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| 1 | Bioprocess-inspired preparation of silica with varied morphologies and potential in lithium storage显示文摘As one of the most delicate bioprocesses in nature,biosilicification is closely related to biosilica with various morphologies,and has provided abundant inspiration to materials synthesis.In the present study,to explore the biosilica formation process and fabricate silica with an exquisite microstructure for lithiumion battery(LIB)electrodes,a bacterial phage(M13)is used as a biotemplate to synthesize silica with diverse morphologies:cylinders,hexagonal prisms,assemblies of smaller cylinders and nanowires.A facile ethanol bath method is conducted to coat the nanowires with nitrogen-containing carbon and carbon-coated SiO_(2) nanowires with mesochannels(C@msSiO_(2) NWs)are first used as anode materials for LIBs.Attributed to the uniform carbon coating and parallel mesochannel structure,the electronic conductivity and capacity to accommodate volume variations were significantly improved.In the electrochemical perfo rmance test,the composites calcined at 750℃(C@msSiO_(2) NWs-750)show an impressive capacity of 653 mA h g^(-1) at a current density of 500 mA g^(-1) and stability(1000 cycles).In view of the electrochemical test outcomes,the prepa ration of a sophisticated structure with an outstanding potential is easily achieved via a biomimetic strategy. | Fuqiang Wan Wenxuan Wang Zhaoyong Zou Hao Xie Hang Ping Zhengyi Fu | 2021 | Journal of Materials Science & Technology2021，，13： | 2 |
| 2 | Management Algorithm for Prevention of Mother-to-child Transmission of Hepatitis B Virus(2022)显示文摘The World Health Organization(WHO)has set the goal of eliminating hepatitis as a threat to public health by 2030.Blocking mother-to-child transmission(MTCT)of hepatitis B virus(HBV)is not only the key to eliminating viral hepatitis,but also a hot issue in the field of hepatitis B prevention and treatment.To standardize the clinical management of preventing MTCT of HBV and achieve zero HBV infection among infants,the Chinese Foundation for Hepatitis Prevention and Control organized experts to compile a management algorithm for prevention of MTCT of HBV based on the latest research progress and guidelines,including 10 steps of pregnancy management and postpartum follow-up,among which screening,antiviral treatment,and infant immunization are its core components. | Zhihua Liu Zhongdan Chen Fuqiang Cui Yang Ding Yunfei Gao Guorong Han Jidong Jia Jie Li Zengde Li Yingxia Liu Qing Mao Ailing Wang Wei Wang Lai Wei Jianhong Xia Qing Xie Xizhong Yang Xueru Yin Hua Zhang Liaoyun Zhang Wenhong Zhang Hui Zhuang Xiaoguang Dou Jinlin Hou | 2022 | Journal of Clinical and Translational Hepatology2022，10，5： | 2 |
| 3 | Systematic analysis of clinical relevance and molecular characterization of m^(6)A in COVID-19 patients显示文摘N6-methyladenosine(m6A)is the most prevalent post-transcriptional RNA modification in mRNA and long non-coding RNAs of eukaryotes,and its biological functions are mediated by m6A writers,erasers and readers.1 A nuclear methyltransferase complex consisting of METTL3,METTL14,WTAP,VIRMA,ZC3H13,RBM15(or RBM15B),YWHAG,TRA2A and CAPRIN1 catalyzes the m6A modifications,acting as m6A writers.1 m6A demethylase ALKBH5 as well as m6A demethylase FTO mediate the demethylation of m6As,acting as the m6A erasers. | Sanqi An Zhouhua Xie Yanyan Liao Junjun Jiang Wenyi Dong Fuqiang Yin Wen-Xing Li Li Ye Jianyan Lin Hao Liang | 2022 | Genes & Diseases2022，9，5： | 1 |
| 4 | Single-Cell Exome Sequencing Reveals Single-Nucleotide Mutation Characteristics of a Kidney Tumor显示文摘 | Xun Xu Yong Hou Xuyang Yin Li Bao Aifa Tang Luting Song Fuqiang Li Shirley Tsang Kui Wu Hanjie Wu Weiming He Liang Zeng Manjie Xing Renhua Wu Hui Jiang Xiao Liu Dandan Cao Guangwu Guo Xueda Hu Yaoting Gui Zesong Li Wenyue Xie Xiaojuan Sun Min Shi Zhiming | 2012 | Cell2012，，5： | 1 |
| 5 | Reversal of cardiomyopathy in patients with congestive heart failure secondary to tachycardia显示文摘 | Zhao Donghua Peng Jian Xiao Zhongbo Zhang Feifei Peng Xinhui Yang Hao Liu Fuqiang Li Yan Xie Yong Huang Xinfu Meng Surong Wu Muli Xu Dingli | 2013 | Journal of Interventional Cardiac Electrophysiology2013，，： | 1 |
| 6 | Measurement of Liver Size and Intrahepatic Blood Flow of Red-eared Turtles by Color Doppler Ultrasound显示文摘In the study,a total of 20 red-eared turtles( half male and half female) were selected to conduct the measurement of liver size and intrahepatic blood flow of red-eared turtles by color Doppler ultrasound. The results showed that the right hepatic lobe could be scanned through the right carotid anterior acoustic window,and the left hepatic lobe could be scanned through the left carotid anterior acoustic window,but the vision would be obstructed by the air in trachea. The liver could also be scanned through the left femoral anterior acoustic window and the right femoral anterior acoustic window when filling of bladder was good. The correlation regression analysis suggested that estimated values of liver showed no linear relationship with weight,the longest back curve and the widest back curve. Through the study,the normal indicators for ultrasound examination of red-eared turtle liver were established,in order to provide a reference for examination of turtle liver. | Cheng Yu Xie Fuqiang | 2015 | Animal Husbandry and Feed Science2015，7，4： | 0 |
| 7 | In situ annealing effects on magnetic properties and variable-range hopping of iron-based ladder material BaFe2S3显示文摘All iron-based superconductors,regardless of their detailed crystal structure,share the same conductive Fe_2X_2(X=As,P,Se,and S)layers as the crucial structural unit[1-8].In the Fe_2X_2 layers,edge-shared FeX_4 tetrahedra form a square lattice in quasi-two-dimensional(quasi-2D)planes.One may wonder what kind of properties will be manifested in the quasi-one-dimensional(quasi-1D)counterparts exhibiting an identical coordination as the above-mentioned | Xuan Zhang Hui Zhang YongHui Ma LingLing Wang JiaNan Chu Tao Hu Gang Mu YuMing Lu ChuanBing Cai FuQiang Huang XiaoMing Xie | 2018 | Science China(Physics,Mechanics & Astronomy)2018，61，7： | 0 |
| 8 | Three-Variable Shifted Jacobi Polynomials Approach for Numerically Solving Three-Dimensional Multi-Term Fractional-Order PDEs with Variable Coefficients显示文摘In this paper,the three-variable shifted Jacobi operational matrix of fractional derivatives is used together with the collocation method for numerical solution of threedimensional multi-term fractional-order PDEs with variable coefficients.The main characteristic behind this approach is that it reduces such problems to those of solving a system of algebraic equations which greatly simplifying the problem.The approximate solutions of nonlinear fractional PDEs with variable coefficients thus obtained by threevariable shifted Jacobi polynomials are compared with the exact solutions.Furthermore some theorems and lemmas are introduced to verify the convergence results of our algorithm.Lastly,several numerical examples are presented to test the superiority and efficiency of the proposed method. | Jiaquan Xie Fuqiang Zhao Zhibin Yao Jun Zhang | 2018 | Computer Modeling in Engineering & Sciences2018，，4： | 0 |
| 9 | A direct spino-cortical circuit bypassing the thalamus modulates nociception显示文摘Nociceptive signals are usually transmitted to layer 4 neurons in somatosensory cortex via the spinothalamic-thalamocortical pathway.The layer 5 corticospinal neurons in sensorimotor cortex are reported to receive the output of neurons in superficial layers;and their descending axons innervate the spinal cord to regulate basic sensorimotor functions.Here,we show that a subset of layer 5 neurons receives spinal inputs through a direct spino-cortical circuit bypassing the thalamus,and thus define these neurons as spino-cortical recipient neurons(SCRNs).Morphological studies revealed that the branches from spinal ascending axons formed a kind of disciform structure with the descending axons from SCRNs in the basilar pontine nucleus(BPN).Electron microscopy and calcium imaging further confirmed that the axon terminals from spinal ascending neurons and SCRNs made functional synaptic contacts in the BPN,linking the ascending sensory pathway to the descending motor control pathway.Furthermore,behavioral tests indicated that the spino-cortical connection in the BPN was involved in nociceptive responses.In vivo calcium imaging showed that SCRNs responded to peripheral noxious stimuli faster than neighboring layer 4 cortical neurons in awake mice.Manipulating activities of SCRNs could modulate nociceptive behaviors.Therefore,this direct spino-cortical circuit represents a noncanonical pathway,allowing a fast sensory-motor transition of the brain in response to noxious stimuli. | Bing Cai Dan Wu Hong Xie Yan Chen Huadong Wang Sen Jin Yuran Song Anan Li Shiqi Huang Sashuang Wang Yingjin Lu Lan Bao Fuqiang Xu Hui Gong Changlin Li Xu Zhang | 2023 | Cell Research2023，33，10： | 0 |
| 10 | Effectiveness of indoor residual spraying on malaria control: a systematic review and meta-analysis显示文摘Background:Indoor residual spraying(IRS)is one of the key interventions recommended by World Health Organization in preventing malaria infection.We aimed to conduct a systematic review and meta-analysis of global studies about the impact of IRS on malaria control.Method:We searched PubMed,Web of Science,Embase,and Scopus for relevant studies published from database establishment to 31 December 2021.Random-effects models were used to perform meta-analysis and subgroup analysis to pool the odds ratio(OR)and 95%confidence interval(CI).Meta-regression was used to investigate potential factors of heterogeneity across studies.Results:Thirty-eight articles including 81 reports and 1,174,970 individuals were included in the meta-analysis.IRS was associated with lower rates of malaria infection(OR=0.35,95%CI:0.27-0.44).The significantly higher effectiveness was observed in IRS coverage≥80%than in IRS coverage<80%.Pyrethroids was identified to show the greatest performance in malaria control.In addition,higher effectiveness was associated with a lower gross domestic product as well as a higher coverage of IRS and bed net utilization.Conclusions:IRS could induce a positive effect on malaria infection globally.The high IRS coverage and the use of pyrethroids are key measures to reduce malaria infection.More efforts should focus on increasing IRS coverage,developing more effective new insecticides against malaria,and using multiple interventions comprehensively to achieve malaria control goals. | Yiguo Zhou Wan-Xue Zhang Eljah Tembo Ming-Zhu Xie Shan-Shan Zhang Xin-Rui Wang Ting-Ting Wei Xin Feng Yi-Lin Zhang Juan Du Ya-Qiong Liu Xuan Zhang Fuqiang Cui Qing-Bin Lu | 2022 | Infectious Diseases of Poverty2022，11，4： | 0 |
| 11 | Progress in niobium-based oxides as anode for fast-charging Li-ion batteries显示文摘With the increasing popularity of electric/hybrid vehicles and the rapid development of 3C electronics,there is a growing interest in high-rate energy storage systems.The rapid development and widespread adoption of lithiumion batteries(LIBs)can be attributed to their numerous advantages,including high energy density,high operating voltage,environmental friendliness,and lack of memory effect.However,the progress of LIBs is currently hindered by the limitations of energy storage materials,which serve as vital components.Therefore,there is an urgent need to address the development of a new generation of high-rate energy storage materials in order to overcome these limitations and further advance LIB technology.Niobium-based oxides have emerged as promising candidates for the fabrication of fast-charging Li-ion batteries due to their excellent rate capability and long lifespan.This review paper provides a comprehensive analysis of the fundamentals,methodologies,and electrochemistries of niobium-based oxides,with a specific focus on the evolution and creation of crystal phases of Nb_(2)O_(5),fundamental electrochemical behavior,and modification methods including morphology modulation,composite technology,and carbon coating.Furthermore,the review explores Nb_(2)O_(5)-derived compounds and related advanced characterization techniques.Finally,the challenges and issues in the development of niobiumbased oxides for high-rate energy storage batteries are discussed,along with future research perspectives. | Fuqiang Xie Junling Xu Qizhong Liao Qingqing Zhang Binyun Liu Lianyi Shao Junjie Cai Xiaoyan Shi Zhipeng Sun Ching-Ping Wong | 2023 | Energy Reviews2023，2，2： | 0 |
| 12 | Sequence homolog-based molecular engineering for shifting the enzymatic pH optimum显示文摘Cell-free synthetic biology system organizes multiple enzymes(parts)from different sources to implement unnatural catalytic functions.Highly adaption between the catalytic parts is crucial for building up efficient artificial biosynthetic systems.Protein engineering is a powerful technology to tailor various enzymatic properties including catalytic efficiency,substrate specificity,temperature adaptation and even achieve new catalytic functions.However,altering enzymatic pH optimum still remains a challenging task.In this study,we proposed a novel sequence homolog-based protein engineering strategy for shifting the enzymatic pH optimum based on statistical analyses of sequence-function relationship data of enzyme family.By two statistical procedures,artificial neural networks(ANNs)and least absolute shrinkage and selection operator(Lasso),five amino acids in GH11 xylanase family were identified to be related to the evolution of enzymatic pH optimum.Site-directed mutagenesis of a thermophilic xylanase from Caldicellulosiruptor bescii revealed that four out of five mutations could alter the enzymatic pH optima toward acidic condition without compromising the catalytic activity and thermostability.Combination of the positive mutants resulted in the best mutant M31 that decreased its pH optimum for 1.5 units and showed increased catalytic activity at pH<5.0 compared to the wild-type enzyme.Structure analysis revealed that all the mutations are distant from the active center,which may be difficult to be identified by conventional rational design strategy.Interestingly,the four mutation sites are clustered at a certain region of the enzyme,suggesting a potential“hot zone”for regulating the pH optima of xylanases.This study provides an efficient method of modulating enzymatic pH optima based on statistical sequence analyses,which can facilitate the design and optimization of suitable catalytic parts for the construction of complicated cell-free synthetic biology systems. | Fuqiang Ma Yuan Xie Manjie Luo Shuhao Wang You Hu Yukun Liu Yan Feng Guang-Yu Yang | 2016 | Synthetic and Systems Biotechnology2016，1，3： | 0 |
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