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| 1 | Suppression of P-gp induced multiple drug resistance in a drug resistant gastric cancer cell line by overexpression of Fas显示文摘AIM To observe the drug sensitizing effect andrelated mechanisms of fas gene transduction onhuman drug-resistant gastric cancer cellSGC7901/VCR(resistant to Vincristine).METHODS The cell cycle alteration wasobserved by FACS.The sensitivity of gastriccancer cells to apoptosis was determined by invitro apoptosis assay.The drug sensitization ofcells to several anti-tumor drugs was observedby MTT assay.Immunochemical method wasused to show expression of P-gp and Topo Ⅱ ingastric cancer cells.RESULTS Comparing to SGC7901 and pBK-SGC7901/VCR,fas-SGC7901/VCR showeddecreasing G2 cells and increasing S cells,theG2 phase fraction of pBK-SGC7901/VCR wasabout 3.0 times that of fas-SGC7901/VCR,but Sphase fraction of fas-SGC7901/VCR was about1.9 times that of pBK-SGC7901/VCR,indicatingS phase arrest of fas-SGC7901/VCR.FACS alsosuggested apoptosis of fas-SGC7901/VCR,fas-SGC7901/VCR was more sensitive to apoptosisinducing agent VM-26 than pBK-SGC7901/VCR.MTT assay showed increased sensitization offas-SGC7901/VCR to DDP,MMC and 5-FU,butsame sensitization to VCR according to pBK-SGC7901/VCR.SGC7901,pBK-SGC7901/ VCRand fas-SGC7901/VCR had positively stainedTopo Ⅱ equally.P-gp staining in pBK- SGC7901/VCR was stronger than in SG07901,but there was little staining of P-gp in fas.SGC7901/VCR.CONCLUSION fas gene transduction couldreverse the MDR of human drug-resistant gastriccancer cell SGC7901/VCR to a degree,possiblybecause of higher sensitization to apoptosis anddecreased expression of P-gp. | Yin F Shi YQ Zhao WP Xiao B Miao JY Fan DM | 2000 | World Journal of Gastroenterology2000，6，5： | 24 |
| 2 | Proteomic analysis of human ovaries from normal and polycystic ovarian syndrome显示文摘 | Ma,X Fan,L Meng,Y Hou,Z Mao,YDL Wang,W Ding,W Liu,JY | 2007 | 南京医科大学学报(自然科学版)2007，27，11： | 20 |
| 3 | Discovery of biclonal origin and a novel oncogene SLC12A5 in colon cancer by single-cell sequencing显示文摘单个房间的定序是为描出的一个强大的工具为个性化的癌症管理的同种细胞的关系和识别关键司机基因。这里,我们执行了结肠癌的一个盒子的单个房间的定序的分析。人口遗传分析在肿瘤房间人口识别了二独立克隆。主要肿瘤克隆作为早 oncogenic 事件怀有 APC 和 TP53 变化,而次要的克隆包含了优势的 CDC27 和 PABPC1 变化。在这二克隆的次要的克隆支持的 APC 和 TP53 变化的缺席从二细胞的起源被导出。体的变化等位基因频率系列的检查另外 21 个整个织物的定序 exome 的盒子在结肠癌揭示了同种细胞的起源的异质。下次,我们识别了在单个房间的水平显示出变化的高频率,但是在人口水平展出了低流行的变异的基因 SLC12A5。变异的 SLC12A5 的功能的描述在结肠癌揭示了它的潜在的 oncogenic 效果。我们的学习在单个房间的水平支持提供第一条 exome 宽的证据那结肠癌能具有 biclonal 起源,并且建议在一个队的低流行的变化可以也在单个水平起重要 protumorigenic 作用。 | Chang Yu Jun Yu Xlaotlan Yao Wllham KK Wu Youyong Lu Senwel Tang Xiangchun Li Li Bao Xiaoxing Li Yong Hou Renhua Wu Min Jian Ruoyan Chen Fan Zhang Lixia Xu Fan Fan Jun He Qiaoyi Liang Hongyi Wang Xueda Hu Minghui He Xiang Zhang Hancheng Zheng Qibin Li Hanjie Wu Yan Chen Xu Yang Shida Zhu Xun Xu Huanming Yang Jian Wang Xiuqing Zhang Joseph JY Sung Yingrui Li Jun Wang | 2014 | Cell Research2014，，6： | 16 |
| 4 | Ameliorating effects of compounds derived from Salvia miltiorrhiza root extract on microcirculatory disturbance and target organ injury by ischemia and reperfusion 显示文摘 | Hart JY Fan JY Horie Y | 2008 | Pharmacol Ther2008，117，2： | 1 |
| 5 | Ameliorating effects of com- pounds derived from Salvia mihiorrhiza root extract on microcir culatory disturbance and target organ injury by ischemia and reperfusion显示文摘 | Han JY Fan JY Horie Y | 2008 | Pharmaeol Ther2008，117，2： | 1 |
| 6 | Potential of 3,4-dihydroxy-phenyl lactic acid for ameliorating ischemia-reperfusioninduced microvascular disturbance in rat mesentery显示文摘 | Han JY Horie Yoshinori Fan JY | 2009 | Am J Physiol Gastrointest Liver Physiol2009，296，1： | 1 |
| 7 | Impact of new oral or intravenous P2Y12 inhibitors and elopidogrel on major ischemic and bleeding events in patients with coronary artery disease: a meta - analysis of randomized trials 显示文摘 | Tang XF Fan JY Meng J | 2014 | Atherosclerosis2014，233，2： | 1 |
| 8 | Eight pathsof ERKI/2 sig nalling pathway regulating hepatocyte proliferation in rat liver regeneration显示文摘 | Li JW WangGP Fan JY | 2011 | Genet2011，90，： | 1 |
| 9 | Experimentalstudy of air entrain ment mode with natural rentilation u-sing shafts in road tunnel fires 显示文摘 | Fan CG Ji J Gao ZH Han JY Sun JH | 2013 | International Journalof Heat and Mass Transfer2013，56，1： | 1 |
| 10 | Foxl2 mutations in chinese families with blepharophimosis syndrome (bpes) 显示文摘 | Fan JY Wang YF Han B | 2011 | Transl Res2011，157，1： | 1 |
| 11 | Silencing of calpain expression reduces the metastatic potcntial of human osteosarcoma cells显示文摘 | Fan DG Dai JY Tang J | | 0，，： | 1 |
| 12 | Effect of norcantharidin on proliferation and invasion of human gallbladder carcinoma GBC-SD cell显示文摘 | Fan YZ Fu JY Zhao ZM el al | 2005 | World J Gastroentero2005，11，16： | 1 |
| 13 | Intracranial pressure wavdorm morphology and intraeranial adaptive capacity 显示文摘 | Fan JY Kirkness C Vicini P | 2008 | Am J Crit Care2008，17，6： | 1 |
| 14 | Primary colorectal lymphoma显示文摘 | Changchien CR Wang JY | 2000 | Dis Colon Rectum2000，43，9： | 1 |
| 15 | Validation of a Chinese version of disease specific quality of life scale(HFS-36)for hemifacial spasm in Taiwan显示文摘 | Huang YC Fan JY Ro LS | 2009 | Health Qual Life Outcomes2009，7，： | 1 |
| 16 | The genome of the cucumber显示文摘 | HUANG S LI R ZHANG Z LI L GU X FAN W LUCAS W J WANG X XIE B NI P REN Y ZHU H LI J LIN K JIN W FEI Z LI G STAUB J KILIAN A VAN DER VOSSEN EA WUY GUO J HE J JIA Z REN Y TIAN G LU Y RUAN J QIANW WANG M HUANG Q LI B XUAN Z CAO J ASAN WUZ ZHANG J CAI Q BAI Y ZHAO B HAN Y LI Y LI X WANG S SHI Q LIU S CHO WK KIM JY XU Y HELLER-USZYNSKA K MIAO H CHENG Z ZHANG S WU J YANG Y KANG H LI M LIANG H REN X SHI Z WEN M JIAN M YANG H ZHANG G YANG Z CHEN R LIU S LI J MA L LIU H ZHOU Y ZHAO J FANG X LI G FANG L LI Y LIUD ZHENG H ZHANG Y QIN N LI Z YANG G YANG S BOLUND L KRISTIANSEN K ZHENG H LI S ZHANG X YANG H WANG J SUN R ZHANG B JIANG S WANG J DUY LI S | 2009 | Cucumis Sativus L NatureGenetics2009，41，： | 1 |
| 17 | Study on the molecular markers of Capsicum wild domesticated species using RAPD analysis显示文摘 | Wang JY Fan MJ Lo SF | 1996 | Journal of Agricultural Research of China1996，45，4： | 1 |
| 18 | Comparison on microsatellite DNA and RAPD markers for germplasm identification of Capsicum annuum显示文摘 | Wang JY Fan M J | 1998 | Journal of Agricultural Research of China1998，47，3： | 1 |
| 19 | Silencing of calpain expression reduces the metastatic potential of human osteosarcoma cells 显示文摘 | Fan DG Dai JY Tang J | 2009 | Cell Biol Int2009，33，12： | 1 |
| 20 | Anisotropic properties of human tibial cortical bone as measured by nanoindentation显示文摘 | Fan Z Swadener JG Rho JY | | 0，，04： | 1 |
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