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| 1 | Regulation of the intestinal microbiota: An emerging therapeutic strategy for inflammatory bowel disease显示文摘The rapid development of metagenomics,metabolomics,and metatranscriptomics provides novel insights into the intestinal microbiota factors linked to inflammatory bowel disease(IBD).Multiple microorganisms play a role in intestinal health;these include bacteria,fungi,and viruses that exist in a dynamic balance to maintain mucosal homeostasis.Perturbations in the intestinal microbiota disrupt mucosal homeostasis and are closely related to IBD in humans and colitis in mice.Therefore,preventing or correcting the imbalance of microbiota may serve as a novel prevention or treatment strategy for IBD.We review the most recent evidence for direct or indirect interventions targeting intestinal microbiota for treatment of IBD in order to overcome the current limitations of IBD therapies and shed light on personalized treatment options. | Bei Yue Zhi-Lun Yu Cheng Lv Xiao-Long Geng Zheng-Tao Wang Wei Dou | 2020 | World Journal of Gastroenterology2020，26，30： | 7 |
| 2 | T cell-depleting nanoparticles ameliorate bone loss by reducing activated T cells and regulating the Treg/Th17 balance显示文摘Estrogen deficiency is one of the most frequent causes of osteoporosis in postmenopausal women.Under chronic inflammatory conditions caused by estrogen deficiency,activated T cells contribute to elevated levels of proinflammatory cytokines,impaired osteogenic differentiation capabilities of bone marrow mesenchymal stem cells(BMMSCs),and disturbed regulatory T cell(Treg)/Th17 cell balance.However,therapeutic strategies that re-establish immune homeostasis in this disorder have not been well developed.Here,we produced T cell-depleting nanoparticles(TDNs)that ameliorated the osteopenia phenotype and rescued the osteogenic deficiency of BMMSCs in ovariectomized(OVX)mice.TDNs consist of monocyte chemotactic protein-1(MCP-1)-encapsulated mesoporous silica nanoparticles as the core and Fas-ligand(FasL)as the corona.We showed that the delicate design of the TDNs enables rapid release of MCP-1 to recruit activated T cells and then induces their apoptosis through the conjugated FasL both in vitro and in vivo.Apoptotic signals recognized by macrophages help skew the Treg/Th17 cell balance and create an immune tolerant state,further attenuating the osteogenic deficiency of BMMSCs and the osteopenia phenotype.Mechanistically,we found that the therapeutic effects of TDNs were partially mediated by apoptotic T cell-derived extracellular vesicles(ApoEVs),which promoted macrophage transformation towards the M2 phenotype.These findings demonstrate that TDNs may represent a promising strategy for treating osteoporosis and other immune disorders. | Xiaoshan Yang Fuxing Zhou Pingyun Yuan Geng Dou Xuemei Liu Siying Liu Xiangdong Wang Ronghua Jin Yan Dong Jun Zhou Yajie Lv Zhihong Deng Shiyu Liu Xin Chen Ying Han Yan Jin | 2021 | Bioactive Materials2021，6，10： | 4 |
| 3 | Can DKI-MRI predict recurrence and invasion of peritumoral zone of hepatocellular carcinoma after transcatheter arterial chemoembolization?显示文摘BACKGROUND Hepatocellular carcinoma(HCC)is a major cause of cancer-related mortality worldwide.Transcatheter arterial chemoembolization(TACE)has been performed as a palliative treatment for patients with HCC.However,HCC is easy to recur after TACE.Magnetic resonance imaging(MRI)has clinical potential in evaluating the TACE treatment effect for patients with liver cancer.However,traditional MRI has some limitations.AIM To explore the clinical potential of diffusion kurtosis imaging(DKI)in predicting recurrence and cellular invasion of the peritumoral liver zone of HCC after TACE.METHODSSeventy-six patients with 82 HCC nodules were recruited in this study and underwent DKI afterTACE. According to pathological examinations or the overall modified response evaluationcriteria in solid tumors (mRECIST) criterion, 48 and 34 nodules were divided into true progressionand pseudo-progression groups, respectively. The TACE-treated area, peritumoral liver zone, andfar-tumoral zone were evaluated on DKI-derived metric maps. Non-parametric U test and receiveroperating characteristic curve (ROC) analysis were used to evaluate the prediction performance ofeach DKI metric between the two groups. The independent t-test was used to compare each DKImetric between the peritumoral and far-tumoral zones of the true progression group.RESULTSDKI metrics, including mean diffusivity (MD), axial diffusivity (DA), radial diffusivity (DR), axialkurtosis (KA), and anisotropy fraction of kurtosis (Fak), showed statistically different valuesbetween the true progression and pseudo-progression groups (P < 0.05). Among these, MD, DA,and DR values were higher in pseudo-progression lesions than in true progression lesions,whereas KA and FAk values were higher in true progression lesions than in pseudo-progressionlesions. Moreover, for the true progression group, the peritumoral zone showed significantlydifferent DA, DR, KA, and FAk values from the far-tumoral zone. Furthermore, MD values of theliver parenchyma (peritumoral and far-tumoral zones) were significantly lower in the trueprogression group than in the pseudo-progression group (P < 0.05).CONCLUSIONDKI has been demonstrated with robust performance in predicting the therapeutic response ofHCC to TACE. Moreover, DKI might reveal cellular invasion of the peritumoral zone by moleculardiffusion-restricted change. | Xin Cao Hao Shi Wei-Qiang Dou Xin-Yao Zhao Ying-Xin Zheng Ya-Ping Ge Hai-Chao Cheng Dao-Ying Geng Jun-Ying Wang | 2022 | World Journal of Gastrointestinal Surgery2022，14，10： | 4 |
| 4 | Identification of a novel mutation in the SRD5A2 gene of one patient with 46,XY disorder of sex development显示文摘 | Shu-Ping Li Li-Wei Li Ming-Xia Sun Xin-Xin Chen Xiu-Feng Wang Zeng-Kui Li Sheng-Yun Zhou Dong-Cai Zhai Shu-Xia Geng Shu-Jun Li Xiao-Wei Dou | 2018 | Asian Journal of Andrology2018，20，5： | 3 |
| 5 | Engineered neutrophil apoptotic bodies ameliorate myocardial infarction by promoting macrophage efferocytosis and inflammation resolution显示文摘Inflammatory response plays a critical role in myocardial infarction(MI)repair.The neutrophil apoptosis and subsequent macrophage ingestion can result in inflammation resolution and initiate regeneration,while the therapeutic strategy that simulates and enhances this natural process has not been established.Here,we constructed engineered neutrophil apoptotic bodies(eNABs)to simulate natural neutrophil apoptosis,which regulated inflammation response and enhanced MI repair.The eNABs were fabricated by combining natural neutrophil apoptotic body membrane which has excellent inflammation-tropism and immunoregulatory properties,and mesoporous silica nanoparticles loaded with hexyl 5-aminolevulinate hydrochloride(HAL).The eNABs actively targeted to macrophages and the encapsulated HAL simultaneously initiated the biosynthesis pathway of heme to produce anti-inflammatory bilirubin after intracellular release,thereby further enhancing the anti-inflammation effects.In in vivo studies,the eNABs efficiently modulated inflammation responses in the infarcted region to ameliorate cardiac function.This study demonstrates an effective biomimetic construction strategy to regulate macrophage functions for MI repair. | Lili Bao Geng Dou Ran Tian Yajie Lv Feng Ding Siying Liu Ruifeng Zhao Lu Zhao Jun Zhou Lin Weng Yan Dong Bei Li Shiyu Liu Xin Chen Yan Jin | 2022 | Bioactive Materials2022，7，3： | 3 |
| 6 | Process optimization of a closed-chamber distillation system for the recovery of FLiNaK molten salt显示文摘Low-pressure distillation has been proposed as a suitable technique for the recovery of carrier salt from molten salt reactor spent fuel.A closed-chamber distillation system,in which the pump is stopped and pressureinduced salt distillation is performed,was arranged for fluoride salt treatment.A stair-step optimization process was demonstrated to improve the recovery efficiency by up to 99%.The pressure change curve was feasible for estimating the distillation process,and a method for displaying the pressure value online in order to determine the endpoint was also developed.The decontamination factor of Nd in the condensate salt was deduced to be greater than 100 with 1 wt%NdF3–FLiNaK distillation.The optimal conditions developed in this study showed a high recovery ratio for the fluoride carrier salt and a high separation efficiency for rare earth products. | Jun-Xia Geng Yang Yang Hai-Ying Fu Yan Luo Qiang Dou Qing-Nuan Li | 2021 | Nuclear Science and Techniques2021，32，1： | 2 |
| 7 | Molecular diagnosis and treatment of meningiomas:an expert consensus(2022)显示文摘Meningiomas are the most common primary intracranial neoplasm with diverse pathological types and complicated clinical manifestations.The fifth edition of the WHO Classification of Tumors of the Central Nervous System(WHO CNS5),published in 2021,introduces major changes that advance the role of molecular diagnostics in meningiomas.To follow the revision of WHO CNS5,this expert consensus statement was formed jointly by the Group of Neuro-Oncology,Society of Neurosurgery,Chinese Medical Association together with neuropathologists and evidence-based experts.The consensus provides reference points to integrate key biomarkers into stratification and clinical decision making for meningioma patients. | Jiaojao Deng Lingyang Hua Liuguan Bian Hong Chen Ligang Chen Hongwei Cheng Changwu Dou Dangmurenjiapu Geng Tao Hong Hongming Ji Yugang Jiang Qing Lan Gang Li Zhixiong Liu Songtao Qi Yan Qu Songsheng Shi Xiaochuan Sun Hajun Wang Yongping You Hualin Yu Shuyuan Yue Jianming Zhang Xiaohua Zhang Shuo Wang Ying Mao Ping Zhong Ye Gong Group of Neuro-Oncology Society of Neurosurgery Chinese Medical Association | 2022 | Chinese Medical Journal2022，135，16： | 1 |
| 8 | Association of a variant in MIR 196A2 with susceptibility to hepatocel|ular carcinoma in ma|e Chi- nese patients with chronic hepatitis B virus infection 显示文摘 | Qi P Dou T H Geng L et ai | 2010 | Hum Im- munol2010，71，6： | 1 |
| 9 | Association of a variant in MIR 196A2 with susceptibility to hepatocellular carcinoma in male Chinese patients with chronic hepatitis B virus infection显示文摘 | QI P DOU T H GENG L | 2010 | Hum Immunol2010，71，6： | 1 |
| 10 | Association of a variant in MIR 196A2 with susceptibility to hepatoeellular carcinoma in male Chinese patients with chronic hepatitis B virus infection显示文摘 | Qi P Dou T Geng L | 2010 | Hum Immunol2010，71，6： | 1 |
| 11 | Recent development of nanomaterials for carbon dioxide electroreduction显示文摘Electrochemical CO_(2) reduction reaction(CO_(2)RR)to produce value‐added products has received tremendous research attention in recent years.With research efforts across the globe,remarkable advancement has been achieved,including the improvement of selectivity for the reduction products,the realization of efficient reduction beyond two electrons,and the delivery of industrially relevant current densities.In this review,we introduce the recent development of nanomaterials for CO_(2)RR,including the zero‐dimensional graphene quantum dots,two‐dimensional materials such as metal chalcogenides and metal/covalent organic framework,singleatom catalysts,and nanostructured metal catalysts.The engineering of materials into three‐dimensional structure will also be discussed.Finally,we will provide a summary of the catalytic performance and perspectives on future development. | Jianjun Su Yong Liu Yun Song Libei Huang Weihua Guo Xiaohu Cao Yubing Dou Le Cheng Geng Li Qiushi Hu Ruquan Ye | 2022 | SmartMat2022，3，1： | 1 |
| 12 | Association of a variant in MIR196A2 with susceptibility to hepatocellular carcinoma in maleChinese patients with chronic hepatitis B virus infection显示文摘 | Qi P Dou TH Geng L | 2010 | Hum Immunol2010，71，6： | 1 |
| 13 | Efficacy of intravitreal conbercept injection on short-and long-term macular edema in branch retinal vein occlusion显示文摘AIM: To observe the best-corrected visual acuity(BCVA) and central foveal thickness(CFT) repeatedly after the intravitreal injection of conbercept(IVC) for treating cystoid macular edema(CME) in branch retinal vein occlusion(BRVO) and explore the relationship between the duration of CME and visual outcome.METHODS: Subgroup analysis was performed to compare short-term(within 90 d of CME onset) and longterm(over 90 d of CME onset) macular edema in BRVO.After an initial IVC, a pro re nata(PRN) strategy was performed according to the recurrence of CFT or decrease of BCVA.Analysis of variance using repeated measurements, statistical analysis following indicators including BCVA and CFT collected at baseline and 1, 3, and 6 mo after IVC.RESULTS: Among the 60 cases included in this retrospective study, 36 were short-term CME, and 24 were long-term CME.There were statistical significances between and within groups of the BCVAs at different time points(P<0.001).The interaction was found between group and time(P=0.006), indicating the difference in the speed of BCVA improvement between groups.In particular, the improvement speed of BCVA in the short-term CME group was faster than that in the long-term CME group.There were significant differences between and with groups of the CFT at different time points(P<0.001).However, the interaction between group and time in relation to CFT had no significant differences(P=0.59).CONCLUSION: IVC treatment for CME following BRVO is effective and safe.The duration of CME before treatment is a significant predictor of the visual outcomes of patients with BRVO.The improvement of vision might be faster with early IVC treatment than with delayed treatment. | Jing-Yi Bai Wen-Ying Wang Zhi-Zhi Dou Bo-Chao Geng Xiao-Yan Xu Yuan-Zhang Zhu Shan-Yao Zhao Min Liu Shao-You Jia Wen-Juan Luo | 2022 | International Journal of Ophthalmology(English edition)2022，15，3： | 1 |
| 14 | Association of a variant in MIR 196A2 with susceptibility to hepatocellular carcinoma in male Chinese patients with chronic hepatitis B virus infection显示文摘 | Qi P Dou TH Geng L | | 0，，06： | 1 |
| 15 | The four reprogramming factors and embryonic development in mice显示文摘 | Yan X.R Yu S.M Lei A.M Hua J.L Chen F.L Li L.W Xie X Yang X.Y Geng W.X and Dou Z.Y | | 0，，05： | 1 |
| 16 | Nuciferine alleviates collagen-induced arthritic in rats by inhibiting the proliferation and invasion of human arthritis-derived fibroblast-like synoviocytes and rectifying Th17/Treg imbalance显示文摘Rheumatoid arthritis(RA)is a chronic autoimmune disorder marked by persistent synovial inflammation and joint degradation,posing challenges in the development of effective treatments.Nuciferine,an alkaloid found in lotus leaf,has shown promising anti-inflammatory and anti-tumor effects,yet its efficacy in RA treatment remains unexplored.This study investigated the antiproliferative effects of nuciferine on the MH7A cell line,a human RA-derived fibroblast-like synoviocyte,revealing its ability to inhibit cell proliferation,promote apoptosis,induce apoptosis,and cause G1/S phase arrest.Additionally,nuciferine significantly reduced the migration and invasion capabilities of MH7A cells.The therapeutic potential of nuciferine was further evaluated in a collagen-induced arthritis(CIA)rat model,where it markedly alleviated joint swelling,synovial hyperplasia,cartilage injury,and inflammatory infiltration.Nuciferine also improved collagen-induced bone erosion,decreased pro-inflammatory cytokines and serum immunoglobulins(IgG,IgG1,IgG2a),and restored the balance between T helper(Th)17 and regulatory T cells in the spleen of CIA rats.These results indicate that nuciferine may offer therapeutic advantages for RA by decreasing the proliferation and invasiveness of FLS cells and correcting the Th17/Treg cell imbalance in CIA rats. | WANG Hao GENG Xiaolong AI Fangbin YU Zhilun ZHANG Yan ZHANG Beibei LV Cheng GAO Ruiyang YUE Bei DOU Wei | 2024 | Chinese Journal of Natural Medicines2024，22，4： | 0 |
| 17 | Association between polymorphisms in the human serotonin transporter gene and lifelong premature ejaculation in the Han population显示文摘 | Dang-Wei Peng Jing-Jing Gao Yuan-Yuan Huang Dong-Dong Tang Pan Gao Chao Li Wei-Qun Liu Xian-Ming Dou Jun Mao Yao Zhang Hao Geng Xian-Sheng Zhang | 2018 | Asian Journal of Andrology2018，20，1： | 0 |
| 18 | Single-cell transcriptome atlas reveals spatiotemporal developmental trajectories in the basal roots of moso bamboo (Phyllostachys edulis)显示文摘Roots are essential for plant growth and development.Bamboo is a large Poaceae perennial with 1642 species worldwide.However,little is known about the transcriptional atlas that underpins root cell-type differentiation.Here,we set up a modified protocol for protoplast preparation and report single-cell transcriptomes of 14279 filtered single cells derived from the basal root tips of moso bamboo.We identified four cell types and defined new cell-type-specific marker genes for the basal root.We reconstructed the developmental trajectories of the root cap,epidermis,and ground tissues and elucidated critical factors regulating cell fate determination.According to in situ hybridization and pseudotime trajectory analysis,the root cap and epidermis originated from a common initial cell lineage,revealing the particularity of bamboo basal root development.We further identified key regulatory factors for the differentiation of these cells and indicated divergent root developmental pathways between moso bamboo and rice.Additionally,PheWOX13a and PheWOX13b ectopically expressed in Arabidopsis inhibited primary root and lateral root growth and regulated the growth and development of the root cap,which was different from WOX13 orthologs in Arabidopsis.Taken together,our results offer an important resource for investigating the mechanism of root cell differentiation and root system architecture in perennial woody species of Bambusoideae. | Zhanchao Cheng Changhong Mu Xiangyu Li Wenlong Cheng Miaomiao Cai Chongyang Wu Jutang Jiang Hui Fang Yucong Bai Huifang Zheng Ruiman Geng Junlei Xu Yali Xie Yuping Dou Juan Li Shaohua Mu Jian Gao | 2023 | Horticulture Research2023，10，8： | 0 |
| 19 | A Compensation Algorithm for Large Element Characterizing the Damage Evolution Process and Its Application to Structure Collisions显示文摘When simulating the process from elastic–plastic deformation,damage to failure in a metal structure collision,it is necessary to use the large shell element due to the calculation efficiency,but this would affect the accuracy of damage evolution simulation.The compensation algorithm adjusting failure strain according to element size is usually used in the damage model to deal with the problem.In this paper,a new nonlinear compensation algorithm between failure strain and element size was proposed,which was incorporated in the damage model GISSMO(Generalized incremental stress state dependent damage model)to characterize ductile fracture.And associated material parameters were calibrated based on tensile experiments of aluminum alloy specimens with notches.Simulation and experimental results show that the new compensation algorithm significantly reduces the dependence of element size compared with the constant failure strain model and the damage model with the linear compensation algorithm.During the axial splitting process of a circular tubular structure,the new compensation algorithm keeps the failure prediction errors low over the stress states ranging from shear to biaxial tension,and achieves the objective prediction of the damage evolution process.This study demonstrates how the compensation algorithm resolves the contradiction between large element size and fracture prediction accuracy,and this facilitates the use of the damage model in ductile fracture prediction for engineering structures. | Wen Liu Lele Zhang Yifan Ru Geng Chen Weiyuan Dou | 2023 | Chinese Journal of Mechanical Engineering2023，36，1： | 0 |
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