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| 1 | Molecular organic geochemical peculiarities of lacustrine core sediments in Fildes Peninsula, King George Island, Antarctica显示文摘The peculiarities of lipids in lacustrine core sediments from Fildes Peninsula, King George Island, Antarctica, are reported. The origin of high-molecular-weight n-alkanes, alkenes, fatty acids, alcohols is supposed to be related to the abundant moss occurring in the sediments. Abundant iso- and ante/so-fatty acids that occur in the sediments indicate a relatively strong bacterial activity in non-ice-cover zone than in other regions in Antarctica. The C18:2 unsaturated fatty acids mainly originate from autochthonous algae in the sediment pool, and the C18:2/C18:0 ratios in the profile are controlled more by paleotemperatures than source assemblies. Long-chain alkenones were identified in freshwater lacustrine sediment in Antarctica for the first time, of which Prymnesiophyceae is assumed to be the source organism. High relative abundance of C37:4 homologue in long-chain alkenone well correlates to the severely cold climate in Antarctica. | ZHANG Gan SHENG Guoying PENG Ping’an ZHENG Honghan | 2000 | Chinese Science Bulletin2000，45，S1： | 13 |
| 2 | Phosphorylcholine polymer nanocapsules prolong the circulation time and reduce the immunogenicity of therapeutic proteins显示文摘蛋白质治疗,治疗学的蛋白质在那里被交付对待混乱,为治疗疾病被认为最安全、很直接的途径。然而,它的应用被有效策略的少量高度为在他们的管理以后在 vivo 交付蛋白质和治疗学的蛋白质的快速的清理限制。这里,我们表明能显著地延长治疗学的蛋白质的发行量时间以及最小化他们的 immunogenicity 的新奇策略。这被与抵抗蛋白质吸附的 crosslinked phosphorylcholine 聚合物的薄层包含单个蛋白质分子完成。通过广泛的细胞的研究,我们证明 crosslinked phosphorylcholine 聚合物壳有效地阻止包含的蛋白质是由巨噬细胞的 phagocytosed,它在 vivo 在 nanoparticles 的清理起一个必要作用。而且,聚合物壳阻止包含的蛋白质被有免疫力的房间识别。作为结果,对治疗学的蛋白质的有免疫力的回答有效地被压制。这个工作描述一个可行方法延长循环时间并且减少治疗学的蛋白质的 immunogenicity,它可以在多样的疾病的治疗支持新奇蛋白质治疗的发展和申请。 | Sheng Liang Yang Liu Xin Jin Gan Liu Jing Wen Linlin Zhang Jie Li Xubo Yuan Irvin S.Y. Chen Wei Chen Hui Wang Linqi Shi Xinyuan Zhu Yunfeng Lu | 2016 | Nano Research2016，9，4： | 11 |
| 3 | Chemical and structural biology of nucleic acids and protein-nucleic acid complexes for novel drug discovery显示文摘Since nucleic acids(DNA and RNA) play very important roles in cells,they are molecular targets of many clinically used drugs,such as anticancer drugs and antibiotics.Because of clinical demands for treating various deadly cancers and drug-resistant strains of pathogens,there are urgent needs to develop novel therapeutic agents.Targeting nucleic acids hasn’t been the mainstream of drug discovery in the past,and the lack of 3D structural information for designing and developing drug specificity is one of the main reasons.Fortunately,many important structures of nucleic acids and their protein complexes have been determined over the past decade,which provide novel platforms for future drug design and discovery.In this review,we describe some useful nucleic acid structures,particularly their interactions with the ligands and therapeutic candidates or even drugs.We summarize important information for designing novel potent drugs and for targeting nucleic acids and protein-nucleic acid complexes to treat cancers and overcome the drug-resistant problems. | GAN JianHua SHENG Jia HUANG Zhen | 2011 | Science China Chemistry2011，54，1： | 9 |
| 4 | Blood Pressure Associated with Arsenic Methylation and Arsenic Metabolism Caused by Chronic Exposure to Arsenic in Tube Well Water显示文摘Objective The effects of arsenic exposure from drinking water, arsenic metabolism, and arsenic methylation on blood pressure(BP) were observed in this study. Methods The BP and arsenic species of 560 participants were determined. Logistic regression analysis was applied to estimate the odds ratios of BP associated with arsenic metabolites and arsenic methylation capability. Results BP was positively associated with cumulative arsenic exposure(CAE). Subjects with abnormal diastolic blood pressure(DBP), systolic blood pressure(SBP), and pulse pressure(PP) usually had higher urinary i As(inorganic arsenic), MMA(monomethylated arsenic), DMA(dimethylated arsenic), and TAs(total arsenic) than subjects with normal DBP, SBP, and PP. The i As%, MMA%, and DMA% differed slightly between subjects with abnormal BP and those with normal BP. The PMI and SMI were slightly higher in subjects with abnormal PP than in those with normal PP. Conclusion Our findings suggest that higher CAE may elevate BP. Males may have a higher risk of abnormal DBP, whereas females have a higher risk of abnormal SBP and PP. Higher urinary i As may increase the risk of abnormal BP. Lower PMI may elevate the BP. However, higher SMI may increase the DBP and SBP, and lower SMI may elevate the PP. | WEI Bing Gan YE Bi Xiong YU Jiang Ping YANG Lin Sheng LI Hai Rong XIA Ya Juan WU Ke Gong | 2017 | Biomedical and Environmental Sciences2017，30，5： | 9 |
| 5 | Involvement of the Mitochondrion-dependent and the Endoplasmic Reticulum Stress-signaling Pathways in Isoliquiritigenin-induced Apoptosis of HeLa Cell显示文摘Objective Isoliquiritigenin(ISL),a licorice chalconoid,is considered to be a bioactive agent with chemopreventive potential.This study investigates the mechanisms involved in ISL-induced apoptosis in human cervical carcinoma HeLa cells.Methods Cell viability was evaluated using a 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl-tetrazolium bromide(MTT)assay.Apoptosis was determined by flow cytometry using an Annexin V-FITC Apoptosis Detection Kit.The intracellular ROS levels were assessed using a 2,7-dichlorofluorescein probe assay.The mitochondrial membrane potential was measured with the dual-emission potential-sensitive probe 5,5',6,6'-tetra-chloro-1,1',3,3'-tetraethyl-imidacarbocyanine iodide(JC-1).The degradation of poly-ADP-ribose polymerase(PARP)protein,the phosphorylation of PKR-like ER kinase(PERK),the phosphorylation of the α-subunit of eukaryotic initiation factor 2(eIF2α),the expression of the 78 kD glucose-regulated protein(GRP 78),and the activation of caspase-12 were analyzed via western blot analysis.Results ISL significantly inhibited the proliferation,the increase in ROS levels and apoptotic rates of HeLa cells in a concentration-dependent manner.Moreover,ISL induced mitochondrial dysfunction,caspase activation,and PARP cleavage,which displayed features of mitochondria dependent on apoptotic signals.Besides,exposure of HeLa cells to ISL triggered endoplasmic reticulum(ER)stress,as indicated by the increase in p-eIF2α and GRP78 expression,ER stress-dependent apoptosis is caused by the activation of ER-specific caspase-12.Conclusion The findings from our study suggest that ISL-induced oxidative stress causes HeLa cell apoptosis via the mitochondrion-dependent and the ER stress-triggered signaling pathways. | YUAN Xuan ZHANG Bo GAN Lu WANG Zhen Hua YU Ba Cui LIU Liang Liang ZHENG Qiu Sheng WANGZhi Ping | 2013 | Biomedical and Environmental Sciences2013，26，4： | 8 |
| 6 | An ion-imprinted polymer supported by attapulgite with a chitosan incorporated sol-gel process for selective separation of Ce(Ⅲ)显示文摘The surface ion-imprinting concept and chitosan incorporated sol-gel process were applied to the synthesis of a new attapulgitesupported polymer for selective separation of Ce(Ⅲ) from aqueous solution.The imprinting mechanism of prepared ion-imprinted polymer were discussed with the Characteristics of FT-IR and SEM.Results from the experiments of adsorption capacity and selectivity suggested that ion-imprinted polymer offered a fast kinetics for the adsorption of Ce(Ⅲ) under the optimum conditions. Its maximum adsorption capacity was 38.02 mg/g,and the selective recognition towards Ce(Ⅲ) was much higher than that of the non-imprinted polymer and attapulgite.The prepared functional polymer was shown to be promising for selective separation and enrichment of trace Ce(Ⅲ) in environmental samples. | Chun Xiang Li Jian Ming Pan Jie Gao Yong Sheng Yan Gan Qing Zhao | 2009 | Chinese Chemical Letters2009，20，8： | 6 |
| 7 | 间歇性多西他赛联合比卡鲁胺治疗去势抵抗性前列腺癌的前瞻性历史对照研究显示文摘持续性多西他赛(DTX)方案在权衡其疗效及生活质量后是否优于间歇性多西他赛治疗去势抵抗性前列腺癌(CRPC)目前尚不清楚。本研究我们对间歇性每三周DTX联合比卡鲁胺治疗CPPC疗效,安全性及生活质量(QoL)进行了评估。A组纳入42例CRPC患者,三周一次给予静脉DTX(75mg m^-2)联合口服比卡鲁胺(50mg,每日一次)。当血清PSA〉50%并伴随稳定影像学证据时,患者进入化疗休息期(停用DXT),一旦出现PSA〉25%或出现其它疾病进展的依据时化疗休息期中止,再次给予DXT化疗,当达到上述标准时化疗休息期不限。B组纳入60例行持续性多西他赛化疗CRPC进行回顾性分析。A组中位PSA无进展时间(8 vs.9个月,P=0.866)及中位总体生存时间(19 vs.21个月,P=0.753)与B组比较无显著统计学差异。A组发生所有级别的粒细胞减少症(33% vs.58%,P=0.013)及恶心/呕吐(11% vs.29%,P=0.024)明显低于B组,A组化疗后总体健康水平及疲劳方面评分与化疗前比较有显著改善(P〈0.05),B组在化疗后与化疗前比较显著增加疲劳、恶心/呕吐及厌食评分俨〈O.05)。间歇性三周一次DXT联合比卡鲁胺治疗去势抵抗性前列腺癌是安全的,能达到与持续性化疗相当的疗效,并可能伴有更好的生活质量。 | Yun-Fei Li Shao-Feng Zhang Tao-Tao Zhang Lei Li Wei Gan Hong-Tao Jia Sheng Xie Hui-Hua Ji Da-Lin He | 2013 | Asian Journal of Andrology2013，15，6： | 5 |
| 8 | Garcinia xanthochymus extract protects PC12 cells from H2O2-induced apoptosis through modulation of PI3K/AKT and NRF2/HO-1 pathways显示文摘The aim of the present study was to investigate the protective effects and underlying mechanisms of Garcinia xanthochymus, a perennial medicinal plant native to Yunnan, China, against H2 O2-induced oxidative damage in rat pheochromacytoma PC12 cells. Preincubation of PC12 cells with fruit Et OAc fraction(fruit-EFr., 12.5–50 μmol·L^(-1)) of G. xanthochymus for 24 h prior to H_2O_2 exposure markedly improved cell viability and increased the activities of antioxidant enzymes(superoxide dismutase, catalase, and heme oxygenase-1 [HO-1]), prevented lactate dehydrogenase release and lipid peroxidation malondialdehyde production, attenuated the decrease of matrix metalloproteinases(MMP), and scavenged reactive oxygen species(ROS). Fruit-EFr. also reduced BAX and cytochrome C expression and improved BCL-2 expression, thereby decreasing the ratio of BAX to BCL-2. Fruit-EFr. activated the nuclear translocation of NRF2 to increase HO-1 and induced the phosphorylation of AKT. Its cytoprotective effect was abolished by LY294002, a specific inhibitor of PI3 K. Taken together, the above findings suggested that fruit-EFr.of G. xanthochymus could enhance cellular antioxidant defense capacity, at least in part, through upregulating HO-1 expression and activating the PI3 K/AKT pathway and that it could suppress H_2O_2-induced oxidative damage via PI3 K/AKT and NRF2/HO-1 signaling pathways. | XU Jing GAN Sheng LI Jun WAND De-Bing CHEN Yu HU Xin YANG Guang-Zhong | 2017 | Chinese Journal of Natural Medicines2017，15，11： | 5 |
| 9 | Bridge Continuous Deformation Measurement Technology Based on Fiber Optic Gyro显示文摘桥牌是现代交通系统的重要部分,变丑是为桥安全评估的一个关键索引。为了完成长跨度桥,很快弄弯测量并且及时并且精确地定位桥最大值变丑,连续变丑测量系统(CDMS ) 在这基于惯性的站台被介绍并且验证纸。第一基于各种各样的桥变丑测量方法,变丑测量的方法基于纤维,眼的旋转罗盘(雾) 被介绍。第二,基本测量原则基于雾被介绍,连续曲线轨道被公式导出。然后,测量精确性在理论被分析,相关因素被介绍保证测量精确性。最后,变丑测量实验越过长江在一座桥上被进行。试验性的结果证明介绍变丑测量方法可行、实际、可靠;系统能精确地并且快速定位最大的变丑并且有广泛、宽广的应用程序前景。 | Weibing GAN Wenbin HU Fang LIU Jianguang TANG Sheng LI Yan YANG | 2016 | Photonic Sensors2016，6，1： | 4 |
| 10 | Prolonging the plasma circulation of proteins by nano- encapsulation with phosphorylcholine-based polymer显示文摘突然在 vivo 循环是到蛋白质治疗学的普遍采纳的一个主要阻碍者。经由显著地展出的一个二拍子的圆舞封装过程与基于 phosphorylcholine 的聚合物的薄层包含蛋白质产生的蛋白质 nanocapsules 延长了血浆半衰期。而且,由与类似的尺寸构造 nanocapsules 但是不同表面费用和化学,我们为延长治疗学的蛋白质的血浆半衰期表明了通用策略。在里面一在里面 vitro 实验,牛的浆液白朊(BSA ) 的四种类型 nanocapsules 在磷酸盐缓冲区与胎儿的牛的浆液(FBS ) 被孵化盐(PBS ) ;由 HeLa 房间的房间举起被监视系统地在循环期间评估表面化学的特征。单个正电子排放计算断层摄影术的断层摄影术(SPECT ) 被采用在静脉内的管理以后在血浆集中的 vivo,以及 quantification 允许 BSA nanoparticle 分发的即时观察。这研究为为临床的使用翻译大量蛋白质提供一个实际方法。 | Linlin Zhang Yang Liu Gan Liu Duo Xu Sheng Liang Xinyuan Zhu Yunfeng Lu Hui Wang | 2016 | Nano Research2016，9，8： | 4 |
| 11 | Delta Shocks and Vacuum States in Vanishing Pressure Limits of Solutions to the Relativistic Euler Equations显示文摘The Riemann problems for the Euler system of conservation laws of energy and momentum in special relativity as pressure vanishes are considered. The Riemann solutions for the pressureless relativistic Euler equations are obtained constructively. There are two kinds of solutions, the one involves delta shock wave and the other involves vacuum. The authors prove that these two kinds of solutions are the limits of the solutions as pressure vanishes in the Euler system of conservation laws of energy and momentum in special relativity. | Gan YIN Wancheng SHENG | 2008 | Chinese Annals of Mathematics,Series B2008，29，6： | 4 |
| 12 | Progress of Jinping Underground laboratory for Nuclear Astrophysics(JUNA)显示文摘Jinping Underground laboratory for Nuclear Astrophysics(JUNA) will take the advantage of the ultra-low background of CJPL lab and high current accelerator based on an ECR source and a highly sensitive detector to directly study for the first time a number of crucial reactions occurring at their relevant stellar energies during the evolution of hydrostatic stars. In its first phase, JUNA aims at the direct measurements of^(25)Mg(p,γ)^(26)Al,^(19)F(p,α)^(16)O,^(13)C(α,n)^(16)O and ^(12)C(α,γ)^(16)O reactions. The experimental setup,which includes an accelerator system with high stability and high intensity, a detector system, and a shielding material with low background, will be established during the above research. The current progress of JUNA will be given. | WeiPing Liu ZhiHong Li JiangJun He XiaoDong Tang Gang Lian Zhu An JianJun Chang Han Chen QingHao Chen XiongJun Chen ZhiJun Chen BaoQun Cui XianChao Du ChangBo Fu Lin Gan Bing Guo GuoZhu He Alexander Heger SuQing Hou HanXiong Huang Ning Huang BaoLu Jia LiYang Jiang Shigeru Kubono JianMin Li KuoAng Li Tao Li YunJu Li Maria Lugaro XiaoBing Luo HongYi Ma ShaoBo Ma DongMing Mei YongZhong Qian JiuChang Qin Jie Ren YangPing Shen Jun Su LiangTing Sun WanPeng Tan Isao Tanihata Shuo Wang Peng Wang YouBao Wang Qi Wu ShiWei Xu ShengQuan Yan LiTao Yang Yao Yang XiangQing Yu Qian Yue Sheng Zeng HuanYu Zhang Hui Zhang LiYong Zhang NingTao Zhang QiWei Zhang Tao Zhang XiaoPeng Zhang XueZhen Zhang ZiMing Zhang Wei Zhao Zuo Zhao Chao Zhou | 2016 | Science China(Physics,Mechanics & Astronomy)2016，59，4： | 3 |
| 13 | Analysis of Clinical Risk Factors Associated With the Prognosis of Severe Multiple-Trauma Patients With Acute Lung Injury显示文摘 | Junsong Wu Lei Sheng Shenhua Wang Qiang Li Mao Zhang Shaowen Xu Jianxin Gan | 2012 | Journal of Emergency Medicine2012，，3： | 2 |
| 14 | Parametrization of woods-saxon potential for heavy-ion systems显示文摘Several elastic scattering angular distributions of ^(12)C from target nuclei of A ≥39 are analyzed to extract the Woods-Saxon potential parameters with the fixed imaginary potential and Coulomb radius parameters.Using the best fitted diffuseness parameters,the correlations of the real part parameters with A_1^(1/3)+ A_2^(1/3) and incident energy are revealed, and the systematic Woods-Saxon potential parameters are presented for nucleus-nucleus interaction.The proposed potential parameters can reproduce not only the elastic scattering angular distributions induced by ^(12)C,but also many elastic scattering angular distributions induced by the projectiles other than ^(12)C,thus providing important inputs for the study of nuclear reactions of heavy-ion systems. | Lin Gan ZhiHong Li HuiBin Sun DanYang Pang Bing Guo YunJu Li Jun Su ShengQuan Yan ErTao Li YouBao Wang Gang Lian ZhiYu Han XinYue Li DongHui Li TianLi Ma ChangJin Pei YangPing Shen Yi Su Sheng Zeng Yong Zhou WeiPing Liu | 2017 | Science China(Physics,Mechanics & Astronomy)2017，60，8： | 2 |
| 15 | The Study of a Micro Channel Integrated Gas Flow Sensor显示文摘 | YU Bolin GAN Zhiyin XU Jingping LIU Sheng | 2009 | Chinese Journal of Electronics2009，18，3： | 2 |
| 16 | Transferrin plays a central role in coagulation balance by interacting with clotting factors显示文摘Coagulation balance is maintained through fine-tuned interactions among clotting factors,whose physiological concentrations vary substantially.In particular,the concentrations of coagulation proteases(pM to nM)are much lower than their natural inactivator antithrombin(AT,〜3μM),suggesting the existence of other coordinators.In the current study,we found that transferrin(norm plasma concentration〜40 μM)interacts with fibrinogen,thrombin,factor Xlla(FXlla),and AT with different affinity to maintain coagulation balance.Normally,transferrin is sequestered by binding with fibrinogen(normal plasma concentration〜10 μM)at a molar ratio of 4:1.In atherosclerosis,abnormally up-regulated transferrin interacts with and potentiates thrombin/FXlla and blocks ATs inactivation effect on coagulation proteases by binding to AT,thus inducing hypercoagulability.In the mouse model,transferrin overexpression aggravated atherosclerosis,whereas transferrin inhibition via shRNA knockdown or treatment with antitransferrin antibody or designed peptides interfering with transferrin-thrombin/FXlla interactions alleviated atherosclerosis.Collectively,these findings identify that transferrin is an important clotting regulator and an adjuster in the maintenance of coagulation balance and modifies the coagulation cascade. | Xiaopeng Tang Zhiye Zhang Mingqian Fang Yajun Han Gan Wang Sheng Wang Min Xue Yaxiong Li Li Zhang Jian Wu Biqing Yang James Mwangi Qiumin Lu Xiaoping Du Ren Lai | 2020 | Cell Research2020，30，2： | 2 |
| 17 | Two new ar-bisabol sesquiterpenes from the stem bark of Fraxinus sielboldiana显示文摘Two new ar-bisabol sequiterpenes,(+)-(7S,10S)-10-epi-7,10-epoxy-3-hydroxy-ar-bisabol-11-ol(1)and(+)-(7R,8R,10S)-10-epi-7,10-epoxy-8-hydroxy-ar-bisabol-11-ol(2),have been isolated by a combination of various column chromatographic techniques including reversed-phase semipreparative HPLC from an ethanol extract of the stem bark of Fraxinus sielboldiana.Their structures were determined by spectroscopic methods including IR,MS,and 1D and 2D NMR experiments.This is the first report of sequiterpenes in the genus Fraxinus. | Sheng Lin Yan-ling Zhang Ming-tao Liu Jia-chen Zi Mao-luo Gan Wei-xia Song Xiao-na Fan Su-juan Wang Yong-chun Yang Jian-gong Shi | 2011 | Acta Pharmaceutica Sinica B2011，1，2： | 2 |
| 18 | Diagnosis,treatment,and prevention of severe acute hepatitis of unknown etiology in children显示文摘Background Severe acute hepatitis of unknown etiology in children has recently exhibited a global trend of concentrated occurrence.This review aimed to summarize the current available information regarding the outbreak of severe acute hepatitis and introduce our hospital’s previous experiences with the diagnosis and treatment of severe acute hepatitis for reference.Data sources Websites including the UK Health Security Agency,European Centre for Disease Prevention and Control,CDC,WHO,and databases including PubMed/Medline,Cochrane Library,Embase and Web of Science were searched for articles on severe acute hepatitis in children.Results As of May 26,2022,a total of 650 cases have been reported in 33 countries;at least 38(6%)children required liver transplantation,and nine(1%)died.Cases are predominantly aged between 3 and 5 years old,and there are no epidemiological links among them.The common manifestations are jaundice,vomiting and pale stools.Adenovirus tested positive in most cases,and SARS-CoV-2 and other viruses were detected in a few cases,but virus particles were not found in liver tissue.Adenovirus immunohistochemistry showed immunoreactivity in the intrasinusoidal lumen from some liver samples.The hierarchical treatment includes symptomatic and supportive therapy,management of coagulation disorders and hepatic encephalopathy,artifcial liver support,and liver transplantation(approximately 6%–10%of cases require liver transplant).Conclusions The etiology of this severe acute hepatitis in children is not clear.The clinical features are severe acute hepatitis with signifcantly elevated liver enzymes.Clinicians need to be alert to children with hepatitis. | Ying‑Hu Chen Jin‑Gan Lou Zi‑Hao Yang Qing‑Jiang Chen Chun‑Zhen Hua Sheng Ye Chen‑Mei Zhang Jie Chen Zong‑Wei Huang Jin‑Dan Yu Zhi‑Gang Gao Qiang Shu | 2022 | World Journal of Pediatrics2022，18，8： | 2 |
| 19 | Hepatic arterial infusion chemotherapy and embolization in the treatment of primary hepatic carcinoma显示文摘HepaticarterialinfusionchemotherapyandembolizationinthetreatmentofprimaryhepaticcarcinomaZHENGChuanSheng,FENGGanSheng,ZHO... | ZHENG Chuan Sheng, FENG Gan Sheng, ZHOU Ru Ming, LIANG Bo, LIANG Hui Min, ZHEN Jun, YU Jian Ming and LIU Hui | 1997 | World Journal of Gastroenterology1997，3，2： | 2 |
| 20 | Persistent organic pollutants in environment of the Pearl River Delta, China: an overview显示文摘 | Jiamo Fu Bixian Mai Guoying Sheng Gan Zhang Xinming Wang Ping’an Peng Xianming Xiao Rong Ran Fanzhong Cheng Xianzhi Peng Zhishi Wang U Wa Tang | 2003 | Chemosphere2003，，9： | 2 |
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