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| 1 | Age and genesis of the Shagou River terraces in eastern Qi-lian Mountains显示文摘The fluvial terrace sequence in eastern Qilian Mountains is a record of periodic uplift events of the Tibetan Plateau. Based on paleomagnetic dating, thermolumines-cence dating, radio carbon dating and loess-paleosol sequence on terraces, we preliminarily determine the ages of five major terraces of the Shagou River, northern side of the Qilian Mountains. The ages of five terraces were about 830, 418, 250,140 and 10 ka, respectively. Analysis on characteristics of terraces show that five major terraces were mainly tectonic genesis. Therefore, five major terraces recorded five strong rising events in the Qilian Mountains during the past 830 ka. The ages of those rising events are about the same as those terraces formation. Sub-terraces, constituting a main terrace, were perhaps mainly formed by climatic changes. | PAN Baotian WU Guangjian WANG Yixiang LIU Zhigang GUAN Qingyu | 2001 | Chinese Science Bulletin2001，46，6： | 18 |
| 2 | Instability characteristics of the East Asian Monsoon recorded by high-resolution loess sections from the last interglacial (MIS5)显示文摘The selection of high-resolution loess sections is needed in order to determine the climatic variability of the East Asian Monsoon during the last interglacial. Two sequences of S1 on the eastern and west-ern sides of the Liupan Mountain were both composed of five paleosol layers and four loess layers,indicating that there were five strong summer monsoon events and four strong winter monsoon events in MIS5. This corresponds with other records of the East Asian Monsoon,along with NGRIP and the North Atlantic records,implying that the climate of the Northern Hemisphere was very instable during the last interglacial. Two layers of paleosols and one layer of loess had developed during MIS5a and MIS5c. Compared with MIS5e,the climate in MIS5a and MIS5c fluctuated more intensively on a millen-nial scale,whereas the climate was relatively stable in MIS5e. | GUAN QingYu PAN BaoTian GAO HongShan LI BingYuan WANG JunPing SU Huai | 2007 | Science China Earth Sciences2007，50，7： | 5 |
| 3 | Rational development of a human antibody cocktail that deploys multiple functions to confer Pan-SARS-CoVs protection显示文摘Structural principles underlying the composition and synergistic mechanisms of protective monoclonal antibody cocktails are poorly defined.Here,we exploited antibody cooperativity to develop a therapeutic antibody cocktail against SARS-CoV-2.On the basis of our previously identified humanized cross-neutralizing antibody H014,we systematically an a lyzed a fully human n aive antibody library and rationally identified a potent neutralizing antibody partner,P17,which confers effective protection in animal model.Cryo-EM studies dissected the nature of the P17 epitope,which is SARS-CoV-2 specific and distinctly different from that of HOI4.High-resolution structure of the SARS-CoV-2 spike in complex with HOM and P17,together with functional investigations revealed that in a two-antibody cocktail,synergistic neutralization was achieved by S1 shielding and conformational locking,thereby blocking receptor attachment and viral membrane fusion,conferring high potency as well as robustness against viral mutation escape.Furthermore,cluster analysis identified a hypothetical 3rd antibody partner for further reinforcing the cocktail as pan-SARS-CoVs therapeutics. | Hangping Yao Yao Sun Yong-Qiang Deng Nan Wang Yongcong Tan Na-Na Zhang Xiao-Feng Li Chao Kong Yan-Peng Xuc Qi Chen Tian-Shu Cao Hui Zhao Xintian Yan Lei Cao Zhe Lv Dandan Zhu Rui Feng Nanping Wu Wenhai Zhang Yuhao Hu Keda Chen Rong-Rong Zhang Qingyu Lv Shihui Sun Yunhua Zhou Run Yan Guan Yang Xinglu Chanjuan Liu Xiangyun Lu Linfang Cheng Hongying Qiu Xing-Yao Huang Tianhao Weng Danrong Shi Weidong Jiang Junbin Shao Lei Wang Jie Zhang Tao Jiang Guojun Lang Cheng-Feng Qinc Lanjuan Li Xiangxi Wang | 2021 | Cell Research2021，31，1： | 5 |
| 4 | Distribution features and controls of heavy metals in surface sediments from the riverbed of the Ningxia-Inner Mongolian reaches, Yellow River, China显示文摘 | GUAN Qingyu WANG Lei PAN Baotian | 2016 | Chemosphere2016，144，： | 1 |
| 5 | Application of zeolitic material synthesized from thermally treated sediment to the removal of trivalent chromium from wastewater显示文摘 | Qingyu Guan Deyi Wu Yan Lin | 2009 | Journal of Hazardous Materials2009，167，13： | 1 |
| 6 | Loess record of climate changes during MIS5 in the Hexi Corridor northwest China 显示文摘 | Guangjian Wu Baotian Pan Qingyu Guan | 2002 | Quaternary Intemational2002，9798，： | 1 |
| 7 | Digestion performance improvement of tributyrin through nano-emulsion preparation technology显示文摘The current research aimed to optimize the preparation technology of tributyrin nano-emulsion(TBNE)to improve its digestion properties, which were investigated through digestion models in vitro and in vivo. The content of each component of TBNE was optimized by response surface methodology(RSM) to improve the z-average particle size and stability of TBNE. The optimized TBNE was evaluated for its digestion properties by in vitro and in vivo models. The preparation conditions of TBNE optimized by RSM were as follows: 61.3% of sorbitol, 32.7% of tributyrin, and 6.0% of modified phospholipid(MP). The predicted z-average particle size of TBNE was(246.02 ± 18.10) nm. The results of the verification test showed that the z-average particle size, zeta potential, conductivity, emulsification activity index, and emulsification stability index of TBNE were(250.02 ± 7.18) nm,(-40.23 ± 0.76) m V,(31.80 ± 2.09) μS/cm,(848.00 ± 84.53) min and(1.14 ± 0.02) m^(2)/g, respectively. The in vitro digestion experiment results showed that the TBNE remained stable in the stomach and was released in the intestine, while the size of TBNE in the gastrointestinal tact was significantly smaller than that of tributyrin(P < 0.05), which made it easier to be digested and absorbed. Compared with tributyrin treatment, TBNE significantly promoted the average body weight at the 7th day, average daily feed intake,average daily gain, feed/gain, ileum weight, and organ index of ileum of Hy-Line BROWN chicks(P < 0.05), and the butyric acid content in the ileal chyme from TBNE and tributyrin treatment were172.18 mg/m L and 100.85 mg/m L(P < 0.01). Therefore, the established TBNE technology in this study could be supposed to improve the digestion properties of tributyrin. | Feng Gao Yaoming Cui Shijia Song Jinfeng Zhu Xinyu Liu Xuyang Ji Hao Zhu Qingyu Jia Qiaohan Lin Junjun Guan | 2022 | Grain & Oil Science and Technology2022，5，3： | 0 |
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