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| 1 | Discovery of biclonal origin and a novel oncogene SLC12A5 in colon cancer by single-cell sequencing显示文摘单个房间的定序是为描出的一个强大的工具为个性化的癌症管理的同种细胞的关系和识别关键司机基因。这里,我们执行了结肠癌的一个盒子的单个房间的定序的分析。人口遗传分析在肿瘤房间人口识别了二独立克隆。主要肿瘤克隆作为早 oncogenic 事件怀有 APC 和 TP53 变化,而次要的克隆包含了优势的 CDC27 和 PABPC1 变化。在这二克隆的次要的克隆支持的 APC 和 TP53 变化的缺席从二细胞的起源被导出。体的变化等位基因频率系列的检查另外 21 个整个织物的定序 exome 的盒子在结肠癌揭示了同种细胞的起源的异质。下次,我们识别了在单个房间的水平显示出变化的高频率,但是在人口水平展出了低流行的变异的基因 SLC12A5。变异的 SLC12A5 的功能的描述在结肠癌揭示了它的潜在的 oncogenic 效果。我们的学习在单个房间的水平支持提供第一条 exome 宽的证据那结肠癌能具有 biclonal 起源,并且建议在一个队的低流行的变化可以也在单个水平起重要 protumorigenic 作用。 | Chang Yu Jun Yu Xlaotlan Yao Wllham KK Wu Youyong Lu Senwel Tang Xiangchun Li Li Bao Xiaoxing Li Yong Hou Renhua Wu Min Jian Ruoyan Chen Fan Zhang Lixia Xu Fan Fan Jun He Qiaoyi Liang Hongyi Wang Xueda Hu Minghui He Xiang Zhang Hancheng Zheng Qibin Li Hanjie Wu Yan Chen Xu Yang Shida Zhu Xun Xu Huanming Yang Jian Wang Xiuqing Zhang Joseph JY Sung Yingrui Li Jun Wang | 2014 | Cell Research2014，，6： | 16 |
| 2 | New fundamental quantum mechanical operator-ordering identities for the coordinate and momentum operators显示文摘In quantum mechanics theory one of the basic operator orderings is Q-P and P-Q ordering,where Q and P are the coordinate operator and the momentum operator,respectively.We derive some new fundamental operator identities about their mutual reordering.The technique of integration within Q-P ordering and P-Q ordering is introduced.The Q-P ordered and P-Q ordered formulas of the Wigner operator are also deduced which makes arranging the operators in either Q-P or P-Q ordering much more convenient. | FAN HongYi | 2012 | Science China(Physics,Mechanics & Astronomy)2012，55，5： | 4 |
| 3 | The s-ordered expansions of the operator function about the combined quadrature μX + νP显示文摘A general framework applicable to deriving the s-ordered operator expansions is presented in this paper.We firstly deduce the s-ordered operator expansion formula of density operator ρ a?,a and introduce the technique of integration within the sordered product of operators (IWSOP).Based on the deduction and the technique,we derive the s-ordered expansions of operators (μX + νP)n and Hn (μX + νP) (linear combinations of the coordinate operator X and the momentum operator P,Hn (x) is Hermite polynomial),respectively,and discuss some special cases of s=1,0,-1.Some new useful operator identities are obtained as well. | HongChun Yuan XueXiang Xu HongYi Fan | 2010 | Science China(Physics,Mechanics & Astronomy)2010，53，10： | 4 |
| 4 | Coherent state and normal ordering method for transiting Hermite polynomials to Laguerre polynomials显示文摘By virtue of the coherent state representation and the operator ordering method we find a new approach for transiting Hermite polynomials to Laguerre polynomials.We also derive the new reciprocal relation of Laguerre polynomials n=0(1) n l n L n(x) = x l l!,and its application in deriving the sum rule of the Wingner function of Fock states is demonstrated.Some new expansion identities about the operator Laguerre polynomial are also derived.This opens a new route of deriving mathematical polynomials formulas by virtute of the quantum mechanical representations and operator ordering technique. | FAN HongYi ZHOU Jun | 2012 | Science China(Physics,Mechanics & Astronomy)2012，55，4： | 3 |
| 5 | A new approach to the time evolution of characteristic function of the density operator obtained by virtue of thermal entangled state representation显示文摘Like the progress made by Dirac that wave function ψ(x) was reformed as x |ψ,where x| is the coordinate representation,we endow the characteristic function χλ = Tr(e λa-λaρ) of density operator ρ with the meaning of wave function of |ρ in the thermal entangled state η| representation in the doubled Fock space,χλ = η = λ|ρ,where |ρ = ρ|η = 0.We find the time evolution of χλ can then be directly and neatly obtained via this approach.The way of deriving the density operator from η = λ | ρ is also presented. | CHEN Feng FAN HongYi | 2012 | Science China(Physics,Mechanics & Astronomy)2012，55，11： | 3 |
| 6 | s-ordering operator expansions of quantum-mechanical fundamental representations and their applications显示文摘We show that the quantum-mechanical fundamental representations, say, the coordinate representation, the coherent state representation, the Fan-Klauder entangled state representation can be recast into s-ordering operator expansion, which is elegant in form and has many applications in deriving new operator identities. This demonstrates that Dirac's symbolic method can be merged into Newton-Leibniz integration theory in a broad way. | FAN HongYi 1,3 , XU YeJun 2 & YUAN HongChun 3,4 1 Department of Materials Science and Engineering, University of Science and Technology of China, Hefei 230026, China 2 Department of Physics Electronic and Engineering, Chizhou University, Chizhou 247000, China 3 Department of Physics, Shanghai Jiao Tong University, Shanghai 200030, China 4 College of Optoelectronic Engineering, Changzhou Institute of Technology, Changzhou 213002, China | 2011 | Science China(Physics,Mechanics & Astronomy)2011，54，12： | 2 |
| 7 | Use of electrosense in the feeding behavior of sturgeons显示文摘The electro-receptive lateral line system appeared early in the evolutionary history of fish.Sturgeons,members of the primitive Chondrostei group,are known for their electroreceptors(ampullae of Lorenzini)on the head,which are thought to be sensitive to weak electric fields in aquatic environments and involved in feeding,mating and migration.Here,we report the results of a set of behavioral and electrophysiological experiments designed to determine the function and characteristics of the electrosense in cultured sturgeons.The results showed Sibe-rian sturgeon(Acipenser baerii Brandt,1869)feeding striking at bio-electric fields produced by living feed-fish enclosed in a gel chamber and at the corrosion field produced by metal rods.With an electric stimulus that mim-ics the bio-electric fields produced by living prey,the relative discharge rate of electrosensory neurons in the dorsal octavolateralis nucleus(DON)was modulated by and phase-locked to sinusoidal stimulus and some units showed selectivity for dipolar direction in white sturgeon(Acipenser transmontanus Richardson,1836).This is the first study to provide the empirical evidence correlating with electrosensory behaviors and electrophysiolog-ical responses in cultured sturgeons,and suggesting that electrosense does play an innate role in feeding behav-ior of sturgeon.We believe this will have important implications for protecting sturgeons in the wild. | Xuguang ZHANG Jiakun SONG Chunxin FAN Hongyi GUO Xiaojie WANG Horst BLECKMANN | 2012 | Integrative Zoology2012，7，1： | 2 |
| 8 | Tripartite entangled state,tripartite entangled Wigner operator and their generalization to an n-mode case显示文摘For entangled three particles one should treat their wave function as a whole.There is no physical meaning talking about the wave function(or Wigner function) for any one of the tripartite,and therefore considering the entangled Wigner function(Wigner operator) is of necessity.In this paper,we introduce a pair of mutually conjugate tripartite entangled state representations for defining the Wigner operator of entangled tripartite.Its marginal distributions and the Wigner function of the three-mode squeezed vacuum state are presented.Deriving wave function from its corresponding tripartite entangled Wigner function is also discussed.Moreover,through establishing the n-mode entangled state representation,we introduce the n-mode entangled Wigner operator,which would be more generally useful in quantum physics. | L CuiHong GU DanDan FAN HongYi WANG YaWei | 2013 | Science China(Physics,Mechanics & Astronomy)2013，56，9： | 2 |
| 9 | Operators' ordering: from Weyl ordering to normal ordering显示文摘By virtue of the technique of integration within an ordered product of operators we present a new approach to obtain operators' normal ordering. We first put operators into their Weyl ordering through the Weyl-Wigner quantization scheme, and then we convert the Weyl ordered operators into normal ordering by virtue of the normally ordered form of the Wigner operator. | FAN HongYi YUAN HongChun CAI GenChang JIANG NianQuan | 2011 | Science China(Physics,Mechanics & Astronomy)2011，54，8： | 2 |
| 10 | General formula for finding motherwavelets by virtueof Dirac ’ s representation theory and the co-herent state显示文摘 | Fan Hongyi Liu Hailiang | 2006 | Opt Lett2006，31，： | 1 |
| 11 | Operator ordering in quantum optics theory andthe development of Dirac ’ s symbolic method 显示文摘 | Fan Hongyi | 2003 | J Opt B :Quantum Semiclass2003，5，： | 1 |
| 12 | Deriving the energy-level gap of some dynamic Hamiltonians in quantum optics by means of the invariant eigenoperator method显示文摘 | FAN Hongyi TANG Xubing GUI Weijun | 2005 | J Opt B2005，7，： | 1 |
| 13 | Supersymmetric Unitary Operator for Some Generalized Jaynes Cummings Model显示文摘 | FAN Hongyi LI Liangshi | 1996 | Commun Theor Phys1996，25，： | 1 |
| 14 | Application of nano powdered rubber in friction materials显示文摘 | Liu Yiqun Fan Zhongqing Ma Hongyi | 2006 | Wear:2006，261，2： | 1 |
| 15 | Psuedo-invariant eigenoperator method for some generalized Jaynes-Cummings mode显示文摘 | LI Hengmei FAN Hongyi | 2009 | Int J Theor Phys2009，48，： | 1 |
| 16 | Quantum fluctuation in thermal vacuum state for mesoscopic LC electric circuit显示文摘 | FAN Hongyi LIANG Xianting | 2000 | Chinese Physics Letter2000，17，3： | 1 |
| 17 | Migration behavior and separation of active components in Glycyrrhiza uralensis Fisch and its commercial extract by micellar electrokinetic pillary chromatography 显示文摘 | Hongyi Zhang Yuquan Fan | 1999 | J Chromatogra A1999，863，： | 1 |
| 18 | Potential roles of PI3K/Akt and Nrf2eKeapl pathways in regulating hormesis of Z-ligustilide in PC12 cells against oxygen and glucose deprivation显示文摘 | HONGYI QI Y/FAN HAN JIANHUI RONG | 2012 | Neuropharmacology2012，62，4： | 1 |
| 19 | New identities about operator Hermite polynomials and their related integration formulas显示文摘By virtue of the technique of integration within an ordered product (IWOP) of operators and the bipartite entangled state representation, we derive some new identities about operator Hermite polynomials in both the single-and two-variable cases. We also find a binomial-like theorem between the single-variable Hermite polynomials and the two-variable Hermite polynomials. Application of these identities in deriving new integration formulas, but without really doing the integration in the usual sense, is demonstrated. | FAN HongYi YUAN HongChun JIANG NianQuan | 2011 | Science China(Physics,Mechanics & Astronomy)2011，54，12： | 1 |
| 20 | Comprehensive characterization of CRC with germline mutations reveals a distinct somatic mutational landscape and elevated cancer risk in the Chinese population显示文摘Objective:Hereditary colorectal cancer(CRC)accounts for approximately 5%–10%of all CRC cases.The full profile of CRC-related germline mutations and the corresponding somatic mutational profile have not been fully determined in the Chinese population.Methods:We performed the first population study investigating the germline mutation status in more than 1,000(n=1,923)Chinese patients with CRC and examined their relationship with the somatic mutational landscape.Germline alterations were examined with a 58-gene next-generation sequencing panel,and somatic alterations were examined with a 605-gene panel.Results:A total of 92 pathogenic(P)mutations were identified in 85 patients,and 81 likely pathogenic(LP)germline mutations were identified in 62 patients,accounting for 7.6%(147/1,923)of all patients.MSH2 and APC was the most mutated gene in the Lynch syndrome and non-Lynch syndrome groups,respectively.Patients with P/LP mutations had a significantly higher ratio of microsatellite instability,highly deficient mismatch repair,family history of CRC,and lower age.The somatic mutational landscape revealed a significantly higher mutational frequency in the P group and a trend toward higher copy number variations in the non-P group.The Lynch syndrome group had a significantly higher mutational frequency and tumor mutational burden than the nonLynch syndrome group.Clustering analysis revealed that the Notch signaling pathway was uniquely clustered in the Lynch syndrome group,and the MAPK and cAMP signaling pathways were uniquely clustered in the non-Lynch syndrome group.Population risk analysis indicated that the overall odds ratio was 11.13(95%CI:8.289–15.44)for the P group and 20.68(95%CI:12.89–33.18)for the LP group.Conclusions:Distinct features were revealed in Chinese patients with CRC with germline mutations.The Notch signaling pathway was uniquely clustered in the Lynch syndrome group,and the MAPK and cAMP signaling pathways were uniquely clustered in the non-Lynch syndrome group.Patients with P/LP germline mutations exhibited higher CRC risk. | Jianfei Yao Yunhuan Zhen Jing Fan Yuan Gong Yumeng Ye Shaohua Guo Hongyi Liu Xiaoyun Li Guosheng Li Pan Yang Xiaohui Wang Danni Liu Tanxiao Huang Huiya Cao Peisu Suo Yuemin Li Jingbo Yu Lele Song | 2022 | Cancer Biology & Medicine2022，19，5： | 1 |
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