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| 1 | Synthesis and properties of phosphorus-containing bio-based epoxy resin from itaconic acid显示文摘A phosphorus-containing bio-based epoxy resin(EADI)was synthesized from itaconic acid(IA)and 9,10-dihydro-9-oxa-10-phosphaphenanthrene 10-oxide(DOPO).As a matrix,its cured epoxy network with methyl hexahydrophthalic anhydride(MHHPA)as the curing agent showed comparable glass-transition temperature and mechanical properties to diglycidyl ether in a bisphenol A(DGEBA)system as well as good flame retardancy with UL94 V-0 grade during a vertical burning test.As a reactive flame retardant,its flame-resistant effect on DGEBA/MHHPA system as well as its influence on the curing behavior and the thermal and mechanical properties of the modified epoxy resin were investigated.Results showed that after the introduction of EADI,not only were the flame retardancy determined by vertical burning test,LOI measurement,and thermogravimetric analysis significantly improved,but also the curing reactivity,glass transition temperature(T g),initial degradation temperature for 5%weight loss(T d(5%)),and flexural modulus of the cured system improved as well.EADI has great potential to be used as a green flame retardant in epoxy resin systems. | MA SongQi LIU XiaoQing JIANG YanHua FAN LiBo FENG JianXiang ZHU Jin | 2014 | Science China Chemistry2014，57，3： | 33 |
| 2 | In, Sn, Pb and Zn Contents and Their Relationships in Ore-forming Fluids from Some In-rich and In-poor Deposits in China显示文摘有在矿石的铟内容的所有充满铟的存款超过 100 x10^(-6)似乎具有锡石硫化物存款或 忍受Sn Pb-Zn 存款,例如在在 Guangxi 的 theDachang Sn 沉积物, Dulong Sn-Zn 在内部蒙古在云南,和 Meng'entaolegai Ag-Pb-Zndeposit 扔,在矿石的铟内容从 98 x 10 ~ (-6)到 236 x 10 ^(-6) ands 与锌和听的内容的好积极关联,和他们的相关系数怎么分别地是 0.8781 和 0.7430 。从象在 Guangxi 和 Huanren Pb-Zn 的 FozichongPb-Zn 存款的如此的 Sn 差的存款的铟内容在辽宁扔通常比 10 x10~ 低(-6), 即,锡是否在存款是在场的,在矿石暗示铟的丰富程度。是否在里面在形成液体或形成矿石的条件的矿石的丰富本身实际上在存款引起了铟的丰富 / 弄空?在学习以后,在石英的液包体在矿化作用的主要阶段结晶几在里面富有并且在中国的 In-poordeposits,这篇论文分析了内容并且学习了变化趋势在里面, Sn,在形成矿石的液体的 Pband Zn。在在里面富有、差的存款的 形成theore 液体的铅和锌的内容在一样的结果表演铺平,并且铅内容从 22 x 10 ~ (-6)到 81 x 10 ^(从 164 x 10 ^的-6)和锌(-6)到 309 x 10 ^(-6),当在在里面富有的存款的形成矿石的液体的铟和锡的内容比 In-poordeposits 的那些高远时,与 1-2 数量级的差别。在在里面富有的存款的 ore-formingfluid 的铟和锡内容是 1.9 x 10 ^(-6)-4.1 x 10 ^(-6) 和 7 x 10 ^(-6)-55 x 10 ^(-6), 并且在二个元素之间有很好的积极关联,与相关系数 of0.9552。在在里面差的存款的形成矿石的液体的铟和听内容是 0.03 x 10 ^(-6)-0.09 x10^(-6) 和 0.4 x 10 ^(-6)-2.0 x 10 ^(-6), 分别地,并且在他们之间没有明显的关联。一方面,这显示在里面富有的形成矿石的液体是在里面富有的存款的形成的材料基础,并且,在另一方面,锡可能在铟的运输和丰富起了一个很重要的作用。 | ZHANG Qian ZHU Xiaoqing HE Yuliang ZHU Zhaohui | 2007 | Acta Geologica Sinica(English Edition)2007，81，3： | 15 |
| 3 | Characteristics of Meso-Cenozoic Igneous Complexes in the South Yellow Sea Basin,Lower Yangtze Craton of Eastern China and the Tectonic Setting显示文摘The South Yellow Sea Basin is partially surrounded by the East Asian continental MesoCenozoic widespread igneous rocks belt.Magnetic anomaly and multi-channel seismic data both reveal the prevalent occurrence of igneous rocks.We preliminarily defined the coupling relation between magnetic anomalies and igneous rock bodies.Some igneous complexes were also recognized by using multi-channel seismic and drilling data.We identified various intrusive and extrusive igneous rock bodies,such as stocks,sills,dikes,laccoliths and volcanic edifice relics through seismic facies analysis.We also forecasted the distribution characteristics of igneous complexes.More than fifty hypabyssal intrusions and volcanic relics were delineated based on the interpretation of magnetic anomaly and dense intersecting multi-channel seismic data.It is an important supplement to regional geology and basin evolution research.Spatial matching relations between igneous rock belts and fractures document that extensional N-E and N-NE-trending deep fractures may be effective pathways for magma intrusion.These fractures formed under the influence of regional extension during the MesoCenozoic after the Indosinian movement.Isotopic ages and crosscutting relations between igneous rock bodies and the surrounding bedded sedimentary strata both indicate that igneous activities might have initiated during the Late Jurassic,peaked in the Early Cretaceous,gradually weakened in the Late Cretaceous,and continued until the Miocene.Combined with previous studies,it is considered that the Meso-Cenozoic igneous activities,especially the intensive igneous activity of the Early Cretaceous,are closely associated with the subduction of the Paleo-Pacific Plate. | PANG Yumao ZHANG Xunhua XIAO Guolin GUO Xingwei WEN Zhenhe WU Zhiqiang ZHU Xiaoqing | 2017 | Acta Geologica Sinica(English Edition)2017，91，3： | 15 |
| 4 | Application of next-generation sequencing technology to precision medicine in cancer: joint consensus of the Tumor Biomarker Committee of the Chinese Society of Clinical Oncology显示文摘Next-generation sequencing(NGS) technology is capable of sequencing millions or billions of DNA molecules simultaneously.Therefore, it represents a promising tool for the analysis of molecular targets for the initial diagnosis of disease, monitoring of disease progression, and identifying the mechanism of drug resistance. On behalf of the Tumor Biomarker Committee of the Chinese Society of Clinical Oncology(CSCO) and the China Actionable Genome Consortium(CAGC), the present expert group hereby proposes advisory guidelines on clinical applications of NGS technology for the analysis of cancer driver genes for precision cancer therapy. This group comprises an assembly of laboratory cancer geneticists, clinical oncologists, bioinformaticians,pathologists, and other professionals. After multiple rounds of discussions and revisions, the expert group has reached a preliminary consensus on the need of NGS in clinical diagnosis, its regulation, and compliance standards in clinical sample collection. Moreover, it has prepared NGS criteria, the sequencing standard operation procedure(SOP), data analysis, report, and NGS platform certification and validation. | Xuchao Zhang Zhiyong Liang Shengyue Wang Shun Lu Yong Song Ying Cheng Jianming Ying Weiping Liu Yingyong Hou Yangqiu Li Yi Liu Jun Hou Xiufeng Liu Jianyong Shao Yanhong Tai Zheng Wang Li Fu Hui Li Xiaojun Zhou Hua Bai Mengzhao Wang You Lu Jinji Yang Wenzhao Zhong Qing Zhou Xuening Yang Jie Wang Cheng Huang Xiaoqing Liu Xiaoyan Zhou Shirong Zhang Hongxia Tian Yu Chen Ruibao Ren Ning Liao Chunyan Wu Zhongzheng Zhu Hongming Pan Yanhong Gu Liwei Wang Yunpeng Liu Suzhan Zhang Tianshu Liu Gong Chen Zhimin Shao Binghe Xu Qingyuan Zhang Ruihua Xu Lin Shen Yilong Wu | 2019 | Cancer Biology & Medicine2019，16，1： | 14 |
| 5 | Monitoring and Warning of Landslides and Debris Flows Using an Optical Fiber Sensor Technology显示文摘Landslides and debris flows are typical geo-hazards which occur in hilly or mountainous regions. Debris flows may result from landslides. Geotechnical instrumentation plays an important role in monitoring and warning of landslides and resulted debris flows. Traditional technologies for monitoring landslides and debris flows have certain limitations. The new optical fiber sensors presented in this paper can overcome those limitations. This paper presents two new optical fiber sensor systems: one is the Fiber Bragg Grating (FBG)-based in-place inclinometer for monitoring landslides and the other is the FBG-based column-net system for monitoring debris flows. This paper presents the calibration results of FBG-based in-place inclinometers in laboratory. It is found that the calibration results are in good agreement with theoretical results. Both the FBG-based in-place inclinometers and the FBG-based column-net system have been installed at a site in Weijiagou valley, Beichuan County, Sichuan Province of China. Some preliminary results have been obtained and reported in the paper. The advantages of the FBG monitoring systems and their potential applications are also presented. | PEI Huafu CUI Peng YIN Jianhua ZHU Honghu CHEN Xiaoqing PEI Laizheng | 2011 | Journal of Mountain Science2011，8，5： | 12 |
| 6 | Overcharge-to-thermal-runaway behavior and safety assessment of commercial lithium-ion cells with different cathode materials:A comparison study显示文摘In this paper,overcharge behaviors and thermal runaway(TR)features of large format lithium-ion(Liion)cells with different cathode materials(LiFePO4(LFP),Li[Ni_(1/3)Co_(1/3)Mn_(1/3)]O_(2)(NCM111),Li[Ni_(0.6)Co_(0.2)Mn_(0.2)]O_(2)(NCM622)and Li[Ni_(0.8)Co_(0.1)Mn_(0.1)]O_(2)(NCM811))were investigated.The results showed that,under the same overcharge condition,the TR of LFP Li-ion cell occurred earlier compared with the NCM Li-ion cells,indicating its poor overcharge tolerance and high TR risk.However,when TR occurred,LFP Li-ion cell exhibited lower maximum temperature and mild TR response.All NCM Liion cells caught fire or exploded during TR,while the LFP Li-ion cell only released a large amount of smoke without fire.According to the overcharge behaviors and TR features,a safety assessment score system was proposed to evaluate the safety of the cells.In short,NCM Li-ion cells have better performance in energy density and overcharge tolerance(or low TR risk),while LFP Li-ion cell showed less severe response to overcharging(or less TR hazards).For NCM Li-ion cells,as the ratio of nickel in cathode material increases,the thermal stability of the cathode materials becomes poorer,and the TR hazards increase.Such a comparison study on large format Li-ion cells with different cathode materials can provide deeper insights into the overcharge behaviors and TR features,and provide guidance for engineers to reasonably choose battery materials in automotive applications. | Zhenpo Wang Jing Yuan Xiaoqing Zhu Hsin Wang Lvwei Huang Yituo Wang Shiqi Xu | 2021 | Journal of Energy Chemistry2021，30，4： | 12 |
| 7 | MdATG18a overexpression improves basal thermotolerance in transgenic apple by decreasing damage to chloroplasts显示文摘High temperature is an abiotic stress factor that threatens plant growth and development.Autophagy in response to heat stress involves the selective removal of heat-induced protein complexes.Previously,we showed that a crucial autophagy protein from apple,MdATG18a,has a positive effect on drought tolerance.In the present study,we treated transgenic apple(Malus domestica)plants overexpressing MdATG18a with high temperature and found that autophagy protected them from heat stress.Overexpression of MdATG18a in apple enhanced antioxidase activity and contributed to the production of increased beneficial antioxidants under heat stress.Transgenic apple plants exhibited higher photosynthetic capacity,as shown by the rate of CO_(2) assimilation,the maximum photochemical efficiency of photosystem II(PSII),the effective quantum yield,and the electron transport rates in photosystems I and II(PSI and PSII,respectively).We also detected elevated autophagic activity and reduced damage to chloroplasts in transgenic plants compared to WT plants.In addition,the transcriptional activities of several HSP genes were increased in transgenic apple plants.In summary,we propose that autophagy plays a critical role in basal thermotolerance in apple,primarily through a combination of enhanced antioxidant activity and reduced chloroplast damage. | Liuqing Huo Xun Sun Zijian Guo Xin Jia Runmin Che Yiming Sun Yanfei Zhu Ping Wang Xiaoqing Gong Fengwang Ma | 2020 | Horticulture Research2020，7，1： | 9 |
| 8 | Circular SAR processing using an improved omega-k type algorithm显示文摘An improved circular synthetic aperture radar(CSAR) imaging algorithm of omega-k(ω-k) type mainly for reconstructing an image on a cylindrical surface is proposed.In the typical CSAR ω-k algorithm,the rage trajectory is approximated by Taylor series expansion to the quadratic terms,which limits the valid synthetic aperture length and the angular reconstruction range severely.Based on the model of the CSAR echo signal,the proposed algorithm directly transforms the signal to the two-dimensional(2D) wavenumber domain,not using approximation processing to the range trajectory.Based on form of the signal spectrum in the wavenumber domain,the formula for the wavenumber domain interpolation of the w-k algorithm is deduced,and the wavenumber spectrum of the reference point used for bulk compression is obtained from numerical method.The improved CSAR ω-k imaging algorithm increases the valid synthetic aperture length and the angular area greatly and hence improves the angular resolution of the cylindrical imaging.Additionally,the proposed algorithm can be repeated on different cylindrical surfaces to achieve three dimensional(3D) image reconstruction.The 3D spatial resolution of the CSAR system is discussed,and the simulation results validate the correctness of the analysis and the feasibility of the algorithm. | Leilei KOU Xiaoqing Wang Jinsong Chong Maosheng Xiang Minhui Zhu | 2010 | Journal of Systems Engineering and Electronics2010，21，4： | 7 |
| 9 | 3D nickel-cobalt diselenide nanonetwork for highly efficient oxygen evolution显示文摘Active, stable and low-cost oxygen evolution reaction(OER) catalyst for electrochemical water splitting is key to efficient energy conversion and storage. Here, we report a three-dimensional(3D) nanonetwork as noble-metal-free electrode consisting of nickel cobalt diselenide(NiCoSe_2) nanobrush arrays on Ni foam(NF) through the initial hydrothermal reaction and subsequent thermal selenization process. Introducing ammonium fluoride as surface controller, different NiCoSe_2 hierarchical architecture can be modulated from nanorods, nanobrush to nanosheets. The unique brush-like NiCoSe_2 possesses high surface area for mass transfer, rough surface with rich active sites, 3D nanostructure preventing the accumulation of O2 bubbles. Compared to NiCoSe_2 nanorods/NF, NiCoSe_2 nanosheets/NF and commercial Ru O2,NiCoSe_2 nanobrush/NF exhibits an enhanced OER performance in alkaline media to reach a low overpotential of 274 m V at the current density of 10 m A/cm2, small Tafel slope and a long-term stability. The developed 3D nanonetwork highlights the nanoscale engineering and offers a promising alternative to noble metal catalysts for electrochemical water oxidation. | Hengli Zhu Rui Jiang Xiaoqing Chen Yueguang Chen Leyu Wang | 2017 | Science Bulletin2017，62，20： | 7 |
| 10 | Madouzi-type (nodular) sedimentary copper deposit associated with the Emeishan basalt显示文摘Ore minerals in the sedimentary-type Cu deposits in the Xuanwei Formation overlying the Emeishan basalt are dominated by copper sulfides and native copper. As the ores mostly exhibit concretionary structure, previous researchers named them the 'Madouzi-type Copper Deposit'. Here the authors carried out mineralogical and isotopic studies on copper nodules in this ore deposit. The mineralogical study shows that copper nodules are composed of copper sulfides that have been cemented by ferruginous amorphous minerals, clay, and carbonaceous fragments in the modes of metasomatism and sedimentation. The nodules are preliminarily present as aggregates of gelatinous material. The isotopic analysis shows that the δ 13CPDB values of an- thraxolite are within the range of-24.8‰--23.9‰, indicating that the anthraxolite is the product of sedimentary metamorphism of in-situ plants. The δ 34SV-CDT values of chalcocite are within the range of 7.6‰-13.1‰, close to those (about 11‰) of Permian seawater. The δ 34SV-CDT values of bornite and chalcopyrite are 21.6‰-22.2‰, similar to the sulfur isotopic composition (20‰) of marine sulfate, indicative of different sources of sulfur. The above characteristics indicate that the copper nodules were formed in such a process that Cu-bearing basalt underwent weathering-leaching and copper-bearing material was transported into waters (e.g., rivers, lakes, and swamps) and then adsorbed on clay and ferruginous amorphous mineral fragments. Then, the copper-bearing material was suspended and transported in the form of gelinite. In lake or swamp environment, it was co-deposited with sediments to form copper nodules. At later stages there occurred metasomatism and hydrothermal su- perimposition, followed by the replacement of chalcocite by bornite and the superimposition of chalcopyrite over bornite, finally resulting in the formation of the 'Madouzi-type' nodular copper deposit. | WANG FuDong ZHU XiaoQing WANG ZhongGang | 2011 | Science China Earth Sciences2011，54，12： | 7 |
| 11 | Lead Isotopic Composition and Lead Source in the Bainiuchang Ag-polymetallic Deposit, Yunnan Province, China显示文摘在云南省的 Bainiuchang 存款,中国,在 Gejiu 矿石地和 Dulong 矿石之间地理上被定位地。除了 > 7000 t Ag 储备,存款也与很多驱散的元素炫耀大规模 Pb, Zn 和 Sn 储备(在里面, Cd, Ge, Ga,等等) 。我们系统地决定了存款的 Pb 同位素作文。海地板 exhalative 是在采矿区域的西北的沉积起源的矿石的 Pb 同位素比率,是 206Pb/204Pb = 17.758-18.537 , 207Pb/204Pb = 15.175-15.862 和 208Pb/204Pb = 37.289-39.424 ,当时那些矿石,那具有 magmatic 在采矿区域的东南的热水的重迭起源,分别地是 206Pb/204Pb = 17.264-18.359 , 207Pb/204Pb = 14.843-15.683 和 208Pb/204Pb = 36.481-38.838 。以在 magmatic 岩石或 magmatic 中的长石的 Pb 同位素作文从采矿区域的整个岩石的样品,我们决定了 Pb 同位素作文并且是获得了 Pb 同位素比率:206Pb/204Pb = 18.224-18.700, 207Pb/204Pb = 15.595-15.797 和 208Pb/204Pb = 38.193-39.608。然后,根据 Pb 同位素,变形岩石的作文取样从原生地,地下室在 Dulong 矿石地里暴露了,我们决定了 Pb 同位素作文并且是获得了同位素比率:206Pb/204Pb = 18.434-19.119, 207Pb/204Pb = 15.644-15.693,和 208Pb/204Pb = 38.514-38.832。并且寒武纪的沉积岩石的 Pb 同位素比率,在 Bainiuchang 采矿区域被暴露,是 206Pb/204Pb = 18.307-19.206, 207Pb/204Pb = 15.622-15.809,和 208Pb/204Pb = 38.436-39.932。由关于他们的 Pb 同位素作文比较矿石的二种类型,在 Bainiuchang 存款的铅主要从比在年龄的 Neoproterozoic 早的降低外壳的 granulite 被导出,这被显示,但是热水的液体可能提供了的 Yanshanian magmatic 象为矿石的 Sn 那样的形成矿石的元素的部分在采矿区域的南方堵住。 | ZHU Chaohui ZHANG Qian SHAO Shuxun ZHU Xiaoqing WANG Dapeng | 2008 | Acta Geologica Sinica(English Edition)2008，82，4： | 7 |
| 12 | Xenograft tumors derived from malignant pleural effusion of the patients with non-small-cell lung cancer as models to explore drug resistance显示文摘Background:Non-small cell lung cancer(NSCLC)patients with epidermal growth factor receptor(EGFR)mutations or anaplastic lymphoma kinase(ALK)fusions show dramatic responses to specific tyrosine kinase inhibitors(TKIs);however,after 10-12 months,secondary mutations arise that confer resistance.We generated a murine xenograft model using patient-derived NSCLC cells isolated from the pleural fluid of two patients with NSCLC to investigate the mechanisms of resistance against the ALK-and EGFR-targeted TKIs crizotinib and osimertinib,respectively.Methods:Genotypes of patient biopsies and xenograft tumors were determined by whole exome sequencing(WES),and patients and xenograft-bearing mice received targeted treatment(crizotinib or osimertinib)accordingly.Xenograft mice were also treated for prolonged periods to identify whether the development of drug resistance and/or treatment responses were associated with tumor size.Finally,the pathology of patients biopsies and xenograft tumors were compared histologically.Results:The histological characteristics and chemotherapy responses of xenograft tumors were similar to the actual patients.WES showed that the genotypes of the xenograft and patient tumors were similar(an echinoderm microtu-bule-associated protein-like 4-ALK(EML4-ALK)gene fusion(patient/xenograft:CTC15035EML4-ALK)and EGFR L858R and T790M mutations(patient/xenograft:CTC15063EGFR L858R,T790M)).After continuous crizotinib or osimertinib treatment,WES data suggested that acquired ALK E1210K mutation conferred crizotinib resistance in the CTC15035EML4-ALK xenograft,while decreased frequencies of EGFR L858R and T790M mutations plus the appearance of v-RAF murine sarcoma viral oncogene homolog B(BRAF)G7V mutations and phosphatidylinositol-4-phosphate 3-kinase catalytic subunit type 2 alpha(PIK3C2A)A86fs frame shift mutations led to osimertinib resistance in the CTC15063EGFR L858R,T790M xenografts.Conclusions:We successfully developed a new method of generating drug resistance xenograft models from liquid biopsies using microfluidic technology,which might be a useful tool to investigate the mechanisms of drug resist-ance in NSCLC. | Yunhua Xu Feifei Zhang Xiaoqing Pan Guan Wang Lei Zhu Jie Zhang Danyi Wen Shun Lu | 2018 | Cancer Communications2018，38，1： | 7 |
| 13 | Enhancing production of ergosterol in Pichia pastoris GS115 by over-expression of 3-hydroxy-3-methylglutaryl CoA reductase from Glycyrrhiza uralensis显示文摘The rate-limiting enzyme in the mevalonic acid(MVA)pathway which can lead to triterpenoid saponin glycyrrhizic acid(GA)is 3-hydroxy-3-methylglutaryl-CoA reductase(HMGR).In order to reveal the effect of copy number variation in the HMGR gene on the MVA pathway,the HMGR gene from Glycyrrhiza uralensis Fisch.(GuHMGR)was cloned and over-expressed in Pichia pastoris GS115.Six recombinant P.pastoris strains containing different copy numbers of the GuHMGR gene were obtained and the content of ergosterol was analyzed by HPLC.The results showed that all the recombinant P.pastoris strains contained more ergosterol than the negative control and the strains with 8 and 44 copies contained significantly more ergosterol than the other strains.However,as the copy number increased,the content of ergosterol showed an increasing–decreasing–increasing pattern.This study provides a rationale for increasing the content of GA through over-expressing the GuHMGR gene in cultivars of G.uralensis. | Ying Liu Xiaoqing Zhu Wendong Li Hao Wen Ya Gao Yong Liu Chunsheng Liu | 2014 | Acta Pharmaceutica Sinica B2014，4，2： | 7 |
| 14 | Modeling experimental study on weathering-leaching of Emeishan basalt and its relation with metallogenesis显示文摘The Emeishan basalt has a high Cu background value (170×10-6 on average), and thus provides a ore-forming material source for copper ores. The collected samples were exposed in basalt lavas of the third segment of the Emeishan basalt eruptive cycle. By using a set of automatically cycling glass apparatuses, weathering-leaching experiments by three kinds of rainwater on the collected samples were carried out in the open system (at normal temperature and normal pressure). The analysis results showed that the most intensive export of Cu occurred under acidic rainwater-induced weathering-leaching conditions, almost 2-3 orders of magnitude the export of Cu by mod-ern air rainwater, and 1-2 orders of magnitude higher than the export of Cu by CO2 rainwater. In addition, the total amount of Zn, Cu, U, Ni and Sr exported by acidic rainwater are greater than 1%. All this indicates that copper in the Emeishan basalt provided the copper source for Cu mineralization at the contact between the basalt and the Maokou Formation limestone at the bottom. | WANG Fudong ZHU Xiaoqing HAN Tao LI Zengsheng | 2010 | Chinese Journal Of Geochemistry2010，29，2： | 6 |
| 15 | Retardant effect of dihydroartemisinin on ulcerative colitis in a JAK2/STAT3-dependent manner显示文摘Dihydroartemisinin(DHA)is a semi-synthetic derivative and the main active metabolite of artemisinin.The purpose of this study was to investigate the effect of DHA on the ulcerative colitis(UC)in both in vivo and in vitro models.Weight,survival rate,colon length,and Disease Activity Index score were used to evaluate the severity of colitis.Reverse transcription quantitative polymerase chain reaction and enzyme-linked immunosorbent assay were used to detect the expressions of cytokines interleukin(IL)-1,IL-1β,IL-4,IL-6,IL-10,IL-12,and tumor necrosis factor-α(TNF-α).The expressions of Janus kinase 2(JAK2)and signal transducer and activator of transcription 3(STAT3),and the phosphorylation of JAK2(p-JAK2)and STAT3(p-STAT3),were measured by western blot analysis.Western blot analysis and immunohistochemistry were used to detect the expressions of tight junction proteins.We found that the weights and colon lengths of mice in dextran sodium sulfate(DSS)+DHA group were significantly lower and longer than those in the DSS group,respectively.Compared with those in the DSS group,the expressions of IL-1β,IL-6,IL-17,and TNF-αin the DSS+DHA and DSS+5-aminosalicylic acid(5-ASA)groups were decreased,while the expressions of IL-4 and IL-10 were significantly upregulated.DHA largely increased the expressions of zonula occludens-1 and occludin.Western blot analysis and/or immunohistochemical staining analysis showed that the expressions of JAK2,STAT3,p-JAK2,and p-STAT3 in DSS+DHA and DSS+5-ASA groups were significantly lower than those in DSS group.DHA has a specific therapeutic effect on UC.The anti-inflammatory mechanism of DHA is related to the blockage of the JAK2/STAT3 signaling pathway.These findings provide evidence that DHA may be a useful drug and is expected to become a promising new treatment for human UC. | Mingrui Jiang Guangjun Zhong Yichao Zhu Liuhua Wang Yuzhe He Qiannan Sun Xiaoqing Wu Xiaolan You Sujun Gao Dong Tang Daorong Wang | 2021 | Acta Biochimica et Biophysica Sinica2021，53，9： | 6 |
| 16 | Effects of plant roots on soil preferential pathways and soil matrix in forest ecosystems显示文摘To characterize effects of plant roots on preferential flow(PF),we measured root length density(RLD)and root biomass(RB) in Jiufeng National Forest Park,Beijing,China.Comparisons were made for RLD and RB between soil preferential pathways and soil matrices.RLD and RB declined with the increasing soil depth(0–10,10–20,20–30,30–40,40–50,50–60 cm) in all experimental plots.RLD was greater in soil preferential pathways than in the surrounding soil matrix and was 69.5,75.0 and72.2 % for plant roots of diameter(d) \1,1 \ d \ 3 and3 \ d \ 5 mm,respectively.Fine root systems had the most pivotal influence on soil preferential flow in this forest ecosystem.In all experimental plots,RB content was the sum of RB from soil preferential pathways and the soil matrix in each soil depth.With respect to 6 soil depth gradient(0–10,10–20,20–30,30–40,40–50,50–60 cm) in each plot,the number of soil depth gradient that RB content was greater in soil preferential pathways than in the soil matrix was characterized,and the proportion was68.2 % in all plots. | Yinghu Zhang Jianzhi Niu Weili Zhu Xiaoqing Du Jiao Li | 2015 | Journal of Forestry Research2015，26，2： | 6 |
| 17 | Lead Isotopic Composition and Lead Source of the Huogeqi Cu-Pb-Zn Deposit,Inner Mongolia,China显示文摘位于 ML Langshan 的北方面的 Huogeqi 矿石地, InnerMongolia 原生地发生在中间 Langshan 组变质岩,和矿体是层状的。在过去的二十年里,许多中国地质学家在 theHuogeqi Cu-Pb-Zn 沉积物上进行了研究,但是在那里,仍然是它的起源上的争吵。存款具有 sedimentafy 变形的重做的起源,一些认为它具有海地板 SEDEXorigin,并且其它有为 magmatic 重迭起源的偏爱的某倡导者。争吵的关键是关于形成矿石的材料的来源没有普通理解。Inthis 纸, Pb 同位素组成地区性阿凯亚早,原生地,基岩,在采矿区域的沉积变形的岩石和火山岩的各种各样的类型, LateProterozoic 和 Hercynian magmatic 被介绍并且与矿石铅作文相比,以便抑制矿石铅的来源。结果显示(1 ) 在矿石的硫化物有同类的 Pb 同位素组成,显示出一个狭窄的变化范围。他们的 ^(206 )Pb/^(204 ) Pbratios 在 17.027-17.317 的一个范围以内;^(207 )Pb/^(204 ) Pb 比率, 15.451-15.786 and^(205 )Pb/^(204 ) Pb 比率, 36.747-37.669;(2 ) Pb 同位素组成 regionalAchaean 早原生地基岩在地球的早阶段的进化的旧 Pb 同位素组成是特征的,它在一个更宽的范围上变化,在矿石的 Pb 同位素组成的思考重要差别。所有这些显示矿石铅的来源与基岩无关;(3 ) 在采矿区域的沉积变形的岩石被高度可变、更放射产生的 Pb 同位素组成描绘,他们的 Pbisotopic 比率显然比矿石的那些高,证明矿石铅没源于这些岩石的变形重做;(4 ) Pb 同位素组成近来 Proterozoicdiorite 斑粝岩和 Hercynian 花岗石比矿石的那些高。同时,在在以后的阶段形成的小型的渗透阶层的使矿物化的细叶脉的硫化物的 Pb 同位素组成与在层状乐队的矿石的硫化物的完全一致,建议这些细叶脉是在变态和迟了的 magmatic 重迭矿化作用罐头的时期期间的层状乐队的矿石的本土的重做的产品被排除;(5 ) 角闪岩,其 protolith 是基本火山岩,作为矿石有一样的 Pb 同位素组成,暗示那矿石领先从基本火山作用可能被导出。那么,为 Huogeqi 存款的 ore-formingmaterials 的来源是如同暴烈的巨大的硫化物(VMS ) 的扔。然而,矿体不在火山岩以内直接发生,并且相反,他们躺火山岩,显示出从那些典型 VMS 类型存款的一些差别。 | ZHU Xiaoqing ZHANG Qian HE Yuliang ZHU Chaohui | 2006 | Acta Geologica Sinica(English Edition)2006，80，4： | 5 |
| 18 | Seismotectonics of the 2008 and 2009 Qaidam Earthquakes and its Implication for Regional Tectonics显示文摘Three magnitude >6 earthquakes struck Qaidam, Qinghai province, China, in November 10th 2008, August 28th and 31st 2009 respectively. The Zongwulongshan fault has often been designated as the active seismogenic structure, although it is at odd with the data. Our continuous GPS station (CGPS), the Xiao Qaidam station, located in the north of the Qaidam basin, is less than 30 km to the southwest of the 2008 earthquake. This CGPS station recorded the near field co-seismic deformation. Here we analyzed the co-seismic dislocation based on the GPS time series and the rupture processes from focal mechanism for the three earthquakes. The aftershocks were relocated to constrain the spatial characteristics of the 2008 and 2009 Qaidam earthquakes. Field geological and geomorphological investigation and interpretation of satellite images show that the Xitieshan fault and Zongwulongshan fault were activated as left lateral thrust during the late Quaternary. Evidence of folding can also be identified. Integrated analyses based on our data and the regional tectonic environment show that the Xitieshan fault is the fault responsible for the 2008 Qaidam earthquake, which is a low dip angle thrust with left lateral strike slip. The Zongwulongshan fault is the seismogenic fault of the 2009 earthquakes, which is a south dipping back thrust of the northern marginal thrust system of the Qaidam basin. Folding takes a significant part of the deformation in the northern marginal thrust system of the Qaidam basin, dominating the contemporary structure style of the northern margin of the Qaidam basin and Qilianshan tectonic system. In this region, this fault and fold system dominates the earthquake activities with frequent small magnitude earthquakes. | CHEN Guihua XU Xiwei ZHU Ailan ZHANG Xiaoqing YUAN Renmao Yann KLINGER Jean-Mathieu NOCQUET | 2013 | Acta Geologica Sinica(English Edition)2013，87，2： | 5 |
| 19 | Predictors of healthcare-seeking behavior among Chinese patients with irritable bowel syndrome显示文摘AIM To analyze predictors of healthcare-seeking behavior among Chinese patients with irritable bowel syndrome(IBS) and their satisfaction with medical care.METHODS Participating patients met IBS Rome Ⅲ criteria(excluding those with organic diseases) and were enrolled in an IBS database in a tertiary university hospital. Participants completed IBS questionnaires in face-to-face interviews. The questionnaires covered intestinal and extra-intestinal symptoms, medical consultations, colonoscopy,medications, and self-reported response to medications during the whole disease course and in the past year. Univariate associations and multivariate logistic regression were used to identify predictors for frequent healthcareseeking behavior(≥ 3 times/year), frequent colonoscopies(≥ 2 times/year), long-term medications, and poor satisfaction with medical care.RESULTS In total, 516 patients(293 males, 223 females) were included. Participants' average age was 43.2 ± 11.8 years. Before study enrollment, 55.2% had received medical consultations for IBS symptoms. Ordinary abdominal pain/discomfort(non-defecation) was an independent predictor for healthcare-seeking behavior(OR = 2.07, 95%CI: 1.31-3.27). Frequent colonoscopies were reported by 14.7% of patients(3.1 ± 1.4 times per year). Sensation of incomplete evacuation was an independent predictor for frequent colonoscopies(OR = 2.76, 95%CI: 1.35-5.67). During the whole disease course, 89% of patients took medications for IBS symptoms, and 14.7% reported they were satisfied with medical care. Patients with anxiety were more likely to report dissatisfaction with medical care(OR = 2.08, 95%CI: 1.20-3.59). In the past year, patients with severe(OR = 1.74, 95%CI: 1.06-2.82) and persistent(OR = 1.66, 95%CI: 1.01-2.72) IBS symptoms sought medical care more frequently.CONCLUSION Chinese patients with IBS present high rates of frequent healthcare-seeking behavior, colonoscopies, and medications, and low satisfaction with medical care. Intestinal symptoms are major predictors for healthcare-seeking behavior. | Wenjuan Fan Dong Xu Min Chang Liming Zhu Guijun Fei Xiaoqing Li Xiucai Fang | 2017 | World Journal of Gastroenterology2017，23，42： | 5 |
| 20 | Sea-floor exhalative sedimentary and magmatic hydrothermal superimposition on the Bainiuchang polymetallic deposit in Yunnan Province: REE geochemical evidence显示文摘In order to study the characteristics of sea-floor exhalative sedimentary and magmatic hydrothermal superimposition on the Bainiuchang polymetallic deposit, the REE compositions of the granites, host-rocks and ores have been systematically analyzed by ICP-MS. As viewed from their REE compositions, the granites show obvious negative Eu anomalies and weak negative Ce anomalies. According to their REE characteristics, the host-rocks were derived partly from sea-floor exhalative sediments. In terms of their REE compositions, the ores can be divided into two groups: one group, of which the samples were collected from the Baiyang segment relatively far away from the Bozhushan granite batholith, possesses positive Eu anomalies or no Eu anomaly and negative Ce anomalies, indicating that ore-forming hydrothermal fluid was relatively reductive and its temperature was higher than 250 ℃. Furthermore, the coinstantaneous presence of positive Eu anomalies and negative Ce anomalies indicate that the convective mixing of a little amount of seawater with hydrothermal fluid had happened while ores were precipitated on ancient sea floor. The other group, of which the samples were mainly collected from the Chuanxindong and Duimenshan segments near the Bozhushan granite batholith, has similar chondrite-monalized REE distribution patterns to those of the magmatic rocks. But as a whole, the REE characteristics of both groups change gradually starting from the Bozhushan granite batholith. Based on the REE characteristics of the granites, host-rocks and ores, it is suggested that the ore-forming metals seem to have come from several different sources. | ZHU Chaohui ZHANG Qian SHAO Shuxun ZHU Xiaoqing HE Yuliang WANG Dapeng | 2007 | Chinese Journal Of Geochemistry2007，26，3： | 4 |
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