|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Numerical simulation of overburden and surface movements for Wongawilli strip pillar mining显示文摘The Wongawilli strip pillar mining technique,which combines the strip pillar mining layout and Wongawilli mining technology,is a new high efficient mining technology for mining under surface structures. The Wongawilli strip pillar mining technique was studied in this paper using theoretical analysis and numerical simulation. As an example,the geological and mining conditions of a coal mine were used to design the Wongawilli strip pillar plans,including the support parameters of the entries and the mining technology. In order to control the surrounding rocks and manage the roof effectively during coal mining,the stress fields,displacement fields and plastic zones were studied by numerical simulation. The stress fields,displacement fields,and plastic zones generated by Wongawilli strip pillar mining were obtained. And the surface movement and deformation were also determined after mining was completed and its effects on surface structures were analyzed and evaluated. The results demonstrate that it is feasible to mine under surface structures with the Wongawilli strip pillar mining technique. This mining method can protect the surface structures from damages. | Guo Wenbing Xu Feiya | 2016 | International Journal of Mining Science and Technology2016，26，1： | 18 |
| 2 | A novel procedure for pollen-based quantitative paleoclimate reconstructions and its application in China显示文摘Traditionally, the evaluation of pollen-based quantitative paleoclimate reconstructions focuses on the ability of calibration sets to infer present climatic conditions and/or the similarity between fossil and modern assemblages. Objective criteria for choosing the most appropriate climate parameter(s) to be reconstructed at a specific site are thus lacking. Using a novel approach for testing the statistical significance of a quantitative reconstruction using random environmental data, in combination with the advantageous large environmental gradients, abundant vegetation types and comprehensive modern pollen databases in China, we describe a new procedure for pollen-based quantitative paleoclimatic reconstructions. First, the most significant environmental variable controlling the fossil pollen assemblage changes is identified. Second, a calibration set to infer changes in this targeted variable is built up, by limiting the modern ranges of other environmental variables. Finally, the pollen-based quantitative reconstruction is obtained and its statistical significance assessed. This novel procedure was used to reconstruct the mean annual precipitation(Pann) from Gonghai Lake in the Lvliang Mountains, and Tianchi Lake in the Liupan Mountains, on the eastern and western fringe of the Chinese Loess Plateau, respectively. Both Pann reconstructions are statistically significant(p<0.001), and a sound and stable correlation relationship exists in their common period, showing a rapid precipitation decrease since 3300 cal yr BP. Thus, we propose that this procedure has great potential for reducing the uncertainties associated with pollen-based quantitative paleoclimatic reconstructions in China. | CHEN JianHui LV FeiYa HUANG XiaoZhong H.John B.BIRKS Richard J.TELFORD ZHANG ShengRui XU QingHai ZHAO Yan WANG HaiPeng ZHOU AiFeng HUANG Wei LIU JianBao WEI GuoYing | 2017 | Science China Earth Sciences2017，60，11： | 6 |
| 3 | Targeting circular RNAs as a therapeutic approach: current strategies and challenges显示文摘Significant progress has been made in circular RNA(circRNA)research in recent years.Increasing evidence suggests that circRNAs play important roles in many cellular processes,and their dysregulation is implicated in the pathogenesis of various diseases.CircRNAs are highly stable and usually expressed in a tissue-or cell type-specific manner.Therefore,they are currently being explored as potential therapeutic targets.Gain-of-function and loss-of-function approaches are typically performed using circRNA expression plasmids and RNA interference-based strategies,respectively.These strategies have limitations that can be mitigated using nanoparticle and exosome delivery systems.Furthermore,recent developments show that the cre-lox system can be used to knockdown circRNAs in a cell-specific manner.While still in the early stages of development,the CRISPR/Cas13 system has shown promise in knocking down circRNAs with high specificity and efficiency.In this review,we describe circRNA properties and functions and highlight their significance in disease.We summarize strategies that can be used to overexpress or knockdown circRNAs as a therapeutic approach.Lastly,we discuss major challenges and propose future directions for the development of circRNA-based therapeutics. | Alina T.He Jinglei Liu Feiya Li Burton B.Yang | 2021 | Signal Transduction and Targeted Therapy2021，6，6： | 5 |
| 4 | Evaluation of the reliability of twin variant analysis in Mg alloys by in situ EBSD technique显示文摘Electron backscatter diffraction(EBSD)is an orientation mapping technique,which has been widely used to study texture evolution and twinning behavior.This work aims to study the variant of{10¯12}twins during tensile deformation of AZ31 Mg alloys.An in-situ tensile stage was used,and coupled with EBSD technique,the variants of twins can be analyzed without releasing the tensile stress.Based on the EBSD maps,the first and second smallest misorientation angles(M_(1)and M 2)between each active twin and respective potential variants were calculated,and the distribution of M_(1)values with tensile strain was obtained.The results indicated that{10¯12}twins were deviated from their ideal orientations with strain increased.The criteria of M_(1)<4°and M 2−M_(1)>2°were suggested to be applied to select the data points for reliable variant identification.Moreover,it confirmed that the deviation of twin relationship was ascribed to the profuse basal glide in matrices and/or twins. | Feiya Liu Changfa Guo Renlong Xin Guilin Wu Qing Liu | 2019 | Journal of Magnesium and Alloys2019，7，2： | 2 |
| 5 | Influence of traffic on the temperature field of tunnel in cold region:A case study on the world’s longest highway spiral tunnel显示文摘The impact of the piston wind caused by vehicle traffic on the temperature field distribution of the tunnel cannot be ignored,especially in spiral tunnels,where the temperature field distribution is more complicated than that in straight tunnels.Based on the world’s longest highway spiral tunnel,this study explores the influence of traffic on the temperature fields of spiral and straight tunnels,and proposes a new design method for laying length of insulation layer.The results show that traffic has a significant effect on the temperature field dis-tribution in the tunnel.The influence degree of different traffic elements decreases in the following order:average vehicle speed>daily traffic>morning rush hour>evening rush hour.The temperature field distribution of spiral tunnels is asymmetry on the left and right compared with straight tunnels,while the influence degree of traffic on the outside of spiral tunnels is similar to that of straight tunnels.Due to the difference of wind direction and traffic direction at different tunnel openings,an asymmetric insulation layer laying method is proposed.It is suggested that the lengths of the insulation layers of the Jinjiazhuang Tunnel should be 1200 m for the right tunnel inlet,700 m for the right tunnel outlet,700 m for the left tunnel inlet,and 1400 m for the left tunnel outlet. | Yifan Jiang Jianyou Yu Ping Zhou Feicong Zhou Jiayong Lin Jinyi Li Ming Lin Feiya Lei Zhijie Wang | 2023 | Underground Space2023，，1： | 2 |
| 6 | The establishment of polypeptide PSMA-targeted chimericantigen receptor-engineered natural killer cells forcastration-resistant prostate cancer and the induction of ferroptosis-related cell death显示文摘Background:The mortality of castration-resistant prostate cancer(CRPC)is high due to lack of an effective treatment.Chimeric antigen receptor(CAR)-based therapy is a promising immunotherapeutic strategy.Here,we aimed to design a novel CAR-natural killer(NK)cells with a clinically significant tumoricidal effect on CRPC.Methods:We constructed novel CAR-NK92MI cells with a CD244-based recombinant lentiviral vector.Different intracellular segments(CD244,NKG2D,or CD3ζ)were screened to identify the best candidate according to cell lysis assay and CD107a expression levels.To enhance the affinity of the CAR to the tumor antigen,we compared an antibody specific for prostate-specific membrane antigen(anti-PSMA)with PSMA-targeted polypeptide(p-PSMA),which was screened by phage display combinatorial library.Then,CAR-NK92MI cells with both a high affinity for PSMA and a strong tumoricidal capacity were generated.In addition,we verified their tumor-killing effect in vitro and in vivo.The release of cytokine by NK92MI cells was compared with that by CAR-NK92MI cells through flow cytometry and enzyme-linked immunosorbent assay.Moreover,ferroptosis-related cell death was explored as a possible underlying mechanism.Results:Three different CAR intracellular regions CAR1(CD244),CAR2(CD244,NKG2D)and CAR3(CD244,NKG2D,and CD3ζ)were constructed.CAR2 was chosen to confer a stronger tumoricidal ability on CAR-NK92MI cells.Compared with anti-PSMA,p-PSMA exhibited enhanced affinity for the tumor antigen.Thus,p-PSMA-CAR-NK92MI cells,which expressed CAR with a polypeptide-based antigen-binding region,an intracellular CD244 and a NKG2D costimulatory domain,were generated.They could selectively and successfully kill PSMA+target cells and exhibited specific lysis rate of 73.19%for PSMA-positive C4-2 cells and 33.04%for PSMA-negative PC3 cells.Additionally,p-PSMA-CAR-NK92MI cells had significantly higher concentrations of IFN-γ,TNF-αand granzyme B than NK92MI cells.In a CRPC cancer xenograft model,p-PSMA-CAR-NK92MI cells significantly inhibited tumor growth and exerted a more consistent killing effect than NK92MI cells.Moreover,ferroptosis is a potential mechanism through which CAR-NK92MI cells attack cancer cells,and is triggered by IFN-γ.Conclusions:p-PSMA-CAR-NK92MI cells can effectively kill CRPCPSMA+cells in vitro and in vivo.This strategy may provide additional treatment options for patients with CRPC. | Liyuan Wu Fei Liu Le Yin Fangming Wang Hui Shi Qinxin Zhao Feiya Yang Dong Chen Xiying Dong Yuchun Gu Nianzeng Xing | 2022 | Cancer Communications2022，42，8： | 2 |
| 7 | Proteomic Analysis of High Temperature Stress-Responsive Proteins in Chrysanthemum Leaves显示文摘Chrysanthemum is one of the most important ornamental flowers in the world,and temperature has a significant influence on its field production.In the present study,differentially expressed proteins were investigated in the leaves of Dendranthema grandiflorum‘Jinba’under high temperature stress using label-free quantitative proteomics techniques.The expressed proteins were comparatively identified and analyzed.A total of 1,463 heat-related,differentially expressed proteins were successfully identified by Liquid Chromatography-tandem Mass Spectrometry(LC-MS/MS),and 1,463 heat-related,differentially expressed proteins were successfully identified by mass spectrometry after a high temperature treatment.Among these,701 proteins were upregulated and 762 proteins were downregulated.The in-depth bioinformatics analysis of these differentially expressed proteins revealed that these were involved in energy metabolism pathways,protein metabolism,and heat shock.In the present study,the investigators determined the changes in the levels of some proteins,and their expression at the protein and molecular levels in chrysanthemum to help reveal the mechanism of heat resistance in chrysanthemum.Furthermore,the present study elucidated some of the proteins correlated to heat resistance in chrysanthemum,and their expression changes at the protein and molecular levels to help reveal the mechanism of heat resistance in this flower species.These results provide a theoretical basis for the selection of new heat resistant varieties of chrysanthemum in the field. | Xin Li Feiya Liao Qiqi Ma Beibei Jiang Yuanzhi Pan Cheng Luo Xinjie Wang Aining Ran | 2021 | Phyton-International Journal of Experimental Botany2021，90，5： | 1 |
| 8 | Force measurement of the integrin-fibronectin interaction显示文摘 | Feiya Li Redick SD Erickson HP | 2003 | Biophys J2003，84，： | 1 |
| 9 | Force measurements of the a5/31 integrin-fibronectin interaction显示文摘 | LI Feiya REDICK S D ERICKSON H P | 2003 | Biophys J2003，84，2： | 1 |
| 10 | Analysis of the Role of General Practitioners Services in Rural Areas during the COVID-19 Epidemic显示文摘Since the outbreak of the COVID-19,various regions of China have been rapidly deployed under the leadership of the Central Committee of the Party to actively prevent and control the COVID-19.The rural areas of my country have weak links to the prevention and management of public health emergencies.Problems include lack of medical and health resources and farmers’low awareness of epidemic prevention.Situations that correspond to the prevention and management of the COVID-19 are more serious.As the patient’s first contact and“gatekeeper”in the fight against the epidemic,the general practitioner is responsible for the“first visit-subsequent ongoing intervention”.This article is about the prevention and control of the COVID-19 epidemics and epidemic prevention in terms of dissemination of knowledge,informed crowd control,joint prevention and control,and standardized management of people.This is a summary of the efforts of general practitioners.Quarantine at home,interactive referrals to medical consortiums,special care for contracted families.The function during the management period aims to analyze the role played by general practitioners during the epidemic and to provide new ideas for the prevention and management of the epidemic.Provide more targeted general practitioner-style services in rural areas to promote the implementation and improvement of health and poverty alleviation.The health level of the rural population provides a theoretical standard. | Zuohua Liu Feiya Li Zihan Liu Qiuxia Wu Xiangyu Li Qiang Wang | 2021 | Journal of Advances in Medicine Science2021，4，2： | 1 |
| 11 | An synchronous and synchronous coupling approach in networked rapid product development显示文摘 | NI Yanrong FAN Feiya YAN Juanqi | 2003 | International Journal of Advanced Manufacturing Technology2003，22，12： | 1 |
| 12 | An asynchronous and synchronous coupling approach in the networked rapid product development显示文摘 | NI Yanrong FAN Feiya YAN Junqi | 2003 | International Journal of Advance Manufacturing Technology2003，22，12： | 1 |
| 13 | An Asynchronous and Synchronous Coupling Approach in Networked Rapid Product Development显示文摘 | Fan Feiya Yan Juanqi | 2003 | International Journal of Advanced Manufacturing Technology2003，22，12： | 1 |
| 14 | A hierarchical vascularized engineered bone inspired by intramembranous ossification for mandibular regeneration显示文摘Mandibular defects caused by injuries,tumors,and infections are common and can severely affect mandibular function and the patient's appearance.However,mandible reconstruction with a mandibular bionic structure remains challenging.Inspired by the process of intramembranous ossification in mandibular development,a hierarchical vascularized engineered bone consisting of angiogenesis and osteogenesis modules has been produced.Moreover,the hierarchical vascular network and bone structure generated by these hierarchical vascularized engineered bone modules match the particular anatomical structure of the mandible.The ultra-tough polyion complex has been used as the basic scaffold for hierarchical vascularized engineered bone for ensuring better reconstruction of mandible function.According to the results of in vivo experiments,the bone regenerated using hierarchical vascularized engineered bone is similar to the natural mandibular bone in terms of morphology and genomics.The sonic hedgehog signaling pathway is specifically activated in hierarchical vascularized engineered bone,indicating that the new bone in hierarchical vascularized engineered bone underwent a process of intramembranous ossification identical to that of mandible development.Thus,hierarchical vascularized engineered bone has a high potential for clinical application in mandibular defect reconstruction.Moreover,the concept based on developmental processes and bionic structures provides an effective strategy for tissue regeneration. | Xin Ye Jianxiang He Shaolong Wang Qianglong Han Dongqi You Bin Feng Feiya Zhao Jun Yin Mengfei Yu Huiming Wang Huayong Yang | 2022 | International Journal of Oral Science2022，14，3： | 1 |
| 15 | An asynchronous and synchronous coupling approach in networked rapid product development显示文摘 | Yanrong Ni Feiya Fan Juanqi Yan Dengzhe Ma Ye Jin | 2003 | The International Journal of Advanced Manufacturing Technology2003，，1： | 1 |
| 16 | Simultaneous determination of ten nucleosides and bases in Ganoderma by micellar electrokinetic chromatography显示文摘Ganoderma(lingzhi)is a famous herbal medicine and edible supplement in oriental countries for a long history.In this study,a simple micellar electrokinetic chromatography(MEKC)method was established for the analysis of nucleosides and bases,the major bioactive components in Ganoderma for the first time.By optimizing the borate concentration,the sodium dodecyl sulfate(SDS)concentration and the pH value of running buffer,10 nucleosides and bases achieved an ideal separation.In real sample analysis,the developed method was successfully used to determine the 10 target analytes in 23 batches of Ganoderma samples from different regions.Results indicated that contents of 10 investigated analytes in each sample showed obvious variation.The principal components analysis(PCA)and hierarchical cluster analysis(HCA)analysis classified the samples into three groups,and the HCA tree visualized the relationships which was mainly contributed by geographical partition.The results indicated geographical origin to be an important factor that affect the accumulation of nucleosides and bases in Ganoderma.In summary,this study provides a simple and practical strategy for quality assessment and cultivation reference of Ganoderma. | Feiya Sheng Songsong Wang Xiao Luo Jianbo Xiao Linfeng Hu Peng Li | 2022 | Food Science and Human Wellness2022，11，2： | 1 |
| 17 | The Jesus Family Movement(1921-1952):AChristian Utopiain China显示文摘1927年至1952年间以山东泰安马庄为中心的耶稣家庭,受当地五旬节派教会神召会活动的影响,将宗教与世俗生活结合起来,并声称按圣经中耶稣的教导,在团体中废除私产和血缘家庭,组织信徒在“共产式”的大家庭中共同劳动,过平均主义的集体生活,走上了建设基督徒理想社会的乌托邦道路。虽然在严酷的岁月中这个团体得以维持和发展,但终因其内在矛盾和社会变化而解体,在实践中充分展示了乌托邦道路的魅力与局限。 | Tao Feiya | 2002 | Social Sciences in China2002，23，3： | 0 |
| 18 | Effects of packaging materials and types on postharvest nutritional quality of mini Pakchoi Brassica chinensis显示文摘The baby leaves of mini Pakchoi Brassica chinensis are gaining popularity due to its pleasant appearance,flavour,tender texture and nutrition.Effects of retail packaging on the nutritional quality of Brassica chinensis at 4℃were studied.Samples were packaged using polyethylene bags(PE-B),polystyrene foam tray covered with polyethylene film(PE-C/PS-T),perforated oriented polypropylene bags(POPP-B)and biaxially oriented polystyrene box(BOPS-B).Weight losses,respiration rate,chlorophyll and carotenoid,vitamin C and nitrate were determined during storage period.After 10 d storage,the weight loss for samples packaged in PE-B was 0.89%,followed by PE-C/PS-T with weight losses of 6%.A significant reduction(>10%)in moisture was observed for the samples packaged in POPP-B and BOPS-B.The variation in respiration rate during storage seemed to form a trend with a sharp decline up to the fourth day.The difference in the reduction of chlorophyll and carotenoid was not significant among the four packages.BOPS-B had a better protective effect on vitamin C loss.The nitrate concentration during storage was within the official limit. | Wu Shimin Shu Feiya Huang Danfeng | 2016 | International Journal of Agricultural and Biological Engineering2016，9，6： | 0 |
| 19 | Ligation of CD180 inhibits IFN-α signaling in a Lyn-PI3K-BTK-dependent manner in B cells显示文摘全身的豺狼座 erythematosus (SLE ) 的一个特点是由汽车反应的 B 房间的各种各样的自身抗体的一致生产。Interferon-α(IFN-α) 发信号高度在 SLE B 房间被激活并且由 B 房间在抗体反应起一个重要作用。以前的研究证明了 CD180 否定的 B 房间,戏剧性地在 SLE 病人被增加,为自身抗体的生产负责。然而,在 CD180 和 IFN-α 之间的协会;未知的发信号的遗体。在现在的学习,我们在调整 IFN-α 的激活上探索了 CD180 的效果;在 B 房间发信号。我们发现 CD180 否定的 B 房间的数字在 MRL/Mp-Fas (lpr/lpr ) 被增加豺狼座容易的老鼠与野类型的老鼠相比。Phenotypic 分析证明 CD180 否定的 B 房间包括了 CD138 + plasmablast/plasma 房间和 GL-7 + 幼芽的中心(GC ) B 房间。尤其是, CD180 的结扎显著地禁止了 IFN-α信号变换器的导致的 phosphorylation 和抄写 2 的使活跃之物(STAT-2 ) 和以在 vitro 的一种 Lyn-PI3K-BTK-dependent 方式的刺激 IFN 的基因(ISG ) 的表示。而且, CD180 的结扎能也禁止 IFN-α在在 vivo 的 B 房间的导致的 ISG 表示。而且,像使用费的受体 7 并且像使用费的受体 9 发信号小径能显著地 downregulate CD180 表示并且调制在 IFN-α 的激活上发信号的 CD180 的禁止的效果;发信号。一起,我们的结果加亮在 CD180 否定的 B 房间的增加的比例和 IFN-α 的激活之间的靠近的协会;在 SLE 发信号。我们的数据提供分子的卓见进 IFN-α 的机制;在为 SLE 处理的 SLE B 房间和一条潜在的治疗学的途径的发信号的激活。 | Ming You Guanjun Dong Fanlin Li Feiya Ma Jing Ren Yujun Xu Huimin Yue Ruijing Tang Deshan Ren Yayi Hou | 2017 | Cellular & Molecular Immunology2017，14，2： | 0 |
| 20 | The Dance Drama Awakeing Lion Becoming a Hit显示文摘On February 22z a national dance drama 一 A wakening Lion , which was created by the Guangzhou Song and Dance Theater, was again staged in the Guangzhou Opera House.The dance drama consists of the background of Sanyuanli Struggle against British Invaders and the core element of the national intangible cultural heritage ——Cantonese lion dance. It won the 11^th Lotus Dance Award in December 2018. And it was popular with young audiences. When it was performed firstly to the public, the tickets were quickly sold out. | Zhou Feiya | 2019 | China & The World Cultural Exchange2019，85，3： | 0 |
您所在的机构暂未开通此部分的功能，请联系管理员