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| 1 | C-reactive protein is a prognostic indicator in patients with perihilar cholangiocarcinoma显示文摘AIM: To evaluate prognostic indicators for the outcome of patients with perihilar extrahepatic cholangiocarcinoma in an unselected cohort. METHODS: We retrospectively analyzed 98 patients with perihilar cholangiocarcinoma. Twenty-three patients (23.5%) underwent tumor resection. Patients with non- resectable tumors underwent either transpapillary or percutaneous transhepatic biliary drainage. Additionally, 32 patients (32.7%) received photodynamic therapy (PDT) and 18 patients (18.4%) systemic chemotherapy. Predefined variables at the time of diagnosis and characteristics considering the mode of treatment were entered into a Cox’s proportional hazards model. Included in the analysis were age, tumor stage following the modified Bismuth-Corlette classification, bilirubin, prothrombin time (PT), C-reactive protein (CRP), carbohydrate antigen 19-9 (CA19-9), history of weight loss, surgical resection, chemotherapy and PDT. RESULTS: The Kaplan-Meier estimate of overall median survival was 10.5 (95%CI: 8.4-12.6) mo. In the univariate analysis, low Bismuth stage, low CRP and surgical resection correlated significantly with better survival. In the multivariate analysis, only CRP (P = 0.005) and surgical resection (P = 0.029) were found to be independently predictive of survival in the cohort. Receiver operating characteristic (ROC) analysis identified a CRP level of 11.75 mg/L as the value associated with the highest sensitivity and specificity predicting a survival > 5 mo. Applying Kaplan-Meier analysis, patients with a CRP < 12 mg/L at the time of diagnosis had a signifi cantly longer median survival than patients with higher values (16.2 vs 7.6 mo; P = 0.009).CONCLUSION: This retrospective analysis identif ied CRP level at the time of diagnosis as a novel indicator for the prognosis of patients with perihilar cholangiocarcinoma. It should be evaluated in future prospective trials on this entity. | Thomas Gerhardt Sabine Milz Michael Schepke Georg Feldmann Martin Wolff Tilman Sauerbruch Franz Ludwig Dumoulin | 2006 | World Journal of Gastroenterology2006，12，34： | 5 |
| 2 | The Cost-Effectiveness of Neoadjuvant Chemoradiation is Superior to a Surgery-First Approach in the Treatment of Pancreatic Head Adenocarcinoma显示文摘 | Daniel E. Abbott Ching-Wei David Tzeng Ryan P. Merkow Scott B. Cantor George J. Chang Matthew Harold Katz David J. Bentrem Karl Y. Bilimoria Christopher H. Crane Gauri R. Varadhachary James L. Abbruzzese Robert A. Wolff Jeffrey E. Lee Douglas B. Evans Jas | 2013 | Annals of Surgical Oncology2013，，3： | 3 |
| 3 | STAT3 inhibition sensitizes colorectal cancer to chemoradiotherapy in vitro and in vivo显示文摘 | Melanie Spitzner Birte Roesler Christian Bielfeld Georg Emons Jochen Gaedcke Hendrik A. Wolff Margret Rave‐Fr?nk Frank Kramer Tim Beissbarth Julia Kitz Jürgen Wienands B. Michael Ghadimi Reinhard Ebner Thomas Ried Marian Grade | 2014 | Int J Cancer2014，，4： | 2 |
| 4 | Smile Design and Treatment Planning With the Help of a Comprehensive Esthetic Evaluation Form显示文摘 | John R. Calamia Jonathan B. Levine Mitchell Lipp George Cisneros Mark S. Wolff | 2011 | Dental Clinics of North America2011，，2： | 1 |
| 5 | Preoperative chemoradiotherapy with capecitabine versus protracted infusion 5-fluorouracil for rectal cancer: A matched-pair analysis显示文摘 | Prajnan Das Edward H. Lin Sumita Bhatia John M. Skibber Miguel A. Rodriguez-Bigas Barry W. Feig George J. Chang Paulo M. Hoff Cathy Eng Robert A. Wolff Marc E. Delclos Sunil Krishnan Nora A. Janjan Christopher H. Crane | 2006 | International Journal of Radiation Oncology Biology Physics2006，，5： | 1 |
| 6 | Global carbon isotopic events associated with mass extinction and glaciation in the late Ordovician显示文摘 | James D Marshall Patrick J Brenchley Paul Mason George A Wolff Ricardo A Astini Linda Hints T?nu Meidla | 1997 | Palaeogeography Palaeoclimatology Palaeoecology1997，，1： | 1 |
| 7 | Phase II Trial of Neoadjuvant Bevacizumab, Capecitabine, and Radiotherapy for Locally Advanced Rectal Cancer显示文摘 | Christopher H. Crane Cathy Eng Barry W. Feig Prajnan Das John M. Skibber George J. Chang Robert A. Wolff Sunil Krishnan Stanley Hamilton Nora A. Janjan Dipen M. Maru Lee M. Ellis Miguel A. Rodriguez-Bigas | 2010 | International Journal of Radiation Oncology Biology Physics2010，，3： | 1 |
| 8 | Structural design actions to mitigate bridge deck cracking显示文摘 | George E Ramey Angela R Wolff Randall L Wright | 1997 | Practice Periodical on Structural Design1997，2，3： | 1 |
| 9 | National Institutes of Health Consensus Development Project on Criteria for Clinical Trials in Chronic Graft-versus-Host Disease: I. The 2014 Diagnosis and Staging Working Group Report显示文摘 | Madan H. Jagasia Hildegard T. Greinix Mukta Arora Kirsten M. Williams Daniel Wolff Edward W. Cowen Jeanne Palmer Daniel Weisdorf Nathaniel S. Treister Guang-Shing Cheng Holly Kerr Pamela Stratton Rafael F. Duarte George B. McDonald Yoshihiro Inamoto Afons | 2014 | Biology of Blood and Marrow Transplantation2014，，： | 1 |
| 10 | The addition of erlotinib to gemcitabine and cisplatin does not appear to improve median survival in metastatic pancreatic cancer显示文摘 | Mohamed A. Khalil Wei Qiao Peter Carlson Binsah George Milind Javle Michael Overman Gauri Varadhachary Robert A. Wolff James L. Abbruzzese David R. Fogelman | 2013 | Investigational New Drugs2013，，5： | 1 |
| 11 | Adipose stem cell (ASC) tissue engineered construct used to treat large anterior mandibular defect: A case report and review of the clinical application of GMP-level ASCs for bone regeneration显示文摘 | George K. Sándor Veikko J. Tuovinen Jan Wolff Mimmi Patrikainen Jari Jokinen Elina Nieminen Bettina Mannerstr?m Olli-Pekka Lappalainen Riitta Suuronen Susanna Miettinen | 2012 | Journal of Oral and Maxillofacial Surgery2012，，： | 1 |
| 12 | Long‐term results of weekly/daily cisplatin‐based chemoradiation for locally advanced squamous cell carcinoma of the anal canal显示文摘 | Cathy Eng George J. Chang Y. Nancy You Prajnan Das Yan Xing Marc Delclos Robert A. Wolff Miguel A. Rodriguez‐Bigas John Skibber Aki Ohinata Spencer Gould Jonathan Phillips Christopher H. Crane | 2013 | Cancer2013，，21： | 1 |
| 13 | Patterns of Locoregional Recurrence After Surgery and Radiotherapy or Chemoradiation for Rectal Cancer显示文摘 | Tse-Kuan Yu Priya R. Bhosale Christopher H. Crane Revathy B. Iyer John M. Skibber Miguel A. Rodriguez-Bigas Barry W. Feig George J. Chang Cathy Eng Robert A. Wolff Nora A. Janjan Marc E. Delclos Sunil Krishnan Prajnan Das | 2008 | International Journal of Radiation Oncology Biology Physics2008，，4： | 1 |
| 14 | Red cell distribution width in anemic patients undergoing transcatheter aortic valve implantation显示文摘AIM: To determine the impact of red blood cell distribution width on outcome in anemic patients undergoing transcatheter aortic valve implantation(TAVI).METHODS: In a retrospective single center cohort study we determined the impact of baseline red cell distribution width(RDW) and anemia on outcome in 376 patients with aortic stenosis undergoing TAVI. All patients were discussed in the institutional heart team and declined for surgical aortic valve replacement due to high operative risk. Collected data included patient characteristics, imaging findings, periprocedural in hospital data, laboratory results and follow up data. Blood samples for hematology and biochemistry analysis were taken from every patient before and at fixed intervals up to 72 h after TAVI including blood count and creatinine. Descriptive statistics were used for patient's characteristics. KaplanMeier survival curves were used for time to event outcomes. A recursive partitioning regression and classification was used to investigate the association between potential risk factors and outcome variables.RESULTS: Mean age in our study population was 81 ± 6.1 years. Anemia was prevalent in 63.6%(n = 239) of our patients. Age and creatinine were identified as risk factors for anemia. In our study population, anemia per se did influence 30-d mortality but did not predict longterm mortality. In contrast, a RDW > 14% showed to be highly predictable for a reduced short- and longterm survival in patients with aortic valve disease after TAVI procedure.CONCLUSION: Age and kidney function determine the degree of anemia. The anisocytosis of red blood cells in anemic patients supplements prognostic information in addition to that derived from the WHO-based definition of anemia. | Katharina Hellhammer Tobias Zeus Pablo E Verde Verena Veulemanns Lisa Kahlstadt Georg Wolff Ralf Erkens Ralf Westenfeld Eliano P Navarese Marc W Merx Tienush Rassaf Malte Kelm | 2016 | World Journal of Cardiology2016，8，2： | 0 |
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