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| 1 | Hydroxysafflor yellow A improves learning and memory in a rat model of vascular dementia by increasing VEGF and NR1 in the hippocampus显示文摘Hydroxysafflor yellow A(HSYA) has angiogenesisregulating and neuro-protective effects, but its effects on vascular dementia(VaD) are unknown. In this study, 30 adult Sprague-Dawley rats were randomly allocated to five groups: normal, sham-operation, VaD alone(bilateral carotid artery occlusion), VaD plus saline(control), and VaD plus HSYA. One week after operation, the HSYA group received one daily tail-vein injection of 0.6 mg/100 g HSYA for two weeks. Five weeks after operation, the spatial memory of all five groups was evaluated by the water maze task, and synaptic plasticity in the hippocampus was assessed by the long-term potentiation(LTP) method. Vascular endothelial growth factor(VEGF) and N-methyl-Daspartic acid receptor 1(NR1) expression in the hippocampus was detected via Western blot. We found that, compared with the group with VaD alone, the group with HSYA had a reduced escape latency in the water maze(P <0.05), and the LTP at CA3-CA1 synapses in the hippocampus was enhanced(P <0.05). Western blot in the late-phase VaD group showed slight up-regulation of VEGF and downregulation of NR1 in the hippocampus, while HSYA significantly up-regulated both VEGF and NR1. Theseresults suggested that HSYA promotes angiogenesis and increases synaptic plasticity, thus improving spatial learning and memory in the rat model of VaD. | Nan Zhang Mengya Xing Yiyi Wang Hao Liang Zhuo Yang Fudong Shi Yan Cheng | 2014 | Neuroscience Bulletin2014，30，3： | 30 |
| 2 | Structural insights of phosphorylated into the recognition FUNDC1 by LC3B in mitophagy显示文摘 | Mengqi Lv Chongyuan Wang Fudong Li Junhui Peng Bin Wen Qingguo Gong Yunyu Shi Yajun-Tang | 2017 | Protein & Cell2017，8，1： | 21 |
| 3 | Antisense MMP-9 RNA inhibits malignant glioma cell growth in vitro and in vivo显示文摘The matrix-degrading metalloproteinases (MMPs), particularly MMP-9, play important roles in the pathogenesis and development of malignant gliomas. In the present study, the oncogenic role of MMP-9 in malignant glioma cells was investigated via antisense RNA blockade in vitro and in vivo. TJ905 malignant glioma cells were transfected with pcDNA3.0 vector expressing antisense MMP-9 RNA (pcDNA-AS-MMP9), which significantly decreased MMP-9 expression, and cell proliferation was assessed. For in vivo studies, U251 cells, a human malignant glioma cell line, were implanted subcutaneously into 4-to 6-week-old BALB/c nude mice. The mice bearing well-established U251 gliomas were treated with intratumoral pcDNA-AS-MMP9-Lipofectamine complex (AS-MMP-9-treated group), subcutaneous injection of endostatin (endostatin-treated group), or both (combined therapy group). Mice treated with pcDNA (empty vector)-Lipofectamine served as the control group. Four or eight weeks later, the volume and weight of tumor, MMP-9 expression, microvessel density and proliferative activity were assayed. We demonstrate that pcDNA-AS-MMP9 significantly decreased MMP-9 expression and inhibited glioma cell proliferation. Volume and weight of tumor, MMP-9 expression, microvessel density and proliferative activity in the antisense-MMP-9-treated and therapeutic alliance groups were significantly lower than those in the control group. The results suggest that MMP-9 not only promotes malignant glioma cell invasiveness, but also affects tumor cell proliferation. Blocking the expression of MMP-9 with antisense RNA substantially suppresses the malignant phenotype of glioma cells, and thus can be used as an effective therapeutic strategy for malignant gliomas. | Cuiyun Sun Qian Wang Hongxu Zhou Shizhu Yu Alain R. Simard Chunsheng Kang Yanyan Li Yanling Kong Tongling An Yanjun Wen Fudong Shi Junwei Hao | 2013 | Neuroscience Bulletin2013，29，1： | 14 |
| 4 | Delay-dependent stability and added damping of SDOF real-time dynamic hybrid testing显示文摘It is well-recognized that a transfer system response delay that reduces the test stability inevitably exists in real-time dynamic hybrid testing (RTDHT).This paper focuses on the delay-dependent stability and added damping of SDOF systems in RTDHT.The exponential delay term is transferred into a rational fraction by the Padé approximation, and the delay-dependent stability conditions and instability mechanism of SDOF RTDHT systems are investigated by the root locus technique.First, the stability conditions are discussed separately for the cases of stiffness, mass, and damping experimental substructure.The use of root locus plots shows that the added damping effect and instability mechanism for mass are different from those for stiffness.For the stiffness experimental substructure case, the instability results from the inherent mode because of an obvious negative damping effect of the delay.For the mass case, the delay introduces an equivalent positive damping into the inherent mode, and instability occurs at an added high frequency mode.Then, the compound stability condition is investigated for a general case and the results show that the mass ratio may have both upper and lower limits to remain stable.Finally, a high-emulational virtual shaking table model is built to validate the stability conclusions. | Chi Fudong Wang Jinting Jin Feng | 2010 | Earthquake Engineering and Engineering Vibration2010，9，3： | 13 |
| 5 | Effect of preparation methods on the performance of CuFe-SSZ-13 catalysts for selective catalytic reduction of NO_x with NH_3显示文摘CuFe-SSZ-13 catalyst showed excellent performance in the selective catalytic reduction of NO_x with NH_3(NH_3-SCR) for diesel engine exhaust purification. To investigate the effect of preparation methods on NH_3-SCR performance, Fe was loaded into one-pot synthesized Cu-SSZ-13 catalysts through solid-state ion-exchange(SSIE), homogeneous deposition precipitation(HDP) and liquid ion-exchange(IE), respectively. Three CuFe-SSZ-13 catalysts showed similar SO_2 resistance, which was better than that of Cu-SSZ-13. The improvement was attributed to the protection of Fe species. Hydrothermal stability of three CuFe-SSZ-13 catalysts was significantly different, which was attributed to the state of active species caused by different preparation methods. Compared with the other two catalysts, more active species existed inside the zeolite pores of CuFe-SSZ-13 SSIE. During hydrothermal aging, the aggregation of these active species in the pores caused the collapse of catalyst structure, ultimately leading to the deactivation of CuFe-SSZ-13 SSIE. In contrast, Fe species was dispersed better on the surface over CuFe-SSZ-13 IE, enhancing the hydrothermal stability of catalysts. Consequently, Fe loading effectively improved the resistance of SO_2 and H_2O over Cu-SSZ-13. For CuFe-SSZ-13, large amounts of active species located inside the zeolite pores are not beneficial for the hydrothermal stability. | Yijiao Wang Lijuan Xie Fudong Liu Wenquan Ruan | 2019 | Journal of Environmental Sciences2019，31，7： | 8 |
| 6 | Madouzi-type (nodular) sedimentary copper deposit associated with the Emeishan basalt显示文摘Ore minerals in the sedimentary-type Cu deposits in the Xuanwei Formation overlying the Emeishan basalt are dominated by copper sulfides and native copper. As the ores mostly exhibit concretionary structure, previous researchers named them the 'Madouzi-type Copper Deposit'. Here the authors carried out mineralogical and isotopic studies on copper nodules in this ore deposit. The mineralogical study shows that copper nodules are composed of copper sulfides that have been cemented by ferruginous amorphous minerals, clay, and carbonaceous fragments in the modes of metasomatism and sedimentation. The nodules are preliminarily present as aggregates of gelatinous material. The isotopic analysis shows that the δ 13CPDB values of an- thraxolite are within the range of-24.8‰--23.9‰, indicating that the anthraxolite is the product of sedimentary metamorphism of in-situ plants. The δ 34SV-CDT values of chalcocite are within the range of 7.6‰-13.1‰, close to those (about 11‰) of Permian seawater. The δ 34SV-CDT values of bornite and chalcopyrite are 21.6‰-22.2‰, similar to the sulfur isotopic composition (20‰) of marine sulfate, indicative of different sources of sulfur. The above characteristics indicate that the copper nodules were formed in such a process that Cu-bearing basalt underwent weathering-leaching and copper-bearing material was transported into waters (e.g., rivers, lakes, and swamps) and then adsorbed on clay and ferruginous amorphous mineral fragments. Then, the copper-bearing material was suspended and transported in the form of gelinite. In lake or swamp environment, it was co-deposited with sediments to form copper nodules. At later stages there occurred metasomatism and hydrothermal su- perimposition, followed by the replacement of chalcocite by bornite and the superimposition of chalcopyrite over bornite, finally resulting in the formation of the 'Madouzi-type' nodular copper deposit. | WANG FuDong ZHU XiaoQing WANG ZhongGang | 2011 | Science China Earth Sciences2011，54，12： | 7 |
| 7 | Modeling experimental study on weathering-leaching of Emeishan basalt and its relation with metallogenesis显示文摘The Emeishan basalt has a high Cu background value (170×10-6 on average), and thus provides a ore-forming material source for copper ores. The collected samples were exposed in basalt lavas of the third segment of the Emeishan basalt eruptive cycle. By using a set of automatically cycling glass apparatuses, weathering-leaching experiments by three kinds of rainwater on the collected samples were carried out in the open system (at normal temperature and normal pressure). The analysis results showed that the most intensive export of Cu occurred under acidic rainwater-induced weathering-leaching conditions, almost 2-3 orders of magnitude the export of Cu by mod-ern air rainwater, and 1-2 orders of magnitude higher than the export of Cu by CO2 rainwater. In addition, the total amount of Zn, Cu, U, Ni and Sr exported by acidic rainwater are greater than 1%. All this indicates that copper in the Emeishan basalt provided the copper source for Cu mineralization at the contact between the basalt and the Maokou Formation limestone at the bottom. | WANG Fudong ZHU Xiaoqing HAN Tao LI Zengsheng | 2010 | Chinese Journal Of Geochemistry2010，29，2： | 6 |
| 8 | Age-related differences in interferon regulatory factor-4 and -5 signaling in ischemic brains of mice显示文摘 | Shou-cai ZHAO Chun WANG Heng XU Wen-qian WU Zhao-hu CHU Ling-song MA Ying-dong ZHANG Fudong LIU | 2017 | Acta Pharmacologica Sinica2017，38，11： | 4 |
| 9 | Elastic Scattering of 7Be on Pb Target显示文摘 | Yang Yanyun Wang Jiansong Wang Qi Huang Meirong Ma Junbing Ma Peng Cao Xiguang Han Jianlong Bai Zhen Jin Shilong Hu Qiang Jin Lei Chen Jiangbo Zhang Xueying Chen Ruofu Hu Zhengguo Xu Shiwei Zhen Chuan Xu Zhiguo Xu Hushan Duan Liming Sun Zhiyu Chen Zhiqiang He Jianjun Li Songlin Lei Xiangguo Fu Fen Zhang Xueheng Yuan Xiaohua Du Chengming Yan Xinshuang Hu Jun Tang Shuwen Ye Ruiping Yang Kun Shi Fudong Zhang Wei Chen Ze Li Long Xu Xing Liu Longxiang Zhang Liyong Lin Qingyun Gou Boxing Xu Ge Zhou Xionghong Zhang Yuhu Xiao Guoqing | 2011 | IMP & HIRFL Annual Report2011，，1： | 4 |
| 10 | Approach to the Design Calculation of Sucker Rod Pumping Systems in Coalbed Methane Wells显示文摘The existing design of the pumping systems mainly focuses on the approximate computational formulae and procedures,which are developed based on the analytic approaches of conventional oil/gas fields.The calculation of polished rod loads usually just concerns about the static and inertial loads.And the computation of gearbox torque generally uses empirical formulae and correction factors.The above modeling procedures,if applied to the coalbed methane(CBM) wells,can not give the desired accuracy of the system design and its pertinent analysis.In this paper,based on the kinematic and dynamic analysis of the pumping system,the kinematic relation of polished rod is analyzed,and the variation of the total loads of polished rod is developed with the limits of CBM well conditions along the string.The gearbox torque calculation model is established by combining the counterbalance effect with the calculated dynamometer cards and torque factors.The application characteristics of this model are demonstrated by the example of ZH002-4 well in Qinshui basin.The interpretations of results show that the cranks of beam units should rotate in a counter clockwise direction viewed with the wellhead to the right.Compared with oil?gas fields,the dynamic and friction to polished rod load ratios are relatively high and the computation of polished rod loads should involve the static and inertial loads,as well as vibration and friction loads.And the dynamic load ratio decreases rapidly during the production.Besides,the total deformation of the string is small in CBM wells.As for balanced operation,the gearbox torque load usually has two approximately equal peaks and the magnitudes of instantaneous torque are just within 50% of unbalanced gearbox loadings.The proposed research improves efficiency of the pumping system,loads the pumping unit more uniformly,and provides the reasonable basis for selecting the units. | WANG Fudong LIU Xinfu Guan Zhichuan LIU Chunhua | 2011 | Chinese Journal of Mechanical Engineering2011，24，6： | 4 |
| 11 | The Lowest Boundary Age of Travertine in Dawanzhangjia Ravine, Huanglong, China显示文摘Objective One of major challenges in paleoenvironmental reconstruction using travertine in the Huanglong area is whether one can accurately determinate the age of travertine through high-precision and high-resolution dating techniques.Previous works of ^(14)C or ESR chronology,however,have shown that the variation of deposition ages of travertine was displayed | WANG Fudong DONG Faqin ZHAO Xueqin ZHANG Haiwei SUN Shiyong DAI Qunwei LI Qiongfang LI Gang MA Pengcheng | 2018 | Acta Geologica Sinica(English Edition)2018，92，2： | 3 |
| 12 | Effects of injection of anti-corticotropin release hormone serum in the lateral ventricles and electroacupuncture analgesia on pain threshold in rats with adjuvant arthritis显示文摘Rat models of adjuvant arthritis were established, and anti-corticotropin release hormone serum injection in the lateral ventricles and electroacupuncture at right Jiaji (EX-B2) were performed. The pain threshold was decreased at 45 and 60 minutes after injection of the anti-corticotropin release hormone serum. Electroacupuncture at Jiaji can resist this effect. Immunohistochemical staining results showed that the expression of corticotropin release hormone in the hypothalamic paraven-tricular nucleus was greater in the electroacupuncture + anti-corticotropin release hormone serum group compared with the anti-corticotropin release hormone serum group. The expression of corticotropin release hormone was correlated with the pain threshold. The effect of endogenous corticotropin release hormone in pain modulation can be obstructed by anti-corticotropin release hormone serum. The analgesia of electroacupuncture can partially resist the depressed pain threshold caused by injection of anti-corticotropin release hormone serum. The analgesic effect of elec-troacupuncture is associated with the corticotropin release hormone content in the hypothalamus. | Yunying Qiao Fudong Wu Jian Wang Xiaolu Cui Congcong Liu Xinlong Zhu | 2012 | Neural Regeneration Research2012，7，21： | 2 |
| 13 | Geochemistry Characteristics of Granodiorite Porphyry in the Degongniuchang Copper Deposit, Muli, Sichuan Province, China显示文摘1 Introduction 1The Sanjiang region in SE Tibet Plateau and NW Yunnan is known to have formed by amalgamation of Gongwanaderived continental blocks and arc terranes as a result of oceanic subduction followed by | MA Pengcheng WANG Fudong XIE Yunxi PENG Dong LI Hujie XU Gang | 2017 | Acta Geologica Sinica(English Edition)2017，91，S1： | 1 |
| 14 | CNPC's Future Exploration Targets for Giant Gas Fields显示文摘Potential exploration targets for giant gas fields Based on the distribution of remaining gas resources,the exploration targets selection as well as an analysis of controlling factors for giant gas | Fan Wenke Zhang Fudong Wang Zongli Yang Dong Yang Shen | 2012 | China Oil & Gas2012，19，3： | 1 |
| 15 | A Preliminary Review on the Metallogeny of Pb-Zn Deposits in China显示文摘Lead and zinc resources are abundant in China, with the reserves of 100 million tons ranking only second in the world. There are more than 3000 lead-zinc mine areas nationwide. The classification of lead-zinc(Pb-Zn) deposits has been a highly controversial issue. From the standpoint of evaluating the potential of mineral resources, we construct a Pb-Zn deposit predictive type of classification scheme, and propose a Pb-Zn deposit comprehensive classification scheme(including 5 classes and 13 sub-types) that regards mineralization as the primary factor and the ore rock as secondary. According to the temporal and spatial distribution of Pb-Zn deposits, we conclude that a multi-period, multi-cycle orogenic environment is the most favorable for lead-zinc deposit growth, that the Proterozoic is the major eon for the growth of igneous-type deposits, the Paleozoic is an important development era for sedimentary Pb-Zn deposits, and the Mesozoic and Cenozoic are the heyday eras of magmatic type lead-zinc deposits. On this basis, we analyse the relationship between tectonic evolution and Pb-Zn metallogenic, and propose that the key factors determining geological mineralization are the metallogenic epoch of mineralization and tectonic environment, which determine the temporal and spatial distribution. | ZHANG Changqing LIU Huan WANG Denghong CHEN Yuchuan RUI Zongyao LOU Debo WU Yue JIA Fudong CHEN Zhenghui MENG Xuyang | 2015 | Acta Geologica Sinica(English Edition)2015，89，4： | 1 |
| 16 | Chemical reactivities of magnesium nanopowders显示文摘 | Yuankui Zhang1 Shijian Liao Yinheng Fan Jie Xu Fudong Wang | 2001 | Journal of Nanoparticle Research2001，3，： | 1 |
| 17 | Preparation and characteristic of a new class of silica/polyimide nanocomposites显示文摘 | Jing Liu Yan Gao Fudong Wang Decai Li Jie Xu | 2002 | Journal of Materials Science2002，，14： | 1 |
| 18 | Preparation and Characteristic of A New Class of SilicafPolyimide Nano- composites显示文摘 | Liu Jing Gao Yan Wang Fudong | 2002 | Journal of Materials Science2002，37，： | 1 |
| 19 | Recent advancement and future challenges of photothermal catalysis for VOCs elimination:From catalyst design to applications显示文摘Photothermal catalysis realizes the synergistic effect of solar energy and thermochemistry,which also has the potential to improve the reaction rate and optimize the selectivity.In this review,the research progress of photothermal catalytic removal of volatile organic compounds(VOCs)by nano-catalysts in recent years is systematically reviewed.First,the fundamentals of photothermal catalysis and the fabrication of catalysts are described,and the design strategy of optimizing photothermal catalysis performance is proposed.Second,the performance for VOC degradation with photothermal catalysis is evaluated and compared for the batch and continuous systems.Particularly,the catalytic mechanism of VOC oxidation is systematically introduced based on experimental and theoretical study.Finally,the future limitations and challenges have been discussed,and potential research directions and priorities are highlighted.A broad view of recent photothermal catalyst fabrication,applications,challenges,and prospects can be systemically provided by this review. | Yang Yang Shenghao Zhao Lifeng Cui Fukun Bi Yining Zhang Ning Liu Yuxin Wang Fudong Liu Chi He Xiaodong Zhang | 2023 | Green Energy & Environment2023，8，3： | 1 |
| 20 | Chemical Reactivities of Magnesium Nanopowders显示文摘 | Yuankui Zhang Shijian Liao Yinheng Fan Jie Xu Fudong Wang | 2001 | Journal of Nanoparticle Research2001，，1： | 1 |
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