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| 1 | Updated diagnosis, treatment and prevention of COVID-19 in children: experts' consensus statement (condensed version of the second edition)显示文摘In the early February,2020,we called up an experts' committee with more than 30 Chinese experts from 11 national medical academic organizations to formulate the first edition of consensus statement on diagnosis,treatment and prevention of coronavirus disease 2019 (COVID-19) in children,which has been published in this journal.With accumulated experiences in the diagnosis and treatment of COVID-19 in children,we have updated the consensus statement and released the second edition recently.The current version in English is a condensed version of the second edition of consensus statement on diagnosis,treatment and prevention of COVID-19 in children.In the current version,diagnosis and treatement criteria have been optimized,and early identification of severe and critical cases is highlighted.The early warning indicators for severe pediatric cases have been summarized which is utmost important for clinical practice.This version of experts consensus will be valuable for better prevention,diagnosis and treatment of COVID-19 in children worldwide. | Kun-Ling Shen Yong-Hong Yang Rong-Meng Jiang Tian-You Wang Dong-Chi Zhao Yi Jiang Xiao-Xia Lu Run-Ming Jin Yue-Jie Zheng Bao-Ping Xu Zheng-De Xie Zhi-sheng Liu Xing-wang Li Li-Kai Lin Yun-Xiao Shang Sai-Nan Shu Yan Bai Min Lu Gen Lu Ji-Kui Deng Wan-Jun Luo Li-Juan Xiong Miao Liu Yu-Xia Cui Le-Ping Ye Jia-Fu Li Jian-Bo Shao Li-Wei Gao Yong-Yan Wang Xue-Feng Wang | 2020 | World Journal of Pediatrics2020，16，3： | 9 |
| 2 | Onset of Coronary Heart Disease is Associated with HCMV Infection and Increased CD14^+CD16^+Monocytes in a Population of Weifang,China显示文摘Objective To investigate the relationship between human cytomegalovirus(HCMV)infection and peripheral blood CD14+CD16+monocytes in the pathogenesis of coronary heart disease(CHD),and to elucidate the mechanism of pathogenesis in CHD by analyzing the correlation between infection,inflammation,and CHD,to provide a basis for the prevention,evaluation,and treatment of the disease.Methods In total,192 patients with CHD were divided into three groups:latent CHD,angina pectoris,and myocardial infarction.HCMV-IgM and-IgG antibodies were assessed using ELISA;CD14+CD16+monocytes were counted using a five-type automated hematology analyzer;mononuclear cells were assessed using fluorescence-activated cell sorting;and an automatic biochemical analyzer was used to measure the levels of triglyceride,cholesterol,high-and low-density lipoprotein cholesterols,lipoprotein,hs-CRp and Hcy.Results The positive rates of HCMV-IgM and-IgG were significantly higher in the CHD groups than in the control group.HCMV infection affects lipid metabolism to promote immune and inflammatory responses.Conclusion HCMV infection has a specific correlation with the occurrence and development of CHD.The expression of CD14+CD16+mononuclear cells in the CHD group was increased accordingly and correlated with acute HCMV infection.Thus,HCMV antibody as well as peripheral blood CD14+CD16+mononuclear cells can be used to monitor the occurrence and development of CHD. | LI Hong Zheng WANG Qin ZHANG Yi Yuan WANG Jin Dong WU Hong Juan ZHANG Mo Gen LI Ji Chen LIU Zhi Jun | 2020 | Biomedical and Environmental Sciences2020，33，8： | 8 |
| 3 | Traditional El Nio and El Ni o Modoki Revisited:Is El Nio Modoki Linearly Independent of Traditional El Nio?显示文摘The present study revisited the first two leading modes of tropical Pacific sea surface temperature anomalies (SSTA) during the period of 1979 2008.It is suggested that the so-called El Nio Modoki,which is captured by the second mode,exists objectively and exhibits obvious differences from traditional El Nio,which is captured by the first mode,in terms of its spatial characteristics.Furthermore,the authors found that El Nio Modoki is linearly independent of traditional El Nio;hence,it cannot be described as part of the traditional El Nio evolution,and vice versa. | LI Gen REN Bao-Hua YANG Cheng-Yun ZHENG Jian-Qiu | 2010 | Atmospheric and Oceanic Science Letters2010，3，2： | 7 |
| 4 | Doublely-doped Mg-Al-Ce-V_(2)O_(7)^(4-)LDH composite film on magnesium alloy AZ31 for anticorrosion显示文摘A doublely-doped layered double hydroxide(LDH)film was produced on an anodized magnesium alloy AZ31.The Ce-doped Mg-Al LDH film was prepared by in-situ hydrothermal treatment method,and the intercalation of vanadate was realized by ion-exchange reaction.The structure,morphology and composition of as-prepared LDH film were investigated by X-ray diffractometer,field-emission scanning electronic microscope and energy dispersive spectrometry.Results indicated that a uniform and compact LDH film was formed and the intercalation of Ce^(3+)and vanadate would change the crystal structure of LDHs.The results of the potentiodynamic polarization,electrochemical impedance spectra,hydrogen evolution and corrosion weight loss tests showed the Ce^(3+)and vanadate anions significantly improve the impedance of LDH film,and the active double-doped LDH film could effectively protect the magnesium substrate from corrosion. | Liang Wu Xingxing Ding Zhicheng Zheng Aitao Tang Gen Zhang Andrej Atrens Fusheng Pan | 2021 | Journal of Materials Science & Technology2021，，5： | 7 |
| 5 | Qualitative analysis for a Wolbachia infection model with diffusion显示文摘We consider a reaction-diffusion model which describes the spatial Wolbachia spread dynamics for a mixed population of infected and uninfected mosquitoes. By using linearization method, comparison principle and Leray-Schauder degree theory, we investigate the influence of diffusion on the Wolbachia infection dynamics.After identifying the system parameter regions in which diffusion alters the local stability of constant steadystates, we find sufficient conditions under which the system possesses inhomogeneous steady-states. Surprisingly,our mathematical analysis, with the help of numerical simulations, indicates that diffusion is able to lower the threshold value of the infection frequency over which Wolbachia can invade the whole population. | HUANG Mu Gen YU Jian She HU Lin Chao ZHENG Bo | 2016 | Science China Mathematics2016，59，7： | 6 |
| 6 | A New Alkaloid from Patrinia scabra显示文摘A new alkaloid has been isolated from the root of Patrinia scabra. Its structure was elucidated as 2-acetamido-3-phenyl propyl 2-benzamido-3-phenyl propionate by extensive spectr- oscopic analysis. | Zheng Bing GU*, Gen Jin YANG, Wen Yong LIU, Ting Zhao LI, Yan QIU, Wei Dong ZHANG College of Pharmacy, Second Military Medical University, Shanghai 200433 | 2002 | Chinese Chemical Letters2002，13，10： | 5 |
| 7 | MAP4K4 induces early blood-brain barrier damage in a murine subarachnoid hemorrhage model显示文摘Sterile-20-like mitogen-activated protein kinase kinase kinase kinase 4(MAP4 K4)is expressed in endothelial cells and activates inflammatory vascular damage.Endothelial cells are important components of the blood-brain barrier.To investigate whether MAP4 K4 plays a role in the pathophysiology of subarachnoid hemorrhage,we evaluated the time-course expression of MAP4 K4 after subarachnoid hemorrhage.A subarachnoid hemorrhage model was established using the intravascular perforation method.The model mice were assigned to four groups:MAP4 K4 recombinant protein,scramble small interfering RNA,and MAP4 K4 small interfering RNA were delivered by intracerebroventricular injection,while PF-06260933,a small-molecule inhibitor of MAP4 K4,was administrated orally.Neurological score assessments,brain water assessments,Evans blue extravasation,immunofluorescence,western blot assay,and gelatin zymography were performed to analyze neurological outcomes and mechanisms of vascular damage.MAP4 K4 expression was elevated in the cortex at 24 hours after subarachnoid hemorrhage,and colocalized with endothelial markers.MAP4 K4 recombinant protein aggravated neurological impairment,brain edema,and blood-brain barrier damage;upregulated the expression of phosphorylated nuclear factor kappa B(p-p65)and matrix metalloproteinase 9(MMP9);and degraded tight junction proteins(ZO-1 and claudin 5).Injection with MAP4 K4 small interfering RNA reversed these effects.Furthermore,administration of the MAP4 K4 inhibitor PF-06260933 reduced blood-brain barrier damage in mice,promoted the recovery of neurological function,and reduced p-p65 and MMP9 protein expression.Taken together,the results further illustrate that MAP4 K4 causes early blood-brain barrier damage after subarachnoid hemorrhage.The mechanism can be confirmed by inhibiting the MAP4 K4/NF-κB/MMP9 pathway.All experimental procedures and protocols were approved by the Experimental Animal Ethics Committee of General Hospital of Northern Theater Command(No.2018002)on January 15,2018. | Zheng Zou Yu-Shu Dong Dong-Dong Liu Gen Li Guang-Zhi Hao Xu Gao Peng-Yu Pan Guo-Biao Liang | 2021 | Neural Regeneration Research2021，16，2： | 5 |
| 8 | Negishi Coupling for Highly Selective Syntheses of Allenes via Ligand Effect and Mechanistic Study via SAESI-MS/MS显示文摘β-H elimination is an intrinsic problem in transition metal-catalyzed reactions.We describe herein an interesting ligand effect for Et2Zn acting as either ethyl provider or H provider,respectively:by applying SPhos or Gorlos-Phos as the ligand,β-H elimination has been successfully controlled in the corresponding Negishi coupling reaction affording different poly-substituted allenes in good yields and excellent selectivities.SAESI-MS (Solvent Assisted Electrospray Ionization Mass Spectrometry) has been applied to successfully capture the highly reactive organometallic intermediates,which show the different coordination behaviors of Pd with SPhos or Gorlos-Phos as the ligand in the catalytic cycle.In addition,the different reactivities of Int 1 and Int 2 towards the formation of the final allene products have been demonstrated via SAESI-MS/MS experiments.These MS studies visualized the whole catalytic cycle for the Negishi coupling reaction while nicely explain the observed reactivity and selectivity. | Yangguangyan Zheng Bukeyan Miao Anni Qin Junzhe Xiao Qi Liu Gen Li Li Zhang Fang Zhang Yinlong Guo Shengming Ma | 2019 | Chinese Journal of Chemistry2019，37，10： | 5 |
| 9 | An Adaptive SVP Simplification Based on Area Difference显示文摘Sound velocity profile(SVP)data is indispensable in the multi-beam data processing.The sampling density is of great importance for SVP to represent the vertical variation of sound velocity accurately and guarantee the accuracy of sound ray tracing(SRT).However,the SVP also affects the SRT efficiency significantly,especially in deep-sea multi-beam sounding data processing.To improve SRT efficiency and ensure SRT accuracy,an adaptive SVP simplification method based on area difference is proposed in this article.Firstly,the relationship between the area difference of the raw SVP and the simplified one and SRT bias is studied,and the relationship model of them is built.Then,by considering the constraint of SRT accuracy,the SVP simplification method and the simplifying SVP procedure SVP are given.Finally,a deep water experiment is conducted to verify the proposed method.Compared to the existing method,the proposed method improves the robustness,feasibility of SVP simplification as well as the accuracy and efficiency of SRT. | Gen ZHENG Jianhu ZHAO Hongmei ZHANG | 2019 | Journal of Geodesy and Geoinformation Science2019，2，4： | 4 |
| 10 | Effects of the momentum dependence of nuclear symmetry potential on pion observables in Sn+Sn collisions at 270 MeV/nucleon显示文摘Within a transport model,we investigated the effects of the momentum dependence of the nuclear symmetry potential on the pion observables in central Sn+Sn collisions at 270 MeV/nucleon.To this end,the quantity U^(∞)_(sym)(ρ_(0))(i.e.,the value of the nuclear symmetry potential at the saturation densityρ_(0) and infinitely large nucleon momentum)was used to characterize the momentum dependence of the nuclear symmetry potential.With a certain L(i.e.,the slope of the nuclear symmetry energy at(ρ_(0))),the characteristic parameter U^(∞)_(sym)(ρ_(0))of the symmetry potential significantly affects the production of−and+and their pion ratios.Moreover,by comparing the charged pion yields,pion ratios,and spectral pion ratios of the theoretical simulations for the reactions ^(108) Sn+^(112) Sn and ^(132)Sn+^(124)Sn with the corresponding data in the SRIT experiments,we found that our results favor a constraint on U^(∞)_(sym)(ρ_(0))(i.e.,−160_(−9)^(+18) MeV),and L is also suggested within a range of 62.7 MeV | Gao‑Feng Wei Xin Huang Qi‑Jun Zhi Ai‑Jun Dong Chang‑Gen Peng Zheng‑Wen Long | 2022 | Nuclear Science and Techniques2022，33，12： | 3 |
| 11 | Inhibitory Effect of Extracellular Polysaccharide EPS-II from Pseudoalteromonas on Candida adhesion to Cornea in vitro显示文摘Objective Fungal keratitis(FK) is a vision-threatening infection,whose treatment requires more effective and safer anti-fungal agent exploitation urgently.With this aim,we focused on the effect of an extracellular polysaccharide on fungal adhesion to human corneal epithelial cells.Methods We performed the cytotoxicity assays of the extracellular polysaccharide EPS-II from an antarctic bacterium Pseudoaltermonas and evaluated its inhibitory effect on Candida albicans cells' adherence to human corneal epithelial cells(HCECs).Results EPS-II,which displayed minor cytotoxicity but also promoted proliferation of HCECs,could inhibit the adherence of yeast cells to HCECs in a dose-dependent manner.EPS-II could also suppress the subsequent PI3K/AKT signaling pathway,and thereby decrease the expression of early inflammatory cytokines.Conclusions ExtracellularpolysaccharideEPS-IIwassuggestedasanewnaturalagentforattenuatingFK. | CHEN Hao ZHENG Zhou CHEN Peng WU Xiang Gen ZHAO Ge | 2012 | Biomedical and Environmental Sciences2012，25，2： | 2 |
| 12 | Microcrystallization and lattice contraction of NiFe LDHs for enhancing water electrocatalytic oxidation显示文摘The lattice-oxygen-mediated mechanism is considered as a reasonable mechanism for the electrochemical catalytic oxygen evolution reaction(OER)of NiFe layered double hydroxides(LDHs).A NiFe LDH with distinct lattice contraction and microcrystallization was synthesized via a simple one-step method using sodium gluconate.The lattice contraction is attributed to the interaction of carbon in sodium gluconate and iron in NiFe LDH.The NiFe LDH with optimized microcrystallization and lattice contraction shows a low overpotential of 217 mV at a current density of 10 mA cm^(−2) and excellent durability of 20 h at a high current density of 100 mA cm^(−2).The results revealed that a contractive metal–oxygen bond could boost the intrinsic activity of active sites and the microcrystallization promotes an increase in the number of active sites in terms of unit area.The chemical environment of oxygen elemental characterization and resistance at different chronopotentiometry times confirm that the lattice oxygen element is indeed involved in the process of OER,supporting the lattice-oxygen-mediated mechanism of NiFe LDH.Density functional theory calculations reveal that contractive metal–oxygen bonds induced a reduction of the adsorption energy barrier of intermediate products,thus improving the intrinsic catalytic activity.The special characteristics of microcrystallization and lattice contraction of NiFe LDH provide a strategy to improve both the number and the intrinsic activity of active sites in a versatile manner. | Zhicheng Zheng Dan Wu Gen Chen Ning Zhang Hao Wan Xiaohe Liu Renzhi Ma | 2022 | Carbon Energy2022，4，5： | 2 |
| 13 | Oral acyclovir induced acute renal failure显示文摘BACKGROUND: The study aimed to investigate the clinical characteristics of acute renal failure(ARF) caused by oral acyclovir.METHODS: A 45-year-old Chinese male patient with acyclovir-induced ARF suffered fromabdominal pain for one day. The pain was extended to the epigastric area from the right lowerquadrant. Transient oliguria was seen in addition to microscopic hematuria and proteinuria. Theserum creatinine concentration was 304 !mol/L. Eight days before the occurrence of ARF, the patienttook oral acyclovir for facial neuritis.RESULTS: His renal function was restored completely following the discontinuation of acyclovir,with continuous renal replacement therapy for 54 hours and some symptomatic treatment.CONCLUSION: The presentation of acute renal failure caused by acyclovir can be diverse, butthe prognosis is good after active treatment. | Jian-biao Meng Xia Zheng Gen Zhang Qiang Fang | 2011 | World Journal of Emergency Medicine2011，2，4： | 2 |
| 14 | The interferon-stimulated exosomal hACE2 potently inhibits SARS-CoV-2 replication through competitively blocking the virus entry显示文摘Since the outbreak of coronavirus disease 2019(COVID-19),it has become a global pandemic.The spike(S)protein of etiologic severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)specifically recognizes human angiotensin-converting enzyme 2(hACE2)as its receptor,which is recently identified as an interferon(IFN)-stimulated gene.Here,we find that hACE2 exists on the surface of exosomes released by different cell types,and the expression of exosomal hACE2 is increased by IFNα/β treatment.In particular,exosomal hACE2 can specifically block the cell entry of SARS-CoV-2,subsequently inhibit the replication of SARS-CoV-2 in vitro and ex vivo.Our findings have indicated that IFN is able to upregulate a viral receptor on the exosomes which competitively block the virus entry,exhibiting a potential antiviral strategy. | Junsong Zhang Feng Huang Baijin Xia Yaochang Yuan Fei Yu Guanwen Wang Qianyu Chen Qian Wang Yuzhuang Li Rong Li Zheng Song Ting Pan Jingliang Chen Gen Lu Hui Zhang | 2021 | Signal Transduction and Targeted Therapy2021，6，6： | 2 |
| 15 | An application of fuzzy set theory to inventory control models 显示文摘 | Gen M Tsujimura Y Zheng D Z | 1997 | Computers and Industrial Engineering1997，33，34： | 1 |
| 16 | Role of microRNA let-7 and effect to HMGA2 in esophageal squamous cell carcinoma显示文摘 | Qing Liu Guo-dong Lv Xu Qin Yue-hua Gen Shu-tao Zheng Tao Liu Xiao-mei Lu | 2012 | Molecular Biology Reports2012，，2： | 1 |
| 17 | Anchoring Active Sites by Pt_(2)FeNi Alloy Nanoparticles on NiFe Layered Double Hydroxides for Efficient Electrocatalytic Oxygen Evolution Reaction显示文摘Strategy of anchoring alloy nanoparticles made up of the efficient catalytic element(e.g.,Ni,Fe)on dodecyl sulfate(DS^(-))-intercalated NiFe layered double hydroxides(DS^(-)-NiFe LDH)obtained by a convenient one-step hydrothermal coprecipitation method for essentially enhancing oxygen evolution reaction(OER)performance was proposed.The results of structural characterization indicate Pt_(2)FeNi alloy nanoparticles evenly distribute on the surface of DS^(-)-NiFe LDH.The sizes of the Pt_(2)FeNi nanoparticles,closely related to their OER performance,could be wellcontrolled by adjusting the amount of H;PtCl;addition.The composite structure of as-prepared product was stable during processes of synthesis,exfoliation,self-assembly,and subsequent electrocatalytic OER.Rigorous electrochemical test proving the contributing catalytic active sites was located at the interface between Pt_(2)FeNi and DS^(-)-NiFe LDH,and the Ni and Fe were the major active elements while O atoms are adsorption sites.The formation of Pt_(2)FeNi nanoparticles could greatly prompt the reduction of Tafel slope.The best-performing Pt_(2)FeNi/DS^(-)-NiFe LDH with a Pt content of 0.98 wt%achieved low overpotential of 204 mV at 10 mA cm^(-2)and 262 mV at 50 mA cm^(-2).This work provides a convenient and effective strategy to create additional active sites for enhancing OER performance of NiFe LDH and make contribution to its wide application. | Zhicheng Zheng Yanru Guo Hao Wan Gen Chen Ning Zhang Wei Ma Xiaohe Liu Shuquan Liang Renzhi Ma | 2022 | Energy & Environmental Materials2022，5，1： | 1 |
| 18 | Multiobjective optimization using genetic algorithm显示文摘 | ZHENG D GEN M CHENG R | 1998 | Engineering Valuation and Cost Analysis1998，2，： | 1 |
| 19 | Controlof Orbitand Controlof Chaosina Class of Dynamic System显示文摘The problem of control of orbit for the dynamic system x ¨+x(1-x)(x-a)=0 is discussed. Any unbounded orbit of the dynamic system can be controlled to become a bounded periodic orbit by adding a periodic step excitation to the system. By using a nonlinear feedback control law presented in this paper the chaos of the dynamic system with excitation and damping is stabilized. This method is more effectual than the linear feedback control. | LI Gen guo (Shanghai Institute of Applied Mathematics and Mechanics, Shanghai University) ZHU Zheng you (Shanghai Institute of Applied Mathematics and Mechanics College of Sciences, Shanghai University) | 1999 | Advances in Manufacturing1999，，4： | 1 |
| 20 | Synthesis and Characterization of the Tetrazole Analogues of α-Amino Acids显示文摘The tetrazole analogues have been synthesized from fluorenylmethoxycarbonyl (Fmoc)- protected amino acids by three steps. The structures of the analogues were characterized by HPLC-MS, 1H NMR and 13C NMR. | Yah Min HUO Gen Hu LEI Yin Mao WEI Xiao Hui ZHENG | 2006 | Chinese Chemical Letters2006，17，12： | 1 |
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