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| 1 | Anti-SARS-CoV-2 activities in vitro of Shuanghuanglian preparations and bioactive ingredients显示文摘Human infection with severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)causes coronavirus disease 2019(COVID-19)and there is no cure currently.The 3CL protease(3CLpro)is a highly conserved protease which is indispensable for CoVs replication,and is a promising target for development of broad-spectrum antiviral drugs.In this study we investigated the anti-SARS-CoV-2 potential of Shuanghuanglian preparation,a Chinese traditional patent medicine with a long history for treating respiratory tract infection in China.We showed that either the oral liquid of Shuanghuanglian,the lyophilized powder of Shuanghuanglian for injection or their bioactive components dose-dependently inhibited SARS-CoV-23CLpro as well as the replication of SARS-CoV-2 in Vero E6 cells.Baicalin and baicalein,two ingredients of Shuanghuanglian,were characterized as the first noncovalent,nonpeptidomimetic inhibitors of SARS-CoV-23CLpro and exhibited potent antiviral activities in a cell-based system.Remarkably,the binding mode of baicalein with SARS-CoV-23CLpro determined by X-ray protein crystallography was distinctly different from those of known 3CLpro inhibitors.Baicalein was productively ensconced in the core of the substrate-binding pocket by interacting with two catalytic residues,the crucial S1/S2 subsites and the oxyanion loop,acting as a“shield”in front of the catalytic dyad to effectively prevent substrate access to the catalytic dyad within the active site.Overall,this study provides an example for exploring the in vitro potency of Chinese traditional patent medicines and effectively identifying bioactive ingredients toward a specific target,and gains evidence supporting the in vivo studies of Shuanghuanglian oral liquid as well as two natural products for COVID-19 treatment. | Hai-xia Su Sheng Yao Wen-feng Zhao Min-jun Li Jia Liu Wei-juan Shang Hang Xie Chang-qiang Ke Hang-chen Hu Mei-na Gao Kun-qian Yu Hong Liu Jing-shan Shen Wei Tang Lei-ke Zhang Geng-fu Xiao Li Ni Dao-wen Wang Jian-ping Zuo Hua-liang Jiang Fang Bai Yan Wu Yang Ye Ye-chun Xu | 2020 | Acta Pharmacologica Sinica2020，41，9： | 32 |
| 2 | Influences of enteral nutrition combined with probiotics on gut microflora and barrier function of rats with abdominal infection显示文摘瞄准:为了调查肠内的的、非肠道的营养和专业版的影响,生命学与腹的感染在肠的微生态学,上皮的紧密的连接,免疫者和老鼠的障碍功能上由内脏交付了。方法:与盲肠的结扎和穿孔方法建立的老鼠腹的感染模型,被划分成三个组:非肠道的营养(PN 组, n = 7 ) , PN+enteral 营养(在组, n = 7 ) 并且在 + 职业人员生命学的 PN +( 职业人员生命学组, n = 7 ) 经由为五天的针空肠造口术和颈静脉。三个组的全部的营养的补充是 isonitrogenic 和 isocaloric。Probiotics 被空肠造口术交付 10 mL/d (1 x 10 (8 ) cfu/mL ) 。老鼠在第六天被打死。在盲肠的排汇物为厌氧的细菌的生长是有教养的并且与随机的放大多态的 DNA 与细菌的组 DNA 指纹侧面分析了。transmembrane 绑定蛋白质(occludin ) 和在在冒号和终端回肠的肠上皮的浆细胞的 IgA 水平被一个免疫组织化学方法测量。在冒号和小肠的肠的上皮的紧密的连接的超微结构被电子显微镜学观察。维纳腔血和肝,肺和 mes 伤寒淋巴结的 homogenated 织物是有教养的决定细菌的 translocations,并且在从门静脉的血的内毒素被检测。结果:(1 ) 内脏种类在的细菌的数量在组和职业人员,关於生命的组在 PN 是比那高级的组。DNA 侧面在在组和职业人员,关於生命的组类似于正常老鼠的。在职业人员生命学组的 DNA 侧面的数字在 PN 组并且在组是多于那的大部分。而且,在 PN 有奇怪的条纹组。( 2 ) occludin 和 IgA 在的表示小并且大肠在在组( 2.309 +/- 0.336 , 15.440 +/- 2.383 )并且专业版关於生命的组( 2.938 +/- 0.515 , 16.230 +/- 3.183 )作为与 PN 组相比被改进( 1.207 +/- 0.587 , P <
0.05 , 11.189 +/- 2.108 , P <
0.01 )。在专业版的 occludin 的表达式关於生命的组(肠:2.93 +/- 0.515;盲肠:3.40 +/- 0.617 ) 比那高在在组(肠:2.309 +/- 0.336;盲肠:2.076 +/- 0.670;P <
0.05 ) 。IgA 的表示,在特别在组(肠:15.440 +/- 2.383 ) 并且在组关於生命的专业版(大肠:12.516 +/- 1.542 ) 显著地作为与 PN 组相比增加了(肠:11.189 +/- 2.108;盲肠:10.160 +/- 1.643;P<0.01 ) 。肠的上皮的紧密的连接和职业人员的微绒毛关於生命的组是比在 PN 组的那些更未经触动的。( 3 )在内毒素的血,肝,肺和 mes 伤寒淋巴节点,和层次的细菌的 translocations 显著地在专业版被减少关於生命( 0.082 +/- 0.029 )并且在( 0.125 +/- 0.040 )作为与 PN 组相比组织( 0.403 +/- 0.181 , P <
0.05 )。结论:申请在与专业版生命学结合了能改进 transmembrane 绑定蛋白质(occludin ) 和 IgA 的表达式,改正肠内菌丛骚乱,维持内脏障碍函数和紧密的连接,并且减少出现毁坏细菌的易位。 | Tong-Yi Shen Huan-Long Qin Zhi-Guang Gao Xiao-Bing Fan Xiao-Ming Hang Yan-Qun Jiang | 2006 | World Journal of Gastroenterology2006，12，27： | 22 |
| 3 | MECHANICAL-ELECTRIC COUPLING DYNAMICAL CHARACTERISTICS OF AN ULTRA-HIGH SPEED GRINDING MOTORIZED SPINDLE SYSTEM显示文摘On the basis of the traditional mechanical model of a grinding wheel rotor and the mechanical-electric coupling model with ideal sinusoidal supply,taking high-frequency converting current of inverter power switches into further consideration,a modified mechanical-electric coupling model is created.The created model consists of an inverter,a motorized spindle,a grinding wheel and grinding loads.Some typical non-stationary processes of the grinding system with two different supplies,including the starting,the speed rising and the break in grinding loads,are compared by making use of the created model.One supply is an ideal sinusoida]voltage source,the other is an inverter.The theoretical analysis of the high-order harmonic is also compared with the experimental result.The material strategy of suppressing high-order harmonic mechanical-electric coupling vibration by optimizing inverter operating parameters is proposed. | LUE Lang XIONG Wanli GAO Hang | 2008 | Chinese Journal of Mechanical Engineering2008，21，5： | 23 |
| 4 | Efficacy of Add-on Montelukast in Nonasthmatic Eosinophilic Bronchitis: The Additive Effect on Airway Inflammation, Cough and Life Quality显示文摘 | Wuping Bao Ping Liu Zhongmin Qiu Li Yu Jingqing Hang Xiaohua Gao Xin Zhou | 2015 | Chinese Medical Journal2015，，1： | 19 |
| 5 | Collagen type Ⅱ suppresses articular chondrocyte hypertrophy and osteoarthritis progression by promoting integrin β1-SMAD1 interaction显示文摘Hypertrophic differentiation is not only the terminal process of endochondral ossification in the growth plate but is also an important pathological change in osteoarthritic cartilage.Collagen type II(COL2A1)was previously considered to be only a structural component of the cartilage matrix,but recently,it has been revealed to be an extracellular signaling molecule that can significantly suppress chondrocyte hypertrophy.However,the mechanisms by which COL2A1 regulates hypertrophic differentiation remain unclear.In our study,a Col2a1 p.Gly1170Ser mutant mouse model was constructed,and Col2a1 loss was demonstrated in homozygotes.Loss of Col2a1 was found to accelerate chondrocyte hypertrophy through the bone morphogenetic protein(BMP)-SMAD1 pathway.Upon interacting with COL2A1,integrinβ1(ITGB1),the major receptor for COL2A1,competed with BMP receptors for binding to SMAD1 and then inhibited SMAD1 activation and nuclear import.COL2A1 could also activate ITGB1-induced ERK1/2 phosphorylation and,through ERK1/2-SMAD1 interaction,it further repressed SMAD1 activation,thus inhibiting BMP-SMAD1-mediated chondrocyte hypertrophy.Moreover,COL2A1 expression was downregulated,while chondrocyte hypertrophic markers and BMP-SMAD1 signaling activity were upregulated in degenerative human articular cartilage.Our study reveals novel mechanisms for the inhibition of chondrocyte hypertrophy by COL2A1 and suggests that the degradation and decrease in COL2A1 might initiate and promote osteoarthritis progression. | Chengjie Lian Xudong Wang Xianjian Qiu Zizhao Wu Bo Gao Lei Liu Guoyan Liang Hang Zhou Xiaoming Yang Yan Peng Anjing Liang Caixia Xu Dongsheng Huang Peiqiang Su | 2019 | Bone Research2019，7，1： | 17 |
| 6 | Oral berberine improves brain dopa/dopamine levels to ameliorate Parkinson’s disease by regulating gut microbiota显示文摘The phenylalanine-tyrosine-dopa-dopamine pathway provides dopamine to the brain.Iin this process,tyrosine hydroxylase(TH)isthe rate-limiting enzyme that hydroxylates tyrosine and generates levodopa(L-dopa)with tetranydrobiopterin(BH_(4))as a coenzyme.Here,we show that oral berberine(BBR)might supply H^(·) through dihydroberberine(reduced BBR produced by bacterial nitroreductase)and promote the production of BHl from dihydrobiopterin;the increased BH,enhances TH activity,which accelerates the production of L-dopa by the gut bacteria.Oral BBR acts in a way similar to vitamins.The L-dopa produced by theintestinal bacteria enters the brain through the circulation and is transformed to dopamine.To verify the gut-brain dialog activatedby BBR's effect,Enterococcus foecalis or Enterococcus faecium was transplanted into Parkinson's disease(PD)mice.The bacteriasignificantly increased brain dopamine and ameliorated PD manifestation in mice;additionally,combination of BBR with bacteriashowed better therapeutic effect than that with bacteria alone.Moreover,2,4,6-trimethy-pyranylium tetrafluoroborate(TMP-TFB)-derivatized matrix-assisted laser desorption mass spectrometry(MALDI-MS)imaging of dopamine identihed elevated striataldopamine levels in mouse brains with oral Enterococcus,and BBR strengthened the imaging intensity of brain dopamine.Theseresults demonstrated that BBR was an agonist of TH in Enterococcus and could lead to the production of L-dopa in the gut.Furthermore,a study of 28 patients with hyperlipidemia conhrmed that oral BBR increased bloodfecal L-dopa by the intestinalbacteria.Hence,BBR might improve the brain function by upregulating the biosynthesis of-dopa in the gut microbiota through avitamin-like effect. | Yan Wang Qian Tong Shu-Rong Ma Zhen-Xiong Zhao Li-Bin Pan Lin Cong Pei Han Ran Peng Hang Yu Yuan Lin Tian-Le Gao Jia-Wen Shou Xiao-Yang Li Xian-Feng Zhang Zheng-Wei Zhang Jie Fu Bao-Ying Wen Jin-Bo Yu Xuetao Cao Jian-Dong Jiang | 2021 | Signal Transduction and Targeted Therapy2021，6，3： | 16 |
| 7 | Machining the Integral Impeller and Blisk of Aero-Engines:A Review of Surface Finishing and Strengthening Technologies显示文摘The integral impeller and blisk of an aero-engine are high performance parts with complex structure and made of difficult-to-cut materials. The blade surfaces of the integral impeller and blisk are functional surfaces for power transmission, and their surface integrity has significant effects on the aerodynamic efficiency and service life of an aero-engine. Thus, it is indispensable to finish and strengthen the blades before use. This paper presents a comprehensive literature review of studies on finishing and strengthening technologies for the impeller and blisk of aero-engines. The review includes independent and integrated finishing and strengthening technologies and discusses advanced rotational abrasive flow machining with back-pressure used for finishing the integral impeller and blisk. A brief assessment of future research problems and directions is also presented. | Youzhi Fu Hang Gao Xuanping Wang Dongming Guo | 2017 | Chinese Journal of Mechanical Engineering2017，30，3： | 15 |
| 8 | The HuangZaoSi Maize Genome Provides Insights into Genomic Variation and Improvement History of Maize显示文摘Maize is a globally important crop that was a classic model plant for genetic studies. Here, we report a 2.2 Gb draft genome sequence of an elite maize line, HuangZaoSi (HZS). Hybrids bred from HZS-improved lines (HILs) are planted in more than 60% of maize fields in China. Proteome clustering of six completed sequeneed maize genomes show that 638 proteins fall into 264 HZS-specific gene families with the majority of contributions from tandem duplication events. Resequencing and comparative analysis of 40 HZSrelated lines reveals the breeding history of HILs. More than 60% of identified selective sweeps were clustered in identity.by.descent conserved regions, and yield-related genes/QTLs were enriched in HZS characteristic selected regions. Furthermore, we dem on strated that HZS-specific family genes were not uniformly distributed in the genome but enriched in improvement/function.related genomic regions. This study provides an important and novel resource for maize genome research and expands our knowledge on the breadth of genomic variation and improvement history of maize. | Chunhui Li Wei Song Yingfeng Luo Shenghan Gao Ruyang Zhang Zi Shi Xiaqing Wang Ronghuan Wang Fengge Wang Jidong Wang Yanxin Zhao Aiguo Su Shuai Wang Xin Li Meijie Luo Shuaishuai Wang Yunxia Zhang Jianrong Ge Xinyu Tan Ye Yuan Xiaochun Bi Hang He Jianbing Yan Yuandong Wang Songnian Hu Jiuran Zhao | 2019 | Molecular Plant2019，12，3： | 15 |
| 9 | Allyl isothiocyanate ameliorates lipid accumulation and inflammation in nonalcoholic fatty liver disease via the Sirt1/AMPK and NF-κB signaling pathways显示文摘BACKGROUND Allyl isothiocyanate(AITC),a classic anti-inflammatory and antitumorigenic agent,was recently identified as a potential treatment for obesity and insulin resistance.However,little is known about its direct impact on the liver.AIM To investigate the effect and underlying mechanism of AITC in nonalcoholic fatty liver disease(commonly referred to as NAFLD).METHODS To establish a mouse and cellular model of NAFLD,C57BL/6 mice were fed a high fat diet(HFD)for 8 wk,and AML-12 cells were treated with 200μM palmitate acid for 24 h.For AITC treatment,mice were administered AITC(100 mg/kg/d)orally and AML-12 cells were treated with AITC(20μmol/L).RESULTS AITC significantly ameliorated HFD-induced weight gain,hepatic lipid accumulation and inflammation in vivo.Furthermore,serum alanine aminotransferase and aspartate aminotransferase levels were markedly reduced in AITC-treated mice.Mechanistically,AITC significantly downregulated the protein levels of sterol regulatory elementbinding protein 1(SREBP1)and its lipogenesis target genes and upregulated the levels of proteins involved in fatty acidβ-oxidation,as well as the upstream mediators Sirtuin 1(Sirt1)and AMPactivated protein kinaseα(AMPKα),in the livers of HFD-fed mice.AITC also attenuated the nuclear factor kappa B(NF-κB)signaling pathway.Consistently,AITC relieved palmitate acid-induced lipid accumulation and inflammation in AML-12 cells in vitro through the Sirt1/AMPK and NF-κB signaling pathways.Importantly,further studies showed that the curative effect of AITC on lipid accumulation was abolished by siRNA-mediated knockdown of either Sirt1 or AMPKαin AML-12 cells.CONCLUSION AITC significantly ameliorates hepatic steatosis and inflammation by activating the Sirt1/AMPK pathway and inhibiting the NF-κB pathway.Therefore,AITC is a potential therapeutic agent for NAFLD. | Chun-Xiao Li Jian-Guo Gao Xing-Yong Wan Yi Chen Cheng-Fu Xu Ze-Min Feng Hang Zeng Yi-Ming Lin Han Ma Ping Xu Chao-Hui Yu You-Ming Li | 2019 | World Journal of Gastroenterology2019，25，34： | 14 |
| 10 | Revised Chronostratigraphic Framework of the Metamorphic Strata in the Jiangnan Orogenic Belt,South China and its Tectonic Implications显示文摘In a re-study of regional geology by the China Geological Survey(CGS),the key problem is in the stratigraphical division and correlation.According to the new isotopic dating of the Meso-and Neoproterozoic in China,there have been great changes in the strata correlation and tectonic explanation.The authors obtained four zircon sensitive high resolution ion micro-probe(SHRIMP) U-Pb datings from the bentonite of the Lengjiaxi Group(822±10 Ma,823±12 Ma and 834±11 Ma) and Banxi Group(802.6±7.6 Ma) in north Hunan Province,which is considered to be the middle part of the Jiangnan Orogenic Belt.On the basis of the zircon dating mentioned above,the end of the Wuling orogen is first limited in the period from 822 Ma to 802 Ma in one continued outcrop(Lucheng section) in Linxiang city,Hunan Province.Combining a series of new zircon U-Pb datings in the Yangtze and Cathaysia blocks,several Neoproterozoic volcanic events and distribution of the metamorphic rocks in the Jiangnan Orogenic Belt have been distinguished.In the context of the global geodynamics,it is useful to set up a practical and high precision chronological framework and basic and unified late Precambrian section in South China. | GAO Linzhi DING Xiaozhong ZHANG Chuanheng CHENJun LIU Yaorong ZHANG Hang LIU Xanxue PANG Weihua | 2012 | Acta Geologica Sinica(English Edition)2012，86，2： | 14 |
| 11 | Phylogeny of Dioscorea sect. Stenophora based on chloroplast matK, rbcL and trnL-F sequences显示文摘Seventeen species, one subspecies and one variety of Dioscorea sect. Stenophora Uline were investi-gated for their phylogenetic relationships based on a sequence analysis of chloroplast matK and rbcL genes and trnL-F intergenic spacer by maximum parsimony and maximum likelihood methods. The results showed that: (a) sect. Stenophora was a strongly supported monophyletic group; (b) D. rockii, D. membranacea, D. banzhuana, and D. simulans formed a moderately supported monophyletic group, and D. prazeri was weakly supported to be sister to this group; (c) D. althaeoides and D. nipponica ssp. nipponica formed a moderately supported clade, and D. nipponica ssp. rosthornii was not a member of this clade; (d) D. zingiberensis and D. sinoparviflora showed a moderate to strong sister relationship; and (e) D. collettii var. hypoglauca and D. collettii var. collettii were sister to each other, but with only weak support. | Xing GAO Yu-Ping ZHU Bao-Cheng WU Ya-Mei ZHAO Jian-Qun CHEN Yue-Yu HANG | 2008 | 植物分类学报2008，46，3： | 12 |
| 12 | Morphine enhances purine nucleotide catabolism in vivo and in vitro显示文摘目的: 在嘌呤 nucleotidecatabolism.Methods 上调查吗啡的效果和机制: 在文化的吗啡依赖和退却和老鼠 C6 glioma 房间的老鼠模型被使用。在血浆的尿酸的集中被 uricase-rapmethod 测量,腺苷脱氨基酶( ADA )和在血浆和纸巾的黄质 oxidase ( XO )被 ADA 和 XO 测试 kit.RT-PCR 测量,弄污的 RT-PCR-Southern 被用来在纸巾和 C6 cells.Results 检验 ADA 和 XO 基因抄本的相对数量:(i)血浆的集中尿酸在管理吗啡的组显著地更高级( P < 0.05 )比控制组;( i i )在吗啡期间,在血浆的管理和退却时期, ADA 和 XO 集中显著地增加了( P < 0.05 );( iii )在顶骨脑叶的 ADA 和 XO 的数量,当在退却的那些纸巾的 ADA 和 XO 的水平组织时,增加的管理吗啡的组的肝,小肠,和骨胳的肌肉减少了;( iv )在顶骨脑叶的 ADA 和 XO 基因的抄本,肝,小肠,并且骨胳的肌肉在管理吗啡的组是更高的。在那些纸巾的 ADA 和 XO 基因的表示在吗啡退却期间回到了控制水平,与骨胳的肌肉的异常;并且吗啡处理导致的 ADA 和 XO 基因的表达式的(v) theupregulation 能被 naloxone.Conclusion 颠倒:嘌呤核苷酸新陈代谢力量上的吗啡的效果是吗啡的重要、新生物化学的药理学机制行动。 | Chang LIU Jian-kai LIU Mu-jie KAN Lin GAO Hai-ying FU Hang ZHOU Min HONG | 2007 | Acta Pharmacologica Sinica2007，28，8： | 12 |
| 13 | Morinda officinalis oligosaccharides increase serotonin in the brain and ameliorate depression via promoting 5-hydroxytryptophan production in the gut microbiota显示文摘Morinda officinalis oligosaccharides(MOO) are an oral drug approved in China for the treatment of depression in China. However, MOO is hardly absorbed so that their anti-depressant mechanism has not been elucidated. Here, we show that oral MOO acted on tryptophan → 5-hydroxytryptophan(5-HTP) → serotonin(5-HT) metabolic pathway in the gut microbiota. MOO could increase tryptophan hydroxylase levels in the gut microbiota which accelerated 5-HTP production from tryptophan;meanwhile, MOO inhibited 5-hydroxytryptophan decarboxylase activity, thus reduced 5-HT generation,and accumulated 5-HTP. The raised 5-HTP from the gut microbiota was absorbed to the blood, and then passed across the blood-brain barrier to improve 5-HT levels in the brain. Additionally, pentasaccharide,as one of the main components in MOO, exerted the significant anti-depressant effect through a mechanism identical to that of MOO. This study reveals for the first time that MOO can alleviate depression via increasing 5-HTP in the gut microbiota. | Zheng-Wei Zhang Chun-Sheng Gao Heng Zhang Jian Yang Ya-Ping Wang Li-Bin Pan Hang Yu Chi-Yu He Hai-Bin Luo Zhen-Xiong Zhao Xin-Bo Zhou Yu-Li Wang Jie Fu Pei Han Yu-Hui Dong Gang Wang Song Li Yan Wang Jian-Dong Jiang Wu Zhong | 2022 | Acta Pharmaceutica Sinica B2022，12，8： | 12 |
| 14 | Comorbidity Burden of Dementia:A Hospital-Based Retrospective Study from 2003 to 2012 in Seven Cities in China显示文摘Dementia is increasing dramatically and imposes a huge burden on society. To date, there is a lack of data on the health status of patients with dementia in China. In an attempt to investigate the comorbidity burden of dementia patients in China at the national level, we enrolled 2,938 patients with Alzheimer's disease(AD), vascular dementia(Va D), or other types of dementia, who were admitted to tertiary hospitals in seven regions of China from January2003 to December 2012. The Charlson Comorbidity Index(CCI) was used to evaluate the comorbidity burden of the patients with dementia. Among these patients, 53.4% had AD, 26.3% had Va D, and 20.3% had other types of dementia. The CCI was 3.0 ± 1.9 for all patients,3.4 ± 1.8 for those with Va D, and 3.0 ± 2.1 for those with AD. The CCI increased with age in all patients, andthe length of hospital stay and daily expenses rose with age and CCI. Males had a higher CCI and a longer stay than females. Moreover, patients admitted in the last 5 years of the study had a higher CCI than those admitted in the first 5 years. We found that the comorbidity burden of patients with dementia is heavy. These findings provide a better understanding of the overall health status of dementia patients, and help to increase the awareness of clinicians and policy-makers to improve medical care for patients. | Qing-Hua Wang Xin Wang Xian-Le Bu Yan Lian Yang Xiang Hong-Bo Luo Hai-Qiang Zou Jie Pu Zhong-He Zhou Xiao-Ping Cui Qing-Song Wang Xiang-Qun Shi Wei Han Qiang Wu Hui-Sheng Chen Hang Lin Chang-Yue Gao Li-Li Zhang Zhi-Qiang Xu Meng Zhang Hua-Dong Zhou Yan-Jiang Wang | 2017 | Neuroscience Bulletin2017，33，6： | 10 |
| 15 | SKIP Confers Osmotic Tolerance during Salt Stress by Controlling Alternative Gene Splicing in Arabidopsis显示文摘译解位于下面的机制种回答到不能生活的应力为改进植物压力抵抗是关键的。大部分在 transcriptional 水平响应盐应力对基因表示的规定被知道;然而,很少在 posttranscriptional 水平对这个过程被知道。最近,我们证明那个翻斗车是与钟基因 pre-mRNAs 交往并且为调整他们拼接的选择和 mRNA 成熟是必要的 spliceosome 的一个部件。在这研究,我们发现 skip-1 植物对盐和渗透的压力过分敏感,并且那个翻斗车为拼接的选择和几咸忍耐的基因的 mRNA 成熟被要求,包括 NHX1, CBL1, P5CS1, RCI2A,和 PAT10。染色体宽的分析表明那个翻斗车调停在咸压力的条件下面许多基因拼接的选择,和在 skip-1 的其他的拼接事件的那个大多数包含 intron 保留和罐头 generatea 在抄录 mRNA 的早熟的结束 codon。翻斗车也控制由 modulating 的其他的拼接 5 和 3 的识别或劈开拼接在咸压力的条件下面的施主和领受人地点。因此,这研究探讨的基本问题拼接的 mRNA 在植物的机械在 posttranscriptional 水平贡献咸压力的回答,并且提供在其他的拼接和盐忍耐之间的一个连接。 | Jinlin Feng dingjing Li Zhaoxu Gao Yaru Lu Junya Yu Qian Zheng Shuning Yan Wenjiao Zhang Hang He Ligeng Ma Zhengge Zhu | 2015 | Molecular Plant2015，8，7： | 10 |
| 16 | The Influence of Seasonal Snow on Soil Thermal and Water Dynamics under Different Vegetation Covers in a Permafrost Region显示文摘Seasonal snow is one of the most important influences on the development and distribution of permafrost and the hydrothermal regime in surface soil. Alpine meadow, which constitutes the main land type in permafrost regions of the Qinghai-Tibet Plateau, was selected to study the influence of seasonal snow on the temperature and moisture in active soil layers under different vegetation coverage. Monitoring sites for soil moisture and temperature were constructed to observe the hydrothermal processes in active soil layers under different vegetation cover with seasonal snow cover variation for three years from 2010 to 2012. Differences in soil temperature and moisture in areas of diverse vegetation coverage with varying levels of snow cover were analyzed using active soil layer water and temperature indices. The results indicated that snow cover greatly influenced the hydrothermal dynamics of the active soil layer in alpine meadows. In the snow manipulation experiment with a snow depth greater than 15 cm, the snow cover postponed both the freeze-fall and thawrise onset times of soil temperature and moisture in alpine LC(lower vegetation coverage) meadows and of soil moisture in alpine HC(higher vegetation coverage) meadows; however, the opposite response occurred for soil temperatures of alpine HC meadows,where the entire melting period was extended by advancing the thaw-rise and delaying the freeze-fall onset time of the soil temperature. Snow cover resulted in a decreased amplitude and rate of variation in soil temperature, for both alpine HC meadows and alpine LC meadows, whereas the distinct influence of snow cover on the amplitude and rate of soil moisture variation occurred at different soil layers with different vegetation coverages. Snow cover increased the soil moisture of alpine grasslands during thawing periods. The results confirmed that the annual hydrothermal dynamics of active layers in permafrost were subject to the synergistic actions of both snow cover and vegetation coverage. | HANG Juan WANG Gen-xu GAO Yong-heng WANG Yi-bo | 2014 | Journal of Mountain Science2014，11，3： | 8 |
| 17 | Endovascular therapy for Acute ischemic Stroke Trial (EAST): study protocol for a prospective, multicentre control trial in China显示文摘Background and purpose:5 recent trials have shown the benefit of endovascular treatment for acute ischaemic stroke(AIS)due to large vessel occlusion of the anterior circulation.This study aims to evaluate the safety and efficacy of Solitaire thrombectomy in patients with moderate-to-severe stroke in the Chinese population,which has a high prevalence of intracranial atherosclerosis.Methods and analysis:This multicentre prospective control study will involve 17 stroke centres in China,and plans to recruit 150 patients in the intervention group,and 150 patients in the medical group,in which patients meet enrolment criteria but refuse intervention.Patients with AIS due to large vessel occlusion indicated for treatment with Solitaire stent retriever within 12 hours of symptom onset,and who meet the inclusion and exclusion criteria,will be enrolled in this study.The primary efficacy endpoint is functional independence as defined by a modified Rankin Scale(mRS)score≤2 at 90 days or by functional improvement as defined by mRS,using shift analysis.The procedural efficacy endpoint is arterial recanalisation of the occluded target vessel measured by a modified Thrombolysis in Cerebral Infarction(mTICI)score equal or superior to 2b right following the use of the study device.The primary safety endpoint is symptomatic intracranial haemorrhage(sICH)within 24±3 hours postprocedure.Ethics and dissemination:The protocol was approved by the Ethics Committee at the coordinating centre and by the local Institutional Review Board of each participating centre.Trial registration number:NCT02350283. | Zhongrong Miao Xiaochuan Huo Feng Gao Xiaoling Liao Chunjuan Wang Ya Peng Yibin Cao Shengli Chen Meng Zhang Changchun Jiang Xiaoxiang Peng Cunfeng Song Liping Wei Qiyi Zhu Zaiyu Guo Li Liu Hang Lin Hua Yang Wei Wu Hui Liang Anding Xu Kangning Chen Xingquan Zhao Yuesong Pan Hao Li Liping Liu Yilong Wang Yongjun Wang EAST investigators | 2016 | Stroke & Vascular Neurology2016，1，2： | 8 |
| 18 | Partial Iterative Decode of Turbo Codes for On-Board Processing Satellite Platform显示文摘There is a contradiction between high processing complexity and limited processing resources when turbo codes are used on the on-board processing(OBP)satellite platform.To solve this problem,this paper proposes a partial iterative decode method for on-board application,in which satellite only carries out limited number of iteration according to the on-board processing resource limitation and the throughput capacity requirements.In this method,the soft information of parity bits,which is not obtained individually in conventional turbo decoder,is encoded and forwarded along with those of information bits.To save downlink transmit power,the soft information is limited and normalized before forwarding.The iteration number and limiter parameters are optimized with the help of EXIT chart and numerical analysis,respectively.Simulation results show that the proposed method can effectively decrease the complexity of onboard processing while achieve most of the decoding gain.. | LI Hang GAO Zhen ZHAO Ming WANG Jing | 2015 | China Communications2015，12，11： | 8 |
| 19 | Association between Plasma Metal Levels and Diabetes Risk: a Case-control Study in China显示文摘Objective Many metals, some of which have been classified as environmental endocrine disruptors, are used extensively in everyday consumer products and are ubiquitous in our living environment. In the present study, we aimed to explore the associations between the prevalence risk of type 2 diabetes and plasma levels of 20 trace elements as well as those of heavy metals in a Han Chinese population. Methods We conducted a case-control study to investigate the associations between plasma concentrations of 20 metals and diabetes in Jiangsu province. A total of 122 newly diagnosed cases of type 2 diabetes and 429 matched controls were recruited from community physical examinations in Suzhou City of Jiangsu Province. Plasma metal levels were measured by inductively-coupled plasma mass spectrometry. Results After adjusting for confounders, plasma vanadium, chromium, manganese, copper, zinc, arsenic, selenium, strontium, palladium, cadmium, cesium, and barium were associated with diabetes risk(P < 0.05). The adjusted OR increased with increasing concentration of vanadium, manganese, copper, zinc, and cesium. Conclusion Many metals, including manganese, copper, zinc, arsenic, selenium, and cadmium in plasma, are associated with the morbidity of diabetes. Monitoring of environmental metal levels and further studies are urgently needed. | LI Xiu Ting YU Peng Fei GAO Yan GUO Wen Hui WANG Jun LIU Xin GU Ai Hua JI Gui Xiang DONG Qiu WANG Bo Shen CAO Ying ZHU Bao Li XIAO Hang | 2017 | Biomedical and Environmental Sciences2017，30，7： | 8 |
| 20 | Cyclosporine treatment in idiopathic membranous nephropathy nephrotic syndrome in adults: a retrospective study spanning 15 years显示文摘背景 Cyclosporine 在在高恶化率仍然是的 adults.But 与自发的膜的 nephropathy ( IMN )治疗肾病的症候群( NS )是有效的操作 cyclosporine 的一个主要 concern.The 方法是这研究的 inconclusive.The 目的是介绍方法怎么滴定没有 relapse.Methods 病人,维持完全的宽恕与的 cyclosporine 证明活体检视有在北京联合医学院医院从 1996~2011 与 cyclosporine 对待至少 1 个月的 NS 的 IMN 是 | TAO Jian-ling LIU Li-li WEN Yu-bing GAO Rui-tong LI Hang LI Ming-xi LI Xue-mei LI Xue-wang | 2011 | Chinese Medical Journal2011，，21： | 8 |
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