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| 1 | Qualitative and quantitative assessment of related substances in the Compound Ketoconazole and Clobetasol Propionate Cream by HPLC-TOF-MS and HPLC显示文摘Related substances in pharmaceutical formulations are associated with their safety, efficacy and stability. However, there is no overall study already published on the assessment of related substances in the Compound Ketoconazole and Clobetasol Propionate Cream. In this work, a reliable HPLC-TOF-MS qualitative method was developed for the analysis of related substances in this preparation with a quick and easy extraction procedure. Besides the active pharmaceutical ingredients, two compounds named ketoconazole impurity B′ optical isomer and ketoconazole impurity E were identified. Furthermore, a new HPLC method for qualitative and quantitative assessment on related substances and degradation products, which were found in the stability test, was established and validated. The single standard to determine multi-components method was applied in the quantitative analysis, which was an effective way for reducing cost and improving accuracy. This study can provide a creative idea for routine analysis of quality control of the Compound Ketoconazole and Clobetasol Propionate Cream. | Wenling Yang Xiaomei Yang Fanghua Shi Zhigang Liao Yongkun Liang Liangzhong Yu Ruixun Wang Qing Li Kaishun Bi | 2019 | Journal of Pharmaceutical Analysis2019，9，3： | 4 |
| 2 | Precambrian Captured Zircon Ages in the Daheigou Formation, Xing’an Block显示文摘The Xing'an Block (XB) is located between the Erguna
Block (EB) and the Songnen Block (SB), which
topographically occupies the northeastern half of the Great
Xing'an Range (Liu et al., 2017). The XB was
traditionally considered to be composed of a Precambrian
metamorphic basement and post-Cambrian cover.
However, the recent geochronological studies show that
the so-called 'Precambrian metamorphic rocks^^ are much
younger in age and considered to be formed in the Early
Paleozoic, indicating no existence of the Precambrian
metamorphic basement. | SONG Wanbing CUI Fanghua YANG Hongzhi ZHANG Li WU Xinwei SHI Jianmin ZHANG Chao | 2019 | Acta Geologica Sinica(English Edition)2019，93，3： | 1 |
| 3 | Dynamics of the SARS-CoV-2 antibody response up to 10 months after infection显示文摘COVID-19 caused by SARS-CoV-2 infection has caused substantial morbidity and mortality worldwide and paralyzed the international economy.Understanding the magnitude and duration of the antibody response to SARS-CoV-2 is important to achieve a balance between curbing the pandemic and minimizing adverse effects on society.1 Although the antibody response to SARS-CoV-2 within 9 months has been extensively studied,2,3,4,5,6 little is known about the magnitude and kinetics of antibody responses for over 9 months.Moreover,with limited observations over 9 months(n<100),2,7,8 several studies have produced inconsistent conclusions about antibody dynamics,suggesting different rates of antiviral antibody positivity at the last follow-up.2,7,8 These studies have been limited by a lack of measurement of neutralizing antibodies(NAbs),7 of inclusion of mild or asymptomatic cases,2,8 and of further exploration of potential predisposing factors for antibody dynamics.2,7 Considering the individual heterogeneity(such as disease severity)8 and time-dependent nature1 of the immune response,in-depth characterization of SARS-CoV-2 antibody kinetics across disease severity groups over a long period is urgently needed.Therefore,we repeatedly tested IgM,IgG,viral spike protein receptor-binding dom(anti-RBD)IgG,and NAb titers in COVID-19 patients during a follow-up period of up to 10 months and explored potential predisposing factors of antibody titers during follow-up. | Hao Wang Yu Yuan Mingzhong Xiao Li Chen Youyun Zhao Haiwei Zhang Pinpin Long Yana Zhou Xi Xu Yanshou Lei Bihao Wu Tingyue Diao Hao Cai Li Liu Zuoyu Shao Jingzhi Wang Yansen Bai Kai Wang Miao Peng Linlin Liu Shi Han Fanghua Mei Kun Cai Yake Lei An Pan Chaolong Wang Rui Gong Xiaodong Li Tangchun Wu | 2021 | Cellular & Molecular Immunology2021，18，7： | 1 |
| 4 | Recombinant adeno-associated virus 8 vector in gene therapy:Opportunities and challenges显示文摘In recent years,significant breakthroughs have been made in the field of gene ther-apy.Adeno-associated virus(AAV)is one of the most promising gene therapy vectors and a powerful tool for delivering the gene of interest.Among the AAV vectors,AAV serotype 8(AAv8)has attracted much attention for its efficient and stable gene transfection into specific tissues.Currently,recombinant AAv8 has been widely used in gene therapy research on a va-riety of diseases,including genetic diseases,cancers,autoimmune diseases,and viral diseases. | Liyuan Zhao Zixuan Yang Minhui Zheng Lei Shi Mengyun Gu Gang Liu Feng Miao Yan Chang Fanghua Huang Naping Tang | 2024 | Genes & Diseases2024，11，1： | 1 |
| 5 | Observations on clinical efficacy of albendazole emulsion in 264 cases of hepatic cystic echinococcosis显示文摘 | Junjie Chai Menghebat Jiao Wei Sun Deyu Liang Bin Shi Jincao Fu Chen Li Xiong Mao Yiding Wang Xiuling Dolikun Guliber Wang Yanchun Gao Fanghua Xiao Shuhua | 2003 | Parasitology International2003，，1： | 1 |
| 6 | Fundamental Understanding of Hydrogen Evolution Reaction on Zinc Anode Surface:A First‑Principles Study显示文摘Hydrogen evolution reaction(HER)has become a key factor affecting the cycling stability of aqueous Zn-ion batteries,while the corresponding fundamental issues involving HER are still unclear.Herein,the reaction mechanisms of HER on various crystalline surfaces have been investigated by first-principle calculations based on density functional theory.It is found that the Volmer step is the ratelimiting step of HER on the Zn(002)and(100)surfaces,while,the reaction rates of HER on the Zn(101),(102)and(103)surfaces are determined by the Tafel step.Moreover,the correlation between HER activity and the generalized coordination number(CN)of Zn at the surfaces has been revealed.The relatively weaker HER activity on Zn(002)surface can be attributed to the higher CN of surface Zn atom.The atomically uneven Zn(002)surface shows significantly higher HER activity than the flat Zn(002)surface as the CN of the surface Zn atom is lowered.The CN of surface Zn atom is proposed as a key descriptor of HER activity.Tuning the CN of surface Zn atom would be a vital strategy to inhibit HER on the Zn anode surface based on the presented theoretical studies.Furthermore,this work provides a theoretical basis for the in-depth understanding of HER on the Zn surface. | Xiaoyu Liu Yiming Guo Fanghua Ning* Yuyu Liu Siqi Shi Qian Li Jiujun Zhang Shigang Lu Jin Yi | 2024 | Nano-Micro Letters2024，16，6： | 0 |
| 7 | Space Weather Service for Chinese Space Science Satellites显示文摘Strategic Priority Research Program on Space Science has gained remarkable achievements. Space Environment Prediction Center(SEPC) affiliated with the National Space Science Center(NSSC) has been providing space weather services and helps secure space missions. Presently, SEPC is capable to offer a variety of space weather services covering many phases of space science missions including planning, design, launch,and orbital operation. The service packages consist of space weather forecasts, warnings, and effect analysis that can be utilized to avoid potential space weather hazard or reduce the damage caused by space storms,space radiation exposure for example. Extensive solar storms that occurred over Chinese Ghost Festival(CGF)in September 2017 led to a large enhancement of the solar energetic particle flux at 1 AU, which affected the near Earth radiation environment and brought great threat to orbiting satellites. Based on the space weather service by SEPC, satellite ground support groups collaborating with the space Tracking, Telemetering and Command system(TT&C) team were able to take immediate measures to react to the CGF solar storm event. | LIU Siqing ZHONG Qiuzhen GONG Jiancun SHI Liqin CHEN Dong MIAO Juan CAI Yanxia BAI Meng MA Wenzhen LI Zhitao LIU Fanghua CHEN Yanhong | 2018 | 空间科学学报2018，38，5： | 0 |
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