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| 1 | X-ray image characteristics and related measurements in the ankles of 118 adult patients with Kashin-Beck disease显示文摘 | Zeng Yi Zhou Zongke Shen Bin Yang Jing Kang Pengde Zhou Xuan Zou Ling Pei Fuxing | 2014 | Chinese Medical Journal2014，，13： | 13 |
| 2 | T cell-depleting nanoparticles ameliorate bone loss by reducing activated T cells and regulating the Treg/Th17 balance显示文摘Estrogen deficiency is one of the most frequent causes of osteoporosis in postmenopausal women.Under chronic inflammatory conditions caused by estrogen deficiency,activated T cells contribute to elevated levels of proinflammatory cytokines,impaired osteogenic differentiation capabilities of bone marrow mesenchymal stem cells(BMMSCs),and disturbed regulatory T cell(Treg)/Th17 cell balance.However,therapeutic strategies that re-establish immune homeostasis in this disorder have not been well developed.Here,we produced T cell-depleting nanoparticles(TDNs)that ameliorated the osteopenia phenotype and rescued the osteogenic deficiency of BMMSCs in ovariectomized(OVX)mice.TDNs consist of monocyte chemotactic protein-1(MCP-1)-encapsulated mesoporous silica nanoparticles as the core and Fas-ligand(FasL)as the corona.We showed that the delicate design of the TDNs enables rapid release of MCP-1 to recruit activated T cells and then induces their apoptosis through the conjugated FasL both in vitro and in vivo.Apoptotic signals recognized by macrophages help skew the Treg/Th17 cell balance and create an immune tolerant state,further attenuating the osteogenic deficiency of BMMSCs and the osteopenia phenotype.Mechanistically,we found that the therapeutic effects of TDNs were partially mediated by apoptotic T cell-derived extracellular vesicles(ApoEVs),which promoted macrophage transformation towards the M2 phenotype.These findings demonstrate that TDNs may represent a promising strategy for treating osteoporosis and other immune disorders. | Xiaoshan Yang Fuxing Zhou Pingyun Yuan Geng Dou Xuemei Liu Siying Liu Xiangdong Wang Ronghua Jin Yan Dong Jun Zhou Yajie Lv Zhihong Deng Shiyu Liu Xin Chen Ying Han Yan Jin | 2021 | Bioactive Materials2021，6，10： | 4 |
| 3 | Monte carlo study on 6 MV photon beams of a CyberKnife stereotactic radiosurgery system显示文摘In this paper,the beam quality and percent depth dose curves for different field sizes of CyberKnife? system were investigated by Monte Carlo simulations using the PENELOPE code,which has been used to simulate 6 MV photon beam.In water phantom,the absolute doses were calculated for Φ10–60 mm collimators,and percent depth dose curves were evaluated for Φ30–60 mm collimators.The agreement of dose distributions of the calculation with measurement was within 3.0%.The mean energy of photon spectrum was 1.46 MeV,and the beam quality index was 0.632,which was slightly smaller than that of measurement. | DONG Xiaoqing LUO Wenyun YUE Kun WANG Chuanshan ZHOU Shiqing PAN Fuxing WANG Enmin WANG Chaozhuang | 2010 | Nuclear Science and Techniques2010，21，1： | 4 |
| 4 | 自然杀伤T细胞对小鼠肝癌移植瘤的抑制作用(英文)显示文摘Objective:The aim of this study was to investigate the inhibition effect of natural killer T(NKT) cells on transplantation hepatocellular carcinoma in mice.Methods:α-galactosylceramide(α-GalCer)-pulsed DC and Hep S were prepared as stimulus.Hepatoma xenograft model was established and mice were randomly divided into 4 groups(n=13 each group):(1) control group,intravenous injection of the same volume of saline.(2) mature DC group,intravenous injection of mature DC cells(4×106 cells).(3) α-GalCer-pulsed HepS group,intravenous injection of α-GalCer-pulsed HepS(4×106 cells).(4) α-GalCer-pulsed mature DC group,intravenous injection of α-GalCer-pulsed DC(4×106 cells).The changes of tumor volume in mice and survival period were measured every 2 days.Percentage of NKT cells in spleens and cytotoxicity of spleen cells were detected by flow cytometry.Tumor tissues were analyzed by histopathological examination.Results:In α-GalCer-pulsed Heps and DC groups,the average survival period was prolonged and tumor volume was markedly decreased,spleen cells and NKT cells were significantly increased,and tumor necrosis was evident,compared to the control group.Conclusion:α-GalCer-pulsed DC and HepS could activate NKT cells in vivo,also increase NKT cells cytotoxicity,inhibit the growth of hepatomas and prolong survival period. | Fuxing Chen Hongdan Zhao Nanzheng Zhang Junquan Liu Zhonghai Zhou Leiqing Sun Yu Zhou | 2011 | The Chinese-German Journal of Clinical Oncology2011，10，5： | 3 |
| 5 | Faceted Kurdjumov-Sachs interface-induced slip continuity in the eutectic high-entropy alloy,AlCoCrFeNi_(2.1)显示文摘Recently,the eutectic high-entropy alloy(EHEA),AlCoCrFeNi_(2.1),can reach a good balance of strength and ductility.The dual-phase alloy exhibits a eutectic lamellar microstructure with large numbers of interfaces.However,the role of the interfaces in plastic deformation have not been revealed deeply.In the present work,the orientation relationship(OR)of the interfaces has been clarified as the Kurdjumov-Sachs(KS)interfaces presenting〈111〉_(B2) 〈110〉_(FCC)and {110} _(B2){111}_(FCC) independent of their morphologies.There exist three kinds of interfaces in the EHEA,namely,The dominating interface and the secondary interface are both non-slip planes and atomistic-scale faceted,facilitating the nucleation and slip transmission of the dislocations.The formation mechanism of the preferred interfaces is revealed using the atomistic geometrical analysis according to the criteria of the low interfacial energy based on the coincidence-site lattice(CSL)theory.In particular,the ductility of the dual-phase alloy originates from the KS interface-induced slip continuity across interfaces,which provides a high slip-transfer geometric factor.Moreover,the strengthening effect can be attributed to the interface resistance for the dislocation transmission due to the mismatches of the moduli and lattice parameters at the interfaces. | Ting Xiong Wenfan Yang Shijian Zheng Zhaorui Liu Yiping Lu Ruifeng Zhang Yangtao Zhou Xiaohong Shao Bo Zhang Jun Wang Fuxing Yin Peter K.Liaw Xiuliang Ma | 2021 | Journal of Materials Science & Technology2021，，6： | 2 |
| 6 | DEAP1 encodes a fasciclin-like arabinogalactan protein required for male fertility in rice显示文摘Arabinogalactan proteins(AGPs)are widely distributed in plant cells.Fasciclin-like AGPs(FLAs)belong to a subclass of AGPs that play important roles in plant growth and development.However,little is known about the biological functions of rice FLA.Herein,we report the identification of a male-sterile mutant of DEFECTIVE EXINE AND APERTURE PATTERNING1(DEAP1)in rice.The deap1 mutant anthers produced aberrant pollen grains with defective exine formation and a flattened aperture annulus and exhibited slightly delayed tapetum degradation.DEAP1 encodes a plasma membrane-associated member of groupⅢplant FLAs and is specifically and temporally expressed in reproductive cells and the tapetum layer during male development.Gene expression studies revealed reduced transcript accumulation of genes related to exine formation,aperture patterning,and tapetum development in deap1 mutants.Moreover,DEAP1 may interact with two rice D6 PROTEIN KINASE-LIKE3 s(OsD6PKL3s),homologs of a known Arabidopsis aperture protein,to affect rice pollen aperture development.Our findings suggested that DEAP1 is involved in male reproductive development and may affect exine formation and aperture patterning,thereby providing new insights into the molecular functions of plant FLAs in male fertility. | Dan Zhou Ting Zou Kaixuan Zhang Pingping Xiong Fuxing Zhou Hao Chen Gongwen Li Kaiyou Zheng Yuhao Han Kun Peng Xu Zhang Shangyu Yang Qiming Deng Shiquan Wang Jun Zhu Yueyang Liang Changhui Sun Xiumei Yu Huainian Liu Lingxia Wang Ping Li Shuangcheng Li | 2022 | Journal of Integrative Plant Biology2022，64，7： | 2 |
| 7 | Improvement of corrosion resistance of AZ91D magnesium alloy by holmium addition显示文摘 | Xuehua Zhou Yuanwei Huang Zhongling Wei Qiurong Chen Fuxing Gan | 2006 | Corrosion Science2006，，12： | 1 |
| 8 | Monte carlo study on 6MV photon beam of a CyberKnife stereotactic radiosurgery system显示文摘 | DONG Xiaoqing LUO Wenyun YUE Kun WANG Chuanshan ZHOU Shiqing PAN Fuxing WANG Enmin WANG Chaozhuang | | 0，，： | 1 |
| 9 | Effects of recovery treatment after large strain on the grain boundary character distributions of subsequently cold rolled and annealed Pb–Ca–Sn–Al alloy显示文摘 | Weiguo Wang Fuxing Yin Hong Guo He Li Bangxin Zhou | 2008 | Materials Science & Engineering A2008，，1： | 1 |
| 10 | A meta-analysis of the Gamma nail and dynamic hip screw in treating peritrochanteric fractures显示文摘 | Ming Liu Zhiming Yang Fuxing Pei Fuguo Huang Shiqiang Chen Zhou Xiang | 2010 | International Orthopaedics2010，，3： | 1 |
| 11 | Cosegregation of the ND4 G11696A mutation with the LHON-associated ND4 G11778A mutation in a four generation Chinese family显示文摘 | Jia Qu Ronghua Li Xiangtian Zhou Yi Tong Li Yang Jie Chen Fuxing Zhao Chunjie Lu Yaping Qian Fan Lu Min-Xin Guan | 2007 | Mitochondrion2007，，1： | 1 |
| 12 | Meta-analysis of Temporary Versus No Clamping in TKA显示文摘 | Huang ZeYu Ma Jun Pei FuXing Yang Jing Zhou ZongKe Kang PengDe Shen Bin | 2013 | Orthopedics (Online)2013，，7： | 1 |
| 13 | Effect of thidiazuron on somatic embryogenesis of Cayratia japonica显示文摘 | Junyan Zhou Hui Ma Fuxing Guo Xintan Luo | 1994 | Plant Cell Tissue and Organ Culture1994，，1： | 1 |
| 14 | Modeling and analytic optimization of dynamic comfort for wheelchair robots undergoing random roads显示文摘To make a rapid comfort assessment and a reasonable dynamic parameters choice of wheelchair robots,this paper proposes a dynamic comfort coefficientκand analytically optimizes the cushion damping.Firstly,a traveling vibration model of the occupantwheelchair system for wheelchair robots running on random roads was created.Secondly,the analytic formula of the occupant RMS(root mean square)acceleration was deduced.Moreover,the dynamic coefficientκwas proposed and its influence laws were revealed.Finally,the cushion system optimal damping ratio was calculated based onκ.The results show that theκvalue is only determined by the parameters of the occupant-wheelchair system.The smaller theκvalue is,the better the dynamic comfort is for wheelchair robots running on random roads.By minimizingκ,the occupant-wheelchair system can achieve a statistically optimal dynamic comfort effect. | Leilei Zhao Yuewei Yu Changcheng Zhou Xiaohan Li Fuxing Yang | 2018 | International Journal of Modeling, Simulation, and Scientific Computing2018，9，5： | 0 |
| 15 | Effects of tranexamic acid on vascular occlusive events and perioperative resuscitation in patients with atrial fibrillation undergoing total joint arthroplasty显示文摘To the Editor:Tranexamic acid(TXA)has recently become popular for use in orthopedic surgeries owing to its efficacy in reducing blood loss,transfusion rates,and mortality without increasing the risk of deep venous thrombosis.ll Although the ideal dosage and route for TXA administration remain unclear,it has become one of the most important parts of the perioperative blood conservation strategy.However,it remains controversial to prescribe TXA to patients with cardiovascular diseases,because of prothrombotic and proconvulsant effects,which potentially increases cardiovascular risk. | Shangkun Tang Zongke Zhou Jing Yang Pengde Kang Bin Shen Fuxing Pei Xiaojun Shi | 2022 | Chinese Medical Journal2022，135，19： | 0 |
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