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| 1 | De novo characterization of the root transcriptome of a traditional Chinese medicinal plant Polygonum cuspidatum显示文摘Various active components have been extracted from the root of Polygonum cuspidatum.However,the genetic basis for their activity is virtually unknown.In this study,25600002 short reads (2.3 Gb) of P.cuspidatum root transcriptome were obtained via Illumina HiSeq 2000 sequencing.A total of 86418 unigenes were assembled de novo and annotated.Twelve,18,60 and 54 unigenes were respectively mapped to the mevalonic acid (MVA),methyl-D-erythritol 4-phosphate (MEP),shikimate and resveratrol biosynthesis pathways,suggesting that they are involved in the biosynthesis of pharmaceutically important anthraquinone and resveratrol.Eighteen potential UDP-glycosyltransferase unigenes were identified as the candidates most likely to be involved in the biosynthesis of glycosides of secondary metabolites.Identification of relevant genes could be important in eventually increasing the yields of the medicinally useful constituents of the P.cuspidatum root.From the previously published transcriptome data of 19 non-model plant taxa,1127 shared orthologs were identified and characterized.This information will be very useful for future functional,phylogenetic and evolutionary studies of these plants. | HAO DaCheng MA Pei MU Jun CHEN ShiLin XIAO PeiGen PENG Yong HUO Li XU LiJia SUN Chao | 2012 | Science China(Life Sciences)2012，55，5： | 36 |
| 2 | Regional Tectonic Transformation in East Kunlun Orogenic Belt in Early Paleozoic: Constraints from the Geochronology and Geochemistry of Helegangnaren Alkali-feldspar Granite显示文摘The Helegangnaren feldspar granite exposed in the eastern part of East Kunlun, is characterized by high concentrations of SiO2 and alkaline, low abundances of Fe, Mg and Ca, metaluminous-weak peraluminous. Trace elements analysis shows that the granite is depleted extremely in Ba, Sr and Eu, and rich in some large-ion lithophile elements and high field strength elements. Besides, the granite has high Ga contents, the values of 104 (Ga/Al) vary from 2.50 to 2.77, which is mainly greater than the lower limit of A-type granites (2.6), and is higher than the I-and S-type granites' average (2.1 and 2.28, respectively). Rare earth element (REE) is characterized by relatively high fractionations of light REE (LREE) and heavy REE (HREE) (LREE/HREE=9.3-13.60, (La/Yb)N =10.92-18.02), pronounced negative Eu anomalies (δEu=0.08-0.13), and exhibits right-dipping gull pattern. Major elements, rare elements and trace elements features show the granite is ascribed to A-type granite and A2 subtype in tectonic genetic type. They are plotted into post-collision or within-plate area in a variety of tectonic discriminations. Geological and geochemical data comprehensively suggest that the granite is formed in a post-collision extensive tectonic setting. Laser ablation inductively coupled plasma mass spectrometry (LA-ICP-MS) zircon U-Pb dating yields a weighted mean age of 425 Ma, belonging to Middle Silurian, which is similar to the age of the post-collision geological events in the region. The differences of magmatic rocks in formation age, rocks assemblage and rocks series systematically indicate that the regional tectonic stress regime in the East Kunlun orogenic belt experienced a major transformation from compress to extension in Middle Silurianin, and the Helegangnaren feldspar granite intruded in the early stage of tectonic transformation. | LI Ruibao PEI Xianzhi LI Zhuochen SUN Yu PEI Lei CHEN Guochao CHEN Youxin LIU Chengjun WEI Fanghui | 2013 | Acta Geologica Sinica(English Edition)2013，87，2： | 35 |
| 3 | Hydrothermal ore deposits in collisional orogens显示文摘Hydrothermal ore deposits at convergent plate boundaries represent extraordinary metal enrichment in the continental crust. They are generally associated with felsic magmatism in extensional settings at high thermal gradients. Although their formation is common during accretionary orogeny, more and more ore deposits have been discovered recently in the collisional orogens of China. Because collisional orogeny was operated in a compressional regime at low thermal gradients, it is not favorable for mobilization of ore-forming elements and thus for the production of hydrothermal ore deposits. Nevertheless, continental collision is generally preceded by oceanic subduction, which enables the preliminary enrichment of ore-forming elements in the mantle wedge due to chemical metasomatism by subducting slab-derived fluids. This gave rise to metal pre-enriched domains in the overriding lithosphere, which may be reactivated by extensional tectonism for hydrothermal mineralization either immediately during accretionary orogeny or at a later time during and after collisional orogeny. It is these tectonic processes that have resulted in the progressive enrichment of ore-forming elements through the geochemical differentiation of the subducting oceanic crust, the metasomatic mantle domains and the mafic juvenile crust, respectively, at different depths. Finally, the reactivation of metal pre-enriched domains by continental rifting in the orogenic lithosphere is the key to the metallogenesis of collisional orogens. | Yongfei Zheng Jingwen Mao Yanjing Chen Weidong Sun Pei Ni Xiaoyong Yang | 2019 | Science Bulletin2019，64，3： | 26 |
| 4 | Northernmost paleo-tethyan oceanic basin in Tibet:Geo-chronological evidence from ^(40)Ar/^(39)Ar age dating of Dur'ngoi ophiolite显示文摘Whole rock 40Ar/39Ar age dating has been conducted on a basalt sample from Dur’ngoi ophiolite, Qinghai Province, which was reported to be the northernmost pa-leo-tethyan oceanic basin in Tibet. A high temperature pla-teau age (345.3±7.9 Ma) with an isochorn age (336.6±7.1 Ma) has been obtained, representing the eruption time of oceanic crust Considering related geological settings, the new age provides constraints on the northernmost pa-leo-tethyan suture zone in Tibet and the tectonic evolution of Paleo-tethys in Northeast Tibet and adjacent areas. | CHEN Liang, SUN Yong, PEI Xianzhi, GAO Ming, FENG Tao, ZHANG Zhongqing & CHEN Wen1. Laboratory of Continental Dynamics, Northwest University, Xi’an 710069, China 2. Department of Geology, Northwest University, Xi’an, 710069, China 3. Institute of Geology, Chinese Academy of Geological Sciences, Beijing, 100037, China | 2001 | Chinese Science Bulletin2001，46，14： | 24 |
| 5 | Special Section:SARS-CoV-2 Preliminary evidence from a multicenter prospective observational study of the safety and efficacy of chloroquine for the treatment of COVID-19显示文摘Effective therapies are urgently needed for the SARS-CoV-2 pandemic.Chloroquine has been proved to have antiviral effect against coronavirus in vitro.In this study,we aimed to assess the efficacy and safety of chloroquine with different doses in COVID-19.In this multicenter prospective observational study,we enrolled patients older than 18 years old with confirmed SARS-CoV-2 infection excluding critical cases from 12 hospitals in Guangdong and Hubei Provinces.Eligible patients received chloroquinephosphate s00 mg,orally,once(half dose)or twice(full dose)daily.Patients treated with non-chloroquine therapy were included as historical controls.The primary endpoint is the time to undetectable viral RNA.Secondary outcomes include the proportion of patients with undetectable viral RNA by day 10 and 14,hospitalization time,duration of fever,and adverse events.A total of 197 patients completed chloroquine treatment,and 176patients were included as historical controls.The median time to achieve an undetectable viral RNA was shorter in chloroquine than in non-chloroquine(absolute difference in medians-6.0 days;95%CI-6.0 to—4.0).The duration of fever is shorter in chloroquine(geometric mean ratio 0.6;95%CIO.5 to 0.8).No serious adverse events were observed in the chloroquine group.Patients treated with half dose experienced lower rate of adverse events than with full dose.Although randomized trials are needed for further evaluation,this study provides evidence for safety and efficacy of chloroquine in COVID-19 and suggests that chloroquine can be a cost-effective therapy for combating the COVID-19 pandemic. | Mingxing Huang Man Li Fei Xiao Pengfei Pang Jiabi Liang Tiantian Tang Shaoxuan Liu Binghui Chen Jingxian Shu Yingying You Yang Li Meiwen Tang Jianhui Zhou Guanmin Jiang Jingfen Xiang Wenxin Hong Songmei He Zhaoqin Wang Jianhua Feng Changqing Lin Yinong Ye Zhilong Wu Yaocai Li Bei Zhong Ruilin Sun Zhongsi Hong Jing Liu Huili Chen Xiaohua Wang Zhonghe Li Duanqing Pei Lin Tian Jinyu Xia Shanping Jiang Nanshan Zhong Hong Shan | 2020 | National Science Review2020，7，9： | 20 |
| 6 | Multimorbidity patterns and association with mortality in 0.5 million Chinese adults显示文摘Background:Few studies have assessed the relationship between multimorbidity patterns and mortality risk in the Chinese population.We aimed to identify multimorbidity patterns and examined the associations of multimorbidity patterns and the number of chronic diseases with the risk of mortality among Chinese middle-aged and older adults.Methods:We used data from the China Kadoorie Biobank and included 512,723 participants aged 30 to 79 years.Multimorbidity was defined as the presence of two or more of the 15 chronic diseases collected by self-report or physical examination at baseline.Multimorbidity patterns were identified using hierarchical cluster analysis.Cox regression was used to estimate the associations of multimorbidity patterns and the number of chronic diseases with all-cause and cause-specific mortality.Results:Overall,15.8%of participants had multimorbidity.The prevalence of multimorbidity increased with age and was higher in urban than rural participants.Four multimorbidity patterns were identified,including cardiometabolic multimorbidity(diabetes,coronary heart disease,stroke,and hypertension),respiratory multimorbidity(tuberculosis,asthma,and chronic obstructive pulmonary disease),gastrointestinal and hepatorenal multimorbidity(gallstone disease,chronic kidney disease,cirrhosis,peptic ulcer,and cancer),and mental and arthritis multimorbidity(neurasthenia,psychiatric disorder,and rheumatoid arthritis).During a median of 10.8 years of follow-up,49,371 deaths occurred.Compared with participants without multimorbidity,cardiometabolic multimorbidity(hazard ratios[HR]=2.20,95%confidence intervals[CI]:2.14-2.26)and respiratory multimorbidity(HR=2.13,95%CI:1.97-2.31)demonstrated relatively higher risks of mortality,followed by gastrointestinal and hepatorenal multimorbidity(HR=1.33,95%CI:1.22-1.46).The mortality risk increased by 36%(HR=1.36,95%CI:1.35-1.37)with every additional disease.Conclusion:Cardiometabolic multimorbidity and respiratory multimorbidity posed the highest threat on mortality risk and deserved particular attention in Chinese adults. | Junning Fan Zhijia Sun Canqing Yu Yu Guo Pei Pei Ling Yang Yiping Chen Huaidong Du Dianjianyi Sun Yuanjie Pang Jun Zhang Simon Gilbert Daniel Avery Junshi Chen Zhengming Chen Jun Lyu Liming Li On Behalf of the China Kadoorie Biobank Collaborative Group | 2022 | Chinese Medical Journal2022，，6： | 17 |
| 7 | Electroacupuncture preconditioning protects against focal cerebral ischemia/reperfusion injury via suppression of dynamin-related protein 1显示文摘Electroacupuncture preconditioning at acupoint Baihui(GV20) can reduce focal cerebral ischemia/reperfusion injury. However, the precise protective mechanism remains unknown. Mitochondrial fission mediated by dynamin-related protein 1(Drp1) can trigger neuronal apoptosis following cerebral ischemia/reperfusion injury. Herein, we examined the hypothesis that electroacupuncture pretreatment can regulate Drp1, and thus inhibit mitochondrial fission to provide cerebral protection. Rat models of focal cerebral ischemia/reperfusion injury were established by middle cerebral artery occlusion at 24 hours after 5 consecutive days of preconditioning with electroacupuncture at GV20(depth 2 mm, intensity 1 m A, frequency 2/15 Hz, for 30 minutes, once a day). Neurological function was assessed using the Longa neurological deficit score. Pathological changes in the ischemic penumbra on the injury side were assessed by hematoxylin-eosin staining. Cellular apoptosis in the ischemic penumbra on the injury side was assessed by terminal deoxyribonucleotidyl transferase-mediated d UTP-digoxigenin nick end labeling staining. Mitochondrial ultrastructure in the ischemic penumbra on the injury side was assessed by transmission electron microscopy. Drp1 and cytochrome c expression in the ischemic penumbra on the injury side were assessed by western blot assay. Results showed that electroacupuncture preconditioning decreased expression of total and mitochondrial Drp1, decreased expression of total and cytosolic cytochrome c, maintained mitochondrial morphology and reduced the proportion of apoptotic cells in the ischemic penumbra on the injury side, with associated improvements in neurological function. These data suggest that electroacupuncture preconditioning-induced neuronal protection involves inhibition of the expression and translocation of Drp1. | Gao-feng Zhang Pei Yang Zeng Yin Huai-long Chen Fu-guo Ma Bin Wang Li-xin Sun Yan-lin Bi Fei Shi Ming-shan Wang | 2018 | Neural Regeneration Research2018，13，1： | 16 |
| 8 | Environmental magnetism and paleoclimatic interpretation of the Sanmenxia loess-paleosol sequence in the southeastern extremity of the Chinese Loess Plateau显示文摘这是多参数矿物质的一份报告在在间隔 ofL1 上的中国黄土高原(CLP ) 的 SE 极限的 Sanmenxialoess-paleosol 两行诗的磁性的结果 - 跨越最后 1 个妈的 L13。这些结果显示出那团特定的磁性的危险性(x) , Xarm 和 SIRM,他们的比率展出平行 stratigraphic 变化。Sincesuperparamagnetic (SP ) 粒子有重要贡献到到顽磁的 X 而是没有贡献,例如,手臂和 SIRM,在 x 之间的强壮的线性关联一(i 顽磁(例如, ARMand SIRM ) 建议生产成土作用的磁性的谷物是主要在里面小单个领域范围。因而,到想在以前的研究的体积 x 的 SP 粒子的重要贡献显然被过高估计。在 Sanmenxia 和中部的谷物尺寸的 2arm/X 数据从 CLP 显示的内地典型黄土节记录强壮的相似,暗示 Jarm/X 可以为监视变化 offerrimagnetic 谷物被认为是可靠指示物缩放。S 比率和 HIRM 的结果((SIRM+IRM_(.3T ))/2 ) 大小显示在与成土作用联系的 paleosols 有软磁铁矿 / 磁赤铁矿和 hardhematite/goethite 的重要改进。 | WANG Xisheng YANG Zhenyu Reidar Levlie SUN Zhiming PEI Junling | 2006 | Chinese Science Bulletin2006，51，22： | 15 |
| 9 | Geochemical Features, Age, and Tectonic Significance of the Kekekete Mafic-ultramafic Rocks, East Kunlun Orogen, China显示文摘The Kekekete mafic-ultramafic rocks are exposed in the Kekesha-Kekekete-Dawate area,which are in the eastern part of the East Kunlun Orogenic Belt.It outcrops as tectonic slices intruding tectonically in the Paleoproterozoic Baishahe Group and the Paleozoic Nachitai Group.The Kekekete mafic and ultramafic rocks is located near the central fault in East Kunlun and lithologically mainly consists of serpentinite,augite peridotite,and gabbro.The LA-ICP-MS zircon U-Pb age of the gabbro is 501±7 Ma,indicating that Kekekete mafic-ultramafic rocks formed in the Middle Cambrian.This rock assemblage is relatively poor in SiO2 and(Na2 O+K2 O) but rich in MgO and SFeO.The chondrite-normalized REE patterns of the gabbro dip slightly to the right;the primitive mantle and MORBnormalized spidergrams of trace elements show enrichment of large-ion lithophile elements(Cs,Rb,Ba,etc.) and no differentiation of high field strength elements.The general dominance of E-MORB features and the geochemical characteristics of OIB suggest that the Kekekete mafic-ultramafic rocks formed in an initial oceanic basin with slightly enriched mantle being featured by varying degrees of mixing of N-MORB depleted mantle and a similar-OIB-type source.From a comprehensive study of the previous data,the author believes that the tectonic history of the East Kunlun region was controlled by a geodynamic system of rifting and extension in the late stages of the Neoproterozoic to early stages of the Early Paleozoic and this formed the paleo-oceanic basin or rift system now represented by the ophiolites along the central fault in East Kunlun,the Kekekete mafic-ultramafic rocks and Delisitan ophiolite. | LI Ruibao PEI Xianzhi LI Zuochen SUN Yu FENG Jianyong PEI Lei CHEN Guochao LIU Chengjun CHEN Youxin | 2013 | Acta Geologica Sinica(English Edition)2013，87，5： | 13 |
| 10 | Evapotranspiration, Yield and Crop Coefficient of Irrigated Maize Under Straw Mulch显示文摘Maize (Zea mays L.), a staple crop grown from June to September during the rainy season on the North China Plain,is usually inter-planted in winter wheat (Triticum aestivum L.) fields about one week before harvesting of the winterwheat. In order to improve irrigation efficiency in this region of serious water shortage, field studies in 1999 and 2001, twodry seasons with less than average seasonal rainfall, were conducted with up to five irrigation applications to determineevapotranspiration, calculate the crop coefficient, and optimize the irrigation schedule with maize under mulch, as well asto establish the effects of irrigation timing and the number of applications on grain yield and water use efficiency (WUE)of maize. Results showed that with grain production at about 8 000 kg ha-1 the total evapotranspiration and WUE ofirrigated maize under mulch were about 380-400 mm and 2.0-2.2 kg m-3, respectively. Also in 2001 WUE of maizewith mulch for the treatment with three irrigations was 11.8% better than that without mulch. In the 1999 and 2001seasons, maize yield significantly improved (P = 0.05) with four irrigation applications, however, further increases werenot significant. At the same time there were no significant differences for WUE with two to four irrigation applications.In the 2001 season mulch lead to a decrease of 50 mm in the total soil evaporation, and the maize crop coefficient undermulch varied between 0.3-1.3 with a seasonal average of 1.0. | ZHANG Xi-Ying CHEN Su-Ying PEI Dong LIU Meng-Yu SUN Hong-Yong | 2005 | Pedosphere2005，15，5： | 12 |
| 11 | Genesis of the Bangbu Orogenic Gold Deposit, Tibet: Evidence from Fluid Inclusion, Stable Isotopes, and Ar-Ar Geochronology显示文摘The Bangbu gold deposit is a large orogenic gold deposit in Tibet formed during the AlpineHimalayan collision. Ore bodies(auriferous quartz veins) are controlled by the E-W-trending Qusong-Cuogu-Zhemulang brittle-ductile shear zone. Quartz veins at the deposit can be divided into three types: pre-metallogenic hook-like quartz veins, metallogenic auriferous quartz veins, and postmetallogenic N-S quartz veins. Four stages of mineralization in the auriferous quartz veins have been identified:(1) Stage S1 quartz+coarse-grained sulfides,(2) Stage S2 gold+fine-grained sulfides,(3) Stage S3 quartz+carbonates, and(4) Stage S4 quartz+ greigite. Fluid inclusions indicate the oreforming fluid was CO_2-N_2-CH_4 rich with homogenization temperatures of 170–261°C, salinities 4.34–7.45 wt% Na Cl equivalent. δ^(18)Ofluid(3.98‰–7.18‰) and low δDV-SMOW(-90‰ to-44‰) for auriferous quartz veins suggest ore-forming fluids were mainly metamorphic in origin, with some addition of organic matter. Quartz vein pyrite has δ^(34)SV-CDT values of 1.2‰–3.6‰(an average of 2.2‰), whereas pyrite from phyllite has δ^(34)SV-CDT 5.7‰–9.9‰(an average of 7.4‰). Quartz vein pyrites yield 206Pb/204 Pb ratios of 18.662–18.764, 207Pb/204 Pb 15.650–15.683, and ^(208)Pb/204 Pb 38.901–39.079. These isotopic data indicate Bangbu ore-forming materials were probably derived from the Langjiexue accretionary wedge. 40Ar/39 Ar ages for sericite from auriferous sulfide-quartz veins yield a plateau age of 49.52 ± 0.52 Ma, an isochron age of 50.3 ± 0.31 Ma, suggesting that auriferous veins were formed during the main collisional period of the Tibet-Himalayan orogen(~65–41 Ma). | PEI Yingru SUN Qingzhong ZHENG Yuanchuan YANG Zhusen LI Wei HUANG Kexian | 2016 | Acta Geologica Sinica(English Edition)2016，90，2： | 12 |
| 12 | A new understanding of the effect of Cr on the corrosion resistance evolution of weathering steel based on big data technology显示文摘In this work,we studied the effect of Cr element on the corrosion resistance evolution of weathering steel based on corrosion big data technology.It suggested that corrosion big data technology is suitable for evaluation of the effect of microalloying Cr element on the corrosion evolution behavior of weathering steel.New understandings prove that the effect of Cr on the corrosion process is dynamic rather than static,the processes is affected by both of the environmental factors and the electrochemical or chemical reactions in the rust layer.Besides,Cr element has both beneficial effect and detrimental effect on the corrosion resistance of weathering steel.The beneficial effect is that the general corrosion resistance of Cr-additional steel is better than that of Cr-free steel,while the detrimental effect is that localized corrosion is intensified as the increase of Cr content in the Cr-additional steel. | Xiaojia Yang Ying Yang Meihui Sun Jinghuan Jia Xuequn Cheng Zibo Pei Qing Li Di Xu Kui Xiao Xiaogang Li | 2022 | Journal of Materials Science & Technology2022，，9： | 12 |
| 13 | Allergy-related Evidences in Relation to Serum IgE:Data from the China State Key Laboratory of Respiratory Disease,2008-2013显示文摘Objective To investigate the serum total IgE(tlgE) and specific IgE(slgE) to common allergens among allergic patients in Guangzhou,China.Methods 7 085 patients were examined for tlgE and slgE to 15 allergens,based on the protocols of reversed enzyme allergosorbent test and the sandwich enzyme-linked immunosorbent assay.Results 3 758(53.04%) patients tested positive for tlgE,and 4 640(65.49%) for slgE.Der pteronyssinus,Der farinae,eggs,and cow's milk were the most common allergens leading to higher positive rates of slgE responses.Several peaks of sensitization were:Der pteronyssinus,Der farinae,and Blomia tropicalis at age 10-12;cow's milk at age below 3;eggs at age 4-6.The mean level and positive rate of tlgE tended to increase in subjects sensitized to more allergens.Sensitization to Der pteronyssinus(OR,1.6;P<0.05),Der farinae(OR,1.5;P<0.05),Blomia tropicalis(OR,1.4;P<0.05),Blattella germanica(OR,1.5;P<0.05),cow's milk(OR,1.3;P<0.05),and soy beans(OR,2.0;P<0.05) were independently correlated with allergy-related conditions in preliminary diagnosis.Conclusion The major allergens in Guangzhou include Der pteronyssinus,Der farinae,cow's milk,and eggs.Sensitization to these allergens appears to be predictors of allergy-related disorder. | SUN Bao Qing CHEN De Hui ZHENG Pei Yan HUANG Hui Min LUO Wen Ting ZENG Guang Qiao ZHANG Xiao Wen | 2014 | Biomedical and Environmental Sciences2014，27，7： | 11 |
| 14 | Simultaneous determination of 15 flavonoids from different parts of Scutellaria baicalensis and its chemometrics analysis显示文摘Objective: The aerial parts of Scutellaria baicalensis were used as Huangqin Tea for thousands of years and mainly contain flavonoids which contribute to its bioactivities. However, there is no appropriate quality evaluation method of Huangqin Tea, and three flavanones of isocarthamidin-7-O-β-D-glucuronide,carthamidin-7-O-β-D-glucuronide, and isoscutellarein-8-O-β-D-glucuronide with high contents in the aerial parts have never been defined quantitatively. Here, an HPLC-DAD method for simultaneous determination of 15 flavonoids and systematically compared their contents and distribution in the roots,stems, leaves, and flowers of S. baicalensis was established.Methods: Under the HPLC-DAD chromatographic conditions, 77 batches of samples of S. baicalensis were analyzed. Meanwhile, the chromatographic fingerprint of different parts of S. baicalensis was established.Subsequently, principal component analysis(PCA), orthogonal projections to latent structures discriminant analysis(OPLS-DA), and clustering heat map were performed based on the contents of 15 flavonoids in different parts of S. baicalensis.Results: The results showed significant differences in the contents and distributions of 15 flavonoids among the different parts of S. baicalensis. The chemical composition of stems showed some similarities to leaves, and their contents were all lower than leaves. The contents of isocarthamidin-7-O-β–glucuronide [(106.66 66 ± 22.68) mg/g], carthamidin-7-O-β-D-glucuronide [(19.82 ± 11.17) mg/g],and isoscutellarein-8-O-β-D-glucuronide [(3.10 ± 1.73) mg/g] were the highest in leaves. The content of apigenin-7-O-β-D-glucopyranoside and chrysin-7-O-β-D-glucuronide were the highest in flowers. The contents of baicalin, baicalein, wogonoside, wogonin, alpinetin, and oroxylin A were higher in roots than in other parts.Conclusion: The method was fully validated and could be effectively used to characterize the contents and distributions of main flavonoids in the different parts of S. baicalensis. It may lay a foundation to establish the quality evaluation system for Huangqin Tea. | Jie Shen Pei Li Chun-nian He Hai-tao Liu Yan-ze Liu Xiao-bo Sun Rong Xu Pei-gen Xiao | 2019 | Chinese Herbal Medicines2019，11，1： | 11 |
| 15 | Bedaquiline-containing regimens in patients with pulmonary multidrug-resistant tuberculosis in China:focus on the safety显示文摘Background:World Health Organization recommends countries introducing new drug and short treatment regimen for drug resistant tuberculosis(DR-TB)should develop and implement a system for active pharmacovigilance that allows for detection,reporting and management of adverse events.The aim of the study is to evaluate the frequency and severity of adverse events(AEs)of bedaquiline-containing regimen in a cohort of Chinese patients with multidrug-resistant(MDR)/extensively drug-resistant(XDR)-TB based on active drug safety monitoring(aDSM)system of New Drug Introduction and Protection Program(NDIP). | Jing-Tao Gao Juan Du Gui-Hui Wu Yi Pei Meng-Qiu Gao Leonardo Martinez Lin Fan Wei Chen Li Xie Yu Chen Hua Wang Long Jin Guo-Bao Li Pei-Lan Zong Yu Xiong Qian-Hong Wu Ming-Wu Li Xiao-Feng Yan Yan-Fang Miao Qing-Shan Cai Xin-Jie Li Da-Peng Bai Shu-Jun Geng Guo-Li Yang Pei-JunTang Yi Zeng Xiao-Hong Chen Tong-Xia Li Cui Cai Yun Zhou Ma Zhuo Jian-Yun Wang Wen-Long Guan Lin Xu Ji-Chan Shi Wei Shu Li-Li Cheng FeiTeng Yu-Jia Ning Shi-Heng Xie Yu-Xian Sun Li-Jie Zhang Yu-Hong Liu | 2021 | Infectious Diseases of Poverty2021，10，2： | 11 |
| 16 | Zircon U-Pb ages of granites at Changba and Huangzhuguan in western Qinling and implications for source nature显示文摘Mesozoic granitoids are widespread in the Qinling-Dabie-Sulu orogenic belt. Precise U-Pb dating on these granitoids can reveal the evolution of the continental collision orogen and thus provide information on the nature of magma sources. This study pre-sents zircon LA-ICP-MS U-Pb dating and whole-rock geochemical analyses for two intrusions at Changba and Huangzhuguan in western Qinling. Zircon U-Pb ages for central and marginal phases of the Huangzhuguang intrusion are 214±1 Ma and 213±3 Ma, respectively. Zircons from the Changba intrusion yield a dominant cluster with an U-Pb age of 213±2 Ma. Collectively, these ages are younger than ages of 220 to 240 Ma for ultrahigh-pressure metamorphism due to the continental collision between the South China Block and the North China Block, corresponding to syn-exhumation magmatism. Some inherited zircons occur in the Changba intrusion, yielding a weighted mean of 206Pb/238U ages at 757±14 Ma. This indicates that the Changba intrusion has the crustal source of mid-Neoproterozoic ages and a tectonic affinity to the South China Block. Geochemically, the two intrusuons are both rich in LILE and LREE but depleted in HFSE and HREE, similar to arc-type igneous rocks. The Huangzhuguang intrusion exhibits linear correlations between SiO2 and the other major oxides, implying chemical evolution from a cognate magma source. It contains mafic enclaves, suggesting possible mixing of felsic-mafic magmas. The Changba granite is rich in Si and K but poor in Fe and Mg as well as has a high value of Fe, suggesting strong differentiation of granitic magma. Therefore, the two intrusions were derived from the Late Triassic anatexis of the continental crust of different compositions in the northern margin of South China Block. This process may be coupled with exhumation of the subducted continental crust in the stage of late collision. | WANG TianGang NI Pei SUN WeiDong ZHAO KuiDong WANG XuDong | 2011 | Chinese Science Bulletin2011，56，7： | 11 |
| 17 | Effects of acupuncturing Tsusanli (S_T36) on expression of nitric oxide synthase in hypothalamus and adrenal gland in rats with cold stress ulcer显示文摘AIM: To study the protective effect of acupuncturing Tsusanli (ST36) on cold stress ulcer, and the expression of nitric oxide synthase (NOS) in hypothalamus and adrenal gland.METHODS: Ulcer index in rats and RT-PCR were used to study the protective effect of acupuncture on cold stress ulcer, and the expression of NOS in hypothalamus and adrenal gland. Images were analyzed with semi-quantitative method.RESULTS: The ulcer index significantly decreased in rats with stress ulcer. Plasma cortisol concentration was up regulated during cold stress, which could be depressed by pre-acupuncture. The expression of NOS1 in hypothalamus increased after acupuncture. The increased expression of NO$2 was related with stress ulcer, which could be decreased by acupuncture. The expression of NOS3 in hypothalamus was similar to NOS2, but the effect of acupuncture was limited. The expression of NOS2 and NOS3 in adrenal gland increased after cold stress, only the expression of NOS1 could be repressed with acupuncture. There was no NOS2 expression in adrenal gland in rats with stress ulcer.CONCLUSION: The protective effect of acupuncturing Tsusanli (Sr36) on the expression of NOS in hypothalamus and adrenal gland can be achieved. | Jin-Ping Sun Hai-Tao Pei Xiang-Lan Jin Ling Yin Qing-Hua Tian Shu-Jun Tian | 2005 | World Journal of Gastroenterology2005，11，32： | 10 |
| 18 | Numerical simulation for determining three zones in the goaf at a fully-mechanized coal face显示文摘According to the theory of ventilation network, a model for a filtration flow field in goaf was built and simulation soft- ware for determining the three zones in goaf has been developed. This software uses no-gap-connection between Visual Basic (VB) and Excel to exchange data, uses Component Object Model (COM) component of MATLAB to plot charts of the three zones and to export the corresponding coordinates of the isolines. An example shows that this software is convenient and simple. By using it, the three zones can be easily determined. The software is convenient in studies and analyses of the three zones in goaf. | HE Xiao-gang ZHANG Ren-wei PEI Xiao-dong SUN Yong TONG Bo-gen HUANG Hua-shan | 2008 | Journal of China University of Mining and Technology2008，18，2： | 10 |
| 19 | Mechanical,Microstructural and Tribological Properties of Reactive Magnetron Sputtered Cr-Mo-N Films显示文摘The Cr-Mo-N films were deposited on high speed steel(HSS) substrates by a DC reactive magnetron sputtering equipment coupled with two horizontal magnetron sources.The effects of substrate negative bias voltage(V_b),substrate temperature(T_s) and gas flow ratio(R= N_2/(N_2 + Ar)) on the microstructure,morphology,as well as the mechanical and tribological properties of the Cr-Mo-N films were investigated by virtue of X-ray diffraction(XRD) analysis,X-ray photoelectron spectroscopy(XPS),field emission scanning electron microscopy(FESEM),atomic force microscopy(AFM),nano-indentation test,ball-on-disk tribometer,and Rockwell indenter et al.With increasing V_b to-100 V,the preferred orientation of the films changed from(111) to(200) and their mechanical and tribological properties were improved gradually,too.It was also found that T_s gave a significant effect on mechanical property enhancement.When the T_s reached 300 ℃,the film obtained the highest hardness and effective elastic modulus of approximately 30.1 and 420.5 GPa,respectively and its critical load increased to about 54 N.With increasing R,the phase transformation from body-centered-cubic(bcc) Cr and hexagonal CrMoN_x multiphase to single face-centered-cubic(fcc) solid solution phase was observed.The correlations between values of hardness(H),effective elastic modulus(E~*),HIE~*,H^3/E^(*2),elastic recovery(1/14) and tribological properties of the films were also investigated.The results showed that the elastic recovery played an important role in the tribological behavior. | Dongli Qi Hao Lei Tiegang Wang Zhiliang Pei Jun Gong Chao Sun | 2015 | Journal of Materials Science & Technology2015，31，1： | 10 |
| 20 | Allele-aware chromosome-level genome assembly of Artemisia annua reveals the correlation between ADS expansion and artemisinin yield显示文摘Artemisia annua is the major natural source of artemisinin,an anti-malarial medicine commonly used worldwide.Here,we present chromosome-level haploid maps for two A.annua strains with different artemisinin contents to explore the relationships between genomic organization and artemisinin production.High-fidelity sequencing,optical mapping,and chromatin conformation capture sequencing were used to assemble the heterogeneous and repetitive genome and resolve the haplotypes of A.annua.Approximately 5o,ooo genes were annotated for each haplotype genome,and a triplication event that occurred approximately 58.12million years ago was examined for the first time in this species.A total of 3,903,467-5,193,414 variants(SNPs,indels,and structural variants)were identified in the 1.5-Gb genome during pairwise comparison between haplotypes,consistent with the high heterozygosity of this species.Genomic analyses revealed a correlation between artemisinin concents and the copy number of amorpha-4,11-dienes ynthasegenes.This correlation was further confirmed by resequencing of 36A.annua samples with varied artemisinin contents.Circular consensus sequencing of transcripts facilitated the detection of paralog expression.Collectively,our study provides chromosome-level allele-aware genome assemblies for two A.annua strains and new insights into the biosynthesis of artemisinin and its regulation,which will contribute to conquering malaria worldwide. | Baosheng Liao Xiaofeng Shen Li Xiang Shuai Guo Shiyu Chen Ying Meng Yu Liang Dandan Ding Junqi Bai Dong Zhang Tomasz Czechowski Yi Li Hui Yao Tingyu Mai Caroline Howard Chao Sun Haitao Liu Jiushi Liu Jin Pei Jihai Gao Jigang Wang Xiaohui Qiu Zhihai Huang Hongyi Li Ling Yuan Jianhe Wei lan Graham Jiang Xu Boli Zhang Shilin Chen | 2022 | Molecular Plant2022，15，8： | 9 |
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