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| 1 | 胆固醇酯转移蛋白基因的蛋白质截断型变异体与冠状动脉性心脏病风险的关系显示文摘随机对照试验结果表明,抑制胆固醇酯转运蛋白(cholesteryl ester transfer protein,CETP)的疗法并不能降低冠状动脉性心脏病(coronary heart disease,CHD)的发生风险。研究失败的可能原因包括靶目标无效、靶目标外小分子的不良反应和随机对照设计因素影响等。在编码药物靶点的基因中具有天然存在的遗传变异,以此为基础,人类研究可以深入了解针对基因产物的治疗的潜在功效和安全性。 | Nomura A Won HH Khera AV Takeuchi F Ito K McCarthy S Emdin CA Klarin D Natarajan P Zekavat SM Gupta N Peloso GM Borecki IB Teslovich TM Asselta R Duga S Merlini PA Correa A Kessler T Wilson JG Bown MJ Hall AS Braund PS Carey DJ Murray MF Kirchner HL Leader JB Lavage DR Manus JN Hartze DN Samani NJ Schunkert H Marrugat J Elosua R McPherson R Farrall M Watkins H Juang JJ Hsiung CA Lin SY Wang JS Tada H Kawashiri MA Inazu A Yamagishi M Katsuya T Nakashima E Nakatochi M Yamamoto K Yokota M Momozawa Y Rotter JI Lander ES Rader DJ Danesh J Ardissino D Gabriel S Willer CJ Abecasis GR Saleheen D Kubo M Kato N Ida Chen YD Dewey FE Kathiresan S 刘莉 叶鹏 | 2017 | 中华高血压杂志2017，25，9： | 2 |
| 2 | Breast cancer in young women显示文摘 | Gabriel CA Domchek SM | 2010 | Breast Cancer Res2010，12，5： | 1 |
| 3 | Serious liver disease induced by infliximab显示文摘 | Gabriel J. Tobon Carlos Ca?as Juan-Jose Jaller Juan-Carlos Restrepo Juan-Manuel Anaya | 2007 | Clinical Rheumatology2007，，4： | 1 |
| 4 | Myocardial perfusion and angioplasty,Comparison of myocardial contrast eehocardiography and scintigraphy显示文摘 | Almeida AG Gabriel HM Coutinho CA | 2002 | Rev Port Cardiol2002，21，78： | 1 |
| 5 | Serious liver disease induced by infliximab显示文摘 | Gabriel J. Tobon Carlos Ca?as Juan-Jose Jaller Juan-Carlos Restrepo Juan-Manuel Anaya | 2007 | Clinical Rheumatology2007，，4： | 1 |
| 6 | Serious liver disease induced by infliximab显示文摘 | Gabriel J. Tobon Carlos Ca?as Juan-Jose Jaller Juan-Carlos Restrepo Juan-Manuel Anaya | 2007 | Clinical Rheumatology2007，，4： | 1 |
| 7 | Breast cancer in young women显示文摘 | Gabriel CA Domchek SM | 2010 | Breast Cancer Res2010，12，5： | 1 |
| 8 | Palladium-catalyzed synthesis of symmetrical urea derivatives by oxidative carbonylation of primary amines in carbon dioxide medium 显示文摘 | Nicola Della Ca Paolo Bottarelli Angela Dibenedctto Michele Aresta Bartolo Gabriele Giuseppe Salerno Mirco Costa | 2011 | Journal of Catalysis2011，282，1： | 1 |
| 9 | Focus on right ventricular outflow tract septal pacing 显示文摘 | Da Costa A Gabriel L Romeyer-Bouchard CA | 2013 | Arch Cardiovasc Dis2013，106，67： | 1 |
| 10 | Palladium-Catalyzed Carbonylation of Multifunctionalized Substituted Alkynes to Quinolinone Derivatives under Mild Conditions显示文摘A highly selective palladium-catalyzed carbonylation of 2-alkynylanilines bearing an amide moiety to condensed six-membered heterocyclic structures has been developed under mild conditions(room temperature and atmospheric pressure of CO).The carbonylative protocol is also compatible with CO surrogates,such as benzene-1,3,5-triyl triformate(TFBen)or the newly developed calix[6]arenes functionalized with six formate groups(CLX[6]CO),which are both capable to release CO in situ.A series of tricyclic fused heterocycles containing the important oxazino-quinolinone scaffold have been selectively obtained(only the 6-endo-dig cyclization mode has been observed)in good to excellent yields(up to 99%). | Aleksandr Voronov Francesco Pancrazzi Ana Maria Constantin Raimondo Maggi Raffaella Mancuso Bartolo Gabriele Diego Olivieri Carla Carfagna Alessandro Casnati Francesco Rispoli Laura Baldini Nicola Della Ca | 2023 | Chinese Journal of Chemistry2023，41，23： | 0 |
| 11 | Palladium Iodide-Catalyzed Selective Carbonylative Double Cyclization of 4-(2-Aminophenyl)-3-yn-1-ols to Dihydrofuroquinolinone Derivatives显示文摘The PdI_(2)/KI-catalyzed oxidative carbonylation of 4-(2-aminophenyl)-3-yn-1-ols,bearing two potential nucleophilic groups in suitable position selectively leads to dihydrofuroquinolinone derivatives in fair to high yields(60%—89%)and excellent turnover numbers(180—267 mol of product per mol of Pd)over 19 examples,through a mechanistic pathway involving initial O-cyclization followed by N-cyclocarbonylation.In such process,the selective catalytic construction of two rings and three new bonds is achieved in one synthetic step to afford high value added fused heterocyclic structures starting from readily available materials. | Raffaella Mancuso Alex De Salvo Patrizio Russo Aurelia Falcicchio Nicola Della Ca’ Leonardo Pantoja Munoz Bartolo Gabriele | 2023 | Chinese Journal of Chemistry2023，41，21： | 0 |
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