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| 1 | OTOTOXIC MODEL OF OXALIPLATIN AND PROTECTION FROM NICOTINAMIDE ADENINE DINUCLEOTIDE显示文摘Oxaliplatin,an anticancer drug commonly used to treat colorectal cancer and other tumors,has a number of serious side effects,most notably neuropathy and ototoxicity.To gain insights into its ototoxic profile,oxaliplatin was applied to rat cochlear organ cultures.Consistent with it neurotoxic propensity,oxaliplatin selectively damaged nerve fibers at a very low dose 1μM.In contrast,the dose required to damage hair cells and spiral ganglion neurons was 50 fold higher(50μM).Oxailiplatin-induced cochlear lesions initially increased with dose,but unexpectedly decreased at very high doses.This non-linear dose response could be related to depressed oxaliplatin uptake via active transport mechanisms.Previous studies have demonstrated that axonal degeneration involves biologically active processes which can be greatly attenuated by nicotinamide adenine dinucleotide(NAD+).To determine if NAD+would protect spiral ganglion axons and the hair cells from oxaliplatin damage,cochlear cultures were treated with oxaliplatin alone at doses of 10μM or 50μM respectively as controls or combined with 20 mM NAD+.Treatment with 10μM oxaliplatin for 48 hours resulted in minor damage to auditory nerve fibers,but spared cochlear hair cells.However,when cochlear cultures were treated with 10μM oxaliplatin plus 20 mM NAD+,most auditory nerve fibers were intact.50μM oxaliplatin destroyed most of spiral ganglion neurons and cochlear hair cells with apoptotic characteristics of cell fragmentations.However,50μM oxaliplatin plus 20 mM NAD+treatment greatly reduced neuronal degenerations and hair cell missing.The results suggested that NAD+provides significant protection against oxaliplatin-induced neurotoxicity and ototoxicity,which may be due to its actions of antioxidant,antiapoptosis,and energy supply. | DING Dalian JIANG Haiyan FU Yong LI Yongqi Richard Salvi Shinichi Someya Masaru Tanokura | 2013 | Journal of Otology2013，8，1： | 9 |
| 2 | Anisotropic Total Variation Regularization Based NAS-RIF Blind Restoration Method for OCT Image显示文摘Based on anisotropic total variation regularization(ATVR), a nonnegativity and support constraints recursive inverse filtering(NAS-RIF) blind restoration method is proposed to enhance the quality of optical coherence tomography(OCT) image. First, ATVR is introduced into the cost function of NAS-RIF to improve the noise robustness and retain the details in the image.Since the split Bregman iterative is used to optimize the ATVR based cost function, the ATVR based NAS-RIF blind restoration method is then constructed. Furthermore, combined with the geometric nonlinear diffusion filter and the Poisson-distribution-based minimum error thresholding, the ATVR based NAS-RIF blind restoration method is used to realize the blind OCT image restoration. The experimental results demonstrate that the ATVR based NAS-RIF blind restoration method can successfully retain the details in the OCT images. In addition, the signal-to-noise ratio of the blind restored OCT images can be improved, along with the noise robustness. | Xuesong Fu Jianlin Wang Zhixiong Hu Yongqi Guo Kepeng Qiu Rutong Wang | 2020 | Journal of Beijing Institute of Technology2020，29，2： | 2 |
| 3 | Germanium nanopyramid arrays showing near-100% absorption in the visible regime显示文摘Solar energy is regarded as one of the most plentiful sources of renewable energy. An extraordinary light-harvesting property of a germanium periodic nanopyramid array is reported in this Letter. Both our theoretical and experimental results demonstrate that the nanopyramid array can achieve perfect broadband absorption from 500- to 800-nm wavelength. Especially in the visible regime, the experimentally measured absorption can even reach 100%. Further analyses reveal that the intrinsic antireflection effect and slow-light waveguide mode play an important role in the ultra-high absorption, which is helpful for the research and development of photovoltaic devices. | Qi Han Yongqi Fu Lei Jin Jingjing Zhao Zongwei Xu Fengzhou Fang Jingsong Gao Weixing Yu | 2015 | Nano Research2015，8，7： | 2 |
| 4 | Localized surface plasmon resonance-based hybrid Au-Ag nanoparticles for detection of Staphylococcus aureus enterotoxin B 显示文摘 | Zhu Shaoli Du Chunlei Fu Yongqi | 2009 | Opt Mater2009，31，11： | 1 |
| 5 | Fabrication of three-dimensional microstructures by two-dimensional slice by slice approaching via focused ion beam milling显示文摘 | Yongqi Fu Ngoi Kok Ann Bryan | 2004 | J Vac Sci Teehnol B2004，22，4： | 1 |
| 6 | A novel one step integration of edge-emitting laser diode with micro-elliptical lens using focused ion beam direct deposition显示文摘 | Yongqi Fu Ngoi Kok Ann Bryan | 2002 | Transactions on semiconductor manufacturing2002，15，1： | 1 |
| 7 | Microfabrication of microlens array by focused ion beam technology显示文摘 | FU Yongqi KOK N BRYAN A | | 0，，03： | 1 |
| 8 | Postharvest quality and physiological responses of clove bud extract dip on ‘Newhall’ navel orange显示文摘 | Rong Zeng Ashan Zhang Jinyin Chen Yongqi Fu | 2012 | Scientia Horticulturae2012，，： | 1 |
| 9 | Microfabrication of microlens array by focused ion beam technology显示文摘 | Fu Yongqi Ngoi Kok Ann Bryan | 2000 | Microelectronic Eng2000，54，： | 1 |
| 10 | Investigation of integrated diffractive/refractive microlens microfabricated by focused ion beam显示文摘 | Yongqi Fu Ngoi Kok Ann Bryan | 2000 | Review of Scientific Instruments2000，71，6： | 1 |
| 11 | Analysis of errors & calibration method for manufacturing multilevel diffractive optical element by ion etching显示文摘 | Fu Yongqi Lu Zhenwu Ma Yueying | 1998 | SPIE1998，3357，： | 1 |
| 12 | Hybrid microdiffractive-refractive optical element with continuous relief fabricated by focused ion beam for single-mode coupling显示文摘 | Fu Yongqi Ngoi K A B Ong N S | 2000 | Applied Optics2000，7，3： | 1 |
| 13 | Impact of carboxymethyl cellulose coating enriched with extract of Impatiens balsamina stems on preservation of ‘Newhall’ navel orange显示文摘 | Rong Zeng Ashan Zhang Jinyin Chen Yongqi Fu | 2013 | Scientia Horticulturae2013，，： | 1 |
| 14 | Impact of carboxymethyl cellulose coating enriched with extract of Impatiens balsamina stems on preservation of ‘Newhall’ navel orange显示文摘 | Rong Zeng Ashan Zhang Jinyin Chen Yongqi Fu | 2013 | Scientia Horticulturae2013，，： | 1 |
| 15 | Preparation of Ag+/TiO2 Composite Coating Film for Preservation of Nanfeng Citrus显示文摘Using tetrabutyl titanate as the precursor,silver nitrate as the load agent,silver-doped titanium dioxide coating film was prepared by sol-gel method.Three agent samples were characterized by X-ray diffraction( XRD) analysis to investigate the crystal structure,which confirmed a synergistic antibacterial effect.The antibacterial and preservative effects of silver-doped titanium dioxide coating film on Nanfeng citrus were investigated preliminarily. Nutritional indicators of ripe Nanfeng citrus before and after preservation were detected to investigate the preservative properties of silver-doped titanium dioxide coating film and compare the effects of different components of composite coating film. The results showed that Ag^+/TiO_2 composite coating film exhibited high antibacterial and preservative effects on Nanfeng citrus under visible light illumination condition. | Xiaoyi LONG Jinyin CHEN Fenju LAI Tianyi LU Yongqi FU Shaolin JIANG Xiaoqiang YU | 2016 | Agricultural Biotechnology2016，5，3： | 1 |
| 16 | Repurposing non-oncology small-molecule drugs to improve cancer therapy: Current situation and future directions显示文摘Drug repurposing or repositioning has been well-known to refer to the therapeutic applications of a drug for another indication other than it was originally approved for.Repurposing non-oncology small-molecule drugs has been increasingly becoming an attractive approach to improve cancer therapy,with potentially lower overall costs and shorter timelines.Several non-oncology drugs approved by FDA have been recently reported to treat different types of human cancers,with the aid of some new emerging technologies,such as omics sequencing and artificial intelligence to overcome the bottleneck of drug repurposing.Therefore,in this review,we focus on summarizing the therapeutic potential of non-oncology drugs,including cardiovascular drugs,microbiological drugs,small-molecule antibiotics,anti-viral drugs,anti-inflammatory drugs,antineurodegenerative drugs,antipsychotic drugs,antidepressants,and other drugs in human cancers.We also discuss their novel potential targets and relevant signaling pathways of these old non-oncology drugs in cancer therapies.Taken together,these inspiring findings will shed new light on repurposing more non-oncology small-molecule drugs with their intricate molecular mechanisms for future cancer drug discovery. | Leilei Fu Wenke Jin Jiahui Zhang Lingjuan Zhu Jia Lu Yongqi Zhen Lan Zhang Liang Ouyang Bo Liu Haiyang Yu | 2022 | Acta Pharmaceutica Sinica B2022，12，2： | 0 |
| 17 | Review of the Research Progress on Static Earth Gravity Field and Vertical Datum in China during 2019—2023显示文摘The contribution presents the representative research progress on global static gravity field modeling,regional geoid/quasigeoid determination,vertical datum study,as well as the theory,algorithm and software for gravity field study in China from 2019 to 2023,which are the highlights of the chapter 6“Progress in Earth Gravity Model and Vertical Datum”in the“2019—2023 China National Report on Geodesy”that submitted to the International Association of Geodesy(IAG).In addition,suggestions are proposed to promote the research in the fields of earth gravity field,geoid/quasigeoid and vertical datumin China according to trends of international geodesy and related disciplines. | Tao JIANG Xinyu XU Yonghai CHU Taoyong JIN Wei LIANG Yihao WU Yanguang FU Yongqi ZHAO Xinwei GUO | 2023 | Journal of Geodesy and Geoinformation Science2023，6，3： | 0 |
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