thermodynamic cycle under constant volume.First,Virial equation and NIST database are applied to formulate SCO_(2)’s property and analyze the thermodynamic cycle,which is aimed to get the optimization equation using the cannon’s exit velocity as objective function.Then the cannon’s structural parameters,such as diaphragm thickness and barrel length,and CO_(2)’s filling mass,are optimized.Finally,the flow field and velocity’s change during the launch process is performed with FLUENT.In field test,the ultra-high pressure sensor and ultra-high speed camera are used to measure the pressure distribution along the barrel’s axial direction and the projectile’s exit velocity under different conditions.The results show that all the performance indexes meet the design requirement.The innovative SCO_(2)cannon in this paper has obvious advantages such as high safety,low cost and fast loading,which can be applied in many situations such as disaster relief,peacekeeping and anti-terrorism.Moreover,the unique energy storage method and thermodynamic design ensure its subsequent development. | ZHANG Fan LIU Hongrui WU You LI Jiaqi YU Huazhang WANG Xiaoliang GUO Baoting YUAN Yixiang | 2021 | Journal of Thermal Science2021，30，1： | 1 |
| 15 | Porphyry-type molybdenum deposiis in the eastern qinling mo belt, central China 显示文摘 | Fan Hongrui Xie Yihan | 1999 | Scientia Geologica Sinica1999，8，1： | 1 |
| 16 | Fluid Inclusion and Carbon-Oxygen Isotope Studies of the Hujiayu Cu Deposit,Zhongtiao Mountains,China:Implications for Synmetamorphic Copper Remobilization显示文摘The Hujiayu Cu deposit,representative of the 'HuBi-type' Cu deposits in the Zhongtiao Mountains district in the southern edge of the North China Craton,is primarily hosted in graphitebearing schists and carbonate rocks.The ore minerals comprise mainly chalcopyrite,with minor sphalerite,siegenite[(Co,Ni)_3S_4],and clausthalite[Pb(S,Se)].The gangue minerals are mainly quartz and dolomite,with minor albite.Four fluid inclusion types were recognized in the chalcopyrite-pyrite-dolomite-quartz veins,including CO_2-rich inclusions(type Ⅰ),low-salinity,liquid-dominated,biphase aqueous inclusions(type Ⅱ),solid-bearing aqueous inclusions(type Ⅲ),and solid-bearing aqueous-carbonic inclusions(type Ⅳ).Type I inclusion can be further divided into two sub-types,i.e.,monophase CO_2 inclusions(type Ⅰa) and biphase CO_2-rich inclusions(with a visible aqueous phase),and type Ⅲ inclusion is divided into a subtype with a halite daughter mineral(type Ⅲa) and a subtype with multiple solids(type Ⅲb).Various fluid inclusion assemblages(FIAs) were identified through petrographic observations,and were classified into four groups.The group-1 FIA,consisting of monophase CO_2 inclusions(type Ⅰa),homogenized into the liquid phase in a large range of temperatures from-1 to 28℃,suggesting post-entrapment modification.The group-2 FIA consists of type Ⅰb,Ⅲb and Ⅳ inclusions,and is interpreted to reflect fluid immiscibility.The group-3 FIA comprises type Ⅱ and Ⅲa inclusions,and the group-4FIA consists of type Ⅱ inclusions with consistent phase ratios.The group-1 and group-2 FIAs are interpreted to be entrapped during mineralization,whereas group-3 and group-4 FIAs probably represent the post-mineralization fluids.The solid CO_2 melting temperatures range from-60.6 to56.6℃ and from-66.0 to-63.4℃ for type Ⅰa and type Ⅳ inclusions,respectively.The homogenization temperatures for type Ⅱ inclusions range from 132 to 170℃ for group-3 FIAs and115 to 219℃ for group-4 FIAs.The halite melting temperatures range from 530 to 562℃ for typeⅢ b and Ⅳ inclusions,whereas those for type Ⅲa inclusions range from 198 to 398℃.Laser Raman and SEM-EDS results show that the gas species in fluid inclusions are mainly CO_2 with minor CH_4,and the solids are dominated by calcite and halite.The calcite in the hosting marble and dolomite in the hydrothermal veins have δ^(13)C_(V-pdb) values of-0.2 to 1.2‰ and-1.2 to-6.3‰,and δ^(18)O_(v-smow) values of 14.0 to 20.8 ‰ and 13.2 to 14.3‰,respectively.The fluid inclusion and carbon-oxygen isotope data suggest that the ore-forming fluids were probably derived from metamorphic fluids,which had reacted with organic matter in sedimentary rocks or graphite and undergone phase separation at 1.4-1.8 kbar and 230-240℃,after peak metamorphism.It is proposed that the Hujiayu Cu deposit consists of two mineralization stages.The early stage mineralization,characterized by disseminated and veinlet copper sulfides,probably took place in an environment similar to sediment-hosted stratiform copper mineralization.Ore minerals formed in this precursor mineralization stage were remobilized and enriched in the late metamorphic hydrothermal stage,leading to the formation of thick quartz-dolomite-sulfides veins. | QIU Zhengjie FAN Hongrui LIU Xuan WEN Bojie HU Fangfang YANG Kuifeng GUO Shuanglong ZHAO Fengchun | 2015 | Acta Geologica Sinica(English Edition)2015，89，3： | 1 |
| 17 | Geochemistry andSr-Nd-Pb-Hf isotopes of the Mesozoic Dadian alkaline intrusivecomplex in the Sulu orogenic belt,eastern China:Implications forcrust-mantle interaction显示文摘 | Lan Tingguang Fan Hongrui Santosh M | 2011 | Chemical Geology2011，285，： | 1 |
| 18 | A novel TNKS/USP25 inhibitor blocks the Wnt pathway to overcome multi-drug resistance in TNKS-overexpressing colorectal cancer显示文摘Modulating Tankyrases(TNKS),interactions with USP25 to promote TNKS degradation,rather than inhibiting their enzymatic activities,is emerging as an alternative/specific approach to inhibit the Wnt/β-catenin pathway.Here,we identified UAT-B,a novel neoantimycin analog isolated from Streptomyces conglobatus,as a small-molecule inhibitor of TNKS-USP25 protein-protein interaction(PPI)to overcome multi-drug resistance in colorectal cancer(CRC).The disruption of TNKS-USP25 complex formation by UAT-B led to a significant decrease in TNKS levels,triggering cell apoptosis through modulation of the Wnt/β-catenin pathway.Importantly,UAT-B successfully inhibited the CRC cells growth that harbored high TNKS levels,as demonstrated in various in vitro and in vivo studies utilizing cell line-based and patient-derived xenografts,as well as APC^(min/+)spontaneous CRC models.Collectively,these findings suggest that targeting the TNKS-USP25 PPI using a small-molecule inhibitor represents a compelling therapeutic strategy for CRC treatment,and UAT-B emerges as a promising candidate for further preclinical and clinical investigations. | Hongrui Zhu Yamin Gao Liyun Liu Mengyu Tao Xiao Lin Yijia Cheng Yaoyao Shen Haitao Xue Li Guan Huimin Zhao Li Liu Shuping Wang Fan Yang Yongjun Zhou Hongze Liao Fan Sun Houwen Lin | 2024 | Acta Pharmaceutica Sinica B2024，14，1： | 0 |
| 19 | Comparison of two end-member styles of epithermal Au-(Cu)deposits显示文摘EPITHERMA Au-(Cu) deposits occur largely in volcano-plutonic arcs (island arcs as well as continentalarcs) associated with subduction zones, with ages similar to those of volcanism. These deposits form atshallow depth,<1 km, and are hosted mainly by volcanic rocks. Modern volcanic-hydrothermal systems provide an analogue to the environment for the ancient intrusion-related and volcanic epithermal deposits. Recent studies also indicate that the volcanic epithennalore deposits are formed from magmatic fluids, although the magmatic signatures have been largely erasedby meteoric water. At depth (fig. 1), the magmatic fluid from the high-level intrusive magma will result in the formation of intrusion-related deposits (e.g. porphyry Cu, Au, Mo deposits). Detailed studies of fluid inclusions and stable isotopes indicate that the hydrothermal system that form these deposits are initially | FAN Hongrui and XIE Yihan Institute of Geology, Chinese Academy of Sciences, Beijing 100029, China | 1999 | Chinese Science Bulletin1999，44，S2： | 0 |
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