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| 1 | Liver fibrogenesis and the role of hepatic stellate cells:new insights and prospects for therapy显示文摘 | Li D Friedman SL | | 0，，： | 5 |
| 2 | In vivo anti-tumor activity of murine hematopoietic stem cells expressing a p185HER2-specific chimeric T-cell receptor gene显示文摘We have confirmed efficient anti-tumor activities of the peripheral lymphocytes transduced with a p185HER2-specific chimeric T-cell receptor gene both in murine and in human in our previous studies. To further test the feasibility of chimeric T-cell receptor in a bone marrow transplantation model, we first, made two murine tumor cell lines: MT901 and MCA-205, to express human p185HER2 by retroviral gene transduction. Murine bone marrow cells were retrovirally transduced to express the chimeric T-cell receptor and gene-modified bone marrow cells were transplanted into lethally irradiated mouse. Six months post transplantation, p185HER2-positive tumor cells:MT-901/HER2 or MCA-205/ HER2 was subcutaneously or intravenously injected to make mouse models simulating primary breast cancer or pulmonary metastasis. The in vivo anti-tumor effects were monitored by the size of the subcutaneous tumor or counting the tumor nodules in the lungs after India ink staining. The size of the subcutaneous tumor was significantly inhibited and the number of pulmonary nodules were significantly decreased in mouse recipients transplanted with chimeric T-cell receptor modified bone marrow cells compared with the control group. Our results suggest the efficient in vivo anti-tumor activities of chimeric T-cell receptor gene modified bone marrow cells. | JIAN MIN YANG MICHAEL S FRIEDMAN MARIANNE T HUBEN JENNIFER FULLER QIAO LI ALFRED E CHANG JAMES J MULE KEVIN T MCDONAGH | 2006 | Journal of Microbiology and Immunology2006，4，2： | 3 |
| 3 | Interactions of Heavy Metal Ions with Paddy Soils as Inferred from Wien Effect Measurements in Dilute Suspensions显示文摘Interactions of three heavy metal ions, Cu2+, Cd2+, and Pb2+, and, for comparison, Na+ with electrodialytic clay fractions (less than 2μm in diameter) of four paddy soils as well as a yellow-brown soil as a control soil were evaluated based on measurements of the Wien effect in dilute suspensions with a clay concentration of 10 g kg-1 in four nitrate solutions of 2×10-4/z mol L-1, where z is the cation valence, and a nitric acid solution of 3×10-5 mol L-1.Field strengths ranging from 15 to 230 kV cm-1 were applied for measuring the electrical conductivities (ECs) of the suspensions. The mean free binding energies between the various cations and all of the soils determined from exchange equilibrium increased in the order: Na+ < Cd2+ < Cu2+ < Pb2+. In general, the ECs of the suspensions in the sodium nitrate solution were smaller than those of the suspensions in the heavy metal solutions because of the lower electrophoretic mobility of sodium compared to the divalent cations. In terms of relative electrical conductivity-field strength relationships, relative electrical conductivity (REC) of suspensions containing various cations at field strengths larger than about 50 kV cm-1 were in the descending order: Na+ > Cu2+ > Cd2+ > Pb2+ for all tested soils. A characteristic parameter of the REC-field strength curves,△REG200, REG at a field strength of 200 kV cm-1 minus that at the local minimum of the concave segment of the REC-field strength curves, characterized the strength of adsorption of the cations stripped off by the applied strong electrical field, and for all soils the values of△REC200 were generally in the order: Na+ < Cu2+≤Cd2+≤Pb2+. | JIANG Jun LI Cheng-Bao ZHAO An-Zhen XU Ren-Kou WANG Yu-Jun S. P. FRIEDMAN | 2006 | Pedosphere2006，16，6： | 3 |
| 4 | Inhibition of PDGF, TGF-β, and Abl signaling and reduction of liver fibrosis by the small molecule Bcr-Abl tyrosine kinase antagonist Nilotinib显示文摘 | Yuqing Liu Zhuo Wang Shu Qin Kwong Eric Lik Hang Lui Scott L. Friedman Fu Rong Li Reni Wing Chi Lam Guo Chao Zhang Hui Zhang Tao Ye | 2011 | Journal of Hepatology2011，，3： | 2 |
| 5 | Comparative outcomes of subcutaneous and transvenous cardioverter-defibrillators显示文摘Background: The comparative outcomes of subcutaneous implantable cardioverter-defibrillator (S-ICD) and transvenous (T-ICD) have not been well studied. The aim of this study was to evaluate the safety and efficacy of currently available S-ICD and T-ICD. Methods: The study included 86 patients who received an S-ICD and 1:1 matched to those who received single-chamber T-ICD by gender, age, diagnosis, left ventricular ejection fraction (LVEF), and implant year. The clinical outcomes and implant complications were compared between the two groups. Results: The mean age of the 172 patients was 45 years, and 129 (75%) were male. The most common cardiac condition was hypertrophic cardiomyopathy (HCM, 37.8%). The mean LVEF was 50%. At a mean follow-up of 23 months, the appropriate and inappropriate ICD therapy rate were 1.2% vs. 4.7%(X^2= 1.854, P=0.368) and 9.3% vs. 3.5%(X^2 = 2.428, P = 0.211) in S-ICD and T-ICD groups respectively. There were no significant differences in device-related major and minor complications between the two groups (7.0% vs. 3.5%, X^2 = 1.055, P = 0.496). The S-ICD group had higher T-wave oversensing than T-ICD group (9.3% vs. 0%, X^2 = 8.390, P=0.007). Sixty-five patients had HCM (32 in S-ICD and 33 in T-ICD). The incidence of major complications was not significantly different between the two groups. Conclusions: The efficacy of an S-ICD is comparable to that of T-ICD, especially in a dominantly HCM patient population. The S-ICD is assodated with fewer major complications demanding reoperation. | Jin-Jun Liang Hideo Okamura Roshini Asirvatham Andrew Schneider David O. Hodge Mei Yang Xu-Ping Li Ming-Yan Dai Ying Tian Pei Zhang Bryan C. Cannon Cong-Xin Huang Paul A. Friedman Yong-Mei Cha | 2019 | Chinese Medical Journal2019，，6： | 2 |
| 6 | Polyglutamine expansion reduces the association of TATA-binding protein with DNA and induces DNA binding-independent neurotoxicity显示文摘 | Friedman MJ Wang CE Li XJ | 2008 | J Biol Chem2008，283，13： | 1 |
| 7 | Wien Effect Characterization of Interactions Between Ions and Charged Sites on Clay Surfaces of Variable-Charge Soils显示文摘To investigate the interactions of oppositely charged sites on the surfaces of variable-charge soil particles with cations and anions,and to evaluate the mean Gibbs free binding and adsorption energies of various cations on particles of red soil and latosol,clay fractions smaller than 2 μm were separated from samples of the two variable-charge soils.Ferric oxides were removed from part of the clay fractions,which were then saturated with various chlorides(NaCl,KCl,CaCl2,CdCl2 or LaCl3).Electrical conductivities(EC) of dilute suspensions of the original and of the iron oxides-free clay fractions in deionized water were measured with the SHP-2 short high-voltage pulse apparatus,which enables measurement of the Wien effect at field strengths(E) from 14 to 250 kV cm-1.The Wien effect(EC-E) curves revealed EC increases of red soil suspensions between 14 and 200 kV cm-1,of 8.3,8.4,12.1,5.9,and 1.2 μS cm-1 for NaCl,KCl,CaCl2,CdCl2,and LaCl3,respectively,reflecting the differing interactions with the various cations and chloride.The EC increments with the iron-free red soil suspensions were higher,being 29.7,17.2,and 15.3 μS cm-1 for NaCl,CaCl2,and CdCl2,respectively.In the natural latosol suspensions the EC increments were practically zero,whereas in the iron-free fractions there were significant EC increments of 10.3,5.7,5.0,and 1.6 μS cm-1 for NaCl,CaCl2,CdCl2,and LaCl3,respectively. | ZHU Hao-Wen WANG Yu-Jun ZHOU Jun JIANG Jun LI Cheng-Bao ZHOU Dong-Mei S. P. FRIEDMAN | 2009 | Pedosphere2009，19，5： | 1 |
| 8 | Liver fibrogenesis and the role of hepatic stellate cells:new imights andprospocts for therapy显示文摘 | Friedman SL | 1999 | J Gastroenterol Hepatol1999，14，7： | 1 |
| 9 | Liver fibrogenesis and the role of hepatic stellate cells:New insights and prospects for therapy显示文摘 | Li D Friedman SL | 1999 | J Gastroenterol Hepatol1999，14，7： | 1 |
| 10 | Liver fibrogenesis and the role of hepatic stellate cells: new insights and prospects for therapy 显示文摘 | Li D Friedman SL | 1999 | J Gastroenterol Hepatol1999，14，7： | 1 |
| 11 | 显示文摘 | Friedman JM | 1999 | Proc Natl Acad Sci USA1999，96，17： | 1 |
| 12 | Liver fibrognesis and the role of hepatic stellate cells:new insights and prospects for therapy显示文摘 | Li D Friedman SL | 1999 | J Gastroenterol Hepalol1999，14，6： | 1 |
| 13 | Induction of apoptosis in uninfected lymphocytes by HIV-1 Tat protein显示文摘 | Li CJ Friedman DJ Wang C | 1995 | Science1995，268，： | 1 |
| 14 | A new method to estimate ad- sorption energies between cations and soil particles via Wien effect measurements in dilute suspensions and an approximate conductivity-activity analogy显示文摘 | Li C B Zhao A Friedman S P | 2005 | Environmental Science & Tech- nology2005，39，17： | 1 |
| 15 | An apparatus for measuring the Wien effect in suspensions显示文摘 | Li C B Friedman S P | 2003 | Colloids and SuTCaces A : Physicochemi- cal and Engineering Aspects2003，222，1： | 1 |
| 16 | Diversion of initial blood flow to prevent whole-blood contamination by skin surface bacteria: an in vitro model显示文摘 | Wagner SJ Robinette D Friedman LI | 2000 | Transfusion2000，40，3： | 1 |
| 17 | Prevalence of Age-Related Macular Degeneration in a Rural Chinese Population: The Handan Eye Study显示文摘 | Ke Yang Yuan Bo Liang Li Qin Gao Yi Peng Ran Shen Xin Rong Duan David S. Friedman Lan Ping Sun Paul Mitchell Ning Li Wang Tien Yin Wong Jie Jin Wang | 2011 | Ophthalmology2011，，7： | 1 |
| 18 | The draft genome of the transgenic tropical fruit tree papaya ( Carica pap aya Linnaeus ) 显示文摘 | MING R HOU S B FENG Y YU Q DIONNE-LAPORTE A SAW J H SENIN P WANG W LY B V LEWIS K L T SALZBERG S L FENG L GONES M R SKELTON R L MURRAYJ E CHEN C QIAN W SHEN J DU P EUSTICE M TONG E TANG H LYONS E PAULL R E MICHAEL T P WALL K RICE D W ALBERT H WANG M L ZHU Y J SCHATZ M NAGARAJAN N ACOB R A GUAN P BLAS A WAI C M ACKERMAN C M REN Y LIU C WANG J M WANG J P NA J SHAKIROV E V HAAS B THIMMAPURAM J NELSON D WANG X BOWERS J E GSCHWEND A R DELCHER A L SINGH R SUZUKI J Y TRIPATHI S NEUPANE K WEI H IRIKURA B PAIDI M JIANG N ZHANG W PRESTING G WINDSOR A NAVAJAS-PEREZ R TORRES M J FELTUS A PORTER B LI Y BURROUGHS A M LUO M C LIU L CHRISTOPHER D A MOUNT S M MOORE P H SUGIMURA T JIANG J SCHULER M A FRIEDMAN V MITCHELL-OLDS T SHIPPEN D E PAMPHILIS C W PALMER J D FREELING M PATERSON A H GONSALVES D WANG L ALAM M | 2008 | Nature2008，452，： | 1 |
| 19 | Liver fibrogenesis and the role of hepatic stellate cells:new insights and prospects for therapy显示文摘 | LI D FRIEDMAN S L | 1999 | J Gastroenterol Hepatol1999，14，： | 1 |
| 20 | Liver fibrosis and the role of hepatic stellat e cells 显示文摘 | LI D FRIEDMAN SL | 1994 | J Gstroenterol Hepatol1994，，14： | 1 |
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