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| 1 | Plant-derived phosphocholine facilitates cellular uptake of anti-pulmonary fibrotic HJT-sRNA-m7显示文摘Pulmonary fibrosis, a progressive chronic disease with a high mortality rate, has limited treatment options. Currently, lung transplantation remains the only effective treatment. Here we report that a small RNA, HJT-sRNA-m7, from a Chinese herbal medicine Hong Jing Tian(HJT, RHODIOHAE CRENULATAE RADIX ET RHIZOMA, Rhodiola crenulata) can effectively reduce the expressions of fibrotic hallmark genes and proteins both in alveolar in vitro and in mouse lung tissues in vivo. We also discovered over one hundred oil-soluble chemicals from HJT decoctions, most of which are found in lipid extracts from other Chinese herbals decoctions, including Pu Gong Ying(PGY, TARAXACI HERBA, Taraxacum mongolicum), Chuan Xin Lian(CXL, changed to 'ANDROGRAPHIS HERBA, Andrographis paniculata'), and Jin Yin Hua(JYH, lonicera japonica or Honeysuckle). We identified the active component in these decoctions as two forms of phosphocholines, PC(18:0/18:2) and PC(16:0/18:2). These PCs potentially could form liposomes with small RNAs to enter human alveolar and gastric cells. Our experimental results suggest an unprecendent lipid complex route through which botanic small RNA can enter human bodies.Our results provide an innovative treatment strategy for oral delivery of siRNAs as therapeutic medication. | Jianchao Du Zhu Liang Jiantao Xu Yan Zhao Xiaoyun Li Yanli Zhang DANDan Zhao Ruxuan Chen Yang Liu Trupti Joshi Jiahui Chang Zhiqing Wang Yanxu Zhang Jindong Zhu Qiang Liu Dong Xu Chengyu Jiang | 2019 | Science China(Life Sciences)2019，62，3： | 21 |
| 2 | The PI3K/Akt/GSK-3β/ROS/eIF2B pathway promotes breast cancer growth and metastasis via suppression of NK cell cytotoxicity and tumor cell susceptibility显示文摘Objective: To examine the effect of pSer9-GSK-3β on breast cancer and to determine whether the underlying metabolic and immunological mechanism is associated with ROS/eIF2B and natural killer(NK) cells.Methods: We employed TWS119 to inactivate GSK-3β by phosphorylating Ser9 and explored its effect on breast cancer and NK cells. The expression of GSK-3β, natural killer group 2 member D(NKG2D) ligands, eIF2B was quantified by PCR and Western blot. We measured intracellular reactive oxygen species(ROS) and mitochondrial ROS using DCFH-DA and MitoSOX^(TM) probe,respectively, and conducted quantitative analysis of cellular respiration on 4T1 cells with mitochondrial respiratory chain complex Ⅰ/Ⅲ kits.Results: Our investigation revealed that TWS119 downregulated NKG2D ligands(H60 a and Rae1), suppressed the cytotoxicity of NK cells, and promoted the migration of 4T1 murine breast cancer cells. Nevertheless, LY290042, which attenuates p-GSK-3β formation by inhibiting the PI3K/Akt pathway, reversed these effects. We also found that higher expression of p Ser9-GSK-3β induced higher levels of ROS, and observed that abnormality of mitochondrial respiratory chain complex Ⅰ/Ⅲ function induced the dysfunction of GSK-3β-induced electron transport chain, naturally disturbing the ROS level. In addition, the expression of NOX3 and NOX4 was significantly up-regulated, which affected the generation of ROS and associated with the metastasis of breast cancer. Furthermore, we found that the expression of pSer535-eIF2B promoted the expression of NKG2D ligands(Mult-1 and Rae1) following by expression of pSer9-GSK-3β and generation of ROS.Conclusions: The PI3K/Akt/GSK-3β/ROS/eIF2B pathway could regulate NK cell activity and sensitivity of tumor cells to NK cells,which resulted in breast cancer growth and lung metastasis. Thus, GSK-3β is a promising target of anti-tumor therapy. | Fengjiao Jin Zhaozhen Wu Xiao Hu Jiahui Zhang Zihe Gao Xiao Han Junfang Qin Chen Li Yue Wang | 2019 | Cancer Biology & Medicine2019，16，1： | 20 |
| 3 | Intestinal Microbiota in Early Life and Its Implications on Childhood Health显示文摘Trillions of microbes reside in the human body and participate in multiple physiological and pathophysiological processes that affect host health throughout the life cycle. The microbiome is hallmarked by distinctive compositional and functional features across different life periods.Accumulating evidence has shown that microbes residing in the human body may play fundamental roles in infant development and the maturation of the immune system. Gut microbes are thought to be essential for the facilitation of infantile and childhood development and immunity by assisting in breaking down food substances to liberate nutrients, protecting against pathogens, stimulating or modulating the immune system, and exerting control over the hypothalamic–pituitary–adrenal axis.This review aims to summarize the current understanding of the colonization and development of the gut microbiota in early life, highlighting the recent findings regarding the role of intestinal microbes in pediatric diseases. Furthermore, we also discuss the microbiota-mediated therapeutics that can reconfigure bacterial communities to treat dysbiosis. | Lu Zhuang Haihua Chen Sheng Zhang Jiahui Zhuang Qiuping Li Zhichun Feng | 2019 | Genomics, Proteomics & Bioinformatics2019，17，1： | 16 |
| 4 | Microfluidic Generation of Microsprings with Ionic Liquid Encapsulation for Flexible Electronics显示文摘Inspired by helical or spiral veins,which endow plants with excellent fexibility and elasticity to withstand storms,we present novel hollow microsprings with ionic liquid encapsulation for fexible and stretchable electronics.Te microsprings were generated by using a coaxial capillary microfuidic device to consecutively spin poly(vinylidene fuoride)(PVDF)presolution and an ionic liquid,which formed laminar fows in the coaxial injection microfuidic channels.Te fast phase inversion of PVDF helps to form the core-shell structure of a microfber and guarantees the in situ encapsulation of ionic liquid.Te hybrid microfber can then spiral and be further solidifed to maintain the helical structure with increasing fow rates of the injection fuids.Because of the feasible and precise control of the injection fuids during the microfuidic spinning,the resultant microsprings have controlled core-shell structures,helical pitches,and corresponding electromechanical properties.By further embedding them into stretchable flms,the simple paradigm of a fexible device shows great conductive performance in tensile tests and even motion cycles,which could be explored as a promising candidate in stretchable sensors,fexible electronics,and electronic skins. | Yunru Yu Jiahui Guo Lingyu Sun Xiaoxuan Zhang Yuanjin Zhao | 2019 | Research2019，，1： | 14 |
| 5 | Increasing yield potential through manipulating of an ARE1 ortholog related to nitrogen use efficiency in wheat by CRISPR/Cas9显示文摘Wheat(Triticum aestivum L.)is a staple food crop consumed by more than 30%of world population.Nitrogen(N)fertilizer has been applied broadly in agriculture practice to improve wheat yield to meet the growing demands for food production.However,undue N fertilizer application and the low N use efficiency(NUE)of modern wheat varieties are aggravating environmental pollution and ecological deterioration.Under nitrogen-limiting conditions,the rice(Oryza sativa)abnormal cytokinin response1 repressor1(are1)mutant exhibits increased NUE,delayed senescence and consequently,increased grain yield.However,the function of ARE1 ortholog in wheat remains unknown.Here,we isolated and characterized three TaARE1 homoeologs from the elite Chinese winter wheat cultivar ZhengMai 7698.We then used CRISPR/Cas9-mediated targeted mutagenesis to generate a series of transgene-free mutant lines either with partial or triple-null taare1 alleles.All transgene-free mutant lines showed enhanced tolerance to N starvation,and showed delayed senescence and increased grain yield in field conditions.In particular,the AABBdd and aabbDD mutant lines exhibited delayed senescence and significantly increased grain yield without growth defects compared to the wild-type control.Together,our results underscore the potential to manipulate ARE1 orthologs through gene editing for breeding of high-yield wheat as well as other cereal crops with improved NUE. | Jiahui Zhang Huating Zhang Shaoya Li Jingying Li Lei Yan Lanqin Xia | 2021 | Journal of Integrative Plant Biology2021，63，9： | 13 |
| 6 | Landslide susceptibility mapping using hybrid random forest with GeoDetector and RFE for factor optimization显示文摘The present study aims to develop two hybrid models to optimize the factors and enhance the predictive ability of the landslide susceptibility models.For this,a landslide inventory map was created with 406 historical landslides and 2030 non-landslide points,which was randomly divided into two datasets for model training(70%)and model testing(30%).22 factors were initially selected to establish a landslide factor database.We applied the GeoDetector and recursive feature elimination method(RFE)to address factor optimization to reduce information redundancy and collinearity in the data.Thereafter,the frequency ratio method,multicollinearity test,and interactive detector were used to analyze and evaluate the optimized factors.Subsequently,the random forest(RF)model was used to create a landslide susceptibility map with original and optimized factors.The resultant hybrid models GeoDetector-RF and RFE-RF were evaluated and compared by the area under the receiver operating characteristic curve(AUC)and accuracy.The accuracy of the two hybrid models(0.868 for GeoDetector-RF and 0.869 for RFE-RF)were higher than that of the RF model(0.860),indicating that the hybrid models with factor optimization have high reliability and predictability.Both RFE-RF GeoDetector-RF had higher AUC values,respectively 0.863 and 0.860,than RF(0.853).These results confirm the ability of factor optimization methods to improve the performance of landslide susceptibility models. | Xinzhi Zhou Haijia Wen Yalan Zhang Jiahui Xu Wengang Zhang | 2021 | Geoscience Frontiers2021，12，5： | 12 |
| 7 | Morphological Hydrogel Microfibers with MXene Encapsulation for Electronic Skin显示文摘Electronic skins with distinctive features have attracted remarkable attention from researchers because of their promising applications in flexible electronics.Here,we present novel morphologically conductive hydrogel microfibers with MXene encapsulation by using a multi-injection coflow glass capillary microfluidic chip.The coaxial flows in microchannels together with fast gelation between alginate and calcium ions ensure the formation of hollow straight as well as helical microfibers and guarantee the in situ encapsulation of MXene.The resultant hollow straight and helical MXene hydrogel microfibers were with highly controllable morphologies and package features.Benefiting from the easy manipulation of the microfluidics,the structure compositions and the sizes of MXene hydrogel microfibers could be easily tailored by varying different flow rates.It was demonstrated that these morphologically conductive MXene hydrogel microfibers were with outstanding capabilities of sensitive responses to motion and photothermal stimulations,according to their corresponding resistance changes.Thus,we believe that our morphologically conductive MXene hydrogel microfibers with these excellent features will find important applications in smart flexible electronics especially electronic skins. | Jiahui Guo Yunru Yu Dagan Zhang Han Zhang Yuanjin Zhao | 2021 | Research2021，，1： | 12 |
| 8 | Efficient Fe(Ⅲ)/Fe(Ⅱ) cycling triggered by MoO2 in Fenton reaction for the degradation of dye molecules and the reduction of Cr(Ⅵ)显示文摘There is a relatively low efficiency of Fe(Ⅲ)/Fe(Ⅱ) conversion cycle and H2 O2 decomposition(<30%) in conventional Fenton process,which further results in a low production efficiency of ·OH and seriously restricts the application of Fenton.Herein,we report that the commercial MoO2 can be used as the cocatalyst in Fenton process to dramatically accelerate the oxidation of Lissamine rhodamine B(L-RhB),where the efficiency of Fe(Ⅲ)/Fe(Ⅱ) cycling is greatly enhanced in the Fenton reaction meanwhile.And the L-RhB solution could be degraded nearly 100% in 1 min in the MoO2 cocatalytic Fenton system under the optimal reaction condition,which is apparently better than that of the conventional Fenton system(~50%).Different from the conventional Fenton reaction where the ’OH plays an important role in the oxidation process,it shows that 1 O2 contributes most in the MoO2 cocatalytic Fenton reaction.However,it is found that the exposed Mo^4+ active sites on the surface of MoO2 powders can greatly promote the rate-limiting step of Fe^3+/Fe^2+ cycle conversion,thus minimizing the dosage of H2 O2(0.400 mmol/L) and Fe^2+(0.105 mmol/L).Interestingly,the MoO2 cocatalytic Fenton system also exhibits a good ability for reducing Cr(Ⅵ) ions,where the reduction ability for Cr(Ⅵ) reaches almost 100% within 2 h.In short,this work shows a new discovery for M002 cocatalytic advanced oxidation processes(AOPs),which devotes a lot to the practical water remediation application. | Bin Shen Chencheng Dong Jiahui Ji Mingyang Xing Jinlong Zhang | 2019 | Chinese Chemical Letters2019，30，12： | 11 |
| 9 | Efficient allelic replacement in rice by gene editing: A case study of the NRT1.1B gene显示文摘Precise replacement of an existing allele in commercial cultivars with an elite allele is a major goal in crop breeding. A single nucleotide polymorphism in the NRT1.1 B gene between japonica and indica rice is responsible for the improved nitrogen use efficiency in indica rice. Herein, we precisely replaced the japonica NRT1.1 B allele with the indica allele, in just one generation, using CRISPR/Cas9 gene-editing technology.No additional selective pressure was needed to enrich the precise replacement events. This work demonstrates the feasibility of replacing any genes with elite alleles within one generation, greatly expanding our ability to improve agriculturally important traits. | Jingying Li Xin Zhang Yongwei Sun Jiahui Zhang Wenming Du Xiuping Guo Shaoya Li Yunde Zhao Lanqin Xia | 2018 | Journal of Integrative Plant Biology2018，60，7： | 11 |
| 10 | Expression of OTUB1 in hepatocellular carcinoma and its effects on HCC cell migration and invasion显示文摘 | Qinggan Ni Jiahui Chen Xia Li Xiaodong Xu Nannan Zhang Ang Zhou Bin Zhou Qian Lu Zhong Chen | 2017 | Acta Biochimica et Biophysica Sinica2017，49，8： | 9 |
| 11 | Visual Fixation Assessment in Patients with Disorders of Consciousness Based on Brain-Computer Interface显示文摘Visual fixation is an item in the visual function subscale of the Coma Recovery Scale-Revised(CRS-R).Sometimes clinicians using the behavioral scales find it difficult to detect because of the motor impairment in patients with disorders of consciousness(DOCs). Braincomputer interface(BCI) can be used to improve clinical assessment because it directly detects the brain response to an external stimulus in the absence of behavioral expression. In this study, we designed a BCI system to assist the visual fixation assessment of DOC patients. The results from 15 patients indicated that three showed visual fixation in both CRS-R and BCI assessments and one did not show such behavior in the CRS-R assessment but achieved significant online accuracy in the BCI assessment. The results revealed that electroencephalography-based BCI can detect the brain response for visual fixation. Therefore,the proposed BCI may provide a promising method for assisting behavioral assessment using the CRS-R. | Jun Xiao Jiahui Pan Yanbin He Qiuyou Xie Tianyou Yu Haiyun Huang Wei Lv Jiechun Zhang Ronghao Yu Yuanqing Li | 2018 | Neuroscience Bulletin2018，34，4： | 9 |
| 12 | Psychological impact of the COVID-19 pandemic on healthcare workers:a cross-sectional study in China显示文摘Background Healthcare workers fighting against the coronavirus disease 2019(COVID-19)pandemic are under tremendous pressure,which puts them at an increased risk of developing psychological problems.Aims This study aimed to investigate the prevalence of psychological problems in different healthcare workers(ie,physicians,medical residents,nurses,technicians and public health professionals)during the COVID-19 pandemic in China and explore factors that are associated with the onset of psychological problems in this population during this public health crisis.Methods A cross-sectional,web-based survey was conducted in February 2020 among healthcare workers during the COVID-19 pandemic.Psychological problems were assessed using the Generalized Anxiety Disorder Scale,Patient Health Questionnaire and Insomnia Severity Index.Logistic regression analyses were used to explore the factors that were associated with psychological problems.Results The prevalence of symptoms of anxiety,depression,insomnia and the overall psychological problems in healthcare workers during the COVID-19 pandemic in China was 46.04%,44.37%,28.75%and 56.59%,respectively.The prevalence of the overall psychological problems in physicians,medical residents,nurses,technicians and public health professionals was 60.35%,50.82%,62.02%,57.54%and 62.40%,respectively.Compared with healthcare workers who did not participate in front-line work,front-line healthcare workers had a higher risk of anxiety,insomnia and overall psychological problems.In addition,attention to negative or neutral information about the pandemic,receiving negative feedback from families and friends who joined front-line work,and unwillingness to join front-line work if given a free choice were three major factors for these psychological problems.Conclusions Psychological problems are pervasive among healthcare workers during the COVID-19 pandemic.Receiving negative information and participating in front-line work appear to be.important risk factors for psychological problems.The psychological health of different healthcare workers should be protected during the COVID-19 pandemic with timely interventions and proper information feedback. | Jianyu Que Le Shi Jiahui Deng Jiajia Liu Li Zhang Suying Wu Yimiao Gong Weizhen Huang Kai Yuan Wei Yan Yankun Sun Maosheng Ran Yanping Bao Lin Lu | 2020 | General Psychiatry2020，33，3： | 8 |
| 13 | Development of ensemble learning models to evaluate the strength of coal-grout materials显示文摘In the loose and fractured coal seam with particularly low uniaxial compressive strength(UCS),driving a roadway is extremely difficult as roof falling and wall spalling occur frequently.To address this issue,the jet grouting(JG)technique(high-pressure grout mixed with coal particles)was first introduced in this study to improve the self-supporting ability of coal mass.To evaluate the strength of the jet-grouted coal-grout composite(JG composite),the UCS evolution patterns were analyzed by preparing 405 specimens combining the influential variables of grout types,curing time,and coal to grout(C/G)ratio.Furthermore,the relationships between UCS and these influencing variables were modeled using ensemble learning methods i.e.gradient boosted regression tree(GBRT)and random forest(RF)with their hyperparameters tuned by the particle swarm optimization(PSO).The results showed that the chemical grout composite has higher short-term strength,while the cement grout composite can achieve more stable strength in the long term.The PSO-GBRT and PSO-RF models can both achieve high prediction accuracy.Also,the variable importance analysis demonstrated that the grout type and curing time should be considered carefully.This study provides a robust intelligent model for predicting UCS of JG composites,which boosts JG design in the field. | Yuantian Sun Guichen Li Nong Zhang Qingliang Chang Jiahui Xu Junfei Zhang | 2021 | International Journal of Mining Science and Technology2021，31，2： | 6 |
| 14 | Characterization of particulate products for aging of ethylbenzene secondary organic aerosol in the presence of ammonium sulfate seed aerosol显示文摘Aging of secondary organic aerosol(SOA) particles formed from OH– initiated oxidation of ethylbenzene in the presence of high mass(100–300 μg/m^3) concentrations of(NH_4)_2SO_4seed aerosol was investigated in a home-made smog chamber in this study.The chemical composition of aged ethylbenzene SOA particles was measured using an aerosol laser time-of-flight mass spectrometer(ALTOFMS) coupled with a Fuzzy C-Means(FCM) clustering algorithm.Experimental results showed that nitrophenol,ethyl-nitrophenol,2,4-dinitrophenol,methyl glyoxylic acid,5-ethyl-6-oxo-2,4-hexadienoic acid,2-ethyl-2,4-hexadiendioic acid,2,3-dihydroxy-5-ethyl-6-oxo-4-hexenoic acid,1H-imidazole,hydrated N-glyoxal substituted1H-imidazole,hydrated glyoxal dimer substituted imidazole,1H-imidazole-2-carbaldehyde,N-glyoxal substituted hydrated 1H-imidazole-2-carbaldehyde and high-molecular-weight(HMW) components were the predominant products in the aged particles.Compared to the previous aromatic SOA aging studies,imidazole compounds,which can absorb solar radiation effectively,were newly detected in aged ethylbenzene SOA in the presence of high concentrations of(NH_4)_2SO_4seed aerosol.These findings provide new information for discussing aromatic SOA aging mechanisms. | Mingqiang Huang Jiahui Zhang Shunyou Cai Yingmin Liao Weixiong Zhao Changjin Hu Xuejun Gu Li Fang Weijun Zhang | 2016 | Journal of Environmental Sciences2016，28，9： | 6 |
| 15 | Research progress of photocatalysis based on highly dispersed titanium in mesoporous SiO_2显示文摘With the development of the human economy and green chemistry, people pay much more attention to environmental safety. Correspondingly, mesoporous TiO_2 and its correlated photocatalysts are able to help people seek for better life. In this review, first of all, we briefly introduce the preparations and applications of mesoporous TiO_2-SiO_2 materials, which exhibit excellent performance in pollutants decomposition and H_2 evolution in photocatalysis. Then, we review the mesoporous composites of TiSiO_2 materials, which are ideal materials used in the photoreduction of air pollutants such as CO_2, NO and NO_2. It is powerfully evident from the literature surveys that these TiO_2 based mesoporous photocatalysts possess a large potential in environment and energy development. | Chencheng Dong Jiahui Ji Zhe Yang Yifei Xiao Mingyang Xing Jinlong Zhang | 2019 | Chinese Chemical Letters2019，30，4： | 5 |
| 16 | Nuclear miR-665 aggravates heart failure via suppressing phosphatase and tensin homolog transcription显示文摘Although numerous miRNAs have been discovered,their functions in the different subcellular organelles have remained obscure.In this study,we found that miR-665 was enriched in the nucleus of cardiomyocytes,and then investigated the underlying role of nuclear miR-665 in heart failure.RNA fluorescence in situ hybridization assays in human heart tissue sections and primary cardiomyocytes showed that miR-665 was localized in the nucleus of cardiomyocytes.Increased expression of nuclear miR-665 was observed not only in the cardiomyocytes isolated from the heart of mice treated in vivo by transverse aortic constriction(TAC),but also in phenylephrine(PE)-treated cultured cardiomyocytes in vitro.To further explore the role of miR-665 in heart failure,a type 9 recombinant adeno-associated virus(rAAV)system was employed to manipulate the expression of miR-665 in mice.Overexpression of miR-665 aggravated TAC-induced cardiac dysfunction,while down-expression of miR-665 showed opposite effects.Bioinformatic prediction and biological validation confirmed that the PTEN(phosphatase and tensin homolog)gene was one of the targets of miR-665 in the nucleus.Furthermore,restoring PTEN expression significantly eliminated the destructive effects of miR-665 over-expression in TAC-induced cardiac dysfunction.Our data showed that nuclear miR-665 aggravates heart failure via inhibiting PTEN expression,which provided a therapeutic approach for heart failure. | Jiahui Fan Xudong Zhang Xiang Nie Huaping Li Shuai Yuan Beibei Dai Jiabing Zhan Zheng Wen Jiangang Jiang Chen Chen Daowen Wang | 2020 | Science China(Life Sciences)2020，63，5： | 4 |
| 17 | The double face of miR-320:cardiomyocytes-derived miR-320 deteriorated while fibroblasts-derived miR-320 protected against heart failure induced by transverse aortic constriction显示文摘MicroRNAs(miRNAs)are aberrantly expressed in the pathophysiologic process of heart failure(HF).However,the functions of a certain miRNA in different cardiac cell types during HF are scarcely reported,which might be covered by the globe effects of it on the heart.In the current study,Langendorff system was applied to isolate card io myocytes(CMs)and cardiac fibroblasts(CFs)from transverse aortic constriction(TAC)-induced mice.Slight increase of miR-320 expression was observed in the whole heart tissue of TAC mice.Interestingly,miR-320 was significantly elevated in CMs but decreased in CFs from TAC mice at different time points.Then,recombinant adeno-associated virus 9 with cell-type-specific promoters were used to manipulate miR-320 expressions in vivo.Both in vitro and in vivo experiments showed the miR-320 overexpression in CMs exacerbated cardiac dysfunction,whereas overexpression of miR-320 in CFs alleviated cardiac fibrosis and hypertrophy.Mechanically,downstream signaling pathway analyses revealed that miR-320 might induce various effects via targeting PLEKHM3 and IFITM1 in CMs and CFs,respectively.Moreover,miR-320 mediated effects could be abolished by PLEKHM3 re-expression in CMs or IFITM1 re-expression in CFs.Interestingly,miR-320 treated CFs were able to indirectly affect CMs function,but not vice versa.Meanwhile,upstream signaling pathway analyses showed that miR-320 expression and decay rate were rigorously manipulated by Ago2,which was regulated by a cluster of cell-type-specific TFs distinctively expressed in CMs and CFs,respectively.Together,we demonstrated that miR-320 functioned differently in various cell types of the heart during the progression of HF. | Xudong Zhang Shuai Yuan Huaping Li Jiabing Zhan Feng Wang Jiahui Fan Xiang Nie Yan Wang Zheng Wen Yanghui Chen Chen Chen Dao Wen Wang | 2021 | Signal Transduction and Targeted Therapy2021，6，3： | 4 |
| 18 | National-scale data-driven rainfall induced landslide susceptibility mapping for China by accounting for incomplete landslide data显示文摘China is one of the countries where landslides caused the most fatalities in the last decades. The threat that landslide disasters pose to people might even be greater in the future, due to climate change and the increasing urbanization of mountainous areas. A reliable national-scale rainfall induced landslide susceptibility model is therefore of great relevance in order to identify regions more and less prone to landsliding as well as to develop suitable risk mitigating strategies. However, relying on imperfect landslide data is inevitable when modelling landslide susceptibility for such a large research area. The purpose of this study is to investigate the influence of incomplete landslide data on national scale statistical landslide susceptibility modeling for China. In this context, it is aimed to explore the benefit of mixed effects modelling to counterbalance associated bias propagations. Six influencing factors including lithology, slope,soil moisture index, mean annual precipitation, land use and geological environment regions were selected based on an initial exploratory data analysis. Three sets of influencing variables were designed to represent different solutions to deal with spatially incomplete landslide information: Set 1(disregards the presence of incomplete landslide information), Set 2(excludes factors related to the incompleteness of landslide data), Set 3(accounts for factors related to the incompleteness via random effects). The variable sets were then introduced in a generalized additive model(GAM: Set 1 and Set 2) and a generalized additive mixed effect model(GAMM: Set 3) to establish three national-scale statistical landslide susceptibility models: models 1, 2 and 3. The models were evaluated using the area under the receiver operating characteristics curve(AUROC) given by spatially explicit and non-spatial cross-validation. The spatial prediction pattern produced by the models were also investigated. The results show that the landslide inventory incompleteness had a substantial impact on the outcomes of the statistical landslide susceptibility models. The cross-validation results provided evidence that the three established models performed well to predict model-independent landslide information with median AUROCs ranging from 0.8 to 0.9.However, although Model 1 reached the highest AUROCs within non-spatial cross-validation(median of 0.9), it was not associated with the most plausible representation of landslide susceptibility. The Model 1 modelling results were inconsistent with geomorphological process knowledge and reflected a large extent the underlying data bias. The Model 2 susceptibility maps provided a less biased picture of landslide susceptibility. However, a lower predicted likelihood of landslide occurrence still existed in areas known to be underrepresented in terms of landslide data(e.g., the Kuenlun Mountains in the northern Tibetan Plateau). The non-linear mixed-effects model(Model 3) reduced the impact of these biases best by introducing bias-describing variables as random effects. Among the three models, Model 3 was selected as the best national-scale susceptibility model for China as it produced the most plausible portray of rainfall induced landslide susceptibility and the highest spatially explicit predictive performance(median AUROC of spatial cross validation 0.84) compared to the other two models(median AUROCs of 0.81 and 0.79, respectively). We conclude that ignoring landslide inventory-based incompleteness can entail misleading modelling results and that the application of non-linear mixed-effect models can reduce the propagation of such biases into the final results for very large areas. | Qigen Lin Pedro Lima Stefan Steger Thomas Glade Tong Jiang Jiahui Zhang Tianxue Liu Ying Wang | 2021 | Geoscience Frontiers2021，12，6： | 4 |
| 19 | Research progress of graphene-based nanomaterials for the environmental remediation显示文摘Graphene is a two-dimensional nanomaterial with huge surface area,high carrier mobility and high mechanical strength.Because of its great potential in nanotechnology and environmental protection,it has attracted much attention in environmental and energy fields since its discovery in 2004.Although graphene is a star material,many reviews have introduced its use in terms of energy,the research progress in the field of environment,especially water pollution control,has been rarely reported.Here,we review exhaustively the research progress of graphene-based materials in environmental pollution remediation in the past ten years.Firstly,the advantages and classification of graphene were introduced.Secondly,the research progress and main achievements of graphene and its composites in the fields of photocatalytic degradation,pollutant adsorption and water treatment were emphatically described,and the mechanism of action in the above fields was summarized.Finally,we discuss the problems existing in the preparation and summarize the application of graphene in the environment. | Xiaoru Pan Jiahui Ji Nana Zhang Mingyang Xing | 2020 | Chinese Chemical Letters2020，31，6： | 4 |
| 20 | In vitro and in vivo studies on the biodegradable behavior and bone response of Mg69Zn27Ca4 metal glass for treatment of bone defect显示文摘In the present work, the biodegradable behavior, cytocompatibility and osteogenesis activity of a Mg69Zn27Ca4 metal glass were investigated. Electrochemical test, immersion test, cytotoxicity test and histopathological evaluation were carried out. The results showed that there was a dense protective layer formed on the surface of Mg69Zn27Ca4 metal glass which could inhibit the degradation process in the Hank’s solution. In vitro cytotoxicity test showed that Mg69Zn27Ca4 metal glass had good biocompatibility. Histopathological evaluation showed that the degradation of Mg69Zn27Ca4 metal glass could promote the new bone formation with no obvious inflammatory reactions. After 2 months implantation, the diameter of the bone defect was reduced from the original φ6 mm to φ3.35 ± 0.40 mm with the degradation of Mg69Zn27Ca4 metal glass. Therefore, it can be concluded that Mg69Zn27Ca4 glass has great potential to be used as bone substitutes. | Junxiu Chen Jiahui Dong Huameng Fu Haifeng Zhang Lili Tan Dewei Zhao Ke Yang | 2019 | Journal of Materials Science & Technology2019，35，10： | 4 |
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