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| 1 | Review on biological degradation of mycotoxins显示文摘The worldwide contamination of feeds and foods with mycotoxins is a significant problem. Mycotoxins pose huge health threat to animals and humans. As well, mycotoxins bring enormous economic losses in food industry and animal husbandry annually. Thus, strategies to eliminate or inactivate mycotoxins in food and feed are urgently needed. Traditional physical and chemical methods have some limitations such as limited efficacy, safety issues, losses in the nutritional value and the palatability of feeds, as well as the expensive equipment required to implement these techniques. Biological degradation of mycotoxins has shown promise because it works under mild, environmentally friendly conditions. Aflatoxin(AF), zearalenone(ZEA) and deoxynivalenol(DON) are considered the most economically important mycotoxins in terms of their high prevalence and significant negative effects on animal performance.Therefore, this review will comprehensively describe the biological degradation of AF, ZEA and DON by microorganisms(including fungi and bacteria) and specific enzymes isolated from microbial systems that can convert mycotoxins with varied efficiency to non-or less toxic products. Finally, some strategies and advices on existing difficulties of biodegradation research are also briefly proposed in this paper. | Cheng Ji Yu Fan Lihong Zhao | 2016 | Animal Nutrition2016，，3： | 24 |
| 2 | Radiolarian record to paleoecological environment change events over the past 1.2 MaBP in the southern South China Sea显示文摘This note studies the Radiolarian fossil groups since 1.2 MaBP in ODP leg 184 site 1143, the southern South China Sea (SCS). The result shows that radiolarian abundance experienced a significant variation: before 0.9 MaBP it remained at the extremely low level, but increased with low extent between 0.9-0.65 Ma, which corresponded to the Mid-Pleistocene Transition stage, and it increased rapidly after 0.65 MaBP. During the whole process, the average abundance became higher and higher in each stage, and showed regularly periodic fluctuations. The obvious increase after 0.65 MaBP is inferred to result from the enhanced up-welling in this region, which was induced by the intensified monsoon circulation after the 'Mid-Pleistocene Transition'. An outstanding result of the spectral analyses is that a long oscillation of - 0.2 Ma cycle was found in the records of radiolarian abundance and complex diversity, which corresponds well to the result of other paleoceanographic indexes. This probably indicated a | YANG Lihong CHEN Muhong WANG Rujian ZHEN Fan | 2002 | Chinese Science Bulletin2002，47，17： | 8 |
| 3 | Occurrence of mycotoxins in feed ingredients and complete feeds obtained from the Beijing region of China显示文摘Background:The current study was carried out to provide a reference for the control of mycotoxin contamination in feed ingredients and complete feeds for swine.Methods:A total of 55 feed ingredients,including 14 corn,13 wheat bran,11 soybean meal and 17 dried distillers grains with solubles(DDGS) as well as 76 complete swine feeds including 7 creep feeds,14 starter feeds,14 grower feeds,18 grower-finisher feeds,10 gestating sow feeds,and 13 lactating sow feeds were randomly collected from15 swine farms located in the Beijing region of China from July to August 2011.Immunoaffinity clean-up,using High-Performance Liquid Chromatography(HPLC) in combination with UV or Fluorescence Detection,was used for quantitative analysis of aflatoxin B,(AFB,),deoxynivalenol(DON),zearalenone(ZEA) and ochratoxin A(OTA) in the ingredients and complete feeds.Results:DON and ZEA were the most prevalent mycotoxins found.DON was detected at percentages of 93,92,54,100 and 97%with a mean level of 1.01,0.44,0.05,1.36 and 0.65 ppm in the samples of corn,wheat bran,soybean meal,DDGS and complete feeds,respectively.The detected percentages of ZEA were 100,100,54,100 and 100 with mean levels of 109.1,14.9,9.2,882.7 and 58.9 ppb in the same samples.In the wheat bran and soybean meal samples,the content of all four mycotoxins were below the maximum limits set by Chinese regulations while the percentage of samples that exceeded regulatory limits were 7,57 and 7%for corn,and 7,14 and 3%for the complete feeds for AFB,,DON and OTA respectively.DDGS showed the most serious mycotoxin contamination and the percentage of samples that exceeded regulatory limits were 6,88 and 41%,for AFB,,DON and ZEA,respectively.Conclusions:This paper is the first to present data on the natural occurrence of AFB,,DON,ZEA and OTA in ingredients and complete feeds obtained from swine farms in China's Beijing region.The data shows that feed ingredients and complete swine feeds obtained from these farms are most often contaminated with DON followed by contamination with AFB,and ZEA. | Xiaoying Li Lihong Zhao Yu Fan Yaxiong Jia Lei Sun Shanshan Ma Cheng Ji Qiugang Ma Jianyun Zhang | 2014 | Journal of Animal Science and Biotechnology2014，5，4： | 7 |
| 4 | Basin assemblages and tectonic evolution in the Bohai Gulfand its neighbors显示文摘According to multi- disciplinary research advances in recent years, three blocks which named Jiaoliao - Bohai block, central North China block and Ordos block are divided. The differences of the tectonic association, types, styles and features in the space, and evolution from Archaean to Cenozoic in the time, between the former two blocks are discussed. Tectonic features and evolution in the four tectonic stages of Precambrian, Indo- China, Yanshanian and Cenozoic are emphasized especially here. All of them described above have inherit and neogenic property. The temporal-spatial change and interaction among basin assemblages in the above four stages are analyzed. Escape tectonic model is employed to interpret coeval compressive and extensional basins in the study area. | Li Sanzhong Xu Shumei Shan Yehua Li Xishuang Zhou Lihong Hao Yinquan Fan Zheqing Liang Huilan | 2000 | Acta Oceanologica Sinica2000，19，4： | 7 |
| 5 | Alleviation of mycotoxin biodegradation agent on zearalenone and deoxynivalenol toxicosis in immature gilts显示文摘Background: The current study was carried out to evaluate the effects of mycotoxin biodegradation agent(MBA, composed of Bacillus subtilis ANSB01 G and Devosia sp. ANSB714) on relieving zearalenone(ZEA) and deoxynivalenol(DON) toxicosis in immature gilts.Methods: A total of forty pre-pubertal female gilts(61.42 ± 1.18 kg) were randomly allocated to four diet treatments: CO(positive control); MO(negative control, ZEA 596.86 μg/kg feed and DON 796 μg/kg feed);COA(CO + 2 g MBA/kg feed); MOA(MO + 2 g MBA/kg feed). Each treatment contained 10 replicates with 1 gilt per replicate. Gilts were housed in an environmentally controlled room with the partially slatted floor.Results: During the entire experimental period of 28 d, average daily gain(ADG) and average daily feed intake(ADFI)of gilts in MO group was significantly reduced compared with those in CO group. The vulva size of gilts was significantly higher in MO group than CO group. In addition, significant increases in the plasma levels of Ig A,Ig G, IL-8, IL-10 and PRL were determined in MO group compared with that in CO group. ZEA and DON in the diet upregulated apoptotic caspase-3 in ovaries and uteri, along with down-regulated the anti-apoptotic protein Bcl-2 in ovaries. The supplementation of MBA into diets co-contaminated with ZEA and DON significantly increased ADG, decreased the vulva sizes, reduced the levels of Ig G, IL-8 and PRL in plasma, and regulated apoptosis in ovaries and uteri of gilts.Conclusions: The present results indicated that feeding diet contaminated with ZEA and DON simultaneously(596.86 μg/kg + 796 μg/kg) had detrimental effects on growth performance, plasma immune function and reproductive status of gilts. And MBA could reduce the negative impacts of these two toxins, believed as a promising feed additive for mitigating toxicosis of ZEA and DON at low levels in gilts. | Donghui Shi Jianchuan Zhou Lihong Zhao Xiaoping Rong Yu Fan Humera Hamid Wenqiang Li Cheng Ji Qiugang Ma | 2018 | Journal of Animal Science and Biotechnology2018，9，3： | 7 |
| 6 | Melatonin enhances radiofrequency-induced NK antitumor immunity,causing cancer metabolism reprogramming and inhibition of multiple pulmonary tumor development显示文摘Surgery is the comm on treatme nt for early lung cancer with multiple pulm onary no dules,but it is often accompanied by the problem of significant malignancy of other nodules in non-therapeutic areas.In this study,we found that a combined treatment of local rad iofreq ue ncy ablati on(RFA)and melatonin(MLT)greatly improved clinical outcomes for early lung cancer patie nts with multiple pulmonary nodules by minimizing lung function injury and reducing the probability of malignant transformation or enlargement of nodules in non-ablated areas.Mechanically,as demonstrated in an associated mouse lung tumor model,RFA not only effectively remove treated tumors but also stimulate antitumor immunity,which could inhibit tumor growth in non-ablated areas.MLT enhanced RFA-stimulated NK activity and exerted synergistic antitumor effects with RFA.Transcriptomics and proteomics analyses of residual tumor tissues revealed enhanced oxidative phosphorylation and reduced acidification as well as hypoxia in the tumor microenvironment,which suggests reprogrammed tumor metabolism after combined treatment with RFA and MLT.Analysis of residual tumor further revealed the depressed activity of MAPK,NF-kappa B,Wnt,and Hedgehog pathways and upregulated P53 pathway in tumors,which was in line with the inhibited tumor growth.Combined RFA and MLT treatment also reversed the Warburg effect and decreased tumor malignancy.These findings thus demonstrated that combined treatment of RFA and MLT effectively inhibited the malignancy of non-ablated nodules and provided an innovative non-invasive strategy for treating early lung tumors with multiple pulmonary nodules.Trial registration:www.chictr.org.cn,identifier ChiCTR2100042695,http://www.chictr.org.cn/showproj.aspx?proj=120931. | Ming Li Bingjie Hao Menghuan Zhang Russel J.Reiter Shumeng Lin Tiansheng Zheng Xiangyun Chen Yanbei Ren Liduo Yue Baigenzhin Abay Guojie Chen Xiao Xu Yufeng Shi Lihong Fan | 2021 | Signal Transduction and Targeted Therapy2021，6，10： | 6 |
| 7 | Risk Factors for Age-Related Macular Degeneration in Elderly Chinese Population in Shenyang of China显示文摘Objective The paper aims to evaluate the risk factors for age‐related macular degeneration (AMD) in elderly Chinese population in Shenyang,a northeast city of China.Methods A case‐control study was conducted to investigate the risk factors for the prevalence of AMD.Ninety three AMD patients diagnosed by a complete ophthalmic examination were recruited as cases from the outpatient departments of two eye hospitals in Shenyang,while 108 normal subjects of similar age and sex were recruited as controls.A questionnaire was administered among both cases and controls.Results AMD patients aged 60 years and older accounted for 75.3%.There were significantly higher educational levels,shorter smoking history,less sunlight exposure and cataract,and higher proportion of antioxidants intake in controls than in AMD patients.The frequency of intake of fruits,legumes,fish and shrimps was significantly higher in controls than in AMD patients.In a binary logistic regression analysis,smoking and cataract were the risk factors for AMD (OR:4.44,95% CI:2.27‐8.69;OR:4.47,95% CI:2.26‐8.85 respectively).The high educational background was a protective factor for AMD (OR:0.761,95% CI:0.51‐0.98).Conclusion A low educational background,smoking and cataract are associated with a higher prevalence of AMD. | JIA LiHong SHEN XueLi FAN Rui SUN Yan PAN XingYue YANH HongMei LIU Lu | 2011 | Biomedical and Environmental Sciences2011，24，5： | 4 |
| 8 | Detection of CYP2E1,a Genetic Biomarker of Susceptibility to Benzene Metabolism Toxicity in Immortal Human Lymphocytes Derived from the Han Chinese Population显示文摘Objective Cytochrome P450 2E1 (CYP2E1) is an important metabolizing enzyme involved in oxidative stress responses to benzene,a chemical associated with bone marrow toxicity and leukemia.We aimed to identify the CYP2E1 genetic biomarkers of susceptibility to benzene toxicity in support of environmental and occupational exposure prevention,and to test whether a model using immortal human lymphocytes might be an efficient tool for detecting genetic biomarkers.Methods Immortalized human lymphocyte cell lines with independent genotypes on four CYP2E1 SNP sites were induced with 0.01% phenol,a metabolite of benzene.CYP2E1 gene function was evaluated by mRNA expression and enzyme activity.DNA damage was measured by Single‐Cell Gel Electrophoresis (SCGE).Results Among the four SNPs,cells with rs2070673TT and rs2030920CC showed higher levels of CYP2E1 transcription and enzymatic activity than the other genotypes in the same SNP site.Cells with higher gene expression genotypes also showed higher comet rates compared with lower gene expression genotypes.Conclusion These results suggest that CYP2E1 rs2070673 and rs2030920 might be the genetic biomarkers of susceptibility to benzene toxicity and that the immortalized human lymphocytes model might be an efficient tool for the detection of genetic biomarkers of susceptibility to chemicals. | ZHANG Juan YIN LiHong LIANG GeYu LIU Ran FAN KaiHong PU YuePu | 2011 | Biomedical and Environmental Sciences2011，24，3： | 4 |
| 9 | Silk materials for medical, electronic and optical applications显示文摘Silk derived from the silkworm Bombyx mori is among the most important fibrous protein biomaterials due to large-scale production from natural sources, excellent biocompatibility, unique mechanical properties and controllable degradation. Silk fibroin can be processed into a variety of formats to match different applications, such as tissue engineering, drug delivery or as the passive substrate of a bio-device. Advances in fabrication technologies provide new possibilities for the combination of silk fibroin with other nanomaterials to functionalize silk fibroin for specialized purposes, including sensing, cell visualization,resistance to ultraviolet light and provision of antibacterial properties. As the requirement for wearable and intelligent devices has become increasingly important over recent years, silk fibroin has been utilized as the active element in electronic and optical instruments. This review summarizes these recent advances in the innovative applications of silk fibroin. | FAN SuNa ZHANG Yi HUANG XiangYu GENG LiHong SHAO HuiLi HU XueChao ZHANG YaoPeng | 2019 | Science China(Technological Sciences)2019，62，6： | 4 |
| 10 | MHSS ARAIM Algorithm Combined with Gross Error Detection显示文摘Due to some shortcomings in the current multiple hypothesis solution separation advanced receiver autonomous integrity monitoring(MHSS ARAIM)algorithm,such as the weaker robustness,a number of computational subsets with the larger computational load,a method combining MHSS ARAIM with gross error detection is proposed in this paper.The gross error detection method is used to identify and eliminate the gross data in the original data first,then the MHSS ARAIM algorithm is used to deal with the data after the gross error detection.Therefore,this makes up for the weakness of the MHSS ARAIM algorithm.With the data processing and analysis from several international GNSS service(IGS)and international GNSS monitoring and assessment system(iGMAS)stations,the results show that this new algorithm is superior to MHSS ARAIM in the localizer performance with vertical guidance down to 200 feet service(LPV-200)when using GPS and BDS measure data.Under the assumption of a single-faulty satellite,the effective monitoring threshold(EMT)is improved about 22.47%and 9.63%,and the vertical protection level(VPL)is improved about 32.28%and 12.98%for GPS and BDS observations,respectively.Moreover,under the assumption of double-faulty satellites,the EMT is improved about 80.85%and 29.88%,and the VPL is improved about 49.66%and 18.24%for GPS and BDS observations,respectively. | Yabin ZHANG Li WANG Lihong FAN Xuanyu QU | 2020 | Journal of Geodesy and Geoinformation Science2020，3，1： | 3 |
| 11 | The pain-related behavior changes correlate with the bone damage in a rat model of rheumatoid arthritis显示文摘Objective: In view of the extensive bone damage in rheumatoid arthritis, we used a commonly utilized animal model to detect behavioral changes in pain-related and the bone damage during the early disease, and to explore the correlation between bone damage and pain-related behavioral changes. Methods: Arthritis were induced in Sprague-Dawley (SD) male rats by injecting complete Freund's adjuvant (CFA) into the tails. Pain-related behavior changes were studied using the Hargreaves, VonFrey, and acetone tests on the 0, 7, 14, day and 28 day after CFA injection. The rats were sacrificed according the same schedule. The bone damage of the right proximal tibia was studied by microCT scan and bone histological slices. Results: Animals developed soft tissue inflammation and polyarthritis on 7 days after CFA injection, and arthritic score proved obvious arthritis were established within the study period. Mechanical hyperalgesia and cold allodynia were present in the affected hind paw from the 7 day through the 28 day, but the heat hyperalgesia and the mechanical allodynia lasted a short time after CFA injection. Trabecular bone number (Tb.N), Tissue Mineral Content (TMC) and Bone Volume to Tissue Volume (BV/TV) in the proximal tibia by microCT scan were also reduced after induction, especial 14 days after CFA injection. The bone histological slices showed the trabecular bone and proteoglycan diminished, the bone damage severity scores became more severely on the 7 day after CFA injection. Using analysis of covariance, these changes had statistical significance compared with baseline. By linear regression analysis demonstrated mechanical hyperalgesia and cold allodynia correlated well with arthritic score, bone damage parameters and bone damage severity scores. Conclusion: Adjuvant-induced arthritis (AA) were observed after CFA injection and lasted within the later experimental period. Pain-related behavioral changes were observed in the early time of AA. Bone damage was also occurred with arthritis development. Pain-related behavioral change correlated well with arthritic score and bone damage parameters. | ZHENG Shicheng WANG Kunzheng FAN Lihong SHI Zhibin CHEN Junchang BAO Hongxiang | 2013 | Journal of Medical Colleges of PLA(China)2013，28，3： | 3 |
| 12 | Recover the abnormal positioning,velocity and timing services caused by BDS satellite orbital maneuvers显示文摘The BeiDou Navigation Satellite System(BDS)provides global Positioning,Velocity,And Timing(PVT)services that are widely used in various areas.The BDS satellites frequently need the orbit maneuvers due to various perturbations to keep satellites in their designed positions.During these maneuvers,PVT services may be abnormal if the data from a maneuvering satellite is used.In this paper we developed an approach to recover the abnormal PVT services.By using BDS observations from multiple tracking stations,the orbital errors of a maneuvering satellite can be in real time obtained and corrected,thereby avoiding any influence on the performance of PVT services.The tests show that the average precision of position,velocity and timing services are improved by 0.8 m,0.1 mm/s and 0.16 ns,respectively,using the developed orbital maneuver recovery approach.In addition,the approach can also be used for the orbital maneuver detection and monitoring. | Rui Tu Rui Zhang Pengfei Zhang Junqiang Han Lihong Fan Xiaochun Lu | 2021 | Satellite Navigation2021，2，1： | 3 |
| 13 | The self-assembled nanoparticle-based trimeric RBD mRNA vaccine elicits robust and durable protective immunity against SARS-CoV-2 in mice显示文摘As COVID-19 continues to spread rapidly worldwide and variants continue to emerge,the development and deployment of safe and effective vaccines are urgently needed.Here,we developed an mRNA vaccine based on the trimeric receptor-binding domain(RBD)of the SARS-CoV-2 spike(S)protein fused to ferritin-formed nanoparticles(TF-RBD).Compared to the trimeric form of the RBD mRNA vaccine(T-RBD),TF-RBD delivered intramuscularly elicited robust and durable humoral immunity as well as a Th 1-biased cellular response.After further challenge with live SARS-CoV-2,immunization with a two-shot low-dose regimen of TF-RBD provided adequate protection in hACE2-transduced mice.In addition,the mRNA template of TF-RBD was easily and quickly engineered into a variant vaccine to address SARS-CoV-2 mutations.The TF-RBD multivalent vaccine produced broad-spectrum neutralizing antibodies against Alpha(B.1.1.7)and Beta(B.1.351)variants.This mRNA vaccine based on the encoded self-assembled nanoparticle-based trimer RBD provides a referenee for the design of mRNA vaccines targeting SARS-CoV-2. | Wenqiang Sun Lihong He He Zhang Xiaodong Tian Zhihua Bai Lei Sun Limin Yang Xiaojuan Jia Yuhai Bi Tingrong Luo Gong Cheng Wenhui Fan Wenjun Liu Jing Li | 2021 | Signal Transduction and Targeted Therapy2021，6，10： | 3 |
| 14 | Bending of functionally graded nanobeams incorporating surface effects based on Timoshenko beam model显示文摘The bending responses of functionally graded(FG) nanobeams with simply supported edges are investigated based on Timoshenko beam theory in this article. The Gurtin-Murdoch surface elasticity theory is adopted to analyze the influences of surface stress on bending response of FG nanobeam. The material properties are assumed to vary along the thickness of FG nanobeam in power law. The bending governing equations are derived by using the minimum total potential energy principle and explicit formulas are derived for rotation angle and deflection of nanobeams with surface effects. Illustrative examples are implemented to give the bending deformation of FG nanobeam. The influences of the aspect ratio, gradient index, and surface stress on dimensionless deflection are discussed in detail. | Lihong Yang Tao Fan Liping Yang Xiao Han Zongbing Chen | 2017 | Theoretical & Applied Mechanics Letters2017，7，3： | 2 |
| 15 | The dark side of browning显示文摘在白脂肪质的织物(WAT ) 的像褐的 adipocyte 开发的正式就职由减少的脂肪过多和增加的精力开销授与众多的新陈代谢的好处。因此, WAT browning 获得了可观的注意让它的潜力颠倒肥胖和它的联系合作病态。然而,这个观点被识别导致 WAT browning 的有害效果的最近的研究沾染了。这评论试图加亮 browning 活动, browning 代理人的有害副作用,以及被建议了调整这的分子的刹车开关系统处理的 overactive 和 underactive 的不利结果。开发支撑 WAT browning 的新陈代谢的改进并且稀释相关不利副作用的新奇策略为在新陈代谢的疾病的治疗开 browning 代理人的治疗学的潜力因此是必要的。 | Kirstin A. Tamucci Maria Namwanje Lihong Fan Li Qiang | 2018 | Protein & Cell2018，9，2： | 2 |
| 16 | Ultrasound-induced biophysical effects in controlled drug delivery显示文摘Ultrasound is widely used in biomedical engineering and has applications in conventional diagnosis and drug delivery.Recent advances in ultrasound-induced drug delivery have been summarized previously in several reviews that have primarily focused on the fabrication of drug delivery carriers.This review discusses the mechanisms underlying ultrasound-induced drug delivery and factors affecting delivery efficiency,including the characteristics of drug delivery carriers and ultrasound parameters.Firstly,biophysical effects induced by ultrasound,namely thermal effects,cavitation effects,and acoustic radiation forces,are illustrated.Secondly,the use of these biophysical effects to enhance drug delivery by affecting drug carriers and corresponding tissues is clarified in detail.Thirdly,recent advances in ultrasound-triggered drug delivery are detailed.Safety issues and optimization strategies to improve therapeutic outcomes and reduce side effects are summarized.Finally,current progress and future directions are discussed. | Lulu Zhang Zhuohua Lin Lan Zeng Fan Zhang Lihong Sun Suhui Sun Ping Wang Menghong Xu Jinxia Zhang Xiaolong Liang Huiyu Ge | 2022 | Science China(Life Sciences)2022，65，5： | 2 |
| 17 | Chitosan- metal complexes as antimicrobial agent: Synthesis, characterization and Structure-activity study显示文摘 | Xiaohui Wang Yumin Du Lihong Fan Hui Liu Ying Hu | 2005 | Polymer Bulletin2005，，1： | 2 |
| 18 | Chitosan-metal com- plexes as antimicrobial agent: Synthesis, characterization and structure activity study显示文摘 | WANG Xiaohui DU Yumin FAN Lihong | 2005 | Polym Bull2005，55，： | 1 |
| 19 | Enzymatic hydrolysis of silk sericin by proteases and antioxidant activities of the hydrolysates显示文摘 | Jinbo Fan Lihong Zheng Fazheng Ren | 2010 | Journal of Food Biochemistry2010，34，： | 1 |
| 20 | Preparation, Characterization and Antimicrobial Activity of Quaternized Carboxymethyl Chitosan and Application as Pulp-cap 显示文摘 | Sun Liping Du Yumin Fan Lihong | 2006 | Polymer2006，47，6： | 1 |
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